PLATFORM SOLUTIONSCREENING

THE SCIENCE OF BETTER

Until now, scientists working

in environmental, food safety,

pharmaceutical, and clinical

laboratories have lacked a

comprehensive screening solution

to aid them in their analyses.

T he Waters® Screening Platform

Solution with UNIFI® is the first

and only comprehensive screening

solution – target, identify, quantify,

and review using a streamlined

analytical workflow that enables

more accurate results across a

wide range of applications.

T he platform is holistically designed,

combining world-class instruments,

software, Waters Analytical

Standards and Reagents, and

chemistries. All backed by Waters’

expert Service and Support, this

is a solution for today’s needs

and tomorrow’s growth.

It’s not just the first total screening solution.It’s an analytical platform that fostersbusiness results.BUSINESS RESULTS.

SCREENING PLATFORM SOLUTION with UNIFI

Integrating chromatography and

mass spectrometry instrumentation

with next-generation informatics,

Waters Screening Platform Solution

with UNIFI makes screening routine

by allowing you to capture complex,

high-end LC-MS data on one platform.

Based on the UNIFI Scientific

Information System, Waters Screening

Platform Solution facilitates data

standardization so that information

can be exchanged and transferred

among departments and third-party

partners. It enables all laboratory

functions to work with a common

backbone of analytical information

comprised of successful methods,

processed results, and historical

data and reports.

Analytical integrationand team collaboration.

Waters Screening Platform Solution with UNIFI workflow

Acquire, compare, quantify, and report using a streamlined

analytical workflow that enables more accurate results across a

wide range of applications.

REDUC E BOT H FALSE POSIT IV ES AND FALSE NEGAT IV ES

With UNIFI’s workflow, you can

always answer the questions:

■■ Screen: Are these targets

in the sample?

■■ Quantify: If so how much?

■■ Discover: What else is

in my sample?

INTEGRATION & COLLABORATION.

Unparalleled confidence

UNIFI facilitates true dynamic

collaboration – providing an

extensible and flexible solution to

meet the varying legislative and

regulatory criteria. Store, make use

of, and share all your data, all your

methods, your reports, and everything

associated with your results.

Nothing is ever forgotten; nothing is

ever lost. Because you can quickly

see what’s been done in the past,

you can make decisions more

quickly, easily, and assuredly.

The UNIFI Platform. Solve screening challenges and achieve the best results possible with maximum confidence.

UNIFI’s Scientific Library is the

ultimate reference resource – a

resource that grows and becomes

more intelligent as you and your

colleagues contribute data.

T he scientific library ensures that

your data is always in context.

It enables you to make use of

your prior work, as well as your

colleagues’ data and findings.

UNIFI is the first-of-its-kind scientific

information system that changes

what you can accomplish with

high-end mass spectrometry and

chromatography, integrating all

results in a single, comprehensive

software solution. Like never before,

this consolidates state-of-the-art data

acquisition, data processing, and data

management software capabilities

in a way that revolutionizes today’s

screening processes.

A mix of 12 sulfonamides were spiked into a sample of bovine milk at 100 µg/L prior to extraction. The 12 sulfonamides were identified in the extracted sample using the accurate mass of molecular ions and retention time contained in the scientific library. The identified components are displayed in the component plot. Information rich MSE data allows for confirmation of the individual sulfonamides using accurate mass high energy fragments obtained in the same injection. Annotated spectra and extracted ion chromatograms are displayed for all low and high energy masses identified for each component.

SCREENING PLATFORM SOLUTION with UNIFI

FOOD AND ENVIRONMENTAL

■■ Chemical residues

(including veterinary drugs,

hormones, illegal dyes,

pesticides, and food packaging

contaminants)

■■ Environmental research

(water analysis)

■■ Natural contaminants

(including mycotoxins, plant

toxins, and phycotoxins)

PHARMAC EUT ICAL

■■ Metabolite identification

■■ Traditional medicine

■■ Biomarker analysis

■■ Impurity analysis

Made of 100% world-class components. Only from Waters.

All components of the Waters Screening Platform Solution work together seamlessly

to produce more accurate data and faster results across a wide range of applications:

CLINICAL

■■ Sports doping

(human and animal sports)

■■ Forensic toxicology

■■ Best-in-class UPLC® and MS

designed and engineered

for total compatibility.

■■ Chemistries designed

specifically with compatible

hardware offerings in mind.

■■ Waters Analytical Standards

and Reagents are specifically

designed with the expertise

of world-class scientists, who

understand the complexities

of screening applications.

You can count on Waters to ensure everyone in your lab is poised to harness the power of this comprehensive

solution. Here’s a bit more detail on what that means:

■■ A single point of contact

for expert service and

support – from installation,

qualification and

validation to training

and maintenance.

Waters Screening Platform Solution with UNIFI.

ACQUIT Y UPLC® I -CLASS SYST EM

■■ Addresses the most critical need

in separation science today –

successfully analyzing compounds

in complex matrices more

rapidly than ever before.

■■ Maximizes peak capacity to

enhance MS sensitivity.

■■ Provides the lowest carryover,

complementing MS sensitivity and

extending linear dynamic range.

■■ Purposefully engineered to

maximize the benefits of

sub-2-µm particle columns

with the lowest dispersion.

■■ With an extended pressure/flow

envelope, it accelerates complex

separations without compromising

chromatographic fidelity.

■■ Delivers world-class sensitivity

through increased chromatographic

resolution and reduced peak widths.

X EVO® G2-XS QTof

■■ Designed for scientists who need

to analyze the broadest range of

compounds in the most complex

and challenging samples.

■■ Takes advantage of StepWave™

ion optics for unsurpassed

levels of durable sensitivity.

■■ Uses proven quantitative Tof

(QuanTof™) technology to deliver

superior UPLC-compatible mass

resolution, matrix-tolerant dynamic

range, quantitative performance,

mass accuracy, and speed of

analysis – simultaneously.

■■ Allows close integration with

UltraPerformance LC® to deliver the

highest quality, most comprehensive

information for quick and accurate

decision-making.

■■ MSE enables data to be

comprehensively catalogued so

that the response of all components

across all data channels (MS,

UV, etc.) is collated and directly

analyzed without the need for

additional acquisitions.

UNIFI SCIENT IF IC INFORMATION SYST EM

■■ Combines all data acquisition, processing,

and reporting functionality within one

informatics platform.

■■ Allows a single, non-targeted data set to be

utilized for qualitative and quantitative or

semi-quantitative analyses.

■■ Look for any component that has evidence of

an indicative fragment, neutral loss, isotopic

pattern of a target, or class of compound.

■■ Improved peak detection with updates to

Apex Software render better quality peaks,

which allows a much lower threshold to

be set – providing improved results.

■■ Having the LC-MS data in a database

allows you to rapidly query the data.

UNIFI provides:

■■ A scalable architecture that grows

as your screening and instrument

system needs change.

■■ Fully customizable reporting capabilities.

■■ An LC-MS solution with network capability.

■■ Application tailored workflows

to aid data review.

■■ Component model enables product ions

from MSE to be fully utilized within each

analysis (e.g. confirmatory analysis),

without the need for further injections.

More innovations and capabilities that play well together.

ACCELERATE &

The Waters Screening Platform

Solution, complete with best-in-

class instruments and a streamlined

informatics solution within a single

platform, significantly increases

efficiencies and productivity so that

labs are able to do more analyses –

faster and more accurately.

On an even larger scale, the UNIFI

scientific library enables researchers

worldwide to capture information

and collaborate seamlessly to

solve challenges never before

possible in isolation. T his means

pushing the pace of progress

across environmental, food safety,

pharmaceutical, and clinical research.

Accelerate your science.Redefine what’s possible.

SCREENING PLATFORM SOLUTION with UNIFI

WAT ERS ANALYT ICAL STANDARDS AND REAGENT S

■■ High-quality standards and reagents

specifically designed to ensure that

your system is fit for the purpose

of Tof screening.

■■ Precisely formulated and ready-to-

use, generating optimal performance

from your LC-MS instruments and

ensuring every analysis gets

off to an accurate start.

■■ Guaranteed purity and composition,

shipped in specifically selected,

clean containers, and come

with Certificate of Analysis

documentation.

■■ Eliminate prep time – freeing up

valuable time for your scientists

to focus in other areas.

■■ Ensure quality and consistency

from day-to-day, system-to-system,

and lab-to-lab with the same

calibrators, controls, and standards

across multi-site laboratories for

easy, quantitative monitoring.

■■ Regular use of the Tof LC-MS

QC Reference Material supports

benchmarking and monitoring

of the system over time; and

enables proactive diagnosis

and troubleshooting of any

challenges that arise.

REDEFINE.

BE ASSURED. CHOOSE WAT ERS GLOBAL SERV IC ES.

Waters Global Services focuses on

optimizing Waters’ products with

superior service, support, upgrades,

training, and Waters Quality Parts.®

Proven Satisfaction

For fourteen consecutive years, an

independent quality auditing firm has

ranked Waters Global Services best-

in-class in providing expert technical

knowledge, quick resolution of system

issues, and process support.1

1 Achievement in Customer Excellence Award, Confirmit/CustomerSat, Inc., 2007-2014; NorthFace ScoreBoard Awardssm, Omega Management Group Corporation, 2001-2006.

Waters, ACQUITY UPLC, Xevo, UPLC, Waters Quality Parts, UltraPerformance LC, UNIFI, and The Science of What’s Possible are registered trademarks of Waters Corporation. QuanTof and StepWave are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2015 Waters Corporation. Printed in the U.S.A. July 2015 720004317EN LM-SIG

Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com

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