sage bionetworks mission sage bionetworks is a non-profit organization with a vision to create a...
TRANSCRIPT
![Page 1: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/1.jpg)
Sage Bionetworks MissionSage Bionetworks is a non-profit organization with a vision to create a “commons”
where integrative bionetworks are evolved by contributor scientists with a shared vision to accelerate the elimination of human disease
Data Repository
Discovery Platform
Building Disease Maps
Commons Pilots
![Page 2: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/2.jpg)
Need: Community-based analysis is required to build accurate models of disease
Within the analytical community:• Quality assessment of data, tools and models• Reproducibility of models• Reusability of data• Validation of models across multiple disease models and patient subtypes
Across the field of biology:• Validation of model predictions in experimental/clinical setting• Accelerated pace towards improved therapeutic development
Clinical Improvement
?
Data curation
Statistical QC
Genomic analysis
Network construction
Network analysis Data mining Validation
?
![Page 3: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/3.jpg)
Watch What I Do, Not What I Say
Real-time tools to track data analysis projects
![Page 4: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/4.jpg)
Reduce, Reuse, Recycle
A Repository of Data, Tools, and Models
![Page 5: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/5.jpg)
Most of the People You Need to Work with Don’t Work with You
An online community to connect people and projects
![Page 6: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/6.jpg)
My Other Computer is Amazon
Cloud-based data stores and compute resources
![Page 7: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/7.jpg)
Do: What will the Synapse Platform and Commons Enable?
• Development of Robust, Reproducible, and Reusable analytical methods
• Integration of Data, Tools and Methods from across community
• Development of a Disease Model Repository
• Forum for New Collaborations between technically and geographically distinct scientific groups
• Access to Cloud-Compute resources co-located with large-scale data
• See also the Platform Vision Document posted on our wiki
Translation of Data to Knowledge to Improved Therapeutic Approaches to Disease: An improved molecular understanding of the causes of disease leading to quicker, more rational and more successful development of new drugs
![Page 8: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/8.jpg)
Synapse Platform and Repository Roadmap
Q1-2011 Q2-2011 Q3-2011 Q4-2011 Q1-2012 Q2-2012
Projects and Datasets
Publicly Hosted Datasets
Synapse Platform Functionality
Data Analysis Capabilities
Tool / Workflow Support
Social Networking & Attribution
Q3-2012 Q4-2012
Demo System Internal Alpha Invited External Beta Public Beta Full Production
Networks and Models
Curation Pipeline
Statistical QC Pipeline
Bioconductor Analysis Packages
Coexpression Networks
Crowd-sourcing web tools
![Page 9: Sage Bionetworks Mission Sage Bionetworks is a non-profit organization with a vision to create a “commons” where integrative bionetworks are evolved by](https://reader035.vdocuments.net/reader035/viewer/2022062713/56649f435503460f94c642f2/html5/thumbnails/9.jpg)
Software Architecture