sel hematopoetik
DESCRIPTION
YarsiTRANSCRIPT
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Sel hemopoetik dan non hemopoetik
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• Teori asal-usul– Polifiletik– Dualistik– Monofiletik
Sel induk (stem cell) Totipoten
CFU GEMM Lymphoid stem cell
GranulositMonosit
Eritroid Megakariosit
Eosinofil
Basofil
Neutrofil
Monosit
Eritrosit TrombositLimfosit
B T
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Sel-sel dalam sum-sum tulang
Sel-sel hemopoetik
Seri eritrosit
Seri mieloidSeri monositSeri limfoidSeri trombosit
Sel-sel non hemopoetikPlasmositHistiosit
fagositikEosinofilikneutrofilikBasofilik
OsteoblasOsteoklasSel lemak
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Nomenklatur : ASCP
Seri granulosit•Mielo/monoblas•Promielosit/promonosit•Mielosit•Meta mielosit•Batang•Segmen
Seri eritroid•Rubriblas•Prorubrisit•Rubrisit•Meta rubrisit•Eritrosit polikrom•Eritrosit
Mielosit: Granula spesifik/sekunderEosinofilNeutrofilBasofil
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Seri trombosit
MegakarioblasPromegakariositMegakariositMetamegakariosittrombosit
Seri limfosit
LimfoblasProlimfositLimfosit: Limfosit B Limfosit T
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Seri leukosit
• Maturasi– Ukuran sel : makin tua makin kecil– Sitoplasma :
» warna: birukemerahan» Granula: tidak adaada
– Inti:» Ukuran : makin tua makin kecil» Bentuk : Bulatberlekuklobus» Warna : merahkebiruan» Kromatin: haluskasar/menggumpal, padat
– Anak inti ; ada tidak ada
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Maturasi sel
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Seri granulositSeri granulosit•Mielo/monoblas•Promielosit/promonosit•Mielosit•Meta mielosit•Batang•Segmen
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NeutrofilProduksi di sumsum tulangFungsi
pertahanan tubuhfagositosis
Granula neutrofil : anti mikroba•Peroksidase•Lisosim•Fosfatase asa,•Fosfatase alkali
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KINETIKA NEUTROFIL
Stem cell pool
Circulating pool
Marginating pool
MetamielositNeutrofil batang, segmen
MieloblasPromielositmielosit
Mitotik pool Post mitotic maturation and storage pool
6-10 hari
Darah: 6-10 jam
Jaringan:3-5 hari
Waktu transit(kira2)Waktu transit(kira2)
Darah: 6-10 jam
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Eosinofil
Produksi: sumsum tulang
Sirkulasi pendek (30 menit)
Granula: peroksidase, plasminogen
Fungsi:
fagositosis infeksi parasit
reaksi alergi
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Basofil
Produksi di sumsum tulangGranula: histamin, heparinPelepasan histamin meningkat pada stimulasi :
Antigenikthermal/suhu
dinginmekanik
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Monosit
Produksi : sumsum tulangSiklus : sumsum
tulangsirkulasijaringan
Granula : peroksidase lisosimMakrofag: menetap bila
ada stimulasibergerak
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Limfosit
Produksi di sumsum tulang dan jaringan limfoid
Fungsi : humoral dan selular
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•Rubriblas•Prorubrisit•Rubrisit•Meta rubrisit•Eritrosit polikrom•Eritrosit
Seri eritrosit
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Perubahan yang terjadi pada maturasi sel
seri eritroid
Ukuran : makin kecilInti :Ukuran : makin kecilbentuk : bulatkromatin: makin kasarnukleoli : menghilangSitoplasma, warna : biru-merah
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Zat yang diperlukan untuk eritropoesis– Asam amino/protein– Vitamin : B12, asam folat, B6, riboflavin,
asam pantotenat, niacin, vit C– Mineral :Fe, Cu, Zn– Hormon : eritropoetin, tiroksin, androgen
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