sgh case 42: 17re167...title sgh case 1: 17re90 author cl cheng created date 11/15/2017 7:40:24 pm
TRANSCRIPT
SGH CASE 42: 17RE167
• Clinical History: • 80+ years old, Female. Cervical lymphadenopathy.
• Specimen: • Left cervical lymph node excision biopsy
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 H&E
Lymph node architecture distorted by a nodular lymphoproliferation
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 H&E
Lymph node architecture distorted by a nodular lymphoproliferation
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 H&E
Lymphproliferation shows a predominance of centroblasts over centrocytes in the follicle centresSGH haematolymphoid workshop 2017. © All Materials are
Copyright of Singapore General Hospital Pathology. No Copy or Reproduction without Permission.
SGH CASE 42: 17RE167 CD20
CD20 highlights the follicles and interfollicular infiltrate of B-cells
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 CD20
CD20 highlights the follicles and interfollicular infiltrate of B-cells
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 CD21
CD21 highlights relatively circumscribed follicular dendritic
meshworksSGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 CD21
CD21 highlights relatively circumscribed follicular dendritic
meshworksSGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 CD10
CD10 highlights follicle centres as well as aberrant interfollicle infiltration by
CD10(+) lymphomatous cellsSGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 CD10
CD10 highlights follicle centres as well as aberrant interfollicle infiltration by
CD10(+) lymphomatous cellsSGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 CD10
CD10 highlights follicle centres as well as aberrant interfollicle infiltration by
CD10(+) lymphomatous cellsSGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 KI67
Some of the follicles are Ki-67 high but others show lower Ki-67
proliferation in comparison to reactive germinal centresSGH haematolymphoid workshop 2017. © All Materials are
Copyright of Singapore General Hospital Pathology. No Copy or Reproduction without Permission.
SGH CASE 42: 17RE167 KI67
Follicle centre showing lower Ki-67 proliferation in comparison to
reactive germinal centresSGH haematolymphoid workshop 2017. © All Materials are
Copyright of Singapore General Hospital Pathology. No Copy or Reproduction without Permission.
SGH CASE 42: 17RE167 IgD
IgD(+) mantle zones are generally attenuated
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 BCL2
Bcl2 is mostly negative in follicle centre cells
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167 BCL2
Bcl2 is mostly negative in follicle centre cells
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.
SGH CASE 42: 17RE167
• Diagnosis• Follicular lymphoma, WHO Grade 3A, bcl-2 negative
SGH haematolymphoid workshop 2017. © All Materials are Copyright of Singapore General Hospital Pathology. No Copy or
Reproduction without Permission.