stroke research in east kent prevention and treatment present and future dr tom webb consultant...
TRANSCRIPT
Stroke Research in East KentPrevention and Treatment
Present and FutureDr Tom Webb
Consultant Neurologist and Stroke PhysicianEKHUFT
June 2014
Stroke Research in East Kent
• Impact of stroke – the importance to research• Improving our prevention of stroke• Improving our treatment of ischaemic stroke• Improving recovery following stroke
Stroke Research in East Kent
• Impact of stroke – the importance to research• Improving our prevention of stroke• Improving our treatment of ischaemic stroke• Improving recovery following stroke
Vascular damage to the brain
• 86,000,000,000• 2,000,000/ min die after stroke• Brain ages by 4 years every hour
untreated
‘Frequent, dangerous, expensive…’
• Commonest cause adult disability
• Major cause of mortality• £3 -£8 bn annual cost to
UK
A unique resource
• 365/365 (33%)• Consultant review
(33%)• MRI for all patients
(16%)• 1500 TIA/ minor
stroke patients 2011-13
Cerebral Microbleeds – small vessels, big problems
• Haemosiderin perivascular deposits• 5 % of well population• 30 % of ischaemic stroke• 60 % of haemorrhagic stroke• May present like TIAs
Cerebral Microbleeds – small vessels, big problems
• Haemosiderin perivascular deposits• 5 % of well population• 30 % of ischaemic stroke• 60 % of haemorrhagic stroke• May present like TIAs
CMBs – what East Kent data might tell us
• How common are they in TIA?• How common are the TIA-like episodes?• Should we look for them with MRI?
CMBs
• Work with UCL research group• Blinded review of East Kent MRs• Correlation with clinical features
Obstructive Sleep Apnoea
• Nocturnal hypopnoea, apnoea and hypoxia• Up to 25 % of men affected• Increased risk of cardiovascular disease…• … and stroke?
OSA and Stroke - Correlation or causation?
• Over 60 % of stroke have OSA• Stroke may cause OSA (but TIAs unlikely to…)• Complex relationship of risks
OSA and Stroke in East Kent
• Examine incidence of OSA in East Kent TIAs• Epworth scores and sleep studies• Should we be screening and treating OSA in TIA clinics?