schedule for conference and workshop€¦ · his main research interests are the biopharmaceutical...

Schedule for Conference and Workshopupdated 2 March 2016

Program Committee

Marc Schneider studied physics and graduated at the Free University Berlin in 1998. In 2002 he finished his PhD at the Max Planck Institute of Colloids and Interfaces, Potsdam. Three Post Doc positions in Potsdam, Genoa and Saarbrücken resulted in becoming professor for Pharmaceutical Nanotechnology and full professor for Pharmaceutics and Biopharmacy at Philipps University Marburg, Germany. Since February 2015 he is head of the institute of Biopharmaceutics and Pharmaceutical Technology at Saarland University. His main research focuses on synthesis and characterisation of novel nano / microparticulate drug delivery systems as well as their interaction with biological barriers.

Claus-Michael Lehr is Professor at Saarland University, and also cofounder and head of the department “Drug Delivery” at the recently established Helmholtz Institute for Pharmaceutical Research Saarland (HIPS). Together with his long lasting colleague Ulrich Schäfer, he developed the BioBarriers conference series and acts as program chair since its beginning in 1997. He received numerous awards and memberships and serves as expert reviewer for research institutions, international corporations and journals. In 2015, the British Magazine „The Medicine Maker“ listed Prof. Lehr as one of the Top 100 drug researchers in the world.

Ulrich Schäfer studied Pharmacy at Kiel University and obtained his Ph.D. at Saarland University in 1980. In December 2010, he was appointed apl Professor by Saarland University. His main research interests are the biopharmaceutical investigations of semisolid dosage forms for dermatological applications, the development of in vitro models determining penetration and permeation of drugs into human skin, and in silico modeling of skin absorption. As second research area, he is involved in research of non-cellular barriers of the lung and pulmonary toxicological and drug delivery aspects of nano-sized systems. Although he has retired in April 2013, he is still closely connected to Saarland University.

Nicole Schneider-Daum studied Food Chemistry at the University of Kaiserslautern before doing her PhD at the German Cancer Research Center (DKFZ) in Heidelberg. She joined the institute of Biopharmaceutics and Pharmaceutical Technology at Saarland University in 2004 and started as senior scientist in the department “Drug Delivery” of the recently established Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) focusing on the establishment of new in vitro models of biological barriers.

Brigitta Loretz studied Microbiology at the University of Innsbruck. In April 2007 she received her PhD at the University of Innsbruck, Dep. of Pharmaceutical Technology for her work on novel strategies for oral gene delivery. As postdoc she joined Prof. Lehr’s group at the Saarland University in June 2007. After the foundation of the Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), she changed to thenew institute and is working there as senior scientist. Her research interests are nanocarriers for intracellular delivery of biopharmaceutics, with a special focus on biodegradable polymers.

Maike Windbergs studied Pharmacy in Düsseldorf. During her PhD in Pharmaceutics on novel biodegradable drug carriers, she spent research stays in Finland and the Netherlands. She performed a postdoctorate at Harvard University (USA) in the field of lab on a chip research, before joining Saarland University and the Helmholtz-Institute for Pharmaceutical Research Saarland as a senior scientist and habilitation candidate. Her research projects span from the design of innovative drug carriers and complex vitro models for skin absorption up to label-free Raman imaging.

Program Committee

Monday, 7 March 2016 – morning session

Non-Invasive Drug Delivery Across Epithelial Barriers

in cooperation with Controlled Release Society / CRS – Local Chapter Germany

9:00 Opening of the Conference by the Programme Chairs

Welcome by Volker Linneweber, President Saarland University, DE

Welcome by Oliver Germershaus, President Controlled Release Society Germany

Session Chairs: Claus-Michael Lehr, Marc Schneider

9:30 Michael Roberts, University of South Australia, AUThe Future of Skin Delivery

10:00 Arwyn Jones, Cardiff University, UKOvercoming Cellular Barriers in Drug Delivery: Pushing and Opening Endocytic Gates and Pathways for Intracellular Targeting

10:30-11:00 Coffee Break and Poster Session

Monday, 7 March 2016 – morning session

Non-Invasive Drug Delivery Across Epithelial Barriers

in cooperation with Controlled Release Society / CRS – Local Chapter Germany

11:00 Julia Ljublimova, Cedars-Sinai Medical Centre, USNanobioconjugates Crossing Multiple Biobarriers Regulate Laminin-411 – Notch Signaling Pathways and Change Glioma Microenvironment by Suppressing the Tumor Growth

Contributed Talks

11:30 Albert Braeuning, Federal Institute for Risk Assessment, DEInterplay of Core or Coating Material Dictates the Translocation of Nanoparticles In Vitro

11:40 Ana Melero, University of Valencia, ESCyclosporin-A Skin Absorption Enabled by Ultraflexible Liposomes

11:50 Mar Másson, University of Iceland, ISModel for Ocular Drug Delivery from Drug Loaded Soft Contact Lenses

12:00-13:30 Lunch

For CRS Members only: 12:00-13:00 Working Lunch and Meeting of Members

Monday, 7 March 2016 – afternoon session

Advanced Nanocarriers for Overcoming Cellular Barriers (1)

Session Chairs: Oliver Germershaus, Udo Bakowsky

13:30 Julien Nicolas, Institut Galien Paris-Sud, FRDrug-initiated Synthesis of Polymer Prodrug Nanoparticles

14:00 Anja Boisen, DTU Nanotech, DKMicro and Nanostructures for Biosensing and Oral Drug Delivery

14:30 Yvonne Perrie, Aston University, GBDeveloping Novel Liposomal Adjuvants Using Microfluidics: Targeted Antigen Delivery and Rapid Scale Up Processes

15:00-15:30 Coffee Break and Poster Session



Session Chairs: Oliver Germershaus, Udo Bakowsky

Contributed Talks

15:30 Alexa Patzelt, Charité – Universitätsmedizin Berlin, DEInvestigation of the Follicular Penetration of Porous BSA Nanocarriers and Determination of the Release Kinetics of a Model Drug

15:40 Valerie Spieler, University of Würzburg, DEClickable Engineered Cytokines – Controlling Macrophage Polarization by Bio-Orthogonal Immobilization

15:50 Christian Wölk, Martin Luther University Halle-Wittenberg, DEEffective Lipid-Mediated DNA Transfer with a Three-Chain Amino-Functionalized Lipid Designed for Lipofection



Session Chairs: Michael Roberts, Lorenz Meinel

16:00 Julien Meissonnier, CATALENT Pharma Solutions, FRLipid Based Formulations for Delivery of Poorly Soluble Compounds

16:25 Gregor Fuhrmann, Imperial College London, GBExtracellular Vesicles as Smart Carriers for Small Molecule Drugs

16:50 Michael Kormann, University of Tübingen, DEIn Vivo Genome Editing Using Chemically Modified mRNA Encoding Site-Specific Nucleases Assembled to Nanoparticles



Session Chairs: Michael Roberts, Lorenz Meinel

Contributed Talks

17:15 Petra O. Nnamani, University of Nigeria, NGNanomaterial from Moringa Oleifera for Rapid Elimination of Viable Escherichia Coli in Drinking Water

17:25 Stefan Lemke, Free University Berlin, DESmartFilms - Oral and Peroral Films for Optimized Delivery of Nanoparticulate or Amorphous Drugs

17:35 Ryuzo Kawamura, Saitama University, JPMotor Protein-Driven Active Substrate for Detection of Cellular Mechanical Response

17:45 Poster Session and Exhibition

19:30 Reception at Science Park Saar, sponsored by Across Barriers

Tuesday, 8 March 2016 – morning session

Probing and Shaping the Bio-Nano-Interface (1)

in cooperation with Galenus Foundation

Session Chairs: Nicole Schneider-Daum, Sarah Gordon

8:15 Welcome by Cornelia Sonntag, Galenus Foundation, AT

8:30 Andreas Bernkop-Schnürch, University of Innsbruck, ATDrug Delivery Across Mucus and Mucosal Barriers

9:00 Carsten Ehrhardt, Trinity College Dublin, IETransport and Efflux Systems at the Air-Blood-Barrier

9:30 Gerrit Borchard, University of Geneva, CHRegulation of Epithelial Permeability: Addressing the Innate Immune System

10:00-10:30 Coffee Break

Tuesday, 8 March 2016 – morning session

Probing and Shaping the Bio-Nano-Interface (2) Session Chairs: Andreas Bernkop-Schnürch, Ulrich F. Schäfer

10:30 Eckart Rühl, Free University Berlin, DETopical Drug Delivery Probed by X-Ray Spectromicroscopy

11:00 Arti Ahluwalia, Centro E. Piaggio, ITDesign and Scaling of Biomimetic Biological Interfaces

Contributed Talks

11:30 Klaus Unfried, IUF Leibniz Research Institute for Environmental Medicine, DEMembrane Dependent Signaling in Lung Epithelial Cells as a Target for Molecular Prevention of Particle-Induced Adverse Health Effects

11:40 Otmar Schmid, Helmholtz Zentrum München, DEDose-Controlled Aerosol Delivery to Epithelial Biobarriers

11:50 Koen Raemdonck, Ghent University, BENatural Nano- and Microcarriers for siRNA Delivery: Extracellular Vesicles and Cytotoxic T-Cells

12:00 Roland Brock, Radboud University Medical Center, NLA Lactoferrin-Derived Cell-Penetrating Peptide for Kidney-Specific Drug Targeting

12:10-13:15 Lunch

Tuesday, 8 March 2016 – afternoon session

Combating Infectious Diseases, Novel Approaches and in Vitro Models (1)

in cooperation with CAAT Europe

Session Chairs: Manfred Ogris, Marc Schneider

13:15 Welcome by Rolf Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, DE

13:30 Rolf W. Hartmann, Helmholtz-Institute for Pharmaceutical Research Saarland, DEInterference with Bacterial Quorum Sensing - A Novel Anti-Virulence Strategy

14:00 Gareth W. Griffiths / Federico Fenaroli, University of Oslo, NOLive Imaging of Biodegradable Nanoparticles during Tuberculosis Infection in Zebrafish Embryos

14:30 Hanne Mørck Nielsen, University of Copenhagen, DKPerspectives for Targeting Infections Applying Antimicrobial Peptides


15:25 Welcome by Mardas Daneshian, CAAT Europe

15:30 Charu Chandrasekera, Physicians Committee for Responsible Medicine, USCombating Disease Models: Addressing Human Relevance in the 21st Century


Combating Infectious Diseases, Novel Approaches and in vitro Models (2)

in cooperation with CAAT Europe

Session Chairs: Mardas Daneshian, Maike Windbergs

16:00 Florian Groeber, ATERA SA, LUComplex Skin Models and Impedance Spectroscopy as New Tools for Hazard Identification and Efficacy Testing

16:25 Helena Kandarova, MatTek, SIin vitro Models of Human Airway, Small Intestine and Skin: Applications for Infectious Disease Research

16:50 Samuel Constant, Epitelix, CHAssess the Bio-Barrier Function of the Human Respiratory System Using in vitro 3D Epithelial Models of Upper (MucilAir) and Small Airways (SmallAir)

Contributed Talks

17:15 Leoni Aengenheister, EMPA, CHEstablishment of a Perfused in vitro Model of the Placental Barrier for Nanoparticle Translocation Studies

17:25 Katrien Van Bocxlaer, University of London, UKStructure and permeability of the skin barrier in cutaneous leishmaniasis


Industry Session

Session Chairs: Mardas Daneshian, Maike Windbergs

Contributed Talks

17:35 Manuel Sacha, Across Barriers, DEIs the Porcine Buccal Mucosa a Suitable In Vitro Model for the Evaluation of Nicotine and Caffeine TransbuccalAbsorption?

17:45 Lars Jansen, Schaefer Technologies GmbH, DEEnabling Rational Design and Development of Nanomedicines: The NanoAssemblrTM Platform

17:55 Karsten König, JenLab GmbH, DEIn Vivo Multimodal Histology with the Multiphoton / CARS Tomograph

18:05 Kelly S. Davidge, Kirkstall Ltd., UKCan Organ-on-a-Chip Technology Really Replace Animal Testing of Drug and Chemical Safety?

18:15 Adjourn and transfer to conference dinner

19:00 Conference Dinner sponsored by PHAST

Wednesday, 9 March 2016 – morning session

European Research Projects on Targeted Delivery to Biological Barriers (1)

ITN PathChooser – Innovative, Mechanistic-Based Strategies for Delivery of Therapeutic Macromolecules Across Cellular and Biological Barriers

8:15 Kenneth A. Dawson, University College Dublin, IEIntroducing ITN PathChooserShort Key Note: New Constructs for Crossing Biological Barriers

Contributed Talks

9:00 Anne Iltzsche, King’s College London, GBUptake and Distribution of ApoE-Targeted Human Serum Albumin Nanoparticles and their Delivery to Neurons in the Mouse Brain

9:10 Xabier Murgia, Helmholtz-Institute for Pharmaceutical Research Saarland, DEMucus-Nanoparticle Interactions Addressed by Multiple Particle Tracking and Aerosol Deposition

9:20 Martina Tuttolomondo, University of Southern Denmark, DKInteraction Studies of Synthetic DMBT1 Peptides with the siRNA

9:30 Diana Hudecz, University College Dublin, IE Investigation of Nanoparticle Interactions with In Vitro Blood-Brain Barrier Co-Culture Model Using Live Cell Imaging



ITN PathChooser – Innovative, Mechanistic-Based Strategies for Delivery of Therapeutic Macromolecules Across Cellular and Biological Barriers

Session Chairs: Students of the PathChooser Project

9:45 David J. Begley, King’s College London, GBDelivery to the Brain: The Blood-Brain Barrier and Beyond

10:15 Marino Zerial, Max-Planck-Institute, DEDelivery of Oligonucleotide Based Drugs, Intracellular Trafficking and Endosomal Escape


ITN NABBA – Design and Development of Advanced NAnomedicines to Overcome Biological BArriersand to Treat Severe Diseases

11:15 Francesco Nicotra, University of Milano-Biocca, ITIntroducing ITN NABBAShort Key Note: Ligands Targeting Aβ-Peptides



IMI COMPACT – Collaboration on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets

Session Chairs: Kenneth Dawson, Claus-Michael Lehr

11:45 Ekkehard Leberer, Sanofi, DEIntroducing IMI COMPACTCOMPACT Consortium: A Public-Private Partnership from the Innovative Medicines Initiative to Develop Nanocarrier Systems for Delivery of Biopharmaceuticals

12:15 Manfred Ogris, University of Munich, DEMultimodal Molecular Imaging to Study Pharmacokinetics and Pharmacodynamics of Nucleic Acid Based Drugs

12:45 Closing Remarks / End of Conference

13:00 – 14:00 Lunch

Wednesday, 9 March 2016 – afternoon session

Workshop on GSP and Bibliometrics

14:00 Michael Gommel, Institut für systemische Medizin- und Organisationsethik, DEAvoiding Scientific Misconduct – Good Scientific Practice as a Compass in Research

15:30 – 16:00 Coffee Break

16:00 Jaap van Harten, ELSEVIER, NLDo Numbers Tell the Tale? Bibliometrics and Research Impact

17:30 Closing Remarks / End of Workshop

We would like to express our gratitude to our principal supporters for providinginfrastructure, logistics, financial and professional support:

Acknowledgment of funding: Supportedby “GradUS global” – promoted by theGerman Academic Exchange Service andfunded by the Federal Ministry ofEducation and Research.

We are thankful to our sponsors* who enable us to bring togetherpeople from all over the world and to provide an inspiring environment:

* listed in alphabetical order

schedule for conference and workshop€¦ · his main research interests are the biopharmaceutical...

Documents