splicing / molecular biology
TRANSCRIPT
Daniela Martínez Rivera
Medicine Student
Splicing allows to create proteins with the coding sequence on the
mature mRNA.
The regulatory mechanism is given by the order in which the exons are located, if the same exons change the order, the
reading changes and thus also the protein.
Most cancer
transcriptomes are
bloated by widespread
intron retention. Kocarnik
, JM. (2015, August 17).
Most cancer transcriptomes are
bloated by widespread intron
retention
Abnormal RNA splicing is
a common characteristic
of most cancers because
helps with the initiation
and metastasis.
Most cancer transcriptomes are
bloated by widespread intron
retention
The retention of introns on
abnormal splicing produced
an abnormal protein.
Most cancer transcriptomes are
bloated by widespread intron
retention
These retained introns were
specific to a particular
cancer, his deregulation may be usefull to
differentiating normal versus
cancerous cells.
Most cancer transcriptomes are
bloated by widespread intron
retention
Student’s observation:
I think the splicing process regarding a
global issue such as the cancer is, will have
a great impact , the deepening
knowledge will help the development of new therapies targeting tumor cells and
also to the prevention of cancer as a
disease and his expression.
'Decoding' gene
regulation. Medical
University of Vienna .
(2015, June 11).
'Decoding' gene regulation
Alternative splicing is a key step in
controlling gene expression, is also
linked to numerous human diseases.
'Decoding' gene regulation
Now, has been reported a
novel type of alternative
splicing that occurs in many
important genes on humans,
the exitron splicing.
'Decoding' gene regulation
Therefore, alternative splicing is giving
promising targets for clinical diagnosis
and therapeutic intervention.
'Decoding' gene regulation
Student’s observation:
I think this research promises a lot of hopes for
the future in the therapy and diagnosis
framework ,even being a theme to deepen, it
has great possibilities to find genes with high
medical relevance.
MEDICAL UTILITY
Medical Utility
Both investigations are
seeking the therapeutic
use of alternative
splicing.
The use of small molecules that inhibit
the splicing also have a anti-tumor
activity and it help to design novel
therapies targeting tumor cells.
Medical Utility
Control of gene expression with the
alternative splicing not only helps the
therapeutic treatment , also to the
prevention of diseases.
Medical Utility
Bibliography
Medical University of Vienna . (2015, June 11). 'Decoding' gene regulation. ScienceDaily. Retrieved August 25, 2015 from http://www.sciencedaily.com/releases/2015/06/150611081526.htm
Kocarnik , JM. (2015, August 17). Most cancer transcriptomes are bloated by widespread intron retention. Fred Hutch. Retrieved August 27, 2015 from http://www.fredhutch.org/en/news/spotlight/imports/most-cancer-transcriptomes-are-bloated-by-widespread-intron-rete.html
Martinez Sánchez, Lina Maria. Biologiamolecular.8.ed.Medellin: UPB. Fac.Medicina.
