With sufficient disease, strobilurin-treated corn

generally suffers less yield-loss than Untreated.

But over-use contributes to

disease resistance.*

* http://www.frac.info/frac/publication/anhang/FRAC_Mono1_2007_100dpi.pdf (After clicking on this link, please scroll down to the 5th bullet point on page 5)

TM

Specialist Technical Group of CropLife International

PURPOSE: Provide fungicide resistance management guidelines to prolong effectiveness of "at risk" fungicides.

• Responsible for global fungicide resistance strategies for all Qo Inhibitor (QoI) Strobiluron-class fungicides.

Qol Inhibitor Working Group is a sub-committee of FRAC

QoI fungicides include: azoxystrobin, pyraclostrobin, trifloxystrobin• All 3 in same cross-resistance group & should be managed accordingly.Participating Committee Companies: BASF, Bayer, DuPont, Syngenta

ALL strobilurin fungicides considered HIGH RISK for fungal resistance*

http://www.frac.info/frac/publication/anhang/FRAC-Code-List2011-final.pdf (After clicking on this link, please scroll down to Page 4 and review FRAC Code 11 compounds)

• Block (wide area) applications of Strobi’s must only be made in mixture with a non-cross-resistant fungicide.

• Alternate strobi applications, whether solo or in mixture, in single or block treatments, with applications of effective fungicides from other cross-resistance groups.

• Limit the total number of strobi applications within a total disease management program, whether applied solo or in mixture with other fungicides.

General guidelines for use of Strobilurin fungicides:

http://www.frac.info/frac/publication/anhang/FRAC_Mono1_2007_100dpi.pdf (After clicking on this link, please scroll down to Page 42 for strobilurin-specific information)

Independent Contract Research – Small-block replicated trials: NOT sponsored by PHC

Propiconazole is an effective, non-cross resistant Foliar Fungicide for Control of Corn Disease

Means followed by same letter are not different.

Iowa State University: 2008 Mean disease rating (% of diseased leaf tissue) By hybrid & treatment, cross-trial summary.

http://masters.agron.iastate.edu/DB/CC/StefflCCProject.pdf

Propiconazole delivers Similar Disease Control

Across Hybrids

Similar Disease ControlMean disease rating (%)

Iowa State University: 2008 Mean disease rating (% of diseased leaf tissue) By location & treatment, cross-trial summary.

http://masters.agron.iastate.edu/DB/CC/StefflCCProject.pdf

Propiconazole also delivers Similar Disease Control

Across LOCATIONS

TM

8 Midwest locations (2007) -- Independent RCB Contract Research

Similar Disease Control Means Comparable Yields

Relatively Low-yielding Scenario

6.6 bu increase

5.8 bu increase

University of Nebraska: http://elkhorn.unl.edu/webvideoj/UserFiles/Image/PDF/Plantsc09-Jackson.pdf

Similar Disease Control Means Comparable Yields

Relatively High-yielding Scenario

Propiconazole defends against Gray Leaf Spot almost as effectively as a strobilurin, but with less

risk of disease-resistance.

TM

TM

Disease pressure varies throughout

the field.

High Pressure

Moderate Pressure

Low Pressure

Protect

Pro

tect

Prote

ct

PROMOTEPR

OM

OTE

PRO

MO

TE

Fungicides PROTECT yield.

ProAct® PROMOTES yield.

Because it’s a pure“Plant Health” strengthener.

• Registered with U. S. Environmental Protection Agency (EPA) as: N-Hibit HX-209, ProAct, and Employ

• 2nd generation of harpin-derived product

• Combination of active domains from 4 different native harpin proteins: HrpN, HrpW, HrpZ, and PopA

ProAct® = Harpin αβ Protein

Harpin αβ protein US-EPA Fact Sheet

Mode of Action: Harpin αβ does not act directly on disease organisms, nor does it permanently alter the DNA of treated plants. Instead, Harpin αβ activates a natural defense mechanism in plants, referred to as systemic acquired resistance (SAR). Harpin αβ and the Harpin protein registered in the year 2000 are structurally and functionally similar.

Harpin αβ protects against certain bacterial, viral, and fungal diseases; soil-borne pathogens; and harmful nematodes and insects. Harpin αβ protein also enhances plant growth and vigor, and increases the yield for a variety of crops, including vegetables, trees, and ornamentals.

Regulatory Information: The first pesticide product ProAct® (EPA Reg # 69834-5) containing Harpin αβ protein as an active ingredient was registered on February 9, 2005.

http://www.epa.gov/pesticides/biopesticides/ingredients/factsheets/factsheet_006506.htm

Schematic of Plant Response to

Harpin Protein Products

Harpin is a pure “Plant Health” Product. ALL it does is IMPROVE Plant Health.

ProAct®, Used alone, Increases Yields in Field Corn

2003 2004 2005 2006 2007 AVERAGE150

160

170

180

190

200ProAct at 0.5 oz/A

CONTROL +7 bu+7 bu

+8 bu+8 bu

Average Corn Yield (bu/A) by Year

+6 bu

+7 bu

6

# on bar = number of data points; includes replicated and commercial field trials

11 57 17 7 98

Primarily NCGA

Demos

Water Control Fungicide + NIS ProAct 0.5 oz/A + Fungicide + NIS

0

5

10

15

Gray Leaf Spot and Common Rust Severity on Ear Leaf (%)

A

C BC

8 replicates per site; treatments applied at VT; summary of all 7 trial locations (IA, IL-3, MN, and NE-2)

Means followed by same letter are not different, (Protected LSD, P=0.1).

Water Control Fungicide + NIS ProAct 0.5 oz/A + Fungicide + NIS

190

200

210

220

B B

A

Corn Yield (bu/A)

“ProAct + Strobi’s” increased Corn yields more than Strobi’s alone.

PHC-contracted Independent Small-block Research: 2009

Strobi @ 6 oz ProAct 0.5 oz + STROB. 6 oz

50%

60%

70%

80%

90%

100%

78%

96%

Strobi @ 6 oz ProAct 0.5 oz + STROB. 6 oz

100%

105%

110%

103.8%

105.7%

Average Yield as % of Control

UTC = 175 bu

8 reps per location; 15 locations; treated at VT; strobilurins applied with NIS 0.25% (v/v).

Success Rate (% Wins)

ProAct + Strobi increased the # of wins versus untreated controls more than Strobi’s alone

10 bushel increase versus

untreated6.7 bushel increase versus

untreated

PHC-contracted Independent Small-block Research: 2009 and 2010

With sufficient disease, strobilurin-treated corn

generally suffers less yield-loss than Untreated.

But over-use contributes to

disease resistance.*

* http://www.frac.info/frac/publication/anhang/FRAC_Mono1_2007_100dpi.pdf (After clicking on this link, please scroll down to the 5th bullet point on page 5)

TM

Can “ProAct® + Propiconazole”

be substituted for strobilurin fungicides, as an aid in the

battle to reduce the likelihood of disease resistance to strobi-

class chemistry?(Without giving up any yield in the process?)

Treatments Yield (bu/A)* Bu Diff. from UTC

Success Rate (% wins)

Untreated Control (Sprayed with Water) 169.99 a - N/A

Propiconazole @ 4 oz + NIS (@ 2 weeks before VT) 171.34 a 1.35 56%

Propiconazole @ 4 oz + ProAct @ .5 oz + NIS (@ 2 weeks before VT) 168.14 a -1.85 11%

Propiconazole @ 4 oz + NIS (@ VT) 173.92 a 3.93 56%

ProAct @ 0.5 oz + NIS (@ VT) 175.01 a 5.02 78%

Propiconazole @ 4 oz + ProAct @ 0.5 oz + NIS (@ VT) 178.88 a 8.89 89%ProAct @ 0.5 oz + NIS (@ V5) fb Propiconazole @4 oz + ProAct @ .5 oz + NIS (@ VT) 179.86 a 9.87 89%

Headline® @ 6 oz + NIS (@ VT) 178.10 a 8.11 67%

Headline AMP @ 10.6 oz + NIS (@ VT) 177.59 a 7.60 89%

Quilt® @ 7 oz + NIS (@ VT) 176.86 a 6.87 89%

Quadris® @ 6 oz + NIS at V5 fb Quilt @ 7 oz + NIS (@ VT) 172.45 a 2.46 44%

CORN YIELD: (n=9 locations, sites with light to high disease levels)

8 reps per location. VT=tasseling. *Mean separation not attempted if Treatment x Location interaction term significant. When letters are presented, means followed by the same letter are not statistically different (Protected LSD, P = 0.1); Values calculated with ARM ST.

ProAct® + Propiconazole increased Corn YIELDS and SUCCESS RATES

as much or more than Strobi’s alonePHC-contracted Independent Small-block Research: 2011

Each registered trademark shown on this page is the property of its owner

Comparable corn yields without resistance pressure

on strobilurin-class fungicides

Each treatment replicated at least 3 times via field-strips at each location.Each registered trademark shown on this page is the property of its owner

Trial ID County Untreated Headline® AMP ProAct with Propiconazole

ST2011303A Webster 209.1 211.4 215.0

ST2011362A Kossuth 198.5 202.6 209.4

ST2011369A Humboldt 194.4 198.0 193.6

ST2011363A Kossuth 185.3 185.1 192.6

ST2011368A Boone 191.2 193.9 189.9

ST2011357A Story 184.6 186.6 184.3

ST2011359A Polk 176.2 173.3 173.4

ST2011356A Polk 162.5 172.2 169.7

Average 187.7 190.4 191.0

ISA-OFN-Managed, Famer-recorded average yields in bu/ac: 2011

• ProAct alone is NOT as effective as strobies or propiconazole at protecting corn from disease-induced yield losses.

• Tank-mixing ProAct with propiconazole increases likelihood of higher yields following application.

• ProAct-treated corn usually yields more than untreated whether disease is present or not.

The use of ProAct & Propiconazole, used in lieu of an application of a strobilurin fungicide can be an effective tool in the battle against the development of resistance to strobilurin class chemistry.

RECOMMENDATIONS

If Gray Leaf Spot pressure is light-to- moderate and unevenly distributed

across area to be treated, apply a tank-mix of ProAct + propiconazole.

If scouting reveals widespread Gray Leaf Spot infection, apply a

strobiluron + triazole combination fungicide product.

TM

ProAct® logo, Plant Health Care, Inc.® logo Save the Strobies™ and Strobie characters are trademarks of Plant Health Care, Inc., Pittsburgh, PA. All other trademarks are the property of their respective owner.

www.savethestrobies.com