safety evaluation of polyethylene glycol (peg) compounds

105

Toxicol. Res.Vol. 31, No. 2, pp. 105-136 (2015)

http://dx.doi.org/10.5487/TR.2015.31.2.105plSSN: 1976-8257 eISSN: 2234-2753 Thematic Perspectives

Open Access

Safety Evaluation of Polyethylene Glycol (PEG)Compounds for Cosmetic Use

Hyun-Jun Jang1, Chan Young Shin2 and Kyu-Bong Kim1

1College of Pharmacy, Dankook University, Cheonan, Korea2Department of Neuroscience, School of Medicine, Konkuk University, Seoul, Korea

(Received June 10, 2015; Revised June 17, 2015; Accepted June 29, 2015)

Polyethylene glycols (PEGs) are products of condensed ethylene oxide and water that can have various

derivatives and functions. Since many PEG types are hydrophilic, they are favorably used as penetration

enhancers, especially in topical dermatological preparations. PEGs, together with their typically nonionic

derivatives, are broadly utilized in cosmetic products as surfactants, emulsifiers, cleansing agents, humec-

tants, and skin conditioners. The compounds studied in this review include PEG/PPG-17/6 copolymer,

PEG-20 glyceryl triisostearate, PEG-40 hydrogenated castor oil, and PEG-60 hydrogenated castor oil.

Overall, much of the data available in this review are on PEGylated oils (PEG-40 and PEG-60 hydroge-

nated castor oils), which were recommended as safe for use in cosmetics up to 100% concentration. Cur-

rently, PEG-20 glyceryl triisostearate and PEGylated oils are considered safe for cosmetic use according to

the results of relevant studies. Additionally, PEG/PPG-17/6 copolymer should be further studied to ensure

its safety as a cosmetic ingredient.

Key words: Polyethylene glycol (PEG), PEG compound, Safety evaluation

INTRODUCTION

Polyethylene glycols (PEGs) are composed of polyether

compounds repeating ethylene glycol units according to the

constituent monomer or parent molecule (as ethylene gly-

col, ethylene oxide, or oxyethylene) (Fig. 1). Most PEGs

are commonly available commercially as mixtures of differ-

ent oligomer sizes in broadly- or narrowly-defined molecu-

lar weight (MW) ranges. For instance, PEG-10,000 typically

designates a mixture of PEG molecules (n = 195 to 265)

having an average MW of 10,000. PEG is also known as

polyethylene oxide (PEO) or polyoxyethylene (POE), with

the three names being chemical synonyms. However, PEGs

mainly refer to oligomers and polymers with molecular

masses below 20,000 g/mol, while PEOs are polymers with

molecular masses above 20,000 g/mol, and POEs are poly-

mers of any molecular mass. Relatively small molecular

weight PEGs are produced by the chemical reaction between

ethylene oxide and water or ethylene glycol (or other eth-

ylene glycol oligomers), as catalyzed by acidic or basic cat-

alysts. To produce PEO or high-molecular weight PEGs,

synthesis is performed by suspension polymerization. It is

necessary to hold the growing polymer chain in solution

during the course of the poly-condensation process. The

reaction is catalyzed by magnesium-, aluminum-, or cal-

cium-organoelement compounds. To prevent coagulation of

polymer chains in the solution, chelating additives such as

dimethylglyoxime are used (1).

PEGs, together with their derivatives, do not have defi-

nite chemical entities, rather, they are compound mixtures

having different chain lengths. PEGs are used in cosmetics

“as is” or in combination with their derivatives in which

their 2 terminal primary hydroxyl groups can create mono-,

di- and poly-esters, amines, ethers and acetals. Further-

more, PEGs can create additional compounds and com-

plexes through a reaction in their ether bridges. Overall,

PEG derivatives may include PEG ethers (e.g. laureths,

ceteths, ceteareths, oleths, and PEG ethers of glyceryl

cocoates), PEG fatty acids (e.g. PEG laurates, dilaurates,

stearates, and distearates), PEG castor oils, PEG amine

Correspondence to: Kyu-Bong Kim, College of Pharmacy, Dank-ook University, 119 Dandae-ro, Cheonan, Chungnam 330-714,KoreaE-mail: [email protected]

Abbreviation: CIR, Cosmetic Ingredient Review; IgG, immunoglob-ulin G; PEGs, polyethylene glycols; PEO, polyethylene oxide; POE,polyoxyethylene; PPG, polypropylene glycol; S-D, Sprague-Dawley.

This is an Open-Access article distributed under the terms of theCreative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestrictednon-commercial use, distribution, and reproduction in anymedium, provided the original work is properly cited.

106 H.-J. Jang et al.

ethers (PEG cocamines), PEG propylene glycols, and other

derivates (e.g., PEG soy sterols and PEG beeswax). Since

many PEG types are hydrophilic, they are favorably used as

penetration enhancers, especially in topical dermatological

preparations (2). Polyethylene glycols (PEGs) and their

derivatives are widely used in cosmetics as surfactants,

cleansing agents, emulsifiers, skin conditioners, and humec-

tants.

Adding to their use in cosmetics, many PEG compounds

also have other applications. Available information from

these uses is included in this assessment where relevant. In

the pharmaceutical industry, for instance, they are used as

ointment bases or vehicles for drugs in capsules, tablet and

pill binders, suppositories, and liquid prescriptions; and in

veterinary drugs as part of parenteral, topical, ophthalmic,

oral, and rectal preparations. Further various applications

were found in soaps and detergents, wood preservation,

printing, chemical mixtures, as well as in industries that

produces textiles, leather, plastics, resins, paper, ceramics,

glass, rubber, petroleum, and metal. Polyoxyethylene sorbi-

tan esters (polysorbates) and polyethylene glycol, with an

average molecular weight of 6,000, are permitted as food

additives in various food products (3,4).

In previous studies, PEGs and various PEG compounds

have been reviewed and assessed well to be concluded as

relatively safe for use in cosmetics under the present condi-

tions of intended use (3,5,6). However, all PEG compounds

were not covered in the previous studies due to their wide

variety, and the introduction of new entities currently used

in cosmetics suggests supplementary evaluation. Thus, it is

essential to continuously monitor the safety and risks of

PEG-derived products being exposed to consumers using

cosmetic products to ensure that no potential health threats

will arise, especially when used extensively and chron-

ically. In this review, we searched for and enumerated the

PEG polymers and their derivatives that are used in cosmet-

ics (Table 1) in order to evaluate the safety of their applica-

tion according to the currently available information in the

literature.

PEG COMPOUNDS FOR COSMETIC USE

PEG/PPG-17/6 copolymer. PEG/PPG-17/6 copolymer

is a randomly produced chemical comprised of an average

of 17 ethylene glycol repeats and 6 propylene glycol repeats

(7). This mixture does not have a specific CAS number,

rather, it is found to be included in the generic CAS num-

ber 9003-11-6, belonging to the general group of “poloxam-

ers”. A cosmetic ingredient review regarding alkyl PEG-

PPG ethers has been conducted, however it was not speci-

fied whether PEG/PPG-17/6 copolymer is a related mixture

based on the given list (8). Accordingly, little is known

about the toxicological properties of PEG/PPG-17/6 copo-

lymer and thus, studies reflected in this review may be

Fig. 1. Polimerization of ethylene glycol.

Safety Assessment of Polyethylene Glycol Compounds 107

Tabl

e1.

PEG

pol

ymer

s an

d th

eir d

eriv

ativ

es in

cos

met

ic

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

PE

G-2

Alm

ond G

lyce

rides

MU

LS

IFA

N C

AO

02

Co-e

muls

ifie

r. I

t is

an e

thoxyla

ted, vir

gin

alm

ond o

il w

ith

non-i

onic

char

acte

r use

d f

or

the

pre

par

atio

n o

f w

/o e

mul-

sions.

Cas

tor

Oil

61791-1

2-6

;

107853-2

8-1

Em

uls

ifyin

g a

gen

ts a

nd s

urf

acta

nts

.

Coca

min

e61791-1

4-8

;

12610-1

5-0

PE

G-2

CO

CA

MIN

ES

abopal

NC

2A

lkal

ine

emuls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Dil

aura

te9005-0

2-0

1P

egosp

erseTM

200 D

L

Nonio

nic

em

uls

ifie

r fo

r neu

tral

and m

ildly

alk

alin

e an

d

acid

ic s

yst

ems.

It

is a

flu

id e

muls

ifie

r, d

isper

sant

and

spre

adin

g a

gen

t.

Dim

eadow

foam

amid

o

ethylm

oniu

m

Met

hosu

lfat

e

PE

G-2

DIM

EA

DO

WF

OA

MA

MID

OE

TH

YL

MO

NIU

M M

ET

HO

SU

LFA

TE

Mea

dow

quat

® H

G

Pro

duce

d b

y r

eact

ing m

eadow

foam

see

d o

il t

o f

orm

this

sulf

ated

(nonch

lori

de)

quat

erniu

m c

om

pound f

or

enhan

c-

ing t

he

condit

ionin

g e

ffec

ts o

f m

eadow

foam

ate.

Dis

tear

ate

109-3

0-8

P

EG

-2 D

IST

EA

RA

TE

Dub D

SD

EG

Em

uls

ifie

r. U

sed i

n c

osm

etic

pro

duct

s.

Hydro

gen

ated

Cas

tor

Oil

61788-8

5-0

;

113148-9

8-4

Em

uls

ifie

r.

Hydro

gen

ated

Tal

low

amin

e

PE

G-2

HY

DR

OG

EN

AT

ED

TA

LL

OW

AM

INE

Pro

tox T

-2

Use

d i

n s

ham

poos.

Em

uls

ifie

r, a

nti

-irr

itan

t, n

eutr

aliz

ing

agen

t, a

nti

-sta

tic

agen

t, a

foam

boost

er a

nd a

mil

d d

eter

-

gen

t.

Lau

rate

SE

Em

uls

ifie

rs.

Mil

k S

oli

dG

AL

AC

TE

NE

Em

oll

ient.

Use

d f

or

del

icat

e an

d d

ry s

kin

s, s

oap

s, s

yndet

s,

sham

poos.

Avai

lable

in p

ow

der

form

.

Ole

amin

eP

EG

-2 O

LE

AM

INE

Sab

opal

NO

2U

sed f

or

alkal

ine

emuls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Ole

ate

106-1

2-7

PE

G-2

OL

EA

TE

Nik

kol

MY

O-2

Lip

ophil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

Soyam

ine

61791-2

4-0

PE

G-2

SO

YA

MIN

EP

roto

x S

-2;

Eth

om

een®

SV

/12

Use

d i

n s

ham

poos.

Em

uls

ifie

r, a

nti

-irr

itan

t, n

eutr

aliz

ing

agen

t, a

nti

-sta

tic

agen

t, a

foam

boost

er a

nd a

mil

d d

eter

-

gen

t.

Ste

arat

e106-1

1-6

P

EG

-2 S

TE

AR

AT

EN

ikkol

MY

S-2

Lip

ophil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

Ste

aryl

Eth

er9005-0

0-9

Acc

onon®

SA

-2U

sed i

n t

he

form

ula

tion o

f co

smet

ic O

/W o

r W

/O e

mul-

sions

in c

om

bin

atio

n w

ith o

ther

em

uls

ifie

rs.

Tal

low

amin

e61791-2

6-2

P

EG

-2 T

AL

LO

W

AM

INE

Het

oxam

ine

T-2

;

Sab

opal

NS

2

Anti

-sta

tic

agen

t an

d a

s em

uls

ifie

r fo

r w

axes

and o

ils.

It

is

form

ed b

y t

he

reac

tion o

f fa

tty p

rim

ary a

min

es w

ith e

th-

yle

ne

oxid

e.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

Dis

odiu

m

ole

amid

o

PE

G-2

Sulf

osu

ccin

ate

Cola

® M

ate

OPA

-30

Char

acte

rize

d b

y m

ildnes

s an

d t

he

abil

ity t

o m

oder

ate

the

irri

tati

on o

f an

ionic

s on t

he

skin

.

PE

G-3

C12-1

8 A

lcohol

ISO

XA

L -

5

O/W

and w

/o e

muls

ifie

r an

d s

olu

bil

izer

. U

sed i

n s

kin

oil

s,

anhydro

us

pre

pra

tions,

mic

roem

uls

ions,

bat

h o

ils

and d

eco-

rati

ve

cosm

etic

s.

Cas

tor

Oil

61791-1

2-6

;

107853-2

8-1

Em

uls

ifie

rs a

nd s

urf

acta

nts

.

Dic

apry

late

/Dic

apra

te68583-5

2-8

PE

G-3

DIC

AP

RY

LA

TE

/

CA

PR

AT

E

Dub 8

10 T

EG

Em

oll

ient.

Use

d i

n c

osm

etic

pro

duct

s.

Dim

ethic

one

Em

uls

il®

S-3

91

Wat

er s

olu

ble

sil

icone

copoly

ol

surf

acta

nt

use

d a

s pla

sti-

cize

r an

d s

olu

bil

izer

in c

osm

etic

syst

ems.

Use

d i

n h

air,

skin

and b

ody c

are.

Dis

tear

ate

91031-4

5-7

;

9005-0

8-7

;

25062-4

9-1

PP

G-5

-LA

UR

ET

H-5

;

PE

G-3

DIS

TE

AR

AT

E

Cuti

na®

TS

; T

egin

® D

1102;

Nik

kol

Est

epea

rl 3

0V

;

Gen

apol®

TS

Pow

der

Opac

ifyin

g a

gen

t an

d p

earl

iese

r fo

r th

e pre

par

atio

n o

f su

r-

fact

ant

was

hin

g a

nd c

lean

sing p

repar

atio

ns.

Lau

ryl

Eth

erG

LY

CO

LE

NE

O/w

type

emuls

ifie

r, s

olu

bil

izer

, em

oll

ient

and h

um

ecta

nt.

It

is n

on-s

tick

y a

nd s

olu

ble

in w

ater

, gly

ceri

n a

s w

ell

as i

n

gly

cols

. U

sed i

n l

oti

ons,

tonic

s an

d g

el.

Ste

arat

e9005-0

8-7

;

155833-4

7-9

Em

uls

ifyin

g a

gen

ts.

Mag

nes

ium

-

PE

G-3

Coca

mid

e S

ulf

ate

122998-7

1-4

MA

GN

ES

IUM

PE

G-3

CO

CA

MID

E

SU

LFA

TE

Hydri

osu

l® A

MG

.30

Thic

ken

er. U

sed i

n c

osm

etic

s.

PE

G-4

25322-6

8-3

PE

G-4

Sab

opeg

200;

PO

GO

L®

200;

Jeec

hem

200

Hum

ecta

nt.

Use

d i

n s

how

er a

nd b

ath p

roduct

s, c

ream

s an

d

loti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

Cel

lulo

seA

LC

OR

AM

NO

SA

N

Rheo

logy m

odif

ier.

It

is a

gel

ling a

gen

t only

for

wat

er/e

tha-

nol

syst

ems.

It

does

not

form

any d

ry f

ilm

on t

he

surf

ace

of

the

skin

(ar

tifi

cial

des

quam

atio

n).

Dih

epta

noat

eP

EG

-4

DIH

EP

TA

NO

AT

EL

iponat

e® 2

-DH

Skin

care

anti

-agin

g, sk

inca

re a

nti

-acn

e, s

kin

care

tre

atm

ent,

skin

care

mois

turi

zati

on, sk

inca

re p

rote

ctio

n, su

n c

are,

colo

r

cosm

etic

s an

d h

air

care

.

Efa

Pro

line

Est

erA

MIN

OE

FA

DE

RM

A

Nouri

shin

g a

gen

t fo

r sk

in s

upple

nes

s, h

air

trea

tmen

t an

d

condit

ionin

g. O

ffer

s an

tice

lluli

tic-

, lo

cal

anti

-infl

amm

atory

-

and b

ioen

erget

ic p

roper

ties

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-4

Lau

rate

9004-8

1-3

PE

G-4

LA

UR

AT

EP

egosp

erse

® 2

00 M

L

Ver

sati

le m

ild H

LB

ran

ge

surf

ace

acti

ve

agen

t. F

or

use

in

pro

duct

s w

ith h

igh c

lari

ty. E

muls

ions

Liq

uid

pro

duct

s

Loti

ons

Liq

uid

pro

duct

s O

ils.

Ole

ate

9004-9

6-0

;

10108-2

5-5

PE

G-4

OL

EA

TE

Je

emat

e 200-O

C;

Hydri

ol®

OP.

2

Use

d a

s em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and b

ath o

ils.

Oli

vat

e226708-4

1-4

PE

G-4

OL

IVA

TE

Oli

vem

700

Use

d i

n c

osm

etic

form

ula

tions.

Poly

gly

cery

l-2

Ste

arat

e72828-1

1-6

PE

G-4

PO

LY

GLY

CE

RY

L-2

ST

EA

RA

TE

Host

acer

in®

DG

SB

Use

d i

n l

iquid

and c

ream

y o

il-i

n-w

ater

em

uls

ions.

Act

s as

an e

muls

ifie

r an

d c

o-e

muls

ifie

r w

ith s

pec

ial

emuls

ifyin

g

effe

ct o

n v

eget

able

oil

s.

Rap

esee

dam

ide

85536-2

3-8

PE

G-4

RA

PE

SE

ED

AM

IDE

Am

idet

® N

; M

asam

ide®

R-4

Liq

uid

non-i

onic

surf

acta

nt

wit

h g

ood t

hic

ken

ing a

nd f

oam

-

ing p

roper

ties

. A

lso a

cts

as c

o-s

urf

acta

nt,

thic

ken

er, em

uls

i-

fier

, m

ois

turi

zers

and s

olu

bil

izer

.

Ste

arat

e9004-9

9-3

;

106-0

7-0

PE

G-4

ST

EA

RA

TE

Jeem

ate

200-D

PS

; N

ikkol

MY

S-4

; S

abow

ax S

E 4

Use

d a

s em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and b

ath o

ils.

Ste

aryl

Eth

er9005-0

0-9

Acc

onon®

SA

-4

Nonio

nic

em

uls

ifie

r an

d w

etti

ng a

gen

t. U

sed i

n b

ath p

rod-

uct

s as

wel

l as

cle

ansi

ng p

roduct

s su

ch a

s co

ld c

ream

s an

d

clea

nsi

ng l

oti

ons.

PE

G-5

C12-C

18 A

lcohol

ISO

XA

L -

12

O/W

non-i

onic

co-e

muls

ifie

r an

d s

olu

bil

izer

. It

is

soli

d a

nd

solu

ble

in t

rigly

ceri

des

, gly

cero

l, p

ropyle

ne

gly

col

as w

ell

as p

arti

ally

solu

ble

in m

iner

al o

ils.

Cas

tor

Oil

61791-1

2-6

PE

G-5

CA

ST

OR

OIL

Eto

casTM

5;

Surf

acto

l® 3

18

O/W

co-e

muls

ifie

r, w

/o c

oem

uls

ifie

r an

d d

isper

sing a

gen

t.

Use

d i

n s

kin

car

e cr

eam

s, l

oti

ons,

bat

h p

roduct

s, s

pra

yab

le

emuls

ions,

eyec

are,

fee

t, h

ands,

nai

ls a

nd s

un p

rote

ctio

n.

Coca

min

eP

EG

-5 C

OC

AM

INE

Pro

tox C

-5A

cts

as e

muls

ifer

, an

ti-i

rrit

ant,

neu

tral

izin

g a

gen

t, a

nti

-sta

tic

agen

t, a

foam

boost

er a

nd a

mil

d d

eter

gen

t.

Lau

rate

9004-8

1-3

Jeem

ate

200-M

LE

muls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Ole

amm

oniu

m

Met

hosu

lfat

e64611-8

1-0

PE

G-5

OL

EA

MM

ON

IUM

ME

TH

OS

UL

FA

TE

Acc

oquat

® O

MS

-5

An e

asy-t

o-u

se o

rgan

ic q

uat

ernar

y a

mm

oniu

m c

om

pound

der

ived

fro

m o

leic

aci

d. A

cts

as w

ater

-solu

ble

condit

ionin

g

and l

ight

mois

turi

zing a

gen

t.

Ole

ate

PE

G-5

OL

EA

TE

HE

TO

XA

MA

TE

MO

- 5

Em

uls

ifie

r, s

urf

acta

nt

and c

oupli

ng a

gen

t.

Rap

esee

d S

tero

l68441-0

3-2

PP

G-5

-LA

UR

ET

H-5

Gen

erol®

R E

5N

onio

nic

co-e

muls

ifie

r fo

r th

e pre

par

atio

n o

f co

smet

ic

emuls

ions

of

the

type

W/O

.

Soyam

ine

61791-2

4-0

Eth

om

een®

SV

/25

Res

in n

eutr

aliz

er, rh

eolo

gy m

odif

ier,

surf

acta

nt,

em

uls

ifie

r

and w

etti

ng a

gen

t. I

t is

use

d i

n a

var

iety

of

hai

r ca

re a

ppli

-

cati

on a

reas

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-5

Ste

arat

e9004-9

9-3

PE

G-5

ST

EA

RA

TE

Het

oxam

ate

SA

-5S

urf

acta

nt/

emuls

ifie

r fo

r oin

tmen

ts, cr

eam

s, l

oti

ons,

fac

e

mois

turi

zers

, an

d o

ther

skin

car

e pro

duct

s.

Ste

aryl

Am

moniu

m

Lac

tate

55896-8

5-0

PE

G-5

ST

EA

RY

L

AM

MO

NIU

M

LA

CT

AT

E

Gen

amin

® K

SL

Anti

stat

ic a

gen

t. U

sed i

n h

air

finis

hin

g r

inse

s, l

iquid

set

ting

loti

ons,

condit

ionin

g s

ham

poos,

hai

r co

loura

nts

, hai

r to

nic

s

and a

ll h

air

afte

r-tr

eatm

ent

pro

duct

s.

Dih

ydro

xypro

pyl

PE

G-5

Lin

ole

amm

oniu

m

Chlo

ride

168677-7

5-6

DIH

YD

RO

XY

PR

OP

YL

PE

G-5

LIN

OL

EA

MM

ON

IUM

CH

LO

RID

E

Incr

oquatTM

SL

-5;

Cola

®

Quat

SL

CC

Condit

ionin

g a

gen

t. G

ives

lubri

city

and h

as v

ery g

ood w

et

com

b p

roper

ties

. C

om

pat

ible

wit

h a

nio

nic

s. U

sed i

n b

ath &

show

er p

roduct

s.

PE

G-6

25322-6

8-2

;

25322-6

8-3

PE

G-6

Plu

raca

re®

E 3

00;

Sab

opeg

300;

Jeec

hem

300

Cosm

etic

form

ula

tions.

Act

s as

a s

olv

ent

and h

um

ecta

nt.

Poss

esse

s nonir

rita

ting a

nd m

ois

turi

zing p

roper

ties

.

Cap

ryli

c/C

apri

c

Gly

ceri

des

52504-2

4-2

PE

G-6

CA

PR

YL

IC/C

AP

RIC

GLY

CE

RID

ES

Sab

oder

m C

C;

Oxypon C

C6;

Teg

oso

ft®

GM

C 6

;

DE

RM

AR

OL

6C

C

Oin

tmen

ts,

crea

ms,

mil

ks

and t

oil

etri

es.

Coca

mid

eA

mid

et®

A/1

8N

on-i

onic

surf

acta

nt

use

d a

s em

uls

ifie

r an

d d

eter

gen

t. U

sed

in h

air

care

.

Dio

leat

e9005-0

7-0

6P

EG

-6 D

IOL

EA

TE

Dub D

O P

EG

-6E

muls

ifie

r. U

sed i

n c

osm

etic

pro

duct

s.

Ole

amin

eP

EG

-6 O

LE

AM

INE

Sab

opal

NO

6A

lkal

ine

emuls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Ole

ate

9004-9

9-0

;

60344-2

6-5

;

9004-9

6-0

PE

G-6

OL

EA

TE

Jeem

ate

300-O

C;

Hydri

ol®

OP.

3;

Nik

kol

MY

O-6

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Sorb

itan

Ole

ate

9005-6

5-6

PE

G-6

SO

RB

ITA

N

OL

EA

TE

Nik

kol

TO

-106V

Use

d i

n c

osm

etic

s.

Sorb

itan

Ste

arat

e9005-6

7-8

PE

G-6

SO

RB

ITA

N

ST

EA

RA

TE

Nik

kol

TS

-106V

Use

d i

n c

osm

etic

s.

Ste

arat

eP

EG

-6 S

TE

AR

AT

EJe

emat

e 300-D

PS

; S

abow

ax

SE

6

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Alm

ond o

il

PE

G-6

E

ster

sA

LM

ON

D O

IL P

EG

-6

ES

TE

RS

Sab

oder

m A

MD

Oin

tmen

ts,

crea

ms,

mil

ks

and t

oil

etri

es.

Hydro

gen

ated

pal

m/p

alm

ker

nel

oil

PE

G-6

Est

ers

HY

DR

OG

EN

AT

ED

PA

LM

/PA

LM

KE

RN

EL

OIL

PE

G-6

ES

TE

RS

Dub G

1218 A

Em

oll

ient.

Incr

easi

ng p

enet

rati

on.

Use

d i

n m

ilk a

nd c

ream

.

PE

G-7

Am

odim

ethic

one

PE

G-7

AM

OD

IME

TH

ICO

NE

SIL

SE

NS

ETM

A-2

1

SP

EC

IAL

TY

SIL

ICO

NE

Use

d in a

queo

us

syst

ems

incl

udin

g s

ham

poos,

rin

se-o

ut co

ndi-

tioner

s, lea

ve-

in c

onditio

ner

s, s

tyling p

roduct

s, b

ody w

ashes

,

bat

h g

els,

liq

uid

soap

s an

d b

ubble

bat

hs,

body w

ashes

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-7

Dim

etic

one

Bee

swax

Bee

swax

6423 W

DO

/W-e

muls

ions

and l

ipst

icks.

Gly

cery

l C

oco

ate

68553-0

3-7

;

68201-4

6-7

;

68105-2

9-1

PE

G-7

GLY

CE

RY

L

CO

CO

AT

E

Em

anon®

HE

; Je

echem

GC

-7;

Sab

oder

m H

E;

Ste

rol

LG

/492;

CE

TA

RO

L H

E 7

Em

oll

ient.

Is

non-i

onic

surf

acta

nt,

per

fum

es a

nd e

xtr

acts

solu

bil

izer

. U

sed i

n h

air

care

, m

en’s

gro

om

ing p

roduct

s,

skin

car

e, b

ath a

nd s

how

er p

roduct

s.

Gly

cery

l S

oyat

eP

EG

-7 G

LY

CE

RY

L

SO

YA

TE

CH

EM

ON

ICTM

SI-

7

SU

RFA

CT

AN

T

Use

d i

n s

ham

poos,

body w

ashes

, sh

ow

er g

el f

orm

ula

tions

and o

ther

per

sonal

car

e fo

rmula

tions.

Act

s as

a n

onio

nic

surf

acta

nt

der

ived

fro

m s

oy o

il.

Hydro

gen

ated

Cas

tor

Oil

61788-8

5-0

PE

G-7

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

Cro

dure

tTM

7;

Cre

mophor®

Wo 7

W/O

em

uls

ifer

, par

ticu

lary

rec

om

men

ded

for

loti

ons.

Use

d

for

bab

y c

are,

body c

are,

fac

ial

care

, su

n c

are,

eye

pro

d-

uct

s, f

acia

l m

ake-

up, li

p p

roduct

s, s

how

er g

el/b

ody.

Oli

vat

e226708-4

1-4

PE

G-7

OL

IVA

TE

Oli

vem

300

Use

d i

n c

osm

etic

form

ula

tions.

Am

moniu

m

dim

ethic

one

PE

G-7

Sulf

ate

AM

MO

NIU

M

DIM

ET

HIC

ON

E P

EG

-7

SU

LFA

TE

SIL

SE

NS

ETM

SA

-1

Use

d i

n s

ham

poos,

condit

ioner

s, b

ody w

ashes

, gel

s,

mouss

es a

nd s

tyli

ng p

roduct

s. A

cts

as a

solu

bil

izer

, co

ndi-

tionin

g a

nd c

om

ple

xin

g a

gen

t.

Dim

ethic

one

PE

G-7

Avoca

doat

eD

IME

TH

ICO

NE

PE

G-7

AV

OC

AD

OA

TE

SIL

SE

NS

ETM

DW

-AV

Use

d i

n h

air

and s

kin

car

e. A

cts

as a

n e

moll

ient,

co-e

muls

i-

fier

and a

surf

acta

nt.

Poss

esse

s co

ndit

ionin

g a

nd s

pre

adin

g

pro

per

ties

.

Coco

ate

DIM

ET

HIC

ON

E P

EG

-7

CO

CO

AT

E

SIL

SE

NS

E®

SW

-12

SP

EC

IAL

TY

SIL

ICO

NE

Use

d i

n h

air

and s

kin

and m

ay b

e use

d i

n p

roduct

s in

clud-

ing c

ream

s, b

ody l

oti

ons,

aft

er-s

hav

e bal

ms

and g

els,

sham

-

poos

and c

ondit

ioner

s. A

cts

as a

condit

ionin

g a

gen

t.

Isost

eara

teD

IME

TH

ICO

NE

PE

G-7

ISO

ST

EA

RA

TE

SIL

SE

NS

E®

DW

-18

SP

EC

IAL

TY

SIL

ICO

NE

Use

d i

n c

ream

s, b

ody l

oti

ons,

aft

er-s

hav

e bal

ms

and g

els,

sham

poos

and c

ondit

ioner

s. A

cts

as a

lubri

cant

and e

mol-

lien

t.

Oli

vat

eD

IME

TH

ICO

NE

PE

G-7

OL

IVA

TE

SIL

SE

NS

ETM

DW

-OU

sed i

n s

kin

car

e an

d h

air

care

lik

e sh

ampoos

and c

ondi-

tioner

s. A

cts

as a

co-e

muls

ifie

r an

d a

n e

moll

ient.

Phosp

hat

e132207-3

1-9

DIM

ET

HIC

ON

E P

EG

-7

PH

OS

PH

AT

EP

ecosi

l® P

S-1

50

Pro

vid

e gre

ater

subst

anti

vit

y, e

nhan

ced s

mooth

ing a

nd s

lip

whil

e re

tain

ing i

ts w

ater

-solu

bil

ity p

roper

ty f

or

ease

of

for-

mula

tion.

Phth

alat

eD

IME

TH

ICO

NE

PE

G-7

PH

TH

AL

AT

ES

ILS

EN

SETM

CA

-1

Use

d i

n s

ham

poos,

condit

ioner

s, b

ody w

ashes

, gel

s,

mouss

es a

nd s

tyli

ng p

roduct

s. A

cts

as a

condit

ionin

g a

nd

com

ple

xin

g a

gen

t.

Succ

inat

eD

IME

TH

ICO

NE

PE

G-7

SU

CC

INA

TE

SIL

SE

NS

ETM

CA

-2

Use

d i

n s

ham

poos,

condit

ioner

s, b

ody w

ashes

, gel

s,

mouss

es a

nd s

tyli

ng p

roduct

s. A

cts

as a

condit

ionin

g a

nd

com

ple

xin

g a

gen

t.

Oli

ve

oil

PE

G-7

Est

ers

103819-4

6-1

OL

IVE

OIL

PE

G-7

ES

TE

RS

Bea

uty

ole

a S

3;

Oli

vat

is 1

Act

s as

a s

econdar

y s

urf

acta

nt

and e

muls

ifie

r or

co-e

muls

i-

fier

in O

/W s

yst

ems.

It

is o

bta

ined

fro

m p

ure

ita

lian

oli

ve

oil

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

Sodiu

m P

EG

-7O

live

Oil

Car

boxyla

te226416-0

5-3

SO

DIU

M P

EG

-7

OL

IVE

OIL

CA

RB

OX

YL

AT

E

Oli

vem

400

Use

d a

s m

ild s

urf

acta

nt

in h

air

and s

kin

car

e pro

duct

s.

Ste

ardim

oniu

m

Hydro

xypro

pyl

PE

G-7

Dim

ethic

one

Phosp

hat

e C

hlo

ride

220714-6

3-6

ST

EA

RD

IMO

NIU

M

HY

DR

OX

YP

RO

PY

L

PE

G-7

DIM

ET

HIC

ON

E

PH

OS

PH

AT

E

CH

LO

RID

E

Pec

osi

l® P

SQ

-418

Fil

m f

orm

ing a

nd e

moll

ient.

Use

d i

n s

ham

poos

and c

ondi-

tioner

s.

PE

G-8

25322-6

8-3

PE

G-8

Sym

pat

ens

PE

G-4

00;

Plu

raca

re®

E 4

00;

Jeec

hem

400;

Sab

opeg

400

Poly

ethyle

ngly

col

wit

h a

ppro

x m

ole

cula

r w

eight

400 (

8

EO

). R

e-fa

ttin

g a

gen

t. E

muls

ions

Liq

uid

pro

duct

s L

oti

ons.

Bee

wax

PE

G-8

BE

ES

WA

XW

ax -

PE

G-8

Bee

swax

;

Coru

m 2

680;

Dub C

IRE

A

Use

d i

n c

ream

s, l

oti

ons,

mak

e-ups,

hai

r ca

re, m

asca

ras,

lip

-

stic

ks,

lip

-bal

ms

and s

unsc

reen

pro

duct

s.

C12-C

20 A

lkyl

Est

erX

AL

IFIN

-15;

XA

LIF

IN 1

5

N-P

O/W

and w

/o e

muls

ifie

r as

wel

l as

solu

bil

izer

. It

is

the

most

his

tophil

ic o

f know

n e

muls

ifie

rs. U

sed i

n o

/w e

muls

ions.

Cel

lulo

seID

RO

RA

MN

OS

AN

Gel

ling a

gen

t, h

um

ecta

nt an

d v

isco

sity

reg

ula

tor

for

emuls

ions

(eas

ily d

isper

sed in w

ater

, re

lativel

y s

hort

dis

solv

ing tim

e).

Dii

sost

eara

teP

EG

-8

DII

SO

ST

EA

RA

TE

Nik

kol

CD

IS-4

00

Em

uls

ifie

r.

Dil

aura

te9005-0

2-0

1P

EG

-8 D

ILA

UR

AT

E

Hal

lSta

r® P

EG

400 D

L;

Jeem

ate

400 D

L;

Sab

oder

m

PD

C

Bio

deg

radab

le e

muls

ifie

r (o

/w),

co-e

muls

ifie

r, e

moll

ient,

lubri

cant

and s

pre

adin

g a

gen

t. U

sed i

n b

ath a

ddit

ives

, fa

cial

clea

nse

rs, fa

cial

skin

car

e an

d h

and &

body c

are.

Dim

ethic

one

Oli

vat

eD

IME

TH

ICO

NE

PE

G-8

AV

OC

AD

OA

TE

Sil

wax

® W

D-A

V

Use

d i

n c

ream

s, b

ody l

oti

ons,

aft

er-s

hav

e bal

ms

and g

els,

sham

poos

and c

ondit

ioner

s. P

oss

esse

s ta

ck r

educe

r an

d

glo

ss e

nhan

cer.

Dio

leat

e9005-0

7-0

6P

EG

-8 D

IOL

EA

TE

Hal

lSta

r® P

EG

400 D

O;

Jeem

ate

400-D

O;

Cit

hro

l 4D

O

Em

oll

ient,

em

uls

ifyin

g a

gen

t (o

/w)

and l

ubri

cant.

Use

d i

n

eye

area

colo

r co

smet

ics,

fac

ial

skin

car

e as

wel

l as

in h

and

& b

ody c

are.

Dis

tear

ate

9005-0

8-0

7P

EG

-8 D

IST

EA

RA

TE

Hal

lSta

r® P

EG

400 D

S;

Jeem

ate

400 D

S;

Peg

osp

erse

®

400 D

S;

Nik

kol

CD

S-4

00

Em

uls

ifie

r (o

/w),

em

oll

ient,

opac

ifyin

g a

gen

t an

d/o

r co

ndi-

tionin

g a

gen

t in

var

ious

pro

duct

s. I

s bio

deg

radab

le a

nd

pla

nt

der

ived

/ v

eget

al b

ased

.

Dodec

enyls

ucc

inat

e

PE

G-8

DO

DE

CE

NY

LS

UC

CIN

AT

E

Surf

ine

SM

2030

Use

d i

n s

how

er g

els,

bab

y p

roduct

s, h

ypoal

lerg

enic

pro

d-

uct

s, m

ake

up r

emover

s, b

ubble

bat

hs,

sham

poos

and b

ody

was

hes

. A

cts

as s

urf

acta

nt

and a

n e

muls

ifie

r.

Gly

cery

l L

aura

teP

EG

-8 G

LY

CE

RY

L

LA

UR

AT

EG

lyce

roxTM

L8

O/W

em

uls

ifie

r. S

uper

fatt

ing a

gen

t an

d s

olu

bil

iser

in a

que-

ous

and a

queo

us

alco

holi

c pre

par

atio

ns.

Em

oll

ient

in

crea

ms

and l

oti

ons.

Dis

per

sant

and w

etti

ng a

gen

t.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-8

Isoce

tyl/

Isost

eary

l E

ther

Ste

arat

eIS

OX

AL

-E

O/W

em

uls

ifie

r an

d s

olu

bil

izer

. It

is

soli

d a

nd s

olu

ble

in t

ri-

gly

ceri

des

, m

iner

al o

ils

and f

atty

est

ers.

Lau

rate

9004-8

1-3

PE

G-8

LA

UR

AT

EH

allS

tar®

PE

G 4

00 M

L;

Jeem

ate

400-M

L

Em

uls

ifie

r (o

/w),

em

oll

ient

and l

ubri

cant.

Is

bio

deg

radab

le

and p

lant

der

ived

/ v

eget

al b

ased

. U

sed i

n a

fter

sun s

kin

care

, bea

ch w

ear

sun c

are,

dai

ly w

ear

sun c

are.

Ole

ate

9004-9

6-0

;

61791-0

0-2

P

EG

-8 O

LE

AT

EJe

emat

e 400-O

C;

Hydri

ol®

OP.

4;

Alk

amuls

® 4

00 M

O

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Sil

ane

PE

G-8

ME

TH

YL

ET

HE

R

TR

IET

HO

XY

SIL

AN

E

BG

BO

-SW

2H

ydro

phil

ic c

oat

ing f

or

pig

men

ts a

nd p

ow

der

s.

Ste

arat

eP

EG

-8 S

TE

AR

AT

EJe

emat

e 400-D

PS

; S

abow

ax

SE

8

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Tri

silo

xan

eS

M3340P

Wet

ting a

gen

t an

d s

urf

acta

nt

hav

ing v

ery l

ow

surf

ace

ten-

sion. C

om

pat

ible

for

Oil

and w

ater

coupli

ng. Im

par

ts s

oft

silk

y f

eel,

long-l

asti

ng c

olo

r pro

tect

ion.

Apri

cot

Ker

nel

Oil

PE

G-8

Est

ers

AP

RIC

OT

KE

RN

EL

OIL

PE

G-8

ES

TE

RS

Via

tenza

® A

pri

cot

PE

8

Obta

ined

by t

rans-

este

rifi

cati

on b

etw

een P

EG

-8 a

nd a

pri

-

cot

ker

nel

oil

. U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s, c

ream

s fo

r fa

ce.

Arg

an O

il

PE

G-8

Est

ers

AR

GA

N O

IL P

EG

-8

ES

TE

RS

Via

tenza

® A

rgan

PE

8U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

face

hygie

ne,

han

d c

are

and c

are

crea

ms.

Avoca

do O

il

PE

G-8

E

ster

sA

VO

CA

DO

OIL

PE

G-8

ES

TE

RS

Via

tenza

® A

voca

do P

E8

Use

d i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, p

rod-

uct

s fo

r ag

ing s

kin

and p

roduct

s fo

r ar

ound t

he

eyes

.

Bab

assu

oil

PE

G-8

Est

ers

Via

tenza

® C

upuac

u P

E8

Use

d i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, c

lean

s-

ing w

ipes

and m

ilks,

per

sonal

and f

ace

hygei

ne

pro

duct

s.

Bao

bab

Oil

PE

G-8

Est

ers

Via

tenza

® B

aobab

PE

8

Use

d i

n b

ath p

roduct

s, s

ham

poos,

cle

ansi

ng w

ipes

and

mil

ks,

han

d c

are

pro

duct

s, p

erso

nal

and f

ace

hygei

ne

pro

d-

uct

s.

Ber

tholl

etia

Exce

lsa

See

d O

il -

PE

G 8

Est

ers

BE

RT

HO

LL

ET

IA

EX

CE

LS

A S

EE

D O

IL

PE

G-8

ES

TE

RS

Hydra

maz

on E

xce

lsa

Use

d i

n s

ham

poos,

liq

uid

and b

ar s

oap

s, s

kin

cle

anse

rs a

nd

toner

s, a

nti

-wri

nkle

cre

ams

and l

oti

ons,

bab

y p

roduct

s an

d

hai

r co

ndit

ionin

g g

els.

Bit

ter

Cher

ry

See

d O

il P

EG

-8E

ster

s

BIT

TE

R C

HE

RR

Y

SE

ED

OIL

PE

G-8

ES

TE

RS

Via

tenza

® C

her

ry P

E8

Use

d i

n s

ham

poos

for

dry

hai

r, b

ath p

roduct

s, s

un c

are,

fac

e

hygie

ne

and i

n c

ream

s fo

r dry

.

Bora

ge

See

d O

il

PE

G-8

Est

ers

BO

RA

GE

SE

ED

OIL

PO

LY

GLY

CE

RY

L-6

ES

TE

RS

Via

tenza

® B

ora

ge

PO

6U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

care

cre

ams

for

dry

and d

amag

ed s

kin

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

Buri

ti O

il P

EG

-8E

ster

sV

iate

nza

® B

uri

ti P

E8

Use

d i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, p

er-

sonal

and f

ace

hygei

ne

pro

duct

s, c

lean

sing w

ipes

and m

ilks.

Coco

a butt

er

PE

G-8

Est

ers

Via

tenza

® C

oco

a P

E8

Use

d i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, c

lean

s-

ing w

ipes

and m

ilks,

per

sonal

and f

ace

hygei

ne

pro

duct

.

Dim

ethic

one

PE

G-8

Am

ine

Sil

amin

e® C

-300

It i

s si

lico

ne

acti

ve,

a u

niq

ue

pat

ente

d w

ater

dis

per

sible

sil

i-

cone

amin

e, w

hic

h p

rovid

es c

ondit

ionin

g, lu

bri

city

, so

ften

-

ing, im

pro

ved

com

bab

ilit

y a

nd m

anag

eabil

ity t

o h

air.

Bee

swax

DIM

ET

HIC

ON

E P

EG

-8

BE

ES

WA

X

UL

TR

AB

EE

® W

D

SIL

ICO

NE

Use

d i

n a

fter

shav

e bal

ms,

mil

d c

lean

sers

, m

akeu

p r

emov-

ers,

cre

ams

and l

oti

ons,

sham

poos

and c

ondit

ioner

s. A

cts

as

an e

moll

ient

and s

urf

acta

nt.

Lan

ola

teD

IME

TH

ICO

NE

PE

G-8

LA

NO

LA

TE

Lan

osi

l®

Act

s as

an e

xce

llen

t sk

in c

ondit

ionin

g e

moll

ient

and a

n

effe

ctiv

e hai

r co

ndit

ionin

g a

gen

t. P

rovid

es g

ood s

hin

e w

ith

an e

xce

llen

t so

ft a

nd v

elvet

y a

fter

fee

l.

Mea

dow

foam

ate

DIM

ET

HIC

ON

E P

EG

-8

ME

AD

OW

FO

AM

AT

EF

anco

rsil

® L

IM-1

Is m

anufa

cture

d b

y c

om

ple

xin

g t

he

fatt

y a

cid o

f th

e nat

ura

l

trig

lyce

ride

mea

dow

foam

see

d o

il (

Lim

nan

thes

Alb

a) w

ith

sili

cone.

Poly

acry

late

Sil

softTM

Surf

ace

Act

s as

a f

ilm

form

er.

Poss

esse

s non-t

ransf

er c

apab

ilit

ies

wit

h e

xce

llen

t fe

el a

nd w

ater

res

ista

nce

. M

ay i

mpro

ve

wea

rabil

ity i

n c

osm

etic

appli

cati

ons.

Succ

inat

eD

IME

TH

ICO

NE

PE

G-8

SU

CC

INA

TE

Sil

ube®

CS

-I

Use

d i

n d

eodora

nt

stic

ks,

fra

gra

nce

oil

s, h

air

condit

ioner

,

crea

ms

and l

oti

ons.

Red

uce

s ta

ck a

nd s

oap

y f

eel.

Aid

s in

reduci

ng t

ack a

nd s

tick

ines

s.

Dis

odiu

m

PE

G-8

Pal

m G

lyce

rides

Sulf

osu

ccin

ate

DIS

OD

IUM

PE

G-8

PAL

M G

LY

CE

RID

ES

SU

LF

OS

UC

CIN

AT

E

Sab

oso

l R

SS

Use

d i

n s

ham

poos,

bubble

-bat

hs

and m

ild d

eter

gen

ts. P

ro-

vid

es s

oft

and u

nif

orm

foam

. P

oss

esse

s good s

kin

fee

l.

Gra

pe

See

d O

il

PE

G-8

Est

ers

GR

AP

E S

EE

D O

IL

PE

G-8

ES

TE

RS

Via

tenza

® G

rape

PE

8U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

face

car

e, h

and c

are,

dai

ly a

nd e

moll

ient

crea

m.

Haz

el S

eed O

il

PE

G-8

Est

ers

HA

ZE

L S

EE

D O

IL

PE

G-8

ES

TE

RS

Via

tenza

® H

azel

PE

8U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air

bat

h p

roduct

s,

dry

fac

e an

d h

and c

ream

s an

d i

n p

erso

nal

.

Hem

p S

eed O

il

PE

G-8

Est

ers

Via

tenza

® H

emp P

E8

Use

d i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

face

car

e, p

erso

nal

hygei

ne

and d

ay c

ream

s.

Mac

adam

ia

Ter

nif

oli

a

See

d O

il P

EG

-8

Est

ers

MA

CA

DA

MIA

TE

RN

IFO

LIA

SE

ED

OIL

PE

G-8

ES

TE

RS

Via

tenza

® M

acad

amia

PE

8U

sed i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, c

ream

s

for

dry

and a

ged

skin

.

Maf

ura

Butt

er

PE

G-8

Est

ers

Via

tenza

® M

afura

PE

8U

sed i

n s

ham

poos,

bat

h p

roduct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s, c

lean

sing w

ipes

and m

ilks.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

Mongongo

Nut

Oil

PE

G-8

Est

ers

Via

tenza

® M

ongongo P

E8

Use

d i

n s

ham

poos,

bat

h p

roduct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s, c

lean

sing w

ipes

and m

ilks.

Oli

ve

Oil

PE

G-8

Est

ers

OL

IVE

OIL

PE

G-8

ES

TE

RS

Via

tenza

® O

live

PE

8U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

face

car

e, d

ay c

ream

s, e

moll

ient,

per

sonal

and f

ace.

Orb

ignya

Ole

ifer

a S

eed

Oil

- P

EG

8

Est

ers

OR

BIG

NY

A

OL

EIF

ER

A S

EE

D

OIL

PE

G-8

ES

TE

RS

Hydra

maz

on O

leif

era

Use

d i

n s

ham

poos,

liq

uid

and b

ar s

oap

s, s

kin

tonin

g a

nd

clea

nsi

ng e

muls

ions.

Act

s as

a n

atura

l, v

eget

able

-der

ived

surf

acta

nt,

anti

-irr

itan

t an

d e

moll

ient.

Pum

pkin

See

d

Oil

PE

G-8

Est

ers

PU

MP

KIN

SE

ED

OIL

PE

G-8

ES

TE

RS

Via

tenza

® P

um

pkin

PE

8U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

body a

nd f

ace

crea

ms

and i

n p

erso

nal

.

Rosa

Rubig

inosa

See

d O

il P

EG

-8E

ster

s

RO

SA

RU

BIG

INO

SA

SE

ED

OIL

PE

G-8

ES

TE

RS

Via

tenza

® R

ose

PE

8U

sed i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

day

cre

ams

for

dry

and d

amag

ed s

kin

.

Saf

flow

er S

eed

Oil

PE

G-8

Est

ers

SA

FF

LO

WE

R S

EE

D

OIL

PE

G-8

ES

TE

RS

Via

tenza

® S

affl

ow

er P

E8

Use

d i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

face

car

e, c

ream

s fo

r dry

skin

.

Scl

eroca

rya

Bir

rea

See

d O

il

PE

G-8

Est

ers

SC

LE

RO

CA

RY

A

BIR

RE

A S

EE

D O

IL

PE

G-8

ES

TE

RS

Via

tenza

® M

arula

PE

8U

sed i

n s

ham

poos,

bat

h p

roduct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s, c

lean

sing w

ipes

and m

ilks.

Ses

ame

Oil

PE

G-8

Est

ers

SE

SA

ME

SE

ED

OIL

PE

G-8

ES

TE

RS

Via

tenza

® S

esam

e P

E8

Use

d i

n s

ham

poos,

bat

h p

roduct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s, c

lean

sing w

ipes

and m

ilks,

fac

e ca

re p

roduct

.

Shea

Butt

er

PE

G-8

Est

ers

SH

EA

BU

TT

ER

PE

G-8

ES

TE

RS

Via

tenza

® S

hea

PE

8U

sed i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, b

ody

pro

duct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s.

Soybea

n O

il

PE

G-8

Est

ers

SO

YB

EA

N O

IL

PE

G-8

ES

TE

RS

Via

tenza

® S

oybea

n P

E8

Use

d i

n s

ham

poos,

bat

h p

roduct

s, b

ody p

roduct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s, c

lean

sing w

ipes

and m

ilks.

Sunfl

ow

er S

eed

Oil

PE

G-8

Est

ers

SU

NF

LO

WE

R S

EE

D

OIL

PE

G-8

ES

TE

RS

Via

tenza

® S

unfl

ow

er P

E8

Use

d i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

per

sonal

and f

ace

hygie

ne

and d

ay c

ream

s.

Sw

eet

Alm

ond

Oil

PE

G-8

Est

ers

SW

EE

T A

LM

ON

D

OIL

PE

G-8

ES

TE

RS

Via

tenza

® A

lmond P

E8

Use

d i

n s

ham

poos,

bat

h p

roduct

s, p

erso

nal

hygei

ne

and

face

hygei

ne

and e

moll

ient

crea

ms

for

face

.

Wat

erm

elon

See

d O

il P

EG

-8E

ster

sW

AT

ER

ME

LO

N S

EE

D

OIL

PE

G-8

ES

TE

RS

Via

tenza

® K

alah

ari

Mel

on

PE

8

Use

d i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, p

er-

sonal

and f

ace

hygei

ne

pro

duct

s.

Whea

t G

erm

Oil

PE

G-8

Est

ers

WH

EA

T G

ER

M O

IL

PE

G-8

ES

TE

RS

Via

tenza

® W

hea

t P

E8

Use

d i

n s

ham

poos

for

dry

and d

amag

ed h

air,

bat

h p

roduct

s,

face

hygie

ne,

em

oll

ient

crea

ms

for

face

.

Xim

enia

Oil

PE

G-8

Est

ers

Via

tenza

® X

imen

ia P

E8

Use

d i

n s

ham

poos,

bat

h p

roduct

s, b

ody p

roduct

s, p

erso

nal

and f

ace

hygei

ne

pro

duct

s, b

aby c

are

pro

duct

s.

PE

G-9

Cas

tor

Oil

61791-1

2-6

PE

G-9

CA

ST

OR

OIL

Het

oxid

e C

-9

Non-i

onic

surf

acta

nt.

It

is b

ased

on h

ydro

phobe

whic

h i

s

then

rea

cted

wit

h e

thyle

ne

oxid

e to

acc

om

pli

sh s

pec

ific

task

s of

wet

ting,

emuls

ific

atio

n, det

ergen

cy,

etc.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-9

Isost

eara

te56002-1

4-3

PE

G-9

IS

OS

TE

AR

AT

EH

ET

OX

AM

AT

E M

I -

9S

urf

acta

nt,

em

uls

ifie

r an

d c

oupli

ng a

gen

t.

Lau

rate

9004-8

1-3

PE

G-9

LA

UR

AT

EH

ET

OX

AM

AT

E L

A -

9

O/W

em

uls

ifie

r, s

urf

acta

nt

and c

oupli

ng a

gen

t. P

oly

oxyl-

ated

der

ivat

ives

of

lauri

c, o

leic

, or

stea

ric

acid

are

em

uls

ifi-

ers,

hum

ecta

nts

, an

d c

oupli

ng a

gen

ts.

Lau

ryl

Eth

erB

rijTM

L9

Anti

-irr

itan

t in

gre

die

nt

for

use

in s

kin

sooth

ing a

nd l

oca

l

anae

sthet

ic m

edic

ated

cre

ams.

Ste

arat

e9004-9

9-3

PE

G-9

ST

EA

RA

TE

Het

oxam

ate

SA

-9

It i

s gen

eral

ly u

sed a

s a

surf

acta

nt/

emuls

ifie

r fo

r oin

tmen

ts,

crea

ms,

loti

ons,

fac

e m

ois

turi

zers

, an

d o

ther

skin

car

e pro

d-

uct

s.

Lau

ryl

PE

G-9

Poly

dim

ethyls

iloxyet

hyl

Dim

ethic

one

A w

ater

solu

ble

sil

icone

copoly

ol

surf

acta

nt

use

d a

s pla

sti-

cize

r an

d s

olu

bil

izer

in c

osm

etic

syst

ems.

Use

d i

n h

air,

skin

and b

ody c

are.

Poly

dim

ethyls

iloxyet

hyl

Dim

ethic

one/

Isooct

yl

Pal

mit

ate

CE

TY

L P

EG

/PP

G-1

0/1

DIM

ET

HIC

ON

ES

ilok®

2216C

A h

ighly

eff

icie

nt

w/o

em

uls

ifie

r an

d a

gre

at w

ater

rep

el-

lent.

Poss

esse

s ex

cell

ent

stab

ilit

y f

or

emuls

ion.

PE

G-1

0

C12-C

18 A

lcohol

ISO

XA

L -

11;

ISO

XA

L -

11

P-F

O/W

non-i

onic

co-e

muls

ifie

r an

d s

olu

bil

izer

. It

is

soli

d a

nd

solu

ble

in t

rigly

ceri

des

, m

iner

al o

ils,

gly

cero

l an

d w

ater

.

Dim

ethic

one

PE

G-1

0

DIM

ET

HIC

ON

EG

ransu

rf 7

7;

Em

uls

il®

S-3

97

Use

d i

n h

air

care

. O

ffer

s lu

bri

cious

feel

ing a

nd s

ubst

anti

v-

ity.

Adds

glo

ss a

nd r

educe

s st

atic

.

Lau

rate

9004-8

1-3

P

EG

-10 L

AU

RA

TE

Nik

kol

MY

L-1

0H

ydro

phil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

Ole

amin

eP

EG

-10 O

LE

AM

INE

Sab

opal

NO

10

Use

d f

or

alkal

ine

emuls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Ole

ate

9004-9

6-0

PE

G-1

0 O

LE

AT

EN

ikkol

MY

O-1

0H

ydro

phil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

Poly

gly

cery

l-2 L

aura

te

PE

G-1

0

PO

LY

GLY

CE

RY

L-2

LA

UR

AT

E

Host

acer

in®

DG

L

Use

d i

n l

iquid

and c

ream

y o

il-i

n-w

ater

em

uls

ions.

Act

s as

a

liquid

em

uls

ifie

r w

ith a

llro

und e

muls

ifyin

g e

ffec

t an

d a

s

solu

bil

izer

for

ether

eal

oil

s.

Rap

esee

d S

tero

l68441-0

3-2

PP

G-5

-LA

UR

ET

H-5

Gen

erol®

R E

10

Use

d i

n c

osm

etic

em

uls

ions

of

the

type

O/W

. A

cts

as a

non-

ionic

co-e

muls

ifie

r.

Sorb

itan

Lau

rate

PE

G-1

0 S

OR

BIT

AN

LA

UR

AT

EL

iposo

rb®

L-1

0U

sed f

or

cosm

etic

s. O

ffer

s em

uls

ifyin

g, th

icken

ing, lu

bri

-

cati

ng, an

d a

nti

-sta

tic

effe

cts.

Ste

arat

e9004-9

9-3

P

EG

-10 S

TE

AR

AT

EN

ikkol

MY

S-1

0H

ydro

phil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

Sunfl

ow

er G

lyce

rides

180254-5

2-8

PE

G-1

0 S

UN

FL

OW

ER

GLY

CE

RID

ES

FL

OR

AS

OL

VS

® P

EG

-10

SU

NF

LO

WE

R

Co-e

muls

ifyin

g a

gen

t, e

moll

ient,

fee

l m

odif

icat

ion/e

nhan

ce-

men

t ag

ent,

fra

gra

nce

solu

bil

izer

and t

ransf

er, an

d s

uper

fat-

ting a

gen

t.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

Dih

ydro

xypro

pyl

PE

G-1

0

Ste

aram

moniu

m

Chlo

ride

Veg

eshin

eTM

Q10

Use

d f

or

skin

car

e, h

air

sham

poos,

condit

ioner

s, s

tyli

ng

gel

s, o

ther

hai

r ca

re p

roduct

s.

Dim

ethic

one

PE

G-1

0P

hosp

hat

e132207-3

1-9

DIM

ET

HIC

ON

E

PE

G-1

0 P

HO

SP

HA

TE

Pec

osi

l® P

S-2

00

Can

be

a "s

truct

ura

l" c

om

ponen

t of

a fo

rmula

tion a

nd i

s

idea

lly s

uit

ed f

or

soli

d d

eliv

ery s

yst

ems

like

lipst

icks,

mak

eup a

nd a

nti

-per

spir

ants

/deo

dora

nts

.

Lau

ryl

PE

G-1

0

Met

hyl

Eth

er

Dim

ethic

one

LA

UR

YL

PE

G-1

0

ME

TH

YL

ET

HE

R

DIM

ET

HIC

ON

E

Sil

ok®

2205

Act

s as

an e

muls

ifie

r fo

r o/w

syst

em a

nd w

ater

-in-s

ilic

one

oil

syst

em. A

lso a

cts

as a

res

in p

last

iciz

er f

or

hai

r st

yli

ng

pro

duct

s.

Tri

s(T

rim

ethyls

iloxy)

Sil

yle

thyl

Dim

ethic

one

Dow

Corn

ing®

ES

-5300

Form

ula

tion A

id

Act

s as

a s

ilic

one

w/o

and w

/si em

uls

ifie

r an

d d

isper

sing

agen

t. I

t is

a n

on-d

ilute

d a

nd low

vis

cosi

ty s

ilic

one

surf

acta

nt.

PE

G-1

1M

ethyl

Eth

er

Dim

ethic

one

PE

G-1

1 M

ET

HY

L

ET

HE

R

DIM

ET

HIC

ON

E

Gra

nsu

rf 7

1U

sed i

n h

air

care

. O

ffer

s lu

bri

cious

feel

ing. A

dds

glo

ss a

nd

reduce

s st

atic

.

PE

G-1

2

25322-6

8-3

PE

G-1

2

Sab

opeg

600;

Plu

raca

re®

E 6

00;

Plu

raca

re®

E 6

00 N

F;

Jeec

hem

600

Use

d i

n c

osm

etic

pre

par

atio

ns.

Act

s as

a s

olv

ent

and a

hum

ecta

nt.

Poss

esse

s nonir

rita

ting a

nd m

ois

turi

zing p

roper

-

ties

.

Cel

lulo

se

Act

s as

a g

elli

ng a

gen

t, h

um

ecta

nt

and v

isco

sity

reg

ula

tor

for

emuls

ions

(eas

ily d

isper

sed i

n w

ater

wit

h a

rel

ativ

ely

short

dis

solv

ing t

ime)

.

Dil

aura

te9005-0

2-0

1P

EG

-12 D

ILA

UR

AT

EH

allS

tar®

PE

G 6

00 D

L;

Jeem

ate

600-D

L

Em

uls

ifie

r (o

/w),

co-e

muls

ifie

r an

d e

moll

ient.

Is

bio

deg

rad-

able

and p

lant

der

ived

/ v

eget

al b

ased

. U

sed i

n a

fter

sun

skin

car

e, f

oot

care

as

wel

l as

in h

and &

body c

are.

Dim

ethic

one

PE

G-1

2

DIM

ET

HIC

ON

EB

RB

526;

FM

-E193

Surf

acta

nt.

Off

ers

smooth

and s

ilky f

eel,

spre

adab

ilit

y i

n

body c

are

as w

ell

as i

n c

olo

r co

smet

ics.

Als

o p

rovid

es s

oft

& s

ilky f

eel,

wet

- &

dry

com

bin

g i

n h

air

care

.

Dio

leat

e9005-0

7-0

6P

EG

-12 D

IOL

EA

TE

Hal

lSta

r® P

EG

600 D

O;

Jeem

ate

600 D

O

Em

uls

ifie

r (o

/w),

co-e

muls

ifie

r an

d e

moll

ient.

Is

bio

deg

red-

able

and p

lant

der

ived

/ v

eget

al b

ased

. U

sed i

n b

ath a

ddi-

tives

, fa

cial

skin

car

e, f

oot

care

, han

d &

body c

are.

Dis

tear

ate

9005-0

8-0

7P

EG

-12 D

IST

EA

RA

TE

Hal

lSta

r® P

EG

600 D

S;

Jeem

ate

600 D

S;

Het

oxam

ate

600 D

S

Em

uls

ifie

r (o

/w),

co-e

muls

ifie

r an

d e

moll

ient.

Is

bio

deg

red-

able

and p

lant

der

ived

/ v

eget

al b

ased

. P

oss

esse

s hai

r cu

ti-

cle

pro

tect

ion.

Dit

alla

te61791-0

1-3

PE

G-1

2 D

ITA

LL

AT

EP

egosp

erse

® 6

00 D

OT

Tal

l oil

bas

ed s

urf

acta

nt.

Lau

rate

9005-0

2-0

1P

EG

-12 L

AU

RA

TE

Hal

lSta

r® P

EG

600 M

L;

Peg

osp

erse

® 6

00 M

L

Em

uls

ifie

r (o

/w),

em

oll

ient

and c

o e

muls

ifyin

g a

gen

t. I

s

bio

deg

radab

le a

nd p

lant

der

ived

/ v

eget

al b

ased

. U

sed i

n

afte

r su

n s

kin

car

e, f

acia

l sk

in c

are,

han

d &

body c

are.

Ole

ate

9004-9

6-0

P

EG

-12 O

LE

AT

EJe

emat

e 600-O

CE

muls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-1

2S

tear

ate

9004-9

9-3

PE

G-1

2 S

TE

AR

AT

EJe

emat

e 600-D

PS

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Dis

odiu

m

PE

G-1

2

Dim

ethic

one

Sulf

osu

ccin

ate

157090-3

7-4

Cola

® M

ate

SI

Extr

a m

ild s

urf

acta

nt

der

ived

fro

m w

ater

solu

ble

sil

icone

copoly

mer

. Is

use

ful

in n

on-i

rrit

atin

g s

kin

cle

ansi

ng a

nd

spec

ialt

y a

ppli

cati

ons.

PE

G-1

4

Dim

ethic

one

PE

G-1

4

DIM

ET

HIC

ON

EA

bil

® B

8843

Use

d i

n h

air

styli

ng f

orm

ula

tions,

liq

uid

foundat

ions,

sham

-

poos,

show

er a

nd b

ath p

repar

atio

ns

and s

hav

ing f

oam

.

Off

ers

good f

oam

ing p

roper

ties

.

Isost

eara

te56002-1

4-3

HE

TO

XA

MA

TE

MI

- 14

Surf

acta

nt,

em

uls

ifie

r an

d c

oupli

ng a

gen

t. P

oly

oxyla

ted

der

ivat

ives

of

lauri

c, o

leic

, or

stea

ric

acid

are

em

uls

ifie

rs,

hum

ecta

nts

, an

d c

oupli

ng a

gen

ts.

Ole

ate

PE

G-1

4 O

LE

AT

EH

ET

OX

AM

AT

E M

O -

14

O/W

em

uls

ifie

r, s

urf

acta

nt

and c

oupli

ng a

gen

t.

Pen

taer

yth

rito

l T

etra

Cap

ryla

te/C

apra

te

(Pro

pose

d)

AX

IMO

L P

TC

-14

Em

oll

ient.

Bel

ongin

g t

o a

new

cla

ss o

f es

ters

that

hav

e a

ver

y l

ow

vis

cosi

ty f

or

thei

r m

ole

cula

r w

eights

.

Ste

arat

eP

EG

-14 S

TE

AR

AT

EH

ET

OX

AM

AT

E M

S -

14

Hum

ecta

nt,

solu

bil

izer

, su

rfac

tant,

and c

oupli

ng a

gen

t.

PE

G-1

5

Cas

tor

Oil

61791-1

2-6

PE

G-1

5 C

AS

TO

R O

ILE

toca

sTM

15;

AL

KE

ST

®

CS

O 1

50

Dis

per

sing a

gen

t, o

/w e

muls

ifie

r, s

olu

bil

iser

and w

/o c

o-

emuls

ifie

r. U

sed i

n s

kin

car

e cr

eam

s, l

oti

ons,

bat

h p

roduct

s,

show

er g

el/b

ody w

ash, li

quid

soap

s, f

acia

l w

ash.

Coca

min

eP

EG

-15 C

OC

AM

INE

Sab

opal

NC

15

Alk

alin

e em

uls

ions,

lik

e hai

r-dye

crea

ms

or

gel

s.

Coco

moniu

m C

hlo

ride

PE

G-1

5

CO

CO

MO

NIU

M

CH

LO

RID

E

Maq

uat

® C

-15

Use

d i

n 2

-in-1

sham

poos,

res

tora

tive

condit

ioner

s, c

ondi-

tionin

g h

airs

pra

y, c

rèm

es a

nd l

oti

ons,

hai

r co

ndit

ioner

s an

d

rinse

s.

Coco

moniu

m

Met

hosu

lfat

e

PE

G-1

5

CO

CO

MO

NIU

M

ME

TH

OS

UL

FA

TE

Maq

uat

® C

-15M

S

Use

d i

n 2

-in-1

sham

poos,

res

tora

tive

condit

ioner

s, c

ondi-

tionin

g h

airs

pra

y, c

rèm

es a

nd l

oti

ons,

hai

r co

ndit

ioner

s an

d

rinse

s.

Gly

cery

l Is

ost

eara

teP

EG

-15 G

LY

CE

RY

L

ISO

ST

EA

RA

TE

Oxypon 2

145

Use

d i

n s

ham

poos,

foam

bat

hs,

show

er g

els,

inti

mat

e

clea

nse

rs, bab

y c

are

pro

duct

s.

Gly

cery

l L

aura

teP

EG

-15 G

LY

CE

RY

L

LA

UR

AT

EG

lyce

rox L

15

Use

d i

n s

ham

poos,

bat

h f

oam

s an

d o

ils,

skin

car

e cr

eam

s

and l

oti

ons,

colo

gnes

, af

ters

hav

es a

nd o

ther

alc

oholi

c sy

s-

tem

s, c

olo

ur

cosm

etic

s an

d a

nti

per

spir

ants

.

Gly

cery

l S

tear

ate

PE

G-1

5 G

LY

CE

RY

L

ST

EA

RA

TE

Nik

kol

TM

GS

-15V

Use

d i

n c

osm

etic

s.

Hydro

gen

ated

Tal

low

amin

e

PE

G-1

5

HY

DR

OG

EN

AT

ED

TA

LL

OW

AM

INE

Pro

tox T

-15

Use

d i

n s

ham

poos.

Act

s as

em

uls

ifer

, an

ti-i

rrit

ant,

neu

tral

iz-

ing a

gen

t, a

nti

-sta

tic

agen

t, a

foam

boost

er a

nd a

mil

d d

eter

-

gen

t.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-1

5

Lau

rate

61791-2

9-5

Jeem

ate

600 M

LE

muls

ifie

r an

d d

isper

sing a

gen

t fo

r cr

eam

s, l

oti

ons

and b

ath

oil

s.

Monom

erat

eH

ET

OX

AM

AT

E M

A -

15

Surf

acta

nt,

em

uls

ifie

r an

d c

oupli

ng a

gen

t. P

oly

oxyla

ted

der

ivat

ives

of

lauri

c, o

leic

, or

stea

ric

acid

are

em

uls

ifie

rs,

hum

ecta

nts

, an

d c

oupli

ng a

gen

ts.

Tal

low

Am

ine

PE

G-1

5 T

AL

LO

W

AM

INE

Sab

opal

NS

15

Alk

alin

e em

uls

ions

like

hai

r-dye

crea

ms

or

gel

s.

PE

G-1

6

25322-6

8-3

PE

G-1

6P

oly

gly

kol

800

Use

d i

n t

ooth

pas

tes

and p

erfu

mes

. A

cts

as a

hum

ecta

nt,

solu

bil

izer

, an

tist

atic

agen

t an

d f

ixat

ive.

Pose

sses

soft

enin

g,

non-i

rrit

atin

g a

nd c

lean

sing p

roper

ties

.

Alm

ond G

lyce

rides

MU

LS

IFA

N C

AO

16

Co-e

muls

ifie

r. I

t is

an e

thoxyla

ted, vir

gin

alm

ond o

il w

ith

non-i

onic

char

acte

r su

pport

ing b

oth

, th

e fo

rmat

ion o

f st

able

w/o

as

wel

l as

o/w

em

uls

ions.

Hydro

gen

ated

Cas

tor

Oil

PE

G-1

6

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

Pro

tach

em C

AH

-16

Use

d i

n p

erso

nal

car

e pro

duct

s. A

cts

as n

on-i

onic

surf

ac-

tant,

em

uls

ifie

r, s

olu

bil

izer

and c

ondit

ioner

.

Mac

adam

ia G

lyce

rides

220459-9

9-4

PE

G-1

6

MA

CA

DA

MIA

GLY

CE

RID

ES

FL

OR

AS

OL

VS

® P

EG

-16

MA

CA

DA

MIA

Co-e

muls

ifyin

g a

gen

t, e

moll

ient,

fra

gra

nce

solu

bil

izer

,

mois

turi

zing a

gen

t, s

olu

bil

izin

g a

gen

t, a

nd s

uper

fatt

ing

agen

t.

PE

G-2

0

25322-6

8-3

PE

G-2

0P

oly

gly

kol

1000

Use

d i

n t

ooth

pas

tes

and p

erfu

mes

. A

cts

as a

hum

ecta

nt,

solu

bil

izer

, an

tist

atic

agen

t an

d f

ixat

ive.

Pose

sses

soft

enin

g,

non-i

rrit

atin

g a

nd c

lean

sing p

roper

ties

.

Alm

ond G

lyce

rides

124046-5

0-0

PE

G-2

0 A

LM

ON

D

GLY

CE

RID

ES

Cro

vol

A-4

0

Use

d in s

oap

form

ula

tions,

bat

h o

il p

roduct

s, s

tyling m

ouss

es,

wat

er-b

ased

aer

oso

ls, an

tiper

spir

ants

and a

stri

ngen

ts. A

cts

as a

hig

h H

LB

nonio

nic

em

uls

ifie

r an

d c

onditio

ner

.

Gly

cery

l L

aura

teP

EG

-20 G

LY

CE

RY

L

LA

UR

AT

ET

agat

® L

2

Surf

acta

nt

and s

olu

bil

izer

in s

ham

poos,

show

er a

nd f

oam

bat

h p

repar

atio

ns

and O

/W e

muls

ions.

Poss

esse

s fo

am

enhan

cing p

roper

ties

.

Gly

cery

l O

leat

eP

EG

-20 G

LY

CE

RY

L

OL

EA

TE

Tag

at®

O 2

VU

sed i

n s

ham

poos,

show

er a

nd f

oam

bat

h p

repar

atio

ns

and

O/W

em

uls

ions.

Gly

cery

l S

tear

ate

68153-7

6-4

PE

G-2

0 G

LY

CE

RY

L

ST

EA

RA

TE

;

PP

G-5

-LA

UR

ET

H-5

Tag

at®

S 2

; C

uti

na®

E 2

4E

muls

ifie

r an

d s

olu

bil

izer

for

sham

poos,

show

er a

nd f

oam

bat

h p

repar

atio

ns

and O

/W e

muls

ions.

Hydro

gen

ated

Lan

oli

n

PE

G-2

0

HY

DR

OG

EN

AT

ED

LA

NO

LIN

Fan

col®

HL

-20

Super

-fat

ting a

gen

t an

d a

solu

bil

izer

. H

elps

for

mic

ro e

mul-

sions.

A g

elli

ng a

gen

t fo

r tr

ansp

aren

t gel

s. U

sed i

n c

ream

s,

loti

ons

and d

ecora

tive

cosm

etic

s.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-2

0

Met

hyl

Glu

cose

Ses

quis

tear

ate

PE

G-2

0

ME

TH

YL

GL

UC

OS

E

SE

SQ

UIS

TE

AR

AT

E

GL

UC

AM

AT

ETM

SS

E-2

0

EM

UL

SIF

IER

Use

d i

n m

akeu

p a

nd i

n s

kin

car

e li

ke

crea

ms

and l

oti

ons.

Act

s as

an o

il i

n w

ater

em

uls

ifie

r, c

lean

ser

and s

tabil

izer

.

Ole

amin

eP

EG

-20 O

LE

AM

INE

Sab

opal

NO

20

Use

d f

or

alkal

ine

emuls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Ole

ate

9004-9

6-0

PE

G-2

0 O

LE

AT

EH

ydri

ol®

OP.

10

Em

uls

ifie

r. U

sed i

n c

osm

etic

s.

Sorb

itan

Iso

stea

rate

66794-5

8-9

PE

G-2

0 S

OR

BIT

AN

ISO

ST

EA

RA

TE

Nik

kol

TI-

10V

Use

d i

n c

osm

etic

s.

Ste

arat

e9004-9

9-3

PE

G-2

0 S

TE

AR

AT

EC

eras

ynt®

840;

Sab

ow

ax S

E 2

0

Use

d i

n p

erso

nal

car

e. A

cts

as a

n e

muls

ifie

r an

d s

uper

fat-

ting a

gen

t. O

ffer

s in

crea

sed v

isco

sity

and s

tabil

ity.

Bis

-PE

G-2

0

Dim

ethic

one

BIS

-PE

G-2

0

DIM

ET

HIC

ON

ES

F 1

388

Enhan

ces

the

soft

sil

ky f

eel

and b

oost

ing f

oam

in w

ater

bas

e pro

duct

s su

ch a

s sh

ampoos,

condit

ioner

s an

d b

ody

was

h a

s w

ell

as w

ash a

bil

ity o

f an

tiper

spir

ants

.

Tri

beh

enin

PE

G-2

0E

ster

sT

RIB

EH

EN

IN

PE

G-2

0 E

ST

ER

SE

muli

um

® 2

2

Use

d i

n s

kin

car

e, s

un c

are,

hai

r ca

re a

nd m

akeu

p a

ppli

ca-

tions.

Off

ers

evan

esce

nt

feel

. Im

pro

ves

spre

adab

ilit

y a

nd

boost

s S

PF.

PE

G-2

2

Lau

rate

61791-2

9-5

Jeem

ate

1000-M

LE

muls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Ole

ate

9004-9

6-0

Jeem

ate

1000-O

CE

muls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Ste

arat

e9004-9

9-3

Jeem

ate

1000-D

PS

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Tal

low

Am

ine

Sab

opal

NS

22

Alk

alin

e em

uls

ions

like

hai

r-dye

crea

ms

or

gel

s.

PE

G-2

3L

aury

l E

ther

LA

UR

ET

H-2

3B

rijTM

L23;

Poly

oxyl

laury

l et

her

NF

Nonio

nic

surf

acta

nt,

solu

bil

iser

and w

etti

ng a

gen

t.

PE

G-2

4

Dim

ethic

one

FM

-2501;

Cosm

ethic

one®

SF

-230

Em

uls

ifia

ble

and i

mpar

ts s

oft

and g

loss

y f

eel

in p

roduct

.

Hydro

gen

ated

Lan

oli

n68648-2

7-1

PE

G-2

4

HY

DR

OG

EN

AT

ED

LA

NO

LIN

Fan

col®

HL

-24;

Super

sat

AW

S-2

4

Super

-fat

ting a

gen

t an

d a

solu

bil

izer

. H

elps

for

mic

ro e

mul-

sions.

A g

elli

ng a

gen

t fo

r tr

ansp

aren

t gel

s. U

sed i

n c

ream

s,

loti

ons,

dec

ora

tive

cosm

etic

s.

PE

G-2

5

Hydro

gen

ated

Cas

tor

Oil

PE

G-2

5

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

Cro

dure

tTM

25

Co-s

olu

bil

iser

and w

/o e

muls

ifie

r. H

elps

to c

ontr

ol

the

con-

sist

ency

of

gel

. U

sed i

n b

ath a

s w

ell

as s

how

er p

roduct

s,

condit

ioner

s, s

ham

poos

and s

tyli

ng p

roduct

s.

Ole

amin

eP

EG

-25 O

LE

AM

INE

Sab

opal

NO

25

Alk

alin

e em

uls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Pab

a11

3010-5

2-9

PE

G-2

5 P

AB

AU

vin

ul®

P25

Use

d i

n s

kin

cosm

etic

s, h

air

care

lik

e gel

s an

d s

ham

poos,

colo

rant,

set

ting l

oti

ons,

norm

al a

nd g

loss

hai

r sp

rays.

Act

s

as a

UV

-B f

ilte

r.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-2

5S

tear

ate

9004-9

9-3

PE

G-2

5 S

TE

AR

AT

EN

ikkol

MY

S-2

5H

ydro

phil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

Tal

low

Am

ine

Sab

opal

NS

25

Alk

alin

e em

uls

ions

like

hai

r-dye

crea

ms

or

gel

s.

PE

G-2

6G

lyce

rine

GLY

CE

RE

TH

-26

Em

oll

ients

, em

uls

ifie

rs,

thic

ken

ers,

sta

bil

izer

s, o

pac

ifie

rs

and p

earl

esce

nt

agen

ts f

or

such

pro

duct

s as

cre

ams,

loti

ons,

shav

ing c

ream

s an

d c

ream

sham

poos.

PE

G-2

7L

anoli

nP

EG

-27 L

AN

OL

IN

Super

-fat

ting c

ondit

ioner

and m

ois

turi

zer.

Res

tore

s lo

st l

ip-

ids

and i

mpar

ts s

hee

n. U

sed i

n h

air

care

and s

kin

car

e fo

r-

mula

tions.

PE

G-2

9C

asto

r O

ilP

EG

-29 C

AS

TO

R O

ILE

toca

sTM

29

Dis

per

sing a

gen

t, o

/w e

muls

ifie

r, s

olu

bil

iser

, w

/o c

o-e

muls

i-

fier

. U

sed i

n s

kin

car

e cr

eam

s, l

oti

ons,

bat

h p

roduct

s,

show

er g

el/b

ody w

ash, li

quid

soap

s an

d f

acia

l w

ash.

PE

G-3

0

Alm

ond G

lyce

rides

MU

LS

IFA

N C

AO

30

Co-e

muls

ifie

r. I

t is

an e

thoxyla

ted, vir

gin

alm

ond o

il w

ith

non-i

onic

char

acte

r use

d f

or

the

pre

par

atio

n o

f o/w

em

ul-

sions.

Cas

tor

Oil

61791-1

2-6

PE

G-3

0 C

AS

TO

R O

ILS

abow

ax E

L 3

0;

Alk

amuls

® B

Use

d i

n t

oil

etri

es, oin

tmen

ts a

nd i

n t

ransp

aren

t gel

s.

Dip

oly

hydro

xyst

eara

te

PE

G-3

0

DIP

OLY

HY

DR

OX

YS

T

EA

RA

TE

Sab

ow

ax P

IS;

Sim

alin

e W

O;

Cit

hro

lTM

DP

HS

Use

d f

or

med

ium

vis

cosi

ty c

ream

s. A

cts

as a

wat

er-i

n-o

il

emuls

ifie

r, t

o s

tabil

ize

all

types

of

oil

eff

ecti

vel

y a

t lo

w c

on-

centr

atio

ns

wit

h t

extu

res

rangin

g f

rom

loti

on t

o t

hic

k c

ream

.

Gly

cery

l C

oco

ate

PE

G-3

0 G

LY

CE

RY

L

CO

CO

AT

ER

ewoder

m®

LI

63

Use

d i

n b

aby s

ham

poo f

orm

ula

tions,

oil

and b

ath f

orm

ula

-

tions.

Poss

esse

s ver

y m

ild. O

ffer

s good s

kin

com

pat

ibil

ity

and m

uco

us

mem

bra

ne

com

pat

ibil

ity.

Gly

cery

l C

oco

ate

68201-4

6-7

PE

G-3

0 G

LY

CE

RY

L

CO

CO

AT

EJe

echem

GC

-30

Use

d i

n b

aby s

ham

poos,

bab

y w

ashes

, se

nsi

tive

skin

form

u-

lati

ons,

fra

gra

nce

s an

d o

ils.

Gly

cery

l S

oyat

eP

EG

-30 G

LY

CE

RY

L

SO

YA

TE

CH

EM

ON

ICTM

SI-

63

SU

RFA

CT

AN

T

Use

d i

n b

aby s

ham

poos,

bab

y w

ashes

, se

nsi

tive

skin

form

u-

lati

ons,

fra

gra

nce

s an

d o

ils

and o

ther

mil

d p

erso

nal

car

e fo

r-

mula

tions.

Act

s as

a n

onio

nic

surf

acta

nt.

Gly

cery

l S

tear

ate

PE

G-3

0 G

LY

CE

RY

L

ST

EA

RA

TE

Tag

at®

SU

sed i

n s

ham

poos,

show

er a

nd f

oam

bat

h p

repar

atio

ns

and

O/W

em

uls

ions.

Lan

oli

n61790-8

1-6

PE

G-3

0 L

AN

OL

INB

EL

LP

OL

L-3

0

Non-i

onic

em

oll

iati

ng s

urf

acta

nt

that

can

be

use

d a

s a

hydro

phil

ic e

muls

ifie

r. I

t is

obta

ined

fro

m s

ecre

tion o

f

shee

p’s

seb

aceo

us

gla

nds.

Ole

amin

eP

EG

-30 O

LE

AM

INE

Sab

opal

NO

30

Alk

alin

e em

uls

ions

like

hai

r-dye

crea

ms

or

gel

s.

Tal

low

Am

ine

PE

G-3

0 T

AL

LO

W

AM

INE

Sab

opal

NS

30

Alk

alin

e em

uls

ions

like

hai

r-dye

crea

ms

or

gel

s.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-3

2

25322-6

8-3

PE

G-3

2

Sym

pat

ens

PE

G-1

500 G

;

Ren

exTM

PE

G 1

500;

Jeec

hem

1450;

Sab

opeg

1500;

Plu

raca

re®

E 1

450 N

NF

Poly

ethyle

ngly

col

wit

h a

ppro

x. m

ole

cula

r w

eight

1500 (

32

EO

). E

muls

ions

Liq

uid

pro

duct

s L

oti

ons.

Ste

arat

eJe

emat

e 1540-D

PS

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.

Sunfl

ow

er S

eed

Oil

PE

G-3

2E

ster

sS

UN

FL

OW

ER

SE

ED

OIL

PE

G-3

2 E

ST

ER

S

Via

tenza

® O

leic

Sunfl

ow

er

PE

32

Use

d i

n s

ham

poos

for

dam

aged

hai

r, b

ath p

roduct

s, f

ace

care

, per

sonal

and f

ace

hygei

ne.

PE

G-3

5

Cas

tor

Oil

PE

G-3

5 C

AS

TO

R O

ILE

toca

sTM

35

O/W

em

uls

ifie

r, w

/o c

oem

uls

ifie

r, s

olu

bil

iser

and d

isper

s-

ing a

gen

t. U

sed i

n s

kin

car

e cr

eam

s, l

oti

ons,

bat

h p

roduct

s,

show

er g

el/b

ody w

ash, li

quid

soap

s an

d f

acia

l w

ash.

Soy G

lyce

rides

61791-2

3-9

PE

G-3

5 S

OY

GLY

CE

RID

ES

Acc

onon®

S-3

5

Low

-mel

t so

lid, w

ater

solu

ble

veg

etab

le o

il d

eriv

ativ

e

obta

ined

fro

m r

efin

ed s

oybea

n o

il. It

is

nonio

nic

and c

om

-

pat

ible

wit

h o

ther

ionic

spec

ies

in f

orm

ula

tion.

PE

G-3

6C

asto

r O

il61791-1

2-6

P

EG

-36 C

AS

TO

R O

ILA

lpic

are

CO

36;

AL

KE

ST

®

CS

O 3

60

Nonio

nic

solu

bil

izin

g a

gen

t fo

r fr

agra

nce

s, e

ssen

tial

oil

s,

lipophil

ic a

ctiv

es a

nd v

itam

ins.

PE

G-4

0

25322-6

8-3

P

EG

-40

Poly

gly

kol

2000 S

Hum

ecta

nt,

solu

bil

izer

, an

tist

atic

agen

t an

d a

fix

ativ

e.

Pose

sses

soft

enin

g, cl

eansi

ng a

nd n

on-i

rrit

atin

g p

roper

ties

.

Cas

tor

Oil

61791-1

2-6

PE

G-4

0 C

AS

TO

R O

ILJe

echem

CA

-40;

Sab

ow

ax E

L 4

0

Use

d f

or

loti

ons,

cre

ams,

hai

r ca

re a

nd l

ipst

icks.

Poss

esse

s

per

fum

e so

lubil

izer

, em

oll

ient,

em

uls

ifie

r, l

ubri

cant,

and

dis

per

sant.

Hydro

gen

ated

Cas

tor

Oil

61788-8

5-0

PE

G-4

0

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

;

PP

G-5

-LA

UR

ET

H-5

Fin

det

® A

RH

/52;

Akypo®

RO

X C

O 4

00;

Sab

ow

ax

EL

H 4

0;

Cre

mophor®

CO

40;

Eum

ulg

in®

HR

E 4

0

Non-i

onic

surf

acta

nt

acts

as

extr

acts

, per

fum

es a

nd v

ita-

min

s so

lubil

izer

. U

sed i

n h

air

care

, m

en’s

gro

om

ing p

rod-

uct

s, s

kin

car

e, b

ath a

nd s

how

er p

roduct

s.

Lan

oli

n8051-8

2-9

;

61790-8

1-6

P

EG

-40 L

AN

OL

INL

anet

o 4

0

Use

d i

n s

ham

poos,

condit

ioner

s, b

ath p

repar

atio

ns,

cre

ams,

loti

ons,

as

wel

l as

soap

and d

eter

gen

t sy

stem

s. A

cts

as a

n

emoll

ient,

lubri

cant

and s

olu

bil

izer

.

Sorb

itan

Per

isost

eara

teP

EG

-40 S

OR

BIT

AN

PE

RIS

OS

TE

AR

AT

ET

ego®

SIS

40

Use

d i

n W

/O s

kin

car

e lo

tions

and c

ream

s an

d b

ath p

rod-

uct

s. O

ffer

s good e

muls

ifyin

g a

nd s

olu

bil

izin

g p

roper

ties

.

Sorb

itan

Per

ole

ate

PE

G-4

0 S

OR

BIT

AN

PE

RO

LE

AT

EA

rlat

oneTM

TV

Spre

adin

g a

gen

t of

exce

pti

onal

ly h

igh e

ffic

iency

as

wel

l as

liquid

W/O

co-e

muls

ifie

r. U

sed i

n b

ath &

show

er p

roduct

s,

bab

y c

are,

body c

are,

fac

ial

care

and s

un c

are.

Ste

arat

e9004-9

9-3

PE

G-4

0 S

TE

AR

AT

E

Jeem

ate

2000-D

PS

Fla

ke;

Nik

kol

MY

S-4

0;

Rit

ox 5

2;

Sab

ow

ax S

E 4

0

Em

uls

ifie

rs a

nd d

isper

sing a

gen

ts f

or

crea

ms,

loti

ons

and

bat

h o

ils.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-4

2B

abas

su G

lyce

rides

PE

G-4

2 B

AB

AS

SU

GLY

CE

RID

ES

Cro

vol

BA

70G

Use

d i

n s

kin

car

e pro

duct

s, d

eter

gen

t cl

eanse

rs, bat

h a

nd

show

er p

roduct

s, s

ham

poos

and c

ondit

ioner

s, s

tyli

ng p

rod-

uct

s, a

fter

shav

es, co

lognes

and b

ody s

pra

ys.

PE

G-4

5P

alm

Ker

nel

Gly

ceri

des

124046-5

2-2

PE

G-4

5

PAL

M K

ER

NE

L

GLY

CE

RID

ES

Cro

vol

PK

-70

Use

d i

n s

kin

car

e pro

duct

s, b

ath a

nd s

how

er p

roduct

s,

sham

poos

and c

ondit

ioner

s, s

tyli

ng p

roduct

s, a

fter

shav

es,

colo

gnes

and b

ody s

pra

ys,

anti

per

spir

ants

and d

eodora

nts

.

Ste

arat

e9004-9

9-3

PE

G-4

5 S

TE

AR

AT

EN

ikkol

MY

S-4

5H

ydro

phil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

PE

G-5

0

Hydro

gen

ated

Cas

tor

Oil

PE

G-5

0

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

Pro

tach

em C

AH

-50

Use

d i

n p

erso

nal

car

e pro

duct

s. A

cts

as n

on-i

onic

surf

ac-

tant,

em

uls

ifie

r, s

olu

bil

izer

and c

ondit

ioner

.

Hydro

gen

ated

Pal

mam

ide

544-3

1-0

Eth

om

id®

HP

/60

Rheo

logy m

odif

ier,

wet

ting a

gen

t. I

t is

an e

thoxyla

ted

amid

e w

hic

h i

s use

d i

n a

var

iety

of

appli

cati

ons

to p

rovid

e

dis

per

sabil

ity a

nd r

heo

logy.

Lan

oli

n61790-8

1-6

PE

G-5

0 L

AN

OL

INB

EL

LP

OL

L-5

0

Non-i

onic

em

oll

iati

ng s

urf

acta

nt

that

can

be

use

d a

s a

hydro

phil

ic e

muls

ifie

r. I

t is

obta

ined

fro

m s

ecre

tion o

f

shee

p’s

seb

aceo

us

gla

nds.

Shea

Butt

erP

EG

-50 S

HE

A

BU

TT

ER

Sheb

u W

SU

sed i

n w

ater

-bas

ed p

roduct

s, s

uch

as

sham

poos,

condit

ion-

ers,

cre

ams,

loti

ons

and o

ther

pro

duct

s. A

cts

as a

n e

moll

ient.

Ste

arat

e9004-9

9-3

PE

G-5

0 S

TE

AR

AT

EM

yrjTM

S50;

Rit

ox 5

3

Co-e

muls

ifie

r fo

r o/w

syst

ems

and c

ondit

ionin

g a

gen

t. U

sed

in b

ody c

are,

fac

ial

care

, bab

y c

are,

cre

ams,

loti

ons,

cle

an-

ers,

toner

s, s

kin

tre

atm

ents

, fe

et, han

ds.

Tal

low

amin

e61791-2

6-2

(g)

Het

oxam

ine

T-5

0

Anti

-sta

tic

agen

t an

d a

s em

uls

ifie

r fo

r w

axes

and o

ils.

It

is

form

ed b

y t

he

reac

tion o

f fa

tty p

rim

ary a

min

es w

ith e

th-

yle

ne

oxid

e.

PE

G-5

4

Cas

tor

Oil

61791-1

2-6

PE

G-5

4 C

AS

TO

R O

ILA

LK

ES

T®

CS

O 5

40

Em

uls

ifie

r, s

olu

bil

izer

, em

oll

ient,

dis

per

sing a

gen

t an

d

hum

ecta

nt.

It

is a

non-i

onic

surf

acta

nt.

Hydro

gen

ated

Cas

tor

Oil

PE

G-4

0

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

Cro

dure

tTM

54

Eff

ecti

ve

solu

bil

iser

of

per

fum

es, es

senti

al o

ils

and l

ipo-

phil

ic a

ctiv

es f

or

use

in m

icro

emuls

ions.

Im

par

ts s

uper

fat-

ting b

enef

its

in d

eter

gen

t sy

stem

s.

PE

G-5

5S

tear

ate

9004-9

9-3

PE

G-5

5 S

TE

AR

AT

EN

ikkol

MY

S-5

5H

ydro

phil

ic e

muls

ifie

r obta

ined

by t

he

addit

ion o

f et

hyle

ne

oxid

e to

fat

ty a

cids.

PE

G-6

0

25322-6

8-3

PE

G-6

0P

oly

gly

kol

3000 S

Act

s as

a s

lip a

nd m

old

-rel

ease

agen

t, s

olu

bil

izer

, ca

rrie

r,

thic

ken

er a

nd a

nti

stat

ic a

gen

t. P

ose

sses

bin

din

g, so

ften

ing

and n

on-i

rrit

atin

g p

roper

ties

.

Alm

ond G

lyce

rides

124046-5

0-0

PE

G-6

0 A

LM

ON

D

GLY

CE

RID

ES

Cro

volTM

A-7

0N

on-i

onic

surf

acta

nt, e

muls

ion s

tabilis

er, dis

per

sant, e

mollie

nt,

pla

stic

iser

, so

lubilis

er, su

per

fattin

g a

gen

t an

d w

etting a

gen

t.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-6

0

Cas

tor

Oil

61791-1

2-6

PE

G-6

0 C

AS

TO

R O

ILJe

echem

CA

-60

Use

d f

or

loti

ons,

cre

ams,

hai

r ca

re a

nd l

ipst

icks.

Poss

esse

s

per

fum

e so

lubil

izer

, em

oll

ient,

em

uls

ifie

r, l

ubri

cant,

and

dis

per

sant.

Corn

Gly

ceri

des

PE

G-6

0 C

OR

N

GLY

CE

RID

ES

Cro

vol

M-7

0

Use

d i

n s

kin

car

e pro

duct

s, s

ham

poos

and c

ondit

ioner

s,

bat

h a

nd s

how

er p

roduct

s, s

tyli

ng p

roduct

s, a

fter

shav

es,

colo

gnes

and b

ody s

pra

ys,

anti

per

spir

ants

and d

eodora

nts

.

Even

ing P

rim

rose

Gly

ceri

des

PE

G-6

0 E

VE

NIN

G

PR

IMR

OS

E

GLY

CE

RID

ES

Cro

vol

EP

70

Use

d i

n s

kin

car

e pro

duct

s, d

eter

gen

t cl

eanse

rs, bat

h a

nd

show

er p

roduct

s, s

ham

poos

and c

ondit

ioner

s, s

tyli

ng p

rod-

uct

s, a

fter

shav

es a

nd c

olo

gnes

.

Hydro

gen

ated

Cas

tor

Oil

61788-8

5-0

PE

G-6

0

HY

DR

OG

EN

AT

ED

CA

ST

OR

OIL

;

PP

G-5

-LA

UR

ET

H-5

Sab

ow

ax E

LH

60;

Cre

mophor®

CO

60;

Eum

ulg

in®

HR

E 6

0

Use

d i

n t

oil

etri

es, oin

tmen

ts a

nd t

ransp

aren

t gel

s.

Lan

oli

n8039-0

9-0

6P

EG

-60 L

AN

OL

INJe

elan

L-6

0

Em

uls

ifie

rs, st

abil

izer

s, e

moll

ients

, m

ois

turi

zers

and a

bso

rp-

tion b

ases

for

crea

ms,

loti

ons,

liq

uid

mak

e-up a

nd g

ener

al

purp

ose

cosm

etic

s.

Mar

acuja

Gly

ceri

des

Cro

volTM

Mar

acuja

Pla

stic

iser

, so

lubil

iser

, su

per

fatt

ing a

gen

t, w

ater

solu

ble

emoll

ient

and c

ounte

r ir

rita

nt.

PE

G-7

5

25322-6

8-3

PE

G-7

5S

ym

pat

ens

PE

G-4

000 G

;

Sab

opeg

4000

Poly

ethyle

ngly

col

wit

h a

ppro

x. m

ole

cula

r w

eight

4000 (

75

EO

). E

muls

ions

Liq

uid

pro

duct

s L

oti

ons.

Lan

oli

n

61790-8

1-6

;

8039-0

9-6

;

61790-8

1-7

;

61790-8

1-8

PE

G-7

5 L

AN

OL

IN

Pro

moll

ient®

AL

PE

G-7

5;

Jeel

an L

-75;

Jeel

an L

-75/5

0;

Fin

det

® L

N/8

750

Eth

oxyla

ted d

eriv

ativ

e of

lanoli

n w

hic

h h

as e

muls

ifyin

g,

solu

bil

izin

g, w

etti

ng a

nd c

lean

sing p

roper

ties

and i

s an

idea

l pro

duct

for

soap

s an

d c

lean

sing g

el.

Mea

dow

foam

See

d O

ilP

EG

-75

ME

AD

OW

FO

AM

OIL

Mea

dow

sol®

75:7

5

Em

uls

ifie

r. H

elps

dis

per

se a

nd w

et p

igm

ents

. B

oost

s an

d

stab

iliz

es t

he

foam

. P

rovid

es t

he

emoll

iency

, co

ndit

ionin

g

and s

uper

fatt

ing p

roper

ties

.

Shea

Butt

er G

lyce

rides

PE

G-7

5

SH

EA

BU

TT

ER

GLY

CE

RID

ES

Cro

vol

SB

75/5

0

Em

uls

ion s

tabil

iser

, w

etti

ng a

gen

t, d

isper

sant

and s

uper

fat-

ting a

gen

t. P

oss

esse

s em

oll

ient,

pla

stic

iser

and s

olu

bil

iser

pro

per

ties

.

PE

G-7

8G

lyce

ryl

Coco

ate

68201-4

6-7

PE

G-7

8 G

LY

CE

RY

L

CO

CO

AT

ED

UB

CG

7E

muls

ifie

r. U

sed i

n b

ath p

repar

atio

n, al

coholi

c lo

tion,

sham

poo, cl

ear

crea

m a

nd s

urf

acta

nt

for

mic

roem

uls

ion.

PE

G-8

0

Gly

cery

l C

oco

ate

PE

G-8

0 G

LY

CE

RY

L

CO

CO

AT

E

Coru

m 9

860;

CH

EM

ON

ICTM

LI-

6875 S

UR

FA

CT

AN

T

Super

-fat

ting a

gen

t, e

asil

y s

olu

ble

in w

ater

, al

cohol

and t

he

maj

ori

ty o

f org

anic

solv

ents

.

Sorb

itan

Lau

rate

9005-6

4-5

;

68154-3

3-6

PE

G-8

0 S

OR

BIT

AN

LA

UR

AT

E

Het

sorb

L-8

0-7

2%

; T

wee

nTM

28;

Alk

amuls

® P

SM

L-8

0/7

2

Em

uls

ifie

r fo

r oil

s, l

ubri

cant,

solv

ent

and v

isco

sity

contr

ol

agen

t. I

t is

an e

thoxyla

ted s

orb

itan

est

er i

dea

l fo

r co

smet

ics

and p

erso

nal

car

e fo

rmula

tions.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-8

1C

asto

r O

ilH

ET

OX

IDE

C -

81

Hum

ecta

nt

and s

olu

bil

izer

.

PE

G-9

0

25322-6

8-3

PE

G-9

0P

lura

care

® E

4000 F

lakes

Use

d i

n c

osm

etic

s fo

rmula

tions.

Act

s as

a h

um

ecta

nt,

bin

der

, so

lubil

izer

and a

bso

rpti

on p

rom

ote

r. P

oss

esse

s non-

irri

tati

ng a

nd m

ois

turi

zing p

roper

ties

.

Apri

cot

Ker

nel

Gly

ceri

des

Use

d i

n s

kin

car

e pro

duct

s, d

eter

gen

t cl

eanse

rs, bat

h a

nd

show

er p

roduct

s, s

ham

poos

and c

ondit

ioner

s, s

tyli

ng p

rod-

uct

s, a

fter

shav

es, co

lognes

and b

ody s

pra

ys.

Dii

sost

eara

te36493-2

5-1

PE

G-9

0

DII

SO

ST

EA

RA

TE

HY

DR

AM

OLTM

PG

DS

ES

TE

R

Use

d i

n h

air

trea

tmen

t, a

nti

per

spir

ant

and d

eodora

nt

and i

n

crea

my g

els.

Act

s as

an e

moll

ient.

Poss

esse

s co

ndit

ionin

g

and v

isco

sity

buil

din

g p

roper

ties

.

PE

G-1

00

Alm

ond G

lyce

rides

MU

LS

IFA

N C

AO

100

Em

uls

ifie

r. I

t is

an e

thoxyla

ted,

vir

gin

sw

eet

alm

ond o

il

wit

h n

on-i

onic

char

acte

r use

d f

or

the

pre

par

atio

n o

f o/w

emuls

ions.

Ste

arat

e9004-9

9-3

(gen

eric

)P

EG

-100 S

TE

AR

AT

E

Hal

lSta

r® P

EG

4400 M

S;

Jeem

ate

4400 D

PS

;

Sab

ow

ax S

E 1

00

Non-i

onic

em

uls

ifie

r (o

/w)

from

pet

roch

emic

al a

nd v

eget

al

sourc

es. U

sed i

n a

fter

sun s

kin

car

e, a

nti

per

spir

ants

, bea

ch

wea

r su

n c

are,

cle

ansi

ng w

ipes

.

PE

G-1

20

Met

hyl

Glu

cose

Dio

leat

e86893-1

9-8

PE

G-1

20 M

ET

HY

L

GL

UC

OS

E D

IOL

EA

TE

Anti

l® 1

20 P

lus;

Ret

hic

k

DO

E120

Use

d i

n h

air

sham

poo, sh

ow

er g

el, fo

am b

ath, li

quid

soap

or

han

d w

ash p

aste

. O

ffer

s ver

y g

ood t

hic

ken

ing p

roper

-

ties

. R

educe

s th

e ir

rita

tion p

ote

nti

al o

f su

rfac

tants

.

PE

G-1

50

25322-6

8-3

PE

G-1

50

Sab

opeg

6000;

Plu

raca

re®

E 6

000 F

lakes

Use

d i

n c

osm

etic

form

ula

tions.

Act

s as

a h

um

ecta

nt,

bin

der

,

solu

bil

izer

s an

d a

bso

rpti

on p

rom

ote

r. P

oss

esse

s nonir

rita

t-

ing a

nd m

ois

turi

zing p

roper

ties

.

Dis

tear

ate

9005-0

8-0

7P

EG

-150

DIS

TE

AR

AT

E

Rew

opal

® P

EG

6000 D

S;

Hal

lSta

r® P

EG

6000 D

S;

RE

WO

PAL

® P

EG

6000

DS

A;

Hal

lSta

r® P

EG

6000

DS

C;

Jeem

ate

6000-D

S;

Nik

kol

CD

S-6

000P

Use

d i

n b

aby s

ham

poos,

mil

d h

air

sham

poos,

foam

bat

hs

and s

how

er s

ham

poos

and s

kin

cle

ansi

ng l

oti

ons.

Off

ers

dis

tinct

ive

vis

cosi

ty m

odif

yin

g e

ffec

t.

Pen

taer

yth

rity

l

Tet

rast

eara

te130249-4

8-8

PE

G-1

50

PE

NT

AE

RY

TH

RIT

YL

TE

TR

AS

TE

AR

AT

E

Cro

thixTM

Rheo

logy m

odif

ier

or

thic

ken

ing a

gen

t. U

sed i

n h

air

sham

-

poos,

anti

dan

dru

ff s

ham

poos,

show

er g

els

and f

oam

bat

hs.

Poly

gly

cery

l-2

Tri

stea

rate

72828-1

1-6

PE

G-1

50

PO

LY

GLY

CE

RY

L-2

TR

IST

EA

RA

TE

Gen

apol®

DA

T 1

00

Use

d i

n s

ham

poos,

body w

ashes

and s

how

er g

els.

Act

s as

an e

asy t

o h

andle

, li

quid

ass

oci

ativ

e th

icken

er a

nd c

ondi-

tionin

g a

gen

t.

Ste

arat

e9004-9

9-3

PE

G-1

50 S

TE

AR

AT

EH

allS

tar®

PE

G 6

000 M

S

Cle

ansi

ng a

gen

t, c

o-e

muls

ifyin

g a

gen

t, e

muls

ifyin

g a

gen

t

(w/o

), s

olu

bil

izin

g a

gen

t an

d t

hic

ken

er. U

sed i

n f

oot

care

,

hai

r co

ndit

ioner

s an

d h

and &

body c

are.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-1

75

Dii

sost

eara

teP

EG

-175

DII

SO

ST

EA

RA

TE

HE

ST

HV

BE

xce

llen

t vis

cosi

ty b

uil

der

for

sham

poo, sh

ow

er g

el, bub-

ble

bat

h.

PE

G-1

80

25322-6

8-3

PE

G-1

80

Plu

raca

re®

E 8

000 F

lakes

Use

d i

n c

osm

etic

s fo

rmula

tions.

Act

s as

a h

um

ecta

nt,

bin

der

, so

lubil

izer

and a

bso

rpti

on p

rom

ote

r. P

oss

esse

s non-

irri

tati

ng a

nd m

ois

turi

zing p

roper

ties

.

PE

G-2

00

Hum

ecta

nt,

show

er a

nd b

ath p

roduct

s, c

ream

s an

d l

oti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

Cas

tor

Oil

PE

G-2

00 C

AS

TO

R O

ILE

toca

sTM

200;

Pro

tach

em C

A-2

00

O/W

em

uls

ifie

r. U

sed i

n b

ath p

roduct

s, l

iquid

soap

s, f

acia

l

was

h, hai

r tr

eatm

ents

, su

n p

rote

ctio

n, m

ale

gro

om

ing, bab

y

care

and h

air

styli

ng.

Gly

cery

l S

tear

ate

Sim

uls

ol

220

Thic

ken

ing, non-i

onic

surf

acta

nt

foam

ing a

gen

t use

d i

n

foam

ing f

orm

ula

s. R

educe

s ir

rita

tion. Is

pre

serv

ativ

e-fr

ee.

Hydro

gen

ated

Gly

cery

l P

alm

itat

e

PE

G-2

00

HY

DR

OG

EN

AT

ED

GLY

CE

RY

L P

AL

MA

TE

Coru

m 9

926;

Rew

oder

m®

LI

520-7

0

Veg

etab

le b

ased

em

uls

ifie

r w

ith s

olu

bil

izin

g a

nd t

hic

ken

-

ing p

roper

ties

. It

is

ver

y c

om

pat

ible

to s

kin

, m

uco

us

mem

-

bra

ne.

Lau

rate

Non-i

onic

wet

ting a

nd d

isper

sing a

gen

t in

colo

r co

smet

ics

solu

bil

izer

s &

sta

bil

izer

s.

PE

G-2

00 U

SP

25322-6

8-3

PE

G-4

Per

fum

e fi

xat

ive.

Mois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

. In

loti

ons,

act

s as

a

clea

nsi

ng a

gen

t.

PE

G-2

20

25322-6

8-3

PE

G-2

20

Poly

gly

kol

10000 P

Use

d i

n s

kin

car

e. A

cts

as a

sli

p a

nd m

old

-rel

ease

agen

t,

solu

bil

izer

, ca

rrie

r, t

hic

ken

er a

nd a

nti

stat

ic a

gen

t. P

ose

sses

bin

din

g, so

ften

ing a

nd n

on-i

rrit

atin

g p

roper

ties

.

PE

G-2

40

25322-6

8-3

PE

G-2

40

Poly

gly

kol

12000 P

Use

d i

n s

kin

car

e. A

cts

as a

sli

p a

nd m

old

-rel

ease

agen

t,

solu

bil

izer

, ca

rrie

r, t

hic

ken

er a

nd a

nti

stat

ic a

gen

t. P

ose

sses

bin

din

g, so

ften

ing a

nd n

on-i

rrit

atin

g p

roper

ties

.

PE

G-3

00

PE

G-6

PE

G-6

Hum

ecta

nt,

how

er a

nd b

ath p

roduct

s, c

ream

s an

d l

oti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

PE

G-3

00 U

SP

PE

G-6

Hum

ecta

nt.

Use

d i

n s

how

er a

nd b

ath p

roduct

s, c

ream

s an

d

loti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

PE

G-4

00

PE

G-4

00

Pro

tach

em 4

00

Use

d i

n p

erso

nal

car

e pro

duct

s. A

cts

as e

moll

ient,

lubri

-

cant,

solv

ent,

em

uls

ifie

r an

d s

tabil

izer

. P

ose

sses

thic

ken

ing,

opac

ifyin

g a

nd s

urf

acta

nt

pro

per

ties

.

PE

G-4

00 U

SP

PE

G-8

Hum

ecta

nt.

Use

d i

n s

how

er a

nd b

ath p

roduct

s, c

ream

s an

d

loti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

PE

G-4

50

25322-6

8-3

PE

G-4

50

Poly

gly

kol

20000 P

Use

d i

n s

kin

car

e. A

cts

as a

sli

p a

nd m

old

-rel

ease

agen

t,

solu

bil

izer

, ca

rrie

r, t

hic

ken

er a

nd a

nti

stat

ic a

gen

t. P

ose

sses

bin

din

g, so

ften

ing a

nd n

on-i

rrit

atin

g p

roper

ties

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-6

00

25322-6

8-3

PE

G-1

2H

um

ecta

nt,

show

er a

nd b

ath p

roduct

s, c

ream

s an

d l

oti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

PE

G-6

00 U

SP

PE

G-1

2H

um

ecta

nt.

Use

d i

n s

how

er a

nd b

ath p

roduct

s, c

ream

s an

d

loti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

PE

G-8

00

25322-6

8-3

PE

G-8

00

Poly

gly

kol

35000 S

Use

d i

n s

kin

car

e. A

cts

as a

sli

p a

nd m

old

-rel

ease

agen

t,

solu

bil

izer

, ca

rrie

r, t

hic

ken

er a

nd a

nti

stat

ic a

gen

t. P

ose

sses

bin

din

g, so

ften

ing a

nd n

on-i

rrit

atin

g p

roper

ties

.

PE

G-6

000

25322-6

8-3

PE

G-1

50

Sli

p a

nd m

old

-rel

ease

agen

t. W

ater

-solu

ble

car

rier

sub-

stan

ce. S

oft

ener

. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

.

PE

G-1

000

25322-6

8-3

PE

G-2

0

Per

fum

e fi

xat

ive.

Soft

ener

. M

ois

ture

-sta

bil

izin

g e

ffec

t in

crea

ms.

Lea

ves

a p

leas

ant

feel

on t

he

skin

. In

loti

ons,

act

s

as a

cle

ansi

ng a

gen

t.

PE

G-2

000

25322-6

8-3

PE

G-4

0

Per

fum

e fi

xat

ive.

Soft

ener

. N

on-g

reas

y l

ubri

cant.

Mois

ture

-

stab

iliz

ing e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

. In

loti

ons,

act

s as

a c

lean

sing a

gen

t.

PE

G-1

500

25322-6

8-3

PE

G-3

2

Per

fum

e fi

xat

ive.

Soft

ener

. N

on-g

reas

y l

ubri

cant.

Mois

ture

-

stab

iliz

ing e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

. In

loti

ons,

act

s as

a c

lean

sing a

gen

t.

PE

G-1

500F

PE

G-3

2H

um

ecta

nt.

Use

d i

n s

how

er a

nd b

ath p

roduct

s, c

ream

s an

d

loti

ons,

sham

poos,

shav

ing p

roduct

s an

d l

iquid

soap

s.

PE

G-3

000

25322-6

8-3

PE

G-6

0

Sli

p a

nd m

old

-rel

ease

agen

t. W

ater

-solu

ble

car

rier

sub-

stan

ce. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a

ple

asan

t fe

el o

n t

he

skin

.

PE

G-3

350

25322-6

8-3

PE

G-7

5P

rota

chem

75

Soft

ener

. S

lip a

nd m

old

-rel

ease

agen

t. M

ois

ture

-sta

bil

izin

g

effe

ct i

n c

ream

s. L

eaves

a p

leas

ant

feel

on t

he

skin

. C

an b

e

use

d i

n t

ransp

aren

t to

oth

pas

tes.

PE

G-4

000

25322-6

8-3

PE

G-9

0

Sli

p a

nd m

old

-rel

ease

agen

t. W

ater

-solu

ble

car

rier

sub-

stan

ce. S

oft

ener

. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

.

PE

G-8

000

25322-6

8-3

PE

G-1

80

Sli

p a

nd m

old

-rel

ease

agen

t. W

ater

solu

ble

car

rier

sub-

stan

ce. S

oft

ener

. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

.

PE

G-1

0000

25322-6

8-3

PE

G-2

20

Sli

p a

nd m

old

-rel

ease

agen

t. W

ater

solu

ble

car

rier

sub-

stan

ce. S

oft

ener

. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-1

2000

25322-6

8-3

PE

G-2

40

Sli

p a

nd m

old

-rel

ease

agen

t. S

oft

ener

.Wat

er s

olu

ble

car

rier

subst

ance

s. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a

ple

asan

t fe

el o

n t

he

skin

.

PE

G-2

0000

25322-6

8-3

PE

G-3

50

Sli

p a

nd m

old

-rel

ease

agen

t. S

oft

ener

. W

ater

-solu

ble

car

rier

subst

ance

s. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a

ple

asan

t fe

el o

n t

he

skin

.

PE

G-3

5000

25322-6

8-3

PE

G-8

00

Sli

p a

nd m

old

-rel

ease

agen

t. W

ater

-solu

ble

car

rier

sub-

stan

ce. S

oft

ener

. M

ois

ture

-sta

bil

izin

g e

ffec

t in

cre

ams.

Lea

ves

a p

leas

ant

feel

on t

he

skin

.

PE

G-2

M25322-6

8-3

PE

G-2

MA

LK

OX

® L

-11

Em

oll

ient

and l

ubri

cant.

Im

pro

ves

wet

com

bin

g a

nd p

ro-

vid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

tion. U

sed

in s

ham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

, lo

tions,

cre

ams.

PE

G-5

M25322-6

8-3

PE

G-5

MR

ita

PE

O-1

Use

d i

n p

erso

nal

car

e pro

duct

s. O

ffer

s m

ildnes

s, l

ubri

city

and f

ilm

form

ing p

roper

ties

.

PE

G-7

M25322-6

8-3

PE

G-7

MA

LK

OX

® E

-20G

Em

oll

ient an

d lubri

cant. I

mpro

ves

wet

com

bin

g a

nd p

ro-

vid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

tion. U

sed i

n

sham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

, lo

tions

and c

ream

s.

PE

G-9

M25322-6

8-3

PE

G-9

MR

ita

PE

O-2

Use

d i

n p

erso

nal

car

e pro

duct

s. O

ffer

s m

ildnes

s, l

ubri

city

and f

ilm

form

ing p

roper

ties

.

PE

G-1

4M

25322-6

8-3

PE

G-1

4M

AL

KO

X®

E-4

5G

Em

oll

ient

and l

ubri

cant.

Im

pro

ves

wet

com

bin

g a

nd p

ro-

vid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

tion. U

sed

in s

ham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

, lo

tions,

cre

ams.

PE

G-2

0M

25322-6

8-3

PE

G-2

0M

AL

KO

X®

E-6

0G

Em

oll

ient

and l

ubri

cant.

Im

pro

ves

wet

com

bin

g a

nd p

ro-

vid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

tion. U

sed

in s

ham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

, lo

tions,

cre

ams.

PE

G-2

3M

25322-6

8-3

PE

G-2

3M

Rit

a P

EO

-3U

sed i

n p

erso

nal

car

e. O

ffer

s m

ildnes

s, l

ubri

city

and f

ilm

form

ing p

roper

ties

.

PE

G-4

5M

25322-6

8-3

PE

G-4

5M

AL

KO

X®

E-7

5G

Act

s as

an e

moll

ient

and l

ubri

cant.

Im

pro

ves

wet

com

bin

g

and p

rovid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

-

tion. U

sed i

n s

ham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

,

loti

ons,

cre

ams.

PE

G-6

5M

25322-6

8-3

PE

G-6

5M

AL

KO

X®

E-1

00

Em

oll

ient

and l

ubri

cant.

Im

pro

ves

wet

com

bin

g a

nd p

ro-

vid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

tion. U

sed

in s

ham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

, lo

tions,

cre

ams.

PE

G-9

0M

25322-6

8-3

PE

G-9

0M

Rit

a P

EO

-18

Use

d i

n p

erso

nal

car

e pro

duct

s. O

ffer

s m

ildnes

s, l

ubri

city

and f

ilm

form

ing p

roper

ties

.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G-1

15M

25322-6

8-3

PE

G-1

15M

AL

KO

X®

E-2

40

Em

oll

ient an

d lubri

cant. I

mpro

ves

wet

com

bin

g a

nd p

ro-

vid

es s

kin

condit

ionin

g, fo

am s

tabil

ity a

nd r

eten

tion. U

sed i

n

sham

poos,

condit

ioner

s, s

oap

bar

/liq

uid

, lo

tions

and c

ream

s.

PE

G-1

60M

25322-6

8-3

PE

G-1

60M

Rit

a P

EO

-27

Use

d i

n p

erso

nal

car

e. O

ffer

s m

ildnes

s, l

ubri

city

and f

ilm

form

ing p

roper

ties

.

Cet

yl

PE

G/P

PG

10/1

Dim

ethic

one

CE

TY

L P

EG

/PP

G-1

0/1

DIM

ET

HIC

ON

ES

eraS

ol®

SC

83-E

Em

uls

ifie

r fo

r W

/O e

muls

ion, fo

r m

ult

iple

em

uls

ions

(W/O

/

W)

and c

o-e

muls

ifie

r fo

r O

/W e

muls

ions.

Cet

yl

PE

G/P

PG

-

7/3

Dim

ethic

one

CE

TY

L P

EG

/PP

G-7

/3

DIM

ET

HIC

ON

ES

eraS

ol®

SC

82

Sil

icone

emuls

ifie

r fo

r W

/O e

muls

ions.

Als

o w

ork

s as

a c

o-

emuls

ifie

r fo

r O

/W e

muls

ions

& f

or

mult

iple

em

uls

ions

(W/

O/W

).

DIM

ET

HIC

ON

E

PE

G/P

PG

-7/4

PH

OS

PH

AT

E

132207-3

1-9

DIM

ET

HIC

ON

E P

EG

/

PP

G-7

/4 P

HO

SP

HA

TE

Pec

osi

l® W

DS

-100

All

ow

s fo

r im

pro

ved

dep

osi

tion o

f si

lico

ne

onto

skin

and

hai

r.

HY

DR

OLY

ZE

D

WH

EA

T

PR

OT

EIN

/PE

G-

20 A

CE

TA

TE

CO

PO

LY

ME

R

175893-7

0-6

HY

DR

OLY

ZE

D

WH

EA

T P

RO

TE

IN/

PE

G-2

0 A

CE

TA

TE

CO

PO

LY

ME

R

Neo

pro

® W

-40

It i

s th

e die

ster

rea

ctio

n p

roduct

of

hydro

lyze

d w

hea

t pro

-

tein

and P

EG

-20 a

nd i

s off

ered

as

a 40%

solu

tion i

n w

ater

.

Opti

miz

e su

bst

anti

vit

y t

o h

air.

Jojo

ba

Oil

PE

G-1

50 E

ster

s329360-7

0-5

JOJO

BA

OIL

PE

G-1

50

ES

TE

RS

FL

OR

AS

OL

VS

® P

EG

-150

HY

D J

OJO

BA

Bodyin

g a

gen

t, c

lari

fyin

g a

gen

t, c

o-e

muls

ifyin

g a

gen

t,

emoll

ient,

fil

m f

orm

er, fr

agra

nce

solu

bil

izer

, hai

r fi

xat

ive,

lubri

cant,

pla

stic

izer

and s

olu

bil

izin

g a

gen

t.

JOJO

BA

WA

X

PE

G-1

20

ES

TE

RS

159518-8

1-7

JOJO

BA

WA

X

PE

G-1

20 E

ST

ER

S

FL

OR

AS

OL

VS

® P

EG

-120

JOJO

BA

; Jo

joba

Aqua

Sol

PE

G-1

20

Bodyin

g a

gen

t, c

lari

fyin

g a

gen

t, c

lean

sing a

gen

t, c

o-e

muls

i-

fyin

g a

gen

t, e

moll

ient,

fee

l m

odif

icat

ion/e

nhan

cem

ent,

fil

m

form

er, fr

agra

nce

solu

bil

izer

and h

air

fixat

ive.

Jojo

ba

Wax

PE

G-8

0 E

ster

s159518-8

1-7

JOJO

BA

WA

X

PE

G-8

0 E

ST

ER

S

FL

OR

AS

OL

VS

® P

EG

-80

JOJO

BA

Bodyin

g a

gen

t, c

lean

sing a

gen

t, c

o-e

muls

ifyin

g a

gen

t,

emoll

ient,

fee

l m

odif

icat

ion/e

nhan

cem

ent

agen

t, f

ragra

nce

solu

bil

izer

, lu

bri

cant

and s

olu

bil

izin

g a

gen

t.

Lau

ryl

PE

G/P

PG

-

18/1

8 M

ethic

one

LA

UR

YL

PE

G/P

PG

-18/1

8

ME

TH

ICO

NE

Dow

Corn

ing®

5200

Form

ula

tion A

id

Use

d i

n s

kin

car

e pro

duct

s su

ch a

s pro

tect

ive

crea

m, cl

eans-

ing l

oti

on, nig

ht

crea

m, su

nsc

reen

cre

am,

bab

y c

ream

, dry

skin

cre

am a

nd l

oti

on a

nd m

ois

turi

zing c

ream

.

Met

hoxy P

EG

-17/

Met

hoxy P

EG

-11/

HD

I Is

ocy

anura

te

Tri

mer

Cro

sspoly

mer

PO

LY

UR

ET

HA

NE

-34

Bay

cusa

n®

C 1

005

Fil

ler.

In r

inse

off

and l

eave

on p

roduct

s, i

t im

par

ts a

pow

-

der

y v

elvet

y f

eeli

ng t

o s

kin

.

PE

G/P

PG

-14/1

4

Dim

ethic

one

Ser

aSol®

SC

89

Pro

-foam

er, O

/W c

o-e

muls

ifie

r, s

tyli

ng r

esin

pla

stic

izer

,

wet

ting a

gen

t, w

et-c

ondit

ionin

g a

gen

t an

d h

um

ecta

nt.


Tabl

e1.

Cont

inue

d

Poly

mer

Funct

ional

Gro

up/C

om

pound

CA

S N

o.

INC

I nam

eC

om

mer

cial

nam

eD

escr

ipti

on a

s co

smet

ic i

ngre

die

nts

.

PE

G/P

PG

-15/1

5

Dim

ethic

one

PE

G/P

PG

-15/1

5

DIM

ET

HIC

ON

ED

ow

Corn

ing®

5330 F

luid

Cle

ar a

nd o

paq

ue

condit

ionin

g s

ham

poos,

rin

se-o

ff c

ondi-

tioner

s, l

eave-

in c

ondit

ionin

g t

reat

men

ts l

ike

det

angle

rs,

hai

r m

asques

, m

ouss

es.

PE

G/P

PG

-15/5

Dim

ethic

one

PE

G/P

PG

-15/5

DIM

ET

HIC

ON

ES

eraS

ol®

SC

91

Pro

-foam

er, O

/W c

o-e

muls

ifie

r, s

tyli

ng r

esin

pla

stic

izer

,

wet

ting a

gen

t, w

et-c

ondit

ionin

g a

gen

t an

d h

um

ecta

nt.

PE

G/P

PG

-17/6

Copoly

mer

Uco

nTM

75-H

-450

Mois

turi

zing b

ody l

oti

ons

and e

ye

mak

e-up r

emover

s. A

cts

as a

n e

moll

ient,

solv

ent

and d

eposi

tion a

gen

t.

PE

G/P

PG

-18/1

8

Dim

ethic

one

PE

G/P

PG

-18/1

8

DIM

ET

HIC

ON

EP

CM

-7919;

BR

B 5

23

It i

s use

d i

n h

air

care

form

ula

tions

to a

dd s

ilkin

ess,

shin

e,

lubri

city

, an

d d

etan

gli

ng.

PE

G/P

PG

-20/1

5

Dim

ethic

one

PE

G/P

PG

-20/1

5

DIM

ET

HIC

ON

ES

F 1

188A

Use

d i

n p

erso

nal

car

e pro

duct

s su

ch a

s hai

r sp

rays,

han

d

loti

on, an

tiper

spir

ants

, sh

avin

g a

ids

and s

ham

poos.

PE

G/P

PG

-25/2

5

Dim

ethic

one

PE

G/P

PG

-25/2

5

DIM

ET

HIC

ON

ES

i-T

ecTM

DM

C 6

031

Use

d i

n p

erso

nal

cle

ansi

ng p

roduct

s, s

un c

are

and s

kin

car

e.

Poss

esse

s fo

am s

tabil

izin

g, w

etti

ng, pla

stic

izin

g a

nd e

muls

i-

fica

tion p

roper

ties

.

PE

G/P

PG

-6/2

Gly

cery

l C

oco

ate

72245-1

1-5

PE

G/P

PG

-6/2

GLY

CE

RY

L

CO

CO

AT

E

Ste

pan

® 7

45 G

C

Condit

ionin

g a

gen

t, v

isco

sity

buil

der

and e

muls

ifie

r. I

t is

a

100%

act

ive

non-i

onic

liq

uid

em

oll

ient.

It

is a

n a

lkoxyla

ted

der

ivat

ive

of

gly

cery

l co

coat

e.

PE

G/P

PG

-6/4

Dim

ethic

one

PE

G/P

PG

-6/4

DIM

ET

HIC

ON

ES

eraS

ol®

SC

90

Pro

-foam

er, O

/W c

o-e

muls

ifie

r, s

tyli

ng r

esin

pla

stic

izer

,

wet

ting a

gen

t, w

et-c

ondit

ionin

g a

gen

t an

d h

um

ecta

nt.

PE

G-1

80/

Lau

reth

-50/

TM

MG

Copoly

mer

373609-4

6-2

PU

RE

TH

IX®

1450

Thic

ken

ing, em

uls

ifyin

g a

gen

t, f

ilm

form

er a

nd h

um

ecta

nt.

PE

G-3

3/A

dip

ic

Aci

d/H

MD

A/

Gly

col C

opoly

mer

(Pro

pose

d).

AX

IOM

AC

T-3

3A

Eff

ecti

ve

hai

r co

ndit

ioner

. It

is

avai

lable

in e

ither

non-i

onic

or

mil

dly

anio

nic

form

.

PP

G-1

2-P

EG

-65

Lan

oli

n O

il68648-3

8-4

PP

G-1

2-P

EG

-65

LA

NO

LIN

OIL

Rit

alan

AW

SU

sed i

n c

osm

etic

form

ula

tions.

Lea

ves

a s

oft

er, sm

ooth

er

emoll

ient

film

than

oth

er w

ater

solu

ble

lan

oli

ns.

PP

G-1

-PE

G-9

Lau

ryl

Gly

col

Eth

er

154248-9

8-3

PP

G-5

-LA

UR

ET

H-5

Eum

ulg

in®

LU

sed i

n a

qeo

us

cosm

etic

pre

par

atio

ns.

Act

s as

a n

on-i

onic

O/W

-em

uls

ifie

r an

d/o

r so

lubil

iser

.

Wax

PE

G-3

Bee

swax

136097-9

3-3

Hydro

phil

ic d

eriv

ativ

e of

nat

ura

l bee

swax

. U

sed i

n c

os-

met

ic e

muls

ions

(o/w

and w

/o t

ype)

, oil

gel

pro

duct

s an

d

dec

ora

tive

cosm

etic

s. O

ffer

s im

pro

ved

oil

gel

ling a

nd o

il

rete

nti

on c

apab

ilit

y.

The

data

wer

e ex

trac

ted

from

Spe

cial

Chem

(htt

p://

cosm

etic

s.spe

cial

chem

.com

/).


related to the general properties of its related mixtures,

unless specific studies can be found. As much as we would

like to know the specific effects of PEG/PPG-17/6 copoly-

mer both in animal and human studies, we suggest that fur-

ther evaluation should be needed if safety issues are found

in its analogue mixtures. PEG/PPG-17/6 copolymer belongs

to a group of copolymers of ethylene and propylene glycols

with a variety of mixed names from a generic formula of

“PPG-n-PEG-m”, where n and m signify their average

respective monomer units bound to each other randomly.

Non-random or block copolymers have specifically assigned

denominations with rules that include “poloxamer”, “merox-

apol” and “poloxamine” (9). Since very little is known about

the specific properties of PEG/PPG-17/6 copolymer, the

generic “poloxamer” will be described in this evaluation.

Poloxamers follow a general formula, where x, y, z values

depend on the mixture type (10). Poloxamers are water sol-

uble and can form gels in a concentrated aqueous solution,

which is reversible to liquid form after lowering the tem-

perature, and vice versa. Viscosity of poloxamers depends

on the increasing percentages of polyoxypropylene hydro-

phobe and polyoxyethylene hydrophile. As mentioned,

PEG/PPG-17/6 copolymer could be under the umbrella of

alkyl PEG-PPG ethers. This compound is produced from

the reaction of an alkyl alcohol to any equivalents of both

ethylene oxide and propylene oxide forming repeats in both

PEG and PPG. Although these ethers are known to be sur-

factant-like molecules, having both hydrophobic and hydro-

philic ends in their chain structures, they differ mainly in

variations of their alkyl length, and the number of PEG and

PPG repeat units in their hydrophobic ends. In each ingredi-

ent, the actual order of repeat units of alkoxides from differ-

ent sources may be block, alternating, or random. PEG/

PPG-17/6 copolymer is known to be of the random type.

Specific physical properties of the alkyl PEG-PPG ethers

are mostly unidentified, with only a known physical form of

clear to slightly yellowish liquids (8). Furthermore, each

ingredient/compound group is expected to have different

properties.

Only the production of poloxamers is known, where gen-

erally it is an ordered mixture of propylene oxide, propyl-

ene glycol, and ethylene oxide prepared at high temperature

and pressure along with an alkaline catalyst (e.g. sodium or

potassium hydroxide), which becomes neutralized to become

part of the final product (11). PEG/PPG-17/6 copolymer has

been identified as a solvent in cosmetic products (12) as

well as an emollient and surfactant (13).

Since no toxicity studies can be found for PEG/PPG-

17/6 copolymer specifically, the general evaluations of its

chemical analogue “poloxamers” are drawn. According to

the Cosmetic Ingredient Review (CIR) expert panel, the

presence of impurities during or after the process of mixing

these compounds is of concern, including 1,4-dioxane, eth-

ylene oxide, and propylene oxide, which are known to be

carcinogenic and/or highly volatile. Thus, it was empha-

sized that purification of end mixtures before incorporation

into cosmetic products should be carried out as a necessity

in order to keep these impurities to very minimum levels of

1 ppm for 1,4-dioxane and 5 ppm for ethylene oxide and

propylene oxide. In addition, toxicology studies for polox-

amers suggested “a low order of toxicity” in all acute to

chronic animal testing, including the negative results for

genotoxicity and carcinogenicity studies. No reproductive

or developmental toxicity studies have been conducted thus

far. In both animal and human testing, poloxamers were not

dermally irritating or sensitizing. Finally, poloxamers are

concluded as safe for cosmetic use according to the current

concentrations applied, and according to the manufactur-

ers’ ability to remove their impurities (8). Accordingly,

PEG/PPG-17/6 copolymer may have the same properties

and effects as long as impurities are kept acceptably low.

However, a more specific assessment for this ingredient is

highly recommended to draw indubitable conclusions for

the safety of its use in cosmetics.

PEG-20 glyceryl triisostearate. PEG-20 glyceryl tri-

isostearate is a nonionic compound with a molecular weight

of more than 1,000, and is used as an emulsifier, dispersing

agent, and solubilizing agent in cosmetics and personal care

products. It is mainly used in both rinse-off cleansing prod-

ucts such as facial cleansers or body washes and leave-on

products such as creams or lotions. The cleansing and

leave-on products contain this chemical up to 20% and 5%,

respectively. PEG-20 glyceryl triisostearate is probably

removed from the water up to 90% by partitioning to solids

during water treatment processes. PEG-20 glyceryl tri-

isostearate is not expected to bioaccumulate due to its high

molecular weight and is not anticipated to cross biological

membranes (14).

The exposure route of PEG-20 glyceryl triisostearate may

be dermal, and the dermal exposure to the notified polymer

is expected to be extensive due to daily application of PEG-

20 glyceryl triisostearate-containing cosmetic products.

Thus, the exposure to PEG-20 glyceryl triisostearate for the

public is expected to be widespread and frequent through

the daily application of cosmetics (14). In spite of the wide-

spread use of PEG-20 glyceryl triisostearate, the previous

safety assessment of this chemical for humans was still not

sufficient. Thus, this report provides the toxicological eval-

uation of PEG-20 glyceryl triisostearate as a cosmetic

ingredient. The toxicological data of PEG-20 glyceryl tri-

isostearate were estimated based on its chemical analogues

including glyceryl triisostearate, sorbitan sesquiisostearate,

and PEG-20 sorbitan fatty acid esters (Table 2) (15-17).

Although these chemicals do not contain all of the func-

tional groups present in PEG-20 glyceryl triisostearate,

some properties of PEG-20 glyceryl triisostearate can be

approximated using the component chemicals. Acute oral


toxicity of the PEG-20 glyceryl triisostearate is expected to

have LD50 of more than 2,000 mg/kg bw. Furthermore, skin

irritation and sensitization testing of PEG-20 glyceryl tri-

isostearate is expected to be negative or weak. Indeed, there

was no evidence of sensitization in the repeat insult patch

test. Eye irritation and mutagenicity of this compound was

not be observed. The main route of exposure to PEG-20

glyceryl triisostearate is expected to be dermal during appli-

cation of cosmetics and personal care products. Interest-

ingly, the high molecular weight and low water solubility of

PEG-20 glyceryl triisostearate could inhibit its absorption

through various routes including dermal, inhalation, and

oral (14). Hence, based on the overall studies, PEG-20 glyc-

eryl triisostearate would not be threatening nor toxic to con-

sumers’ health.

PEG-40 hydrogenated castor oil. PEG-40 hydroge-

nated castor oil, as the name implies, is a hydrogenated cas-

tor oil-derived PEG with an average of 40 moles ethylene

oxide. It is mixed through the etherification and esterifica-

tion of hydrogenated castor oil glyceride and fatty acid

products, having forty equivalents of ethylene oxide (18).

PEG-40 hydrogenated castor oil (trade name: Cremophor

RH 40) is utilized as a non-ionic solubilizer and emulsify-

ing agent. It had been used to solubilize many cosmetic

products including ethereal oils, perfume compositions,

vitamins, and hydrophobic active substances in aqueous

and/or alcoholic solutions. The identified concentrations of

PEG-40 hydrogenated castor oil in products are in the range

of 0.00007% to 22%, in which the maximum known con-

centration of 22% is contained in leave-on products (19).

There were few toxicological assessment data available

for this specific compound. A patch test was conducted on

20 human volunteers using 100% concentration of PEG-40

hydrogenated castor oil on the skin of the back area and

observed after 24 and 48 hrs. No further details were stated,

however no sign of irritation was concluded. Nevertheless,

another single patch test using only 0.25% PEG-40 hydro-

genated castor oil as part of a formulation showed a mild

reaction in 1 out of 20 human volunteers, which could be

related to other ingredients in the formulation or an isolated

hypersensitivity case (Table 2) (20).

A repeated insult patch test was conducted in 120 human

volunteers with a formulation containing 0.05% PEG-40

hydrogenated castor oil. A volume of 0.10 mL of the for-

mulation was applied for 24 hrs on the back area of each

Table 2. Toxicological data of PEG compounds

Chemical

compoundStudies Animal Result Ref.

Glyceryl

triisostearate

Acute oral toxicity Rat LD50 > 2 g/kg bw

(16)

Skin irritation Rabbit Non-irritant

Skin sensitization Guinea pig Non-sensitizing

Eye irritation Rabbit Non-irritant

Mutagenicity Not mutagenic

Sorbitan

sesquiisostearate


(17)

Skin irritation Guinea pig Weak irritant

Repeat insult patch test human Non-sensitizing

Eye irritation Rabbit Mild irritant

Mutagenicity No data available

PEG-20 sorbitan

fatty acid esters


(15)

Skin irritation Rabbit Non-irritant

Repeat insult patch test human Non-sensitizing

Eye irritation Rabbit Mild irritant

Mutagenicity Not mutagenic

PEG-40

Hydrogenated

Castor Oil

Acute toxicity Rat LD50 > 15.0 g/kg (23)

Subchronic toxicity Rat No signs of abnormalities (19)

Sensitization test Human Non-sensitizing effect (20,23,29)

Dermal studies Rat No microscopic changes (24)

Skin irritation Mouse, Rat No signs of irritation (25,31)

Reproductive and teratogenicity Rat No significant maternal or fetal toxicity effects (19)

PEG-60

Hydrogenated

Castor Oil

Acute toxicity Rat LD50 > 5 g/kg (26)

Sensitization test Human No sign of irritation (27)

Ocular irritation Rabbit Minimal irritation (28)

Dermal studies Rat The change within the normal range (29)

Genotoxicity Mouse No signs of toxicity (30)


subject through occlusive patching on Mondays, Wednes-

days, and Fridays of the 3-week testing period. Challenge

patching was carried out on previously untreated sites after

a 2-week non-treatment period. Observations of the treated

sites showed one incident of almost imperceptible ery-

thema among 5 subjects during the induction phase of the

study, while one of these subjects showed a mild reaction

during 24 and 48 hrs of the challenge patching. Another

subject who did not show a reaction during the induction

test also showed an almost imperceptible erythema during

the challenge test. Follow-up testing of the 2 subjects who

showed a reaction during the challenge test showed lesser

reactions in which clinical significance could not be con-

cluded. Thus, the overall findings of the study established a

non-sensitizing effect of PEG-40 hydrogenated castor oil

(Table 2) (29). A similar study using a higher concentration

of PEG-40 hydrogenated castor oil at 0.25% in a formula-

tion was tested in 86 subjects. During the induction testing,

2 subjects showed a mild reaction but not during challenge

testing. One subject who did not show a reaction in the

induction testing showed a faint erythema only at the 24 hr

grading period. Results could not conclude a sensitizing

effect of the chemical at this concentration (Table 2) (23).

PEG-40 hydrogenated castor oil was also investigated for

its sub-chronic treatment toxicity potential in animals. The

first experiment was investigated in Sprague-Dawley (S-D)

rats given an oral feed containing 0 (control), 10,000,

32,000, and 64,000 ppm of PEG-40 hydrogenated castor oil

(20 males and 20 females in each group except 10,000,

which had 25 animals of each gender). All animals sur-

vived during the experiment period and no significant feed-

ing, body weight, or hematological changes were observed

in any group. Necropsy further revealed no signs of abnor-

malities in the internal body components. In another study,

a 6-month feeding period for PEG-40 hydrogenated castor

oil was conducted in 3 male and 3 female beagle dogs using

0 (control), l.0%, 2.5%, and 5.0% concentrations. Observa-

tions during the study showed no significant changes in

behavior, feeding, or body weight. Hematological and other

biochemical parameters were of the same levels as the con-

trol group. One low-dose-treated animal died for reasons

unrelated to the treatment. Necropsy further supported no

evidence of toxicity in the feeding study (Table 2) (19).

Dermal studies for PEG-40 hydrogenated castor oil, con-

tained at a concentration of 0.25% in a formulation, were

conducted in 10 male and 10 female S-D rats through daily

applications, 5 days a week for 13 consecutive weeks. The

formulation was given at 1,640 mg/kg/day, which was

believed to be 100 times greater than the average daily use

by human consumers. During the entire duration of the

study, all rats survived and no abnormal changes in behav-

ior, body weight, hematology, urinalysis or chemical chem-

istry parameters were reported. In contrast, mild skin

irritation at the treated site was observed starting on day 5

until the end of the study, as well as a significant elevation

in hepatic weights in male rats when compared with the

controls. Nevertheless, the finding was not considered rele-

vant for toxicology since no microscopic changes were

observed (Table 2) (24).

Skin irritation studies for PEG-40 hydrogenated castor oil

contained at a concentration of 20% in a micro-emulsion

were conducted in mice. The application site was the left

ear that was given a single dose of 10 µL of the material,

while the right ear served as a control. During the 6 days

observation, no signs of irritation could be seen in the

treated ear with a 20% concentration of PEG-40 hydroge-

nated castor oil (Table 2) (25). Another dermal irritation test

using 20.66% PEG-40 hydrogenated castor oil, contained in

a micro-emulsion gel, was conducted in male albino rats

using the Draize method. Treated groups were given 0.5 g

of the formulation, for 3 consecutive days, in a 5 cm2 dor-

sal side shaved skin area. A negative (no treatment) and a

positive (0.8% aq. formalin) control group was present.

During the 3 days of observation, no signs of skin irritation

could be seen for the test material, and the histopathologi-

cal exam yielded negative skin irritation results (Table 2)

(31).

Feeding studies for the assessment of reproductive and

teratogenic effects of PEG-40 hydrogenated castor oil were

conducted in pregnant S-D rats. One group (30 rats) was

given 50,000 ppm and another 27 rats were given 100,000-

ppm PEG-40 hydrogenated castor oil from gestational day 0

to gestational day 20, while another 2 groups of untreated

control were raised. Pregnant animals were monitored and

assessed for signs of toxicity during gestation, and were

sacrificed at gestational day 20 for fetal examination.

Examinations of the mother and fetuses did not reveal any

signs of toxicity. Although resorption and malformations/

anomalies were found in some animals in the highest dose

group, similar changes were also found in the control group,

showing no significant differences. Thus, the researchers

conducting the study could not conclude teratogenicity for

PEG-40 hydrogenated castor oil. Studies were also con-

ducted in 4 groups of pregnant NMRI mice using 5,000

ppm (25 mice) and 10,000 ppm (31 mice) PEG-40 hydroge-

nated castor oil from day 6 to 15 of gestation; the other 2

groups were raised as controls. During the study, no signifi-

cant maternal or fetal toxicity effects were found, and some

malformations in fetuses in the treated groups were also

comparable to the control groups (Table 2) (19).

PEG-60 hydrogenated castor oil. PEG-60 hydroge-

nated castor oil is a hydrogenated castor oil-derived poly-

ethylene glycol with an average of 60 moles ethylene oxide.

It is mixed through the etherification and esterification of

hydrogenated castor oil glyceride and fatty acid products,

having sixty equivalents of ethylene oxide. PEG-60 hydro-

genated castor oils had 349 reported uses (with a similar


function to PEG-40 hydrogenated castor oil) by the time of

the CIR panel meeting. Their uses are expected to increase

in the following years. The identified concentrations of

PEG-60 hydrogenated castor oil in products are in the range

of 0.00004% to 18%, in which the maximum known con-

centration of 18% is contained in leave-in non-coloring hair

products (18).

From the clinical reports of PEG-60 hydrogenated castor

oil, a 27-year-old male patient with acute myeloblastic leu-

kemia, receiving chemotherapy containing enocitabine,

developed a high-grade fever and erythroblastopenia 6

hours after intravenous administration. PEG-60 hydroge-

nated castor oil was present in the enocitabine. A follow-up

study evaluation of dosing enocitabine alone showed simi-

lar symptoms. When the patient’s bone marrow was co-cul-

tured with enocitabine or PEG-60 hydrogenated castor oil,

significant growth inhibition of late erythroid progenitors

was observed with the patient’s IgG present. The research-

ers suggested that the immunological suppression effects of

PEG-60 hydrogenated castor oil could be due to its hapten

effect on the hypersensitive reaction of the patient’s IgG

(18). In another study, a 21-consecutive-day occlusive patch

test was conducted for PEG-60 hydrogenated castor oil,

with a 3% concentration in a formulation, in 12 human vol-

unteers. Interestingly, the test concluded the formulation to

be non-irritating (21). Thus, PEG-60 hydrogenated castor

oil, when given according to the regulated dose, should be

non-irritating to healthy consumers, while caution should be

observed for individuals with immunosuppression or auto-

immune syndromes.

Acute toxicity studies were conducted for PEG-60 hydro-

genated castor oil in various animals including male and

female Beagle dogs, male and female cynomolgus mon-

keys, male New Zealand white rabbits, male Hartley guinea

pigs, and male S-D rats. Overall results showed systemic

and irritant effects only in dogs, and not in the other ani-

mals tested, indicating species-specific effects (22).

Sub-chronic dermal toxicity studies of PEG-60 hydroge-

nated castor oil were conducted in 10 female ChR-CD rats

through daily topical applications (5 times a week for 13

weeks) of 284 or 2,840 mg/kg of a formulation containing

3.0% PEG-60 hydrogenated castor oil. Treated sites showed

slight erythema and dryness, but this was seen in both the

experimental and control groups. Necropsy did not find any

lesions, however significant hepatic weight and renal-to-

body ratio changes were observed. Nevertheless, these

changes were within the normal range of laboratory param-

eters, and no further histopathological changes were noted

(Table 2) (29).

A sensitization study (similar methods to PEG-40 hydro-

genated castor oil) in 102 human subjects with 3.0% PEG-

60 hydrogenated castor oil formulation showed no sign of

irritation in the subjects during the induction phase. During

the challenge phase, only a doubtful reaction in one subject

was observed after 48 hrs of testing, which further showed

negative results for sensitization during a follow-up test

(Table 2) (27).

Genotoxicity studies were conducted for PEG-60 hydro-

genated castor oil using a reverse mutation test in the Sal-

monella typhimurium strains TA100, TA98, TA1535, and

TA1537, and in Escherichia coli strain WP2uvrA, with and

without metabolic activation. Concentrations of the mate-

rial tested ranged from 313 to 5,000 µg/plate, and positive

controls were used including 9-aminoacridine, sodium

azide, 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide, and 2-

aminoanthracene. Results showed no significant increase in

revertant colony numbers at all concentrations, test strains,

and metabolic conditions using PEG-60 hydrogenated cas-

tor oil, whereas genotoxic results were found in the posi-

tive controls. A chromosome aberration study was also

conducted in Chinese hamster V79 cells using the same

concentrations as mentioned above. Mitomycin C and

dimethylnitrosamine were used as positive controls. Results

showed a dose-dependent cell proliferation inhibition in the

“without metabolic activation conditions” 24-48 hrs after

treatment. The test material with metabolic activation

showed only slight cell proliferation inhibition 6 hours after

treatment, even at the highest dose. Overall, PEG-60 hydro-

genated castor oil did not show chromosome aberrations

under the experimental conditions, and it was concluded

that the material was not genotoxic. Similar studies on the

mouse micronucleus of 5 male and 5 female BDF1 mice

were conducted by giving single intraperitoneal injections

of 2,000 mg/kg bw dosage of PEG-60 hydrogenated castor

oil to experimental groups, and saline or mitomycin C to the

control groups. Bone marrow cells collected at 24, 48, and

72 hrs post-treatment showed no relevant changes in micro-

nucleated polychromatic or normochromatic erythrocytes.

No signs of toxicity were observed, further supporting its

non-genotoxic properties (Table 2) (30).

An ocular irritation test was also conducted for a 3.0%

PEG-60 hydrogenated castor oil formulation, which caused

minimal irritation to the eyes in 2 out of 6 rabbits tested

after instillation. After 48 hrs, all signs had disappeared

(Table 2) (28).

CONCLUSIONS

PEGs have a wide variety of PEG-derived mixtures due

to their readily linkable terminal primary hydroxyl groups

in combination with many possible compounds and com-

plexes such as ethers, fatty acids, castor oils, amines, pro-

pylene glycols, among other derivatives. PEGs and their

derivatives are broadly utilized in cosmetic products as sur-

factants, emulsifiers, cleansing agents, humectants, and skin

conditioners. However, studies are lacking concerning those

specific PEG-derived mixtures that we have evaluated in

this review. Little is known about PEG/PPG-17/6 copoly-


mer and PEG-20 glyceryl triisostearate, while some studies

are available for PEG-40 hydrogenated castor oil and PEG-

60 hydrogenated castor oil as PEGylated oils, regarding

their safety and toxicity in humans and animals. Reviews

were mostly carried out on the general compound, with

details in a few individual studies. Nevertheless, the pres-

ent review summarizes the results of the known toxicity

studies of these compounds in focus (Table 2).

PEG/PPG-17/6 copolymer has particularly little toxico-

logical information, thus further investigation is obviously

needed for it to be continually utilized in cosmetics and

other products with human exposure. PEG-20 glyceryl

triisostearate-related studies have shown an LD50 of

> 2,000 mg/kg bw in rat acute oral studies. Furthermore,

this compound was observed to be non-irritating to rabbit

skin and eyes, non-sensitizing to guinea pig skin, and non-

mutagenic (further details unknown). Both PEG-40 and

PRG-60 hydrogenated castor oils were generally non-irritat-

ing and non-sensitizing to human skin up to 100% concen-

tration. This was also supported by animal studies. Intravenous

exposure to PEG-60 hydrogenated castor oil may cause

hypersensitive or further immunosuppressive effects as

found in a leukemia patient undergoing chemotherapy. Nev-

ertheless, acute intravenous administration of PEG-60

hydrogenated castor oil to various animal species generally

did not show toxic effects up to the highest administered

dose of 100 mg/kg. However, Beagle dogs showed some

reactions that may show species-specific effects of PEG-60

hydrogenated castor oil. Repeated-dose toxicity with PEG-

40 hydrogenated castor oil in both S-D rats and Beagle dogs

did not show toxic effects up to 64,000-ppm and 5.0% dos-

age concentrations, respectively. Acute oral toxicity studies

in rats of both PEG-40 and PEG-60 hydrogenated castor

oils have shown LD50 values of 0.25% at 15.0 g/kg and

3.0% at 5.0 g/kg, respectively. Sub-chronic dermal expo-

sure of both mixtures to rats (0.25% PEG-40 and 0.3%

PEG-60 hydrogenated castor oils) showed slight erythema

(as well as in the controls), but did not cause any toxic

effects. PEG-60 hydrogenated castor oil showed minimal

eye irritation. PEG-60 hydrogenated castor oil was not

genotoxic in bacteria or mammalian cells. Thus, these

related PEGylated oils were concluded as safe for use in

cosmetics according to regulating bodies and reviews found

in this evaluation.

Unfortunately, no reliable safety or toxicity studies could

be found for other PEG derivatives being evaluated in this

review. Nevertheless, PEGs and PEG derivatives were gen-

erally regulated as safe for use in cosmetics, with the condi-

tions that impurities and by-products, such as ethylene

oxides and 1,4-dioxane, which are known carcinogenic

materials, should be removed before they are mixed in cos-

metic formulations. Ultimately, specific assessment studies

for each chemical mixture are prompted for the exact evalu-

ation of their safety in cosmetic use.

ACKNOWLEDGMENT

This work was supported by a grant from the Foundation

of Korea Cosmetics Industry Institute in 2014.

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