science foresight: a hesi synthesis & strategy initiative

Science Foresight: A HESI Synthesis & Strategy Initiative

Dr. Anthony Holmes, NC3Rs, Co-Chair of HESI Program Strategy and Stewardship Committee Dr. Ron Hines, Yale University School of Public Health, HESI Chair of Emerging Issues Committee

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What does Science Foresight mean to HESI?

To meet our mission, HESI requires

• Currency

• Innovation

• Perspective

• Outreach

The Science Foresight Strategy is just ONE tool HESI uses to achieve

this aim.AH

HESI has developed these resources before…

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What you will see today

• Initial synthesis

• A living document

• A launch pad for strategy

• A call for input

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So how was this constructed?

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Forecasts Drawn from EXTERNAL Sources

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Plus survey input from HESI stakeholders…

Board of Trustees(50% public sector, 50% private sector)

Emerging Issues Science Advisory Board (70% public sector, 30% private sector)

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Started here!

Finishing here

HESI SCIENCE FORESIGHT 2021-2031PLANETARY PRESSURES SOCIETAL INFLUENCES PRACTICE OF SCIENCE INDIVIDUAL AND

POPULATION HEALTH

Issue Driven Opportunities and Future Challenges

New Technologies

EXTERNAL SOURCE VIEWxxxxxxxxxxxxxxxxxxxxxxxxx

HESI STAKEHOLDER VIEWxxxxxxxxxxxxxxxxxxxxxxxxx







External View

HESI Stakeholder

View

External View

HESI Stakeholder

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External View

HESI Stakeholder

View

External View

HESI Stakeholder

View

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Think about…

• What areas are YOU/ YOUR ORGANIZATION seeing as a priority AND where you’d be interested in collaborating with HESI?

• What are the SPECIFIC NEEDS within these emerging areas that should be addressed via a collaborative forum?

RH

HESI SCIENCE FORESIGHT 2021-2031


New Technologies

EXTERNAL SOURCE VIEW

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HESI STAKEHOLDER VIEWPLANETARY PRESSURES

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• Impact of Alternative & Renewable Energy Sources

• Climate Change• Population Growth• Waste Management Demands• Sustainability of Natural

Resources (i.e., water, air, minerals)

• Biodiversity Protections• Preserving Infrastructure

• Ocean Conservation• Novel Environmental Exposures• Air Pollution• Food Safety & Security • Transportation Demand &

Expansion• Unintended Consequences of

COVID-19 Pandemic

• Impact of Energy Transition• Public Health and Ecological Impacts of Climate Change• Environmental Exposures and Ecological & Health Outcomes • Chemical Bans: Substitutions and Sustainability • Plastics & Microplastics • Universal Decline of Biodiversity• Waste Management• Chemical Lifecycle Analysis & Management

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New Technologies


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HESI STAKEHOLDER VIEW









SOCIETAL INFLUENCES

• Public Skepticism of Science• Impact of Misinformation on Health &

Science• Improving Science Communication• Culture of Open Access Science • Regulatory and Legal Framework of

Open Access Science• Research Funding and Reward

System in Science• Impact of Political and Economic

Instability on Science • Diversity and Inequity in STEM • Lack of Investment in Preventative

Care• Workplace Design/ Evolving

Occupational Practices• Ethics of Artificial Intelligence

• Unintended Consequences of Technology Advancement

• Social Media and the Collection & Exchange of Information

• Public Perception of Risk vs. Hazard• Transparency and Trust in Science• Health Equity: Diversity and Inclusion• Need for Universal Regulatory

Standards Globally • Limited STEM Experts in Resource

Poor Areas• Reduction of Research Funding

• Pressure to Reduce Pharmaceutical Prices

• Integration of New Methods & Science in Regulation

• Regulation Density • Transition to a Circular Economy • Stricter, "Risk-Free" Chemical

Regulation• Integrating Health & Environmental

Sciences and Social Sciences

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New Technologies


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PRACTICE OF SCIENCE

• Animal Alternative Testing Methods, 3Rs• Open Science: Sharing & Communication of Data• Integration of Toxicology & Epidemiology• Risk-based Regulatory Decision Making • Epigenetics• Vaccine Development • Exposure Science: Human and Ecological Risk Assessment• Citizen Science• Rapid Advancement & Implementation of New Science

• Pressure to End Animal Testing - Shift to in vitro Methods • Enhanced Collaboration within the Science Community • Disease-focused Environmental Toxicology • Microbiome-driven Science • Satisfy Data Protection Demands• Integration of Culture and Science • Sustainable Chemical Use

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New Technologies


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INDIVIDUAL AND POPULATION HEALTH

• Preventative Medicine• Age-related Disorder• Drug Resistance • Chronic Disease

Survivorship• Neurological Illness• Immunotherapy• Health Equity & Disparities

• Immune Susceptibility• Biomarker Use in Clinical

Care• Regulation & Carcinogenic

Risk

• Prevention and Control of Communicable & Non-communicable Disease

• Antibiotic Resistance• Aging Population• Access to Healthcare in Rural Areas• Environmental Exposures & Disease • Microbiome Science • Population Health • CRISPR Technology• Food Safety

• Occupational Chemical Safety• Exposome Science• Infectious Disease Surveillance • Vaping/Tobacco Use • Public Health Nutrition • Impact of Mental Health Challenges• Legalization of Drugs and Drug

Addiction

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HESI SCIENCE FORESIGHT 2021-2031PLANETARY PRESSURES SOCIETAL INFLUENCES PRACTICE OF SCIENCE INDIVIDUAL AND

POPULATION HEALTH

NEW TECHNOLOGIES

New Technologies









External View

HESI Stakeholder View

External View


External View


External View


HESI STAKEHOLDER VIEW• Artificial Intelligence: Computational Modeling

& Machine Learning• Block-chain, NFT • Artificial Organs, Tissue, Organ Chips, etc. • Cell, Immuno-, and Gene Therapy • Personal Exposure Monitoring Data: Role in

Health and Disease• Evolution of Lab-based Technologies • in vitro and other cell-based Technologies • Robotics • Gene Editing Technology • Precision Agriculture• Satellite Imaging Technologies

EXTERNAL SOURCE VIEWArtificial Intelligence: Robotics & Smart ManufacturingSmart Farming: Advancements in Agricultural EquipmentHigh Density DataGenome Editing 3D PrintingPersonal Health Tracking Devices & BiosensorsEnergy Saving Equipment: Resources & Approaches Renewable Energy Equipment: Resources & Approaches Novel Vaccine TechnologiesNovel Food Technologies (i.e. lab made meat)

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How will HESI use this information?

1) Map against current/planned programming

2) Prioritize and develop NEW areas of science

3) Monitor for opportunity in areas not initially prioritized

4) Iterate and refresh

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Questions for YOU• What areas are YOU/

YOUR ORGANIZATION seeing as a priority AND where you’d be interested in collaborating with HESI?

• What are the SPECIFIC NEEDS within these emerging areas that should be addressed via a collaborative forum?

RH

For more information or share input…

Email us at [email protected]

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mailto:[email protected]

science foresight: a hesi synthesis & strategy initiative

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