Hodgkin-Huxley model simulator

Katrin Valdson Kristiina Pokk

Marit Asula

Tartu 2015

Introduction

I� = g�(V − E� )+ g�n⁴(V − E�)+ g�ₐm³h(V − E�ₐ)

Simulator

Simulator

Topics of the simulator exercises

Part I: Equilibrium PotentialPart II: Membrane PotentialPart III: The Action PotentialPart IV: The Fast Sodium ChannelPart V: The Delayed RectifierPart VI: Voltage-Gated Channel Parameters

TTX

● neurotoxin● found in pufferfish, octupuses,

marine worms, amphibians● deadly in very small amounts● blocks Na ion channels● prevents action potential from

happening

TEA

● Tetraethylammonium

● found in simple salts

● used in pharmacological research

● blocks K ion channels● prolonged action potential

Pronase

● group of proteolytic enzymes● extracellular fluid of a species

bacteria in soil● blocks only the Na inactivation gate● results in prolonged action potential