study program 2014/2015 subjects of the 5-10. semesters ...€¦ · up ms pharmacy major – 5-10th...

UP MS Pharmacy major – 5-10th semesters obligatory courses - Course descriptions – academic year of 2014/2015

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University of Pécs

Medical School

PHARMACY Major

STUDY PROGRAM 2014/2015

Subjects of the 5-10. semesters

(obligatory subjects and criterion requirements)


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5th semester

OPG‐BFR ......... Biopharmacy .................................................................................................................. 3 OPG‐FG1 ......... Pharmacognosy 1 ........................................................................................................... 5 OPG‐GK1 ......... Pharmaceutical Chemistry 1 ........................................................................................ 10 OPG‐GT1 ......... Pharmaceutical Technology 1 ...................................................................................... 13 OPO‐IMM ....... Basic Immunology ........................................................................................................ 16 OPO‐MI1 ......... Microbiology 1 ............................................................................................................. 18 6th semester

OPG‐FG2 ......... Pharmacognosy 2 ......................................................................................................... 20 OPG‐GK2 ......... Pharmaceutical Chemistry 2 ........................................................................................ 26 OPG‐GT2 ......... Pharmaceutical Technology 2 ...................................................................................... 30 OPO‐KTN ......... Pathophysiology........................................................................................................... 33 OPO‐MA2 ........ Microbiology 2 ............................................................................................................. 37 OPR‐SG2 ......... Professional Practice 2 ................................................................................................. 39 7th semester

OPG‐GH1 ........ Pharmacodynamics 1 ................................................................................................... 41 OPG‐GI2 .......... Pharmaceutical Practice and Management 1 .............................................................. 44 OPG‐GK3 ......... Pharmaceutical Chemistry 3 ........................................................................................ 47 OPG‐GT3 ......... Pharmaceutical Technology 3 ...................................................................................... 50 OPO‐KE1 ......... Public Health 1 ............................................................................................................. 53 8th semester

OPG‐GH2 ........ Pharmacodynamics 2 ................................................................................................... 55 OPG‐GI3 .......... Pharmaceutical Practice and Management 2 .............................................................. 58 OPG‐GK4 ......... Pharmaceutical Chemistry 4 ........................................................................................ 61 OPG‐GT4 ......... Pharmaceutical Technology 4 ...................................................................................... 64 OPO‐KE2 ......... Public Health 2 ............................................................................................................. 67 OPO‐KL1 ......... Clinical Studies 1 .......................................................................................................... 72 9th semester

OPG‐FID .......... Herbal Medicine and Herbs in Nutrition ...................................................................... 74 OPG‐GS3 ......... Pharmacodynamics 3 ................................................................................................... 76 OPG‐KLF .......... Clinical Pharmacology .................................................................................................. 80 OPG‐PMG ....... Problemsolving Pharmacy ........................................................................................... 82 OPG‐TOX ......... Toxicology .................................................................................................................... 84 OPG‐UI4.......... Pharmaceutical Practice and Management 3 .............................................................. 86 OPO‐KL2 ......... Clinical Studies 2 .......................................................................................................... 89 OPO‐KLV ......... Clinical Laboratory Investigations ................................................................................ 92 OPS‐SG3 ......... Professional Practice Before State Examination 1 ....................................................... 94 10th semester

OPS‐SG4 ......... Professional Practice Before State Examination 2 ....................................................... 97


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OPG-BFR BIOPHARMACY Course director: DR. ATTILA DÉVAY, associate professor Department of Pharmacotechnology

2 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GT1 parallel + OPO-EL1 completed

Topic

Aim of this course is to introduce biopharmaceutical aspects of medicines taking into account dosage forms and routes of administration. Basic pharmacokinetic aspects (kinetics of active agents, compartmental analysis, routes of administration), some in vitro and in silico biopharmaceutical practices (using special biopharmaceutical softwares) are presented, bioequivalence studies of medicines are discussed. Students learn to design and develop pharmaceutical dosage forms according to biopharmaceutical requirements. Single and repeated dosing calculations are discussed according to pharmaceutical and physiological aspects.

Conditions for acceptance of the semester

Accepted work report Accepted written assessments

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations.

Reading material

Leon Shargel, A. B.C: .Applied Biopharmaceutics and Pharmacokinetics, Yu, Stamford Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel www.boomer.org www.gytsz.pte.hu www.sciencedirect.com

Lectures

1 Subject and general approach of biopharmacy Dr. Dévay Attila 2 Subject and general approach of biopharmacy Dr. Dévay Attila 3 Drug delivery systems and the input options Dr. Dévay Attila 4 Drug delivery systems and the input options Dr. Dévay Attila 5 Biopharmaceutical classification of substances and pharmaceutical preparations Dr. Dévay Attila 6 Biopharmaceutical classification of substances and pharmaceutical preparations Dr. Dévay Attila 7 Biopharmaceutical basics of drug qualification I. (drug liberation studies) Dr. Dévay Attila 8 Biopharmaceutical basics of drug qualification I. (drug liberation studies) Dr. Dévay Attila 9 Biopharmaceutical basics of drug qualification II. (dissolution and absorption models) Dr. Dévay Attila 10 Biopharmaceutical basics of drug qualification II. (dissolution and absorption models) Dr. Dévay Attila 11 Biopharmaceutical basics of drug qualification II. (IVIVC, original and generic preparations) Dr. Dévay Attila 12 Biopharmaceutical basics of drug qualification II. (IVIVC, original and generic preparations) Dr. Dévay Attila


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13 LADME system and its control options I. Dr. Dévay Attila 14 LADME system and its control options I. Dr. Dévay Attila 15 LADME system and its control options II. Dr. Dévay Attila 16 LADME system and its control options II. Dr. Dévay Attila 17 Written test Dr. Dévay Attila 18 Written test Dr. Dévay Attila 19 Biopharmaceutical basics of medicinal therapy I. (dermal and transdermal therapy) Dr. Dévay Attila 20 Biopharmaceutical basics of medicinal therapy I. (dermal and transdermal therapy) Dr. Dévay Attila 21 Biopharmaceutical basics of medicinal therapy II. (eye, nasal and ear preparations) Dr. Dévay Attila 22 Biopharmaceutical basics of medicinal therapy II. (eye, nasal and ear preparations) Dr. Dévay Attila 23 Biopharmaceutical basics of medicinal therapy III. (hormonal disorders) Dr. Dévay Attila 24 Biopharmaceutical basics of medicinal therapy III. (hormonal disorders) Dr. Dévay Attila 25 Biopharmaceutical basics of medicinal therapy IV. (chronotherapy, cardiovascular diseases, astma) Dr. Dévay Attila 26 Biopharmaceutical basics of medicinal therapy IV. (chronotherapy, cardiovascular diseases, astma) Dr. Dévay Attila 27 Biopharmaceutical basics of medicinal therapy V. (specific medicinal therapy) Dr. Dévay Attila 28 Biopharmaceutical basics of medicinal therapy V. (specific medicinal therapy) Dr. Dévay Attila

Practices

Seminars

Exam topics/questions

Students will receive the topic lists in the Institute and/or on the website. http://gytsz.pte.hu/?q=node/45 At the end of semesters, students take oral exam. The criterion of starting the oral exam is to pass a written “Minimum Test” (MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam. Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to unsatisfactory grade.

Participants

Dr. Dévay Attila (DEAHABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)


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OPG-FG1 PHARMACOGNOSY 1 Course director: DR. GYÖRGYI HORVÁTH, associate professor Department of Pharmacognosy

5 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 42 practices + 0 seminars = total of 70 hours Course headcount limitations (min-max.): min. 3 – max. 40 Prerequisites: OPO-GN2 completed

Topic

Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary. In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising problems, with special emphasis on processing information from literature, databases and the internet. Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their effective substances in general, preparing for the detailed knowledge and analysis of drugs in the spring semester


Satisfactory fulfilment of 1 written test based on the lectures. Fulfilment of all laboratory practices and 4 written tests based on the material of the practices. Absences and missed practices: participation is compulsory in the lab practices, 1 absence is allowed. Students are allowed to make up for the missed lab practice, but should agree with the lab instructor in advance.


Students are allowed to make up for the missed lab practice, but should agree with the lab instructor in advance.

Reading material

Compulsory literature: Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London-New York, 2000 Recommended literature: 1. Aronson J.K. (ed.): Meylers Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009 2. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition. Pharmaceutical Press, London-Chicago, 2002 3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Thieme, Exeter; Stuttgart; New

York, 2003 4. Poole C.F., Poole S.K.: Chromatography Today, Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991 5. WHO Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants, 2003

Lectures

1 Scope and subject of pharmacognosy. Dr. Farkas Ágnes 2 Scientific and Hungarian name of medicinal plants and drugs. Basic ethnobotany. Dr. Farkas Ágnes 3 Wild, protected and cultivated medicinal plants; medicinal plant breeding. Dr. Farkas Ágnes 4 Plant biotechnology, gene technology. Dr. Farkas Ágnes 5 Natural substances in pharmaceutical research. Dr. Horváth Györgyi 6 (Traditional) herbal medicines and dietary supplements. Dr. Horváth Györgyi 7 Tea drugs, primary processing of medicinal plants, plant extracts. Industrial medicinal plants. Dr. Farkas Ágnes 8 Qualification and phytochemical evaluation of medicinal plants. Dr. Farkas Ágnes


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9 Phytotherapy. Dr. Horváth Györgyi 10 Aromatherapy. Dr. Horváth Györgyi 11 Medicinal plants in the homeopathy. Dr. Horváth Györgyi 12 Drugs of fungus and animal origin. Dr. Horváth Györgyi 13 Photosynthesis and related methabolic pathways of effective substances. Dr. Molnár Péter 14 Role of nitrate- and sulphate-reduction in synthesis of effective substances. Dr. Molnár Péter 15 Synthesis, role of carbohydrates. Dr. Molnár Péter 16 Usage of carbohydrates. Dr. Molnár Péter 17 Synthesis, role and usage of lipids. Dr. Molnár Péter 18 Oils and waxes. Dr. Molnár Péter 19 Biosynthesis of terpenoids. Dr. Molnár Péter 20 Classification of terpenoids. Dr. Molnár Péter 21 Test. Dr. Horváth Györgyi 22 Test. Dr. Horváth Györgyi 23 Biosynthesis and role of amino acids and proteins. Dr. Molnár Péter 24 Biosynthesis and role of amino acids and proteins. Dr. Molnár Péter 25 General features of alkaloids. Dr. Molnár Péter 26 Classification of alkaloids. Dr. Molnár Péter 27 General features of phenoloids. Dr. Molnár Péter 28 Classification of phenoloids. Dr. Molnár Péter

Practices

1 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 2 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 3 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 4 Drugs with carbohydrate content. 5 Microscopic distinction of starch grains. 6 Cytochemical detection of starch and inulin. 7 Drugs containing inorganic and organic acids. 8 Drugs containing inorganic and organic acids. 9 Equiseti herba contamination with Equisetum palustre; analysis of the epidermis and other morpho-anatomical features. 10 Drugs with essential oil I. Lamiaceae. 11 Menthae piperitae folium. 12 Identification of Thymi vulgaris herba and Serpylli herba on the basis of glandular trichomes. 13 Drugs with essential oil II. Apiaceae. 14 Identification of Anisi vulgaris fructus, Carvi fructus, Foeniculi fructus, Coriandri fructus on the basis of histological

features, with the help of a drug atlas.


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15 Investigation of Lupuli flos. 16 Drugs with essential oil III. Asteraceae. 17 Investigation of Matricariae flos on the basis of Ph.Hg. VIII. 18 Distinction of Solidaginis herba and Solidaginis virgaureae herba based on micromorphological features. 19 Iridoids, diterpenes. 20 Triterpene saponins. 21 Histological comparison of Valerianae radix and Primulae radix. 22 Alkaloid-containing drugs I. Solanaceae. 23 Alkaloid-containing drugs I. Boraginaceae, Fabaceae, Papaveraceae. 24 Comparison of Belladonnae folium and Stramonii folium on the basis of cleared preparations. 25 Alkaloid-containing drugs II. Erythroxylaceae, Strychnaceae. 26 Alkaloid-containing drugs II. Rubiaceae. 27 Alkaloid-containing drugs II. Theaceae, Sterculiaceae, Apocynaceae. 28 Amino acids. 29 Peptides and proteins. 30 Identification of Phaseoli pericarpium by calcium-oxalate prisms. 31 Steroid-containing drugs. Investigation of Avenae herba. 32 Cardenolic glycosides. 33 Characterisation of Digitalis purpureae folium and Digitalis lanatae folium. 34 Phenoloids I. 35 Morphological and histological investigation of Hyperici herba. 36 Histological characterisation of Sennae folium, Sennae fructus acutifoliae and Sennae fructus angustifoliae. 37 Phenoloids II. 38 Characterisation of Cotini folium with histochemical reactions. 39 Cleared preparations of Juglandis folium. 40 Final test. 41 Final test. 42 Final test.

Seminars


1. Scope and subject of Pharmacognosy. Herbaria. 2. Scientific and Hungarian name of medicinal plants; binomial nomenclature; pharmaceutical name of drugs. 3. Ethno-pharmacobotany. 4. Natural compounds in pharmaceutical research. 5. Classification of herbal medicines. 6. Significance of photosynthesis, structure and chemical composition of the chloroplast. Light reactions of photosynthesis. 7. The nitrogen cycle, nitrogen fixation. 8. Nitrogen assimilation and sulphate reduction. Nitrogen- and sulphur-containing compounds in the pharmaceutical practice. 9. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic acid;

C4 and CAM type plants. 10. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins,

mannans, gummi arabicum, heteropolysaccharides: occurrence, medicinal usage. 11. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-α-phosphatidic acid, cholamine,

choline, serine, inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids.

12. Fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants. 13. Structure of arachidonic acid, ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Physical and

chemical parameters of fats and oils, occurrence in plants, medicinal usage. 14. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and

utilisation of waxes. 15. Prostaglandins: discovery, occurrence; chemical structure; biosynthetic precursor; biological effects, medicinal usage.

Polyacetylenes: synthesis, features, occurrence in plants, biological role. 16. Isoprenoid compounds I. Isoprene rule; modes of linking of isoprene units; natural and artificial polyisoprenes. 17. Isoprenoid compounds II. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA),

isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis. 18. Isoprenoid compounds III. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few examples;

occurrence, biological role, medicinal usage.


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19. Isoprenoid compounds IV. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role, application in medicine.

20. Isoprenoid compounds V. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins.

21. Proteinogenic amino acids I.: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine, glutamic acid, glutamine, histidine, leucine, isoleucine.

22. Proteinogenic amino acids II.: Structural formula and chemical name of lysine, methionine, phenylalanine, proline, hydroxyproline, serine, threonine, tryptophan, tyrosine, valine.

23. Important amino acid reactions I. a.) Basic reaction of transamination; b.) reductive desamination → formation of α-amino acids from α-keto acids (α-oxo acids); c.) formation of glutamine from glutamic acid.

24. Important amino acid reactions II.: a.) Decarboxylation; b.) oxidative desamination; c.) formation of asparagine from aspartic acid 25. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid

and carbamide. Allantoin, as the most well-known plant ureid. 26. Specific amino acids: chemical structure of γ-amino-butyric acid (GABA), β-amino-butyric acid (BABA) and β-alanine;

formation, significance in plants; chemical transformation. 27. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA).

Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

28. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromelain, ficin).

29. The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

30. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in their biosynthesis (ornitin, lysine, phenylalanine, tyrosine, tryptophan, histidine).

31. Alkaloids II. Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure).

32. Alkaloids III. Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

33. Alkaloids IV. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline).

34. Alkaloids V. Tropane alkaloids – Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortropane, tropane, tropine (3α-hydroxi-tropane) and tropic acid. Atropine, hyosciamine, scopolamine – structure, occurrence, biological effect, application in medicine and elsewhere.

35. Alkaloids VI. Structure of pseudotropine (3β-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect.

36. Alkaloids VII. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine. 37. Alkaloids VIII. Opium alkaloids: a.) Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid. 38. Alkaloids IX. Opium alkaloids: b.) Structure of morphine; biological effect, medical usage. Structure, biological effects and

medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. 39. Alkaloids X. LSD as the most important representative of ergot alkaloids: chemical structure, biological effects. Biological effects

and medical application of further important ergot alkaloids. 40. Alkaloids XI. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and

caffeine; occurrence, biological effects, usage. 41. Alkaloids XII. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence in plants; usage.

Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing quaternary nitrogen. The most important alkaloid-containing plant families.

42. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of β-phenyl-propionic acid, trans (E)-cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic acid and quinic acid).

43. Phenoloids II. The hydroquinone – para-benzoquinone transformation. Quinone derivatives and their significance in plant biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in plants, significance in biology and medicine.

44. Phenoloids III. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in plants.

45. Phenoloids IV. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

46. Phenoloids V. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance.


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47. Phenoloids VI. Flavonoids: Structure of α- and γ-pyran, α- and γ-pyrone and coumarin (α-pyrone condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and isolation of rutin (vitamin P).

48. Phenoloids VII. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants, biological effects and medical significance of anthocyanin colouring agents.

49. Phenoloids VIII. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-β-D-glucose. Occurrence, features and application of tannins.

50. Phenoloids IX. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.

51. Wild and protected medicinal plants, collection of medicinal plants. 52. Cultivation and breeding of medicinal plants; plant biotechnology and gene technology. 53. Tea drugs, primary processing, extracts. 54. Industrial medicinal plants. 55. Qualification and phytochemical evaluation of medicinal plants, requirements of the pharmacopoeia. 56. Phytotherapy; types, licensing and distribution of herbal medicines. 57. Aromatherapy 58. Homeopathy 59. Drugs of fungus and animal origin.

Participants

Dr. Farkas Ágnes (FAADAB.T.JPTE)


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OPG-GK1 PHARMACEUTICAL CHEMISTRY 1 Course director: DR. PÁL PERJÉSI, professor Department of Pharmaceutic Chemistry

6 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPA-BA1 completed + OPA-AN2 completed + OPA-SV1 completed

Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Pharmacopoeal analysis of selected inorganic substances. Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.


The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. The student has to write a notebook about the performed practice. 70 % of the performed quantitative determinations should be accepted. The students have to write two midterm tests. One re-take chance is allowed after both tests. Both semester tests results should be above 60 %. The students have to write nini-tests at least four times on the practice. The average of the results must exceed 50%.


Missed practices could be made up during the make-up opportunities announced by the department. During each make-up session only one missed practice can be executed.

Reading material

European Pharmacopoeia, EDQM Publication. Pharmaceutical Chemistry Practice I. , laboratory manual, University of Pécs. D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams & Wilkins,

Philadelphia, 2002 Lecture notes

Lectures

1 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances.

Dr. Perjési Pál 2 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of

substances. Dr. Perjési Pál 3 Identification and qualitative tests of the European Pharmacopoeia Dr. Perjési Pál 4 Identification and qualitative tests of the European Pharmacopoeia Dr. Perjési Pál 5 Physical and physicochemical methods of the European Pharmacopoeia Dr. Perjési Pál 6 Physical and physicochemical methods of the European Pharmacopoeia. Dr. Perjési Pál 7 Instrumental (IR, UV-VIS) and chromatographic (TLC, HPLC) methods of the European Pharmacopoeia Dr. Perjési Pál 8 Instrumental (IR, UV-VIS) and chromatographic (TLC, HPLC) methods of the European Pharmacopoeia Dr. Perjési Pál 9 Molecular mechanisms of drug action. Receptor theories Dr. Perjési Pál 10 Molecular mechanisms of drug action. Receptor theories Dr. Perjési Pál 11 Structural and physical chemistry of drug action. Structure-activity relationships. Dr. Perjési Pál 12 Structural and physical chemistry of drug action. Structure-activity relationships. Dr. Perjési Pál


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13 Drug metabolism. Phase 1 and Phase 2 transformations. Dr. Perjési Pál 14 Drug metabolism. Phase 1 and Phase 2 transformations. Dr. Perjési Pál 15 General anaesthetics Dr. Perjési Pál 16 General anaesthetics Dr. Perjési Pál 17 Sedative-Hypnotics Dr. Perjési Pál 18 Sedative-Hypnotics Dr. Perjési Pál 19 Narcotic analgesics and their antagonists I Dr. Huber Imre 20 Narcotic analgesics and their antagonists Dr. Huber Imre 21 Narcotic-analgesics and their antagonists II. Dr. Huber Imre 22 Narcotic-analgesics and their antagonists II. Dr. Huber Imre 23 Anticonvulsant drugs Dr. Huber Imre 24 Anticonvulsant drugs Dr. Huber Imre 25 Antipsychotics. Neuroleptics Dr. Perjési Pál 26 Antipsychotics. Neuroleptics Dr. Perjési Pál 27 Anxiolytics. Dr. Perjési Pál 28 Anxiolytics Dr. Perjési Pál

Practices

1 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations. The pharmacopoeial nomenclature of substances.

2 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations. The pharmacopoeial nomenclature of substances



5 Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum. Natrii chloridum, Chloraminum.




9 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 10 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 11 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 12 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 13 Oxygen and oxygen compounds. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum. 14 Oxygen and oxygen compounds. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum. 17 Sulfur and sulfur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum. 21 Nitrogen and nitrogen compounds. Ammonii chloridum. Natrii nitris. Kalii nitras, Bismuthi subnitras.


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25 Phosphorus and phosphorus compounds. Calcii hydrogenphosphas, Tricalcii phosphas, Natrii dihydrogenphosphas, Dinatrii phosphas, Arsenii trioxidum.

29 Carbon and carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas. 33 Silicon and compounds. Alkali metals, Alkaline earth metals. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxidum,

Magnesii trisilicas, Silica colloidalis hydrica. 37 Boron and aluminium compounds. Acidum boricum. Borax. Aluminii sulfas, Alumen. Aluminii oxidum hydricum 41 Transition metals I. Zinci oxidum, Zinci chloridum, Hydrargyrum chloratum amidatum (Ph.Hg.VII.), Barii sulfas 45 Transition metals II. Cupri sulfas, Ferrosi sulfas, Ferri chloridum, Kalii permanganas. 49 Complete pharmacopoeial analysis of one substance. 51 Complete pharmacopoeial analysis of one substance. 53 Complete pharmacopoeial analysis of one substance. 55 Complete pharmacopoeial analysis of one substance

Seminars


Written exam covering the topics of the lectures and the laboratory practices. The result of written exam must exceed 60%. According to the results of midterm tests, practical work and written exam final grade

will be determined. The result of the midterm tests may imply maximum 20%, the practical work maximum 5% and the result of the written exam maximum 75%. Participation on the exam on the first examdate is obligatory.

Participants

Kulcsár Győző (KUGDAA.T.JPTE)


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OPG-GT1 PHARMACEUTICAL TECHNOLOGY 1 Course director: DR. ATTILA DÉVAY, associate professor Department of Pharmacotechnology

7 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 70 practices + 0 seminars = total of 98 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-BFM parallel + OPR-LAT completed

Topic

Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients. Further studies include review of national and international pharmacopoeias. Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official formula. Practices of quality control of medicines are carried out as well. Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.


Accepted preparations made on practices Accepted work reports Accepted practical and theoretical assessments



Reading material

International Pharmacopoeias European Pharmacopoeia Hungarian National Formulary: Formulae Normales VII (FoNo VII.) James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel Mansoor A. Khan, Indra K. Reddy: Pharmaceutical and Clinical Calculations, CRC Press Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press www.gytsz.pte.hu www.sciencedirect.com Attila Dévay: The Theory and Practice of Pharmaceutical Technology, PTE-Pécs (electronic book)

Lectures

1 Definiation of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical technology, basic terms.

Dr. Dévay Attila 2 Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical

technology, basic terms. Dr. Dévay Attila 3 Dispensing and compounding at a pharmacy (measurement, treatment of substances) Dr. Dévay Attila 4 Dispensing and compounding at a pharmacy (measurement, treatment of substances) Dr. Dévay Attila 5 Basics of technological operations, biopharmaceutical aspects Dr. Dévay Attila 6 Basics of technological operations, biopharmaceutical aspects Dr. Dévay Attila 7 Technological importance of substances Dr. Dévay Attila


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8 Technological importance of substances Dr. Dévay Attila 9 Dissolution Dr. Dévay Attila 10 Dissolution Dr. Dévay Attila 11 Excipients used to increase of API’s solubility Dr. Dévay Attila 12 Excipients used to increase of API’s solubility Dr. Dévay Attila 13 Mixing and stirring Dr. Dévay Attila 14 Mixing and stirring Dr. Dévay Attila 15 Heat transferes Dr. Dévay Attila 16 Heat transferes Dr. Dévay Attila 17 Interaction and incompatibility of pharmaceutical preparations Dr. Dévay Attila 18 Interaction and incompatibility of pharmaceutical preparations Dr. Dévay Attila 19 Written test Dr. Dévay Attila 20 Written test Dr. Dévay Attila 21 Sterilization, depyrogenation, aseptic working, eye preparations Dr. Dévay Attila 22 Sterilization, depyrogenation, aseptic working, eye preparations Dr. Dévay Attila 23 Preparation and examination of injection (API, excipients, solvents, containers, examination) Dr. Dévay Attila 24 Preparation and examination of injection (API, excipients, solvents, containers, examination) Dr. Dévay Attila 25 Infusions and implants. The most important class of injectable and plantable preparations Dr. Dévay Attila 26 Infusions and implants. The most important class of injectable and plantable preparations Dr. Dévay Attila 27 Written test Dr. Dévay Attila 28 Written test Dr. Dévay Attila

Practices

General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions

Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations

Complex solutions, mixtures, drops

Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops

Preparation and examination of pure solutions, alcoholic solutions

Preparation and examination of syrups and colloid solutions

Preparation and examination of mucilages and colloid solutions

Assessment

Sterilizing, isotonisation, calculations, eye drops

Preparation of eye drops, ointments

Preparation and examination of injections

Preparation and examination of infusions


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Preparation and examination of emulsions and suspensions

End semester assessment

Seminars


The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

Participants

Dr. Diós Péter (DIPOAAO.PTE), Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


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OPO-IMM BASIC IMMUNOLOGY Course director: DR. PÉTER NÉMETH, professor Department of Immunology and Biotechnology

2 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min-max.): min. 5 – max. 200 Prerequisites: OPA-BA1 completed + OPO-MB2 completed

Topic

Introduction to the current immunobiology. Organisation of the human immune system: organs, tissues, cellular and molecular components. Regulation of immune functions: recognition, differentiation, effector functions, memory formation, suppression of the immune response, immunological tolerance. Main aspects of the physiological and pathological immune response. Basic immunopathological aspects of immune related diseases including allergy, autoimmune diseases, organ transplantation, immunity against tumours.


Participation on the lectures. No more absences as 3.


No.

Reading material

A.K. Abbas, A.H. Lichtman and A. Pillai: Cellular and Molecular Immunology, 6th edition, Elsevier More details see on www.immbio.hu

Lectures

1 Introduction, historical overview, main aspects and perspectives in the theoretical and practical immunology - immunobiology. Composition of the immune system: organs, tissues and cells.

Dr. Németh Péter 2 Molecular components of the immunological recognition: MHC, structure and genetics of the classes, their role in the

immune functions. Dr. Németh Péter 3 Antibodies and B cell receptors (molecular structure, functions, subclasses). Recognition of antigens by B cells and

immunoglobulins. Definition of the antigens, relations between the structure, feature, origin and the immunological recognition. Antigen-antibody reactions.

Dr. Németh Péter 4 T cell receptors, co-receptors and adhesion molecules. Dr. Németh Péter 5 Recognition of antigen by T-cells. Antigen presentation and MHC-restriction. Dr. Németh Péter 6 Lymphocyte maturation and expression of antigen receptor genes. Dr. Berki Timea 7 B cell development in the bone marrow. Maturation stages and environmental regulators. Dr. Balogh Péter 8 T cell development in the thymus. Maturation stages and environmental regulators. Dr. Pongrácz Judit 9 Innate immunity. Inflammation. Dr. Berki Timea 10 The early phase of T cell activation. The CD3 complex, and signal transduction, role of CD45 molecule, accessory

molecules. Immunological recognition of superantigens. Dr. Berki Timea 11 T cell activation II. Th1, Th2 differentiation, the nature and role of the cytokines Dr. Berki Timea 12 A brief overview of immune responses. Lymphocyte recirculation, role of the microenviroment. Dr. Berki Timea 13 The central phase of the immune response, cellular interactions, B cell activation, T-B cell cooperation, antibody production,

the role of adhesion molecules and cytokines. Dr. Berki Timea


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14 Regulation of immunoglobulin isotype expression, affinity maturation of B cells. Dr. Boldizsár Ferenc 15 Maintenance of the immunological memory and its role in immune response regulation. Comparisons of the primary and

secondary immune response. Dr. Balogh Péter 16 Suppression of immune response. Role of the antigen, antigen presenting cells, T and B lymphocytes and cytokines.

Immunoglobulin-immunoglobulin interactions, anti-idiotype network. Dr. Németh Péter 17 Complement system (molecular components, activation pathways). Dr. Berki Timea 18 Regulation of the effector functions. Immunoglobulin mediated immune reactions. Fc receptors. Dr. Németh Péter 19 Effector mechanisms of cell mediated immunity (CMI): Cytotoxicity. Dr. Engelmann Péter András 20 Systemic and local immunity. Mucosa and skin associated immune system. Dr. Németh Péter 21 Cellular and molecular mechanism of the immunological tolerance and the tolerance induction. Dr. Németh Péter 22 Hypersensitivities. Cellular and molecular mechanism of allergies. T cell mediated macrophage activation, delayed type

hypersensitivity (DTH). Dr. Németh Péter 23 Basic properties of the autoimmunity and the autoimmune reactions. Miss-regulation of the immune system: development of

organ-specific and systemic autoimmune diseases Dr. Németh Péter 24 Immundeficiency diseases: inherited and acquired. Dr. Balogh Péter 25 HIV infection and the pathomechanism of AIDS Dr. Kvell Krisztián 26 Immunological aspects of organ transplantation. Dr. Németh Péter 27 Immunity against tumors. Dr. Németh Péter 28 New opportunities in the medical biotechnology: individual diagnostics and immune-based therapies. Dr. Pongrácz Judit

Practices

Seminars


Multiple choice questions prepared according to the subject of the lectures. Details see on www.immbio.hu

Participants


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OPO-MI1 MICROBIOLOGY 1 Course director: DR. JÚLIA SZEKERES, professor Department of Medical Microbiology and Immunology

2 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min-max.): min. 1 – max. 100 Prerequisites: OPA-BA1 completed + OPO-MB2 completed

Topic

During the course the morphology, physiology of microbes, the techniques of disinfection and sterilization, the basics of antimicrobial therapy and the drugs used will be discussed. The host-parasite interactions, the factors playing roles in the pathogenesis of infections, the defense mechanisms of the host and the modes of prevention will be detailed. In this semester some lecture from systematic bacteriology are given. The objective is to provide a solid microbiological basis that will contribute to understanding detailed microbiology and further pharmacological studies.


Attendance of the lectures is up to the judgement of the student. The materials of the lectures will be a part of the examinations. The students will have to successfully complete a written colloquium in the exam period


-

Reading material

Denyer SP ,Hodges NA, Gorman SP: Hugo and Russell’s Pharmaceutical Microbiology, Blackwell Science Ltd 2004, ISBN: 0-632-06467-0

Lectures

1 Introduction the subject of microbiology, Taxonomy Dr. Emődy Levente 2 Morphology and structure of bacteria - essential cell components Dr. Tigyi Zoltán 3 Morphology and structure of bacteria - accessorial cell components Dr. Tigyi Zoltán 4 The physiology of bacteria, nutration types and growth of bacteria Dr. Kocsis Béla 5 Microbial genetics I. Dr. Tigyi Zoltán 6 Microbial genetics II. Dr. Tigyi Zoltán 7 Sterilization Dr. Bátai Istvánné 8 Disinfection Dr. Bátai Istvánné 9 Microbiological evaluation of drugs. Pyrogenicity testing Dr. Kocsis Béla 10 Antimicrobial drugs - general information. Pharmacodynamic and pharmacokinetic effects Dr. Kocsis Béla 11 Inhibitiors of bacterial cell wall synthesis Dr. Kocsis Béla 12 Inhibitors of bacterial protein synthesis Dr. Kocsis Béla 13 Antibiotics that inhibit nucleic acid synthesis. Drugs that inhibit other biochemical targets Dr. Kocsis Béla 14 Mechanisms of Resistance Dr. Kocsis Béla 15 Pathogenicity and virulence Dr. Emődy Levente


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16 Immunology of infectious diseases I Dr. Polgár Beáta 17 Immunology of infectious diseases II. Dr. Polgár Beáta 18 Immunology of infectious diseases III. Dr. Polgár Beáta 19 Immunotherapy I Dr. Polgár Beáta 20 Immunotherapy II. Dr. Polgár Beáta 21 Vaccinology I. Dr. Emődy Levente 22 Vaccinology II. Dr. Emődy Levente 23 Pyogenic bacteria I Dr. Bátai Istvánné 24 Pyogenic bacteria II. Dr. Bátai Istvánné 25 Pyogenic bacteria III. Dr. Bátai Istvánné 26 Enteric bacteria and gastrointestinal pathogens I. Dr. Tigyi Zoltán 27 Enteric bacteria and gastrointestinal pathogens II. Dr. Tigyi Zoltán 28 Enteric bacteria and gastrointestinal pathogens III. Dr. Tigyi Zoltán

Practices

Seminars


Written exam consists of multiple choice questions

Participants


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OPG-FG2 PHARMACOGNOSY 2 Course director: DR. GYÖRGYI HORVÁTH, associate professor Department of Pharmacognosy

5 credit ▪ final exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 42 practices + 0 seminars = total of 70 hours Course headcount limitations (min-max.): min. 3 – max. 40 Prerequisites: OPG-FG1 completed

Topic

Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary. In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising problems, with special emphasis on gathering information from literature, databases and the internet. Course objective and role in the curriculum: students should become familiar with the general, phytochemical and pharmacological features of drugs applied in pharmaco- and phythotherapy.


Criteria of acceptance of the semester: Satisfactory fulfilment of 1 written test based on the lectures. Fulfilment of all laboratory practices. Students have to write successful tests based on the material of the practices on every week. Absences and missed practices: participation is compulsory in the lab practices, 1 absence is allowed.


Students are allowed to make up for the missed lab practice, but should agree with the lab instructor in advance.

Reading material

Compulsory literature: Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London-New York, 2000 Recommended literature: 1. Aronson J.K. (ed.): Meyler’s Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009 2. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002 3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition, Thieme, United Kingdom-

Stuttgart-USA, 2003 4. Poole C.F., Poole S.K.: Chromatography Today, Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991 5. WHO Guidelines on good agricultural and collection practices (GACP) for medicinal plants, 2003 6. Györgyi Horváth: Drug Reactions in the Pharmacognosy, teaching supplement for the pharmacognosy practices, University

of Pécs, Medical School, 2011.

Lectures

1 Drugs containing monoterpenes, essential oils Dr. Horváth Györgyi 2 Drugs containing monoterpenes, essential oils Dr. Horváth Györgyi 3 Essential oils Dr. Horváth Györgyi 4 Essential oils Dr. Horváth Györgyi 5 Iridoid-containing drugs Dr. Horváth Györgyi 6 Iridoid-containing drugs Dr. Horváth Györgyi 7 Drugs containing sesquiterpenes Dr. Molnár Péter 8 Drugs containing diterpenes and terpenophenols Dr. Molnár Péter


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9 Drugs containing triterpenes Dr. Molnár Péter 10 Drugs containing steroids, saponins and cardenolides Dr. Molnár Péter 11 Drugs containing alkaloids of ornithine, lysine and phenylalanine origin Dr. Molnár Péter 12 Drugs containing alkaloids of ornithine, lysine and phenylalanine origin Dr. Molnár Péter 13 Drugs containing alkaloids of tryptophan and histidine origin Dr. Molnár Péter 14 Drugs containing alkaloids of tryptophan and histidine origin Dr. Molnár Péter 15 Purine-containing drugs Dr. Molnár Péter 16 Drugs containing specific amino acid derivatives Dr. Molnár Péter 17 Drugs containing cyanogenic glycosides Dr. Horváth Györgyi 18 Drugs containing glucosinolates Dr. Horváth Györgyi 19 Drugs containing phenylpropanoid derivatives Dr. Horváth Györgyi 20 Drugs containing phloroglucin derivatives Dr. Horváth Györgyi 21 Drugs containing coumarin derivatives Dr. Horváth Györgyi 22 Drugs containing furanocoumarin derivatives Dr. Horváth Györgyi 23 Drugs containing anthraquinone derivatives Dr. Horváth Györgyi 24 Drugs containing naphthoquinone derivatives Dr. Horváth Györgyi 25 Drugs containing flavonoids Dr. Horváth Györgyi 26 Drugs containing flavonoids Dr. Horváth Györgyi 27 Drugs containing polyphenols Dr. Horváth Györgyi 28 Drugs containing tannins. Dr. Horváth Györgyi

Practices

1 Accident and fire-protection instruction. 2 General methods of analysis for drugs of plant origin. 3 Nitrate detection in drinking water suitable for tea extraction and in nettle tea. 4 Analysis of carbohydrate containing drugs. 5 Analysis of carbohydrate containing drugs. 6 Honey adulteration test. 7 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 8 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 9 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 10 Analysis of essential oil containing drugs. 11 Essential oil extraction for quantitative measurements. 12 Detection of essential oil components. 13 Extraction and detection of nicotine and caffeine. 14 Extraction and detection of nicotine and caffeine. 15 Soxhlet-extraction (demonstration).


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16 Extraction and detection of atropine and scopolamine. 17 Extraction and detection of atropine and scopolamine. 18 Written test: Phytochemistry I. 19 Extraction and detection of alliin. 20 Extraction and detection of alliin. 21 Extraction and detection of alliin. 22 Quantitative determination of total flavonoid content. 23 Quantitative determination of total flavonoid content. 24 Quantitative determination of total flavonoid content. 25 Detection of phenoloids. 26 Detection of phenoloids. 27 Detection of phenoloids. 28 Quantitative determination of total tannin content. 29 Quantitative determination of total tannin content. 30 Quantitative determination of total tannin content. 31 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 32 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 33 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 34 Analysis of drugs containing saponins. 35 Analysis of drugs containing saponins. 36 Written test: phytochemistry II. 37 Separation of carotenoids with column chromatography (demonstration). 38 Separation of carotenoids with column chromatography (demonstration). 39 Separation of carotenoids with column chromatography (demonstration). 40 Drug identification practice: Histology and phytochemistry. 41 Drug identification practice: Histology and phytochemistry. 42 Drug identification practice: Histology and phytochemistry.

Seminars


Final exam: Students are required to demonstrate their theoretical and practical knowledge based on the material of both semesters. Students can sit

for the final exam only after the successfully accomplished first semester and the satisfactory fulfilment of all practices in the second semester.

In the frame of the entrance exam students must identify and characterise 5 drugs. Following the successful entrance exam students pick 2 exam questions.

The grade of the final exam is based on the written tests of the second semester, drug identification and the result of the oral exam. Drugs to be identified at the entrance exam (according to Ph.Hg. VIII.): Absinthii herba – Agar – Agni casti fructus - Agrimoniae herba – Allii ursini herba – Aloë capensis – Althaeae folium – Althaeae radix – Angelicae radix – Anisi fructus – Anisi stellati fructus – Aurantii amari epicarpium et mesocarpium – Avenae herba – Betulae folium – Calami rhizoma – Calendulae flos – Cannabis sativae fructus – Capsici fructus – Cardamomi fructus - Cardui benedicti herba – Carvi fructus – Caryophylli flos – Centaurii herba in toto – Chamomillae romanae flos – Chelidonii herba – Cimicifugae radix - Cinchonae cortex - Cinnamomi cortex – Coriandri fructus – Cotini folium – Crataegi folium cum flore – Crataegi fructus – Croci stigma – Cucurbitae semen – Curcumae xanthorrhizae rhizoma – Ephedrae herba – Epilobii herba – Equiseti herba – Eucalypti folium – Farfarae folium – Filipendulae ulmariae herba – Foeniculi dulcis fructus – Frangulae cortex – Gentianae radix – Ginkgo folium – Ginseng radix – Graminis rhizoma – Hederae helicis folium – Hibisci sabdariffae flos – Hippocastani semen – Hyperici herba – Ipecacuanhae radix – Ipecacuanhae radicis pulvis - Juglandis folium – Juniperi pseudo-fructus – Lavandulae flos – Leonuri cardiacae herba – Lichen islandicus – Lini semen – Liquiritiae radix – Lythri herba - Lupuli flos – Malvae sylvestris flos – Marrubii herba – Matricariae flos – Meliloti herba - Melissae folium – Menthae piperitae folium – Menyanthidis trifoliatae folium – Millefolii herba – Ononidis radix – Origani herba – Papaveris rhoeados flos – Papaveris caput – Phaseoli legumen – Plantaginis lanceolatae folium – Plantaginis ovatae seminis tegumentum - Podophylli rhizoma – Polygoni avicularis herba – Populi gemma – Primulae radix – Quercus cortex – Ratanhiae radix - Rhamni purschianae cortex – Ricini semen - Robiniae pseudoacaciae flos – Rosae pseudo-fructus c. seminibus/s. seminibus – Rosmarini folium – Rubi fruticosi folium – Salicis cortex – Salviae officinalis folium – Sambuci flos – Sambuci fructus – Saponariae albae radix – Secale cornutum – Sennae folium – Sennae acutifoliae / angustifoliae fructus – Silybi mariani fructus – Sinapis albae semen – Solani amylum – Solidaginis herba – Sophorae flos – Stramonii folium – Symphyti radix – Tanaceti parthenii herba – Thymi herba – Tiliae flos – Tragacantha –Urticae folium – Uvae ursi folium – Valerianae radix – Verbasci flos – Visci stipes – Zingiberis rhizoma


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Exam questions: I. General part. Phytochemistry. 1. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic acid;

C4 and CAM type plants. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins, mannans, gummi arabicum, heteropolysaccharides: occurrence, medicinal usage.

2. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-α-phosphatidic acid, cholamine, choline, serine, inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids. Physical and chemical characteristics of fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants.

3. Arachidonic acid, prostaglandins: discovery, occurrence, chemical structure, biological effects, medical usage. Structure of ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and utilisation of waxes. Polyacetylenes: synthesis, features, occurrence in plants, biological role.

4. Isoprenoid compounds. Isoprene rule; modes of linking of isoprene units; occurrence, biological role, medicinal application; natural and artificial polyisoprenes. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA), isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few examples; occurrence, biological role, medicinal usage.

5. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role, application in medicine. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins.

6. Proteinogenic amino acids: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine, glutamic acid, glutamine, histidine, leucine, isoleucine, lysine, methionine, phenylalanine, proline, hydroxyproline, serine, threonine, tryptophan, tyrosine, valine.

7. Important amino acid reactions a.) Basic reaction of transamination; b.) reductive desamination; formation of alpha-amino acids from alpha-keto acids (alpha-oxo acids); c.) formation of glutamine from glutamic acid; d.) decarboxylation; e.) oxidative desamination; f.) formation of asparagine from aspartic acid. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid and carbamide. Allantoin, as the most well-known plant ureid.

8. Specific amino acids: chemical structure of gamma-amino-butyric acid (GABA), beta-amino-butyric acid (BABA) and beta-alanine; formation, significance in plants; chemical transformation. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA). Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

9. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromealin, ficin). The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

10. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in their biosynthesis (ornithine, lysine, phenylalanine, tyrosine, tryptophan, histidine). Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure). Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

11. Alkaloids II. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline). Tropane alkaloids – Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortropane, tropane, tropine (3α-hydroxi-tropane) and tropic acid. Atropine, hyosciamine, scopolamine – structure, occurrence, biological effect, application in medicine and elsewhere.

12. Alkaloids III. Structure of pseudotropine (3-beta-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine.

13. Alkaloids IV. Opium alkaloids: Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid. Structure of morphine; biological effect, medical usage. Structure, biological effects and medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. LSD as the most important representative of ergot alkaloids: chemical structure, biological effects. Biological effects and medical application of further important ergot alkaloids.

14. Alkaloids V. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and caffeine; occurrence, biological effects, usage. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence in plants; usage. Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing quaternary nitrogen. The most important alkaloid-containing plant families.

15. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of beta-phenyl-propionic acid, trans (E)-cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic acid and quinic acid). The hydroquinone para-benzoquinone transformation. Quinone derivatives and their significance in plant biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in plants, significance in biology and medicine.


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16. Phenoloids II. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in plants. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

17. Phenoloids III. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance. Flavonoids: Structure of alpha- and gamma-pyran, alpha- and gamma-pyrone and coumarin alpha-pyrone condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and isolation of rutin (vitamin P).

18. Phenoloids IV. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants, biological effects and medical significance of anthocyanin colouring agents. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-beta-D-glucose. Occurrence, features and application of tannins.

19. Phenoloids V. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.

II. Drugs 1. Drugs containing carbohydrates: Mel depuratum, Manna, Pulpa tamarindorum, Rosae pseudo-fructus, Solani amylum, Tritici

amylum, Maydis amylum, Oryzae amylum, Lana gossypii, Agar, Acaciae gummi (Gummi arabicum), Tragacantha, Helianthus tuberosus

2. Drugs containing mucilage-like carbohydrates: Lichen islandicus, Althaeae radix, Althaeae folium, Malvae sylvestris folium et flos, Salep tuber, Graminis rhizoma, Cyamopsidis tetragonolobae semen, Farfarae folium et flos, Lini semen, Cydoniae semen

3. Carbohydrate-containing drugs stimulating non-specific immune reactions: Echinaceae radix, Eupatorii herba, Arnicae flos, Visci stipes, Calendulae flos, Tiliae flos, Foenugraeci semen

4. Drugs containing polar, non-polar fats, oils and waxes of plant origin: Lecitin, Ricini oleum virginale, Helianthi annui oleum raffinatum, Lini oleum virginale, Soiae oleum raffinatum, Carthami oleum raffinatum, Brassicae napae oleum, Arachidis oleum raffinatum, Butyrum cacao, Jojoba, Cera carnauba

5. Drugs containing essential oil: Menthae piperitae folium, Lavandulae flos, Basilici herba, Orthosiphonis folium, Melissae folium, Thymi herba, Serpylli herba, Origani herba, Majoranae herba, Saturejae herba, Hyssopi herba, Salviae officinalis folium, Rosmarini folium, Rosae petalum, Juniperi pseudo-fructus, Camphor, Eucalypti folium, Carvi fructus, Coriandri fructus, Aurantii amari epicarpium et mesocarpium, Cardamomi fructus, Myrrha

6. Essential oils: Anisi aetheroleum, Aurantii amari floris aetheroleum, Aurantii dulcis aetheroleum, Carvi aetheroleum, Caryophylli floris aetheroleum, Cinnamomi zeylanici corticis aetheroleum, Citronellae aetheroleum, Coriandri aetheroleum, Eucalypti aetheroleum, Foeniculi amari fructus aetheroleum, Juniperi aetheroleum, Lavandulae aetheroleum, Limonis aetheroleum, Matricariae aetheroleum, Melaleucae aetheroleum, Menthae piperitae aetheroleum, Myristicae fragrantis aetheroleum, Pini silvestris aetheroleum, Rosmarini aetheroleum, Salviae sclareae aetheroleum, Thymi aetheroleum

7. Drugs containing iridoids: Plantaginis lanceolatae folium, Euphrasiae herba, Lamii albi herba, Harpagophyti radix, Agni casti fructus, Verbenae herba, Valerianae radix, Gentianae radix, Menyanthidis trifoliatae folium, Centaurii herba, Oleae folium

8. Drugs containing sesquiterpenes: Chamomillae romanae flos, Millefolii herba, Matricariae flos, Tanaceti parthenii herba, Cynarae folium, Absinthii herba, Cardui benedicti herba, Inulae radix, Arnicae flos, Bardanae radix, Cichorii radix et herba, Taraxaci radix et herba, Pyrethri flos

9. Drugs containing diterpenes and triterpenes: Colophonium, Marrubii herba, Ballotae nigrae herba, Taxi baccatae folium, Liquiritiae radix, Quillajae cortex, Verbasci flos, Saponariae albae radix, Primulae radix, Polygalae radix, Pruni africanae cortex, Hederae helicis folium, Betulae folium, Veronicae herba, Ononidis radix, Solidaginis virgaureae herba, Solidagnis herba, Centellae asiaticae herba, Hippocastani semen, Calendulae flos, Avenae herba, Cimicifugae rhizoma

10. Drugs containing adaptogenic triterpenes, sterols and saponins: Ginseng radix, Eleuterococci radix, Urticae radix et folium, Epilobii herba, Cucurbitae semen, Dioscoreae tuber, Trigonellae foenigraeci semen, Rusci rhizoma, Sabalis serratulae fructus

11. Drugs containing bufadienolides, cardenolides: Digitalis purpureae folium, Digitalis lanatae folium, Strophanthi semen, Scillae bulbus, Adonidis herba, Convallariae herba, Nerii folium, Hellebori radix, Leonuri cardiacae herba

12. Drugs containing specific amino acids, amino acid derivatives and amines: Allii sativi bulbus, Allii ursini folium, Allii cepae bulbus, Bursae pastoris herba, Galegae herba, Phaseoli legumen

13. Drugs containing alkaloids of ornithine and lysine origin: Belladonnae radix et folium, Hyoscyami folium, Stramonii folium, Cocae folium, Nicotianae folium, Pulmonariae herba, Symphyti radix, Lobeliae herba, Laburni semen, Sarothamni scoparii herba

14. Drugs containing alkaloids of phenylalanine origin: Capsici fructus, Ephedrae herba, Papaveris fructus sine seminibus, Opium crudum, Chelidonii herba et radix, Fumariae herba, Berberidis radicis cortex, Colchici tuber, Ipecacuanhae radix, Boldi folium, Tubokurarin-curare

15. Drugs containing alkaloids of tryptophan origin: Secale cornutum, Rauwolfiae radix, Vincae minoris herba, Catharanthi herba, Strychni semen, Curare, Cinchonae cortex, Uncariae tomentosae radix, Passiflorae herba, Physostigmae semen

16. Drugs containing purine structure effective substances: Coffeae semen, Theae folium, Cacao semen, Guarana, Mate folium, Colae semen


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17. Drugs containing terpenoid alkaloids: Aconiti tuber, Veratri rhizoma et radix, Solani herba 18. Drugs containing cyanogenic glycosides, isothiocyanate derivatives: Amygdalae amarae semen, Lini semen, Sinapis nigrae semen 19. Drugs containing phloroglucin and terpenophenol derivatives: Filicis maris rhizoma, Lupuli flos, Cannabis herba 20. Drugs containing phenol- and phenylpropionic acid derivatives: Cinnamomi cortex, Caryophylli flos, Zingiberis rhizoma, Anisi

fructus, Anisi stellati fructus, Foeniculi dulcis fructus, Calami rhizoma, Petroselini fructus, Balsamum peruvianum, Filipendulae ulmariae herba, Salicis cortex, Curcumae xanthorrhizae rhizoma

21. Drugs containing quinone- and anthraquinone derivatives, naphthoquinone- and dianthrone derivatives: Uvae ursi folium, Vitis-idaeae folium, Frangulae cortex, Rhamni purshianae cortex, Rhei radix, Aloe, Juglandis folium, Alkannae radix, Droserae herba, Lawsoniae folium, Sennae folium et fructus, Hyperici herba

22. Drugs containing coumarins, furocoumarins, lignans and flavanolignans: Meliloti herba, Angelicae radix, Ammeos visnagae fructus, Ammi majoris fructus, Levistici radix, Apii fructus, Podophylli rhizoma, Silybi mariani fructus

23. Drugs containing flavonoids: Tiliae flos, Sambuci flos, Equiseti herba, Crataegi folium cum flore, Crataegi fructus, Violae herba cum floris, Ginkgo folium, Stoechados flos, Populi gemma, Propolis, Ribis nigri folium

24. Drugs containing tannins, polyphenols: Galla, Quercus cortex, Ratanhiae radix, Hamamelidis folium, Tormentillae rhizoma, Anserinae herba, Gei radix et rhizoma, Agrimoniae herba, Fragariae folium, Alchemillae herba, Polygoni avicularis herba, Rubi idaei folium, Rubi fruticosi folium, Coryli folium, Myrtilli folium et fructus, Lythri herba

Participants

Dr. Horváth Györgyi (HOGAAA.T.JPTE), Dr. Molnár Péter (MOPGAAO.PTE)


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6 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GK1 completed + OPG-GT1 completed

Topic

Introduction to molecular aspects and structure-activity relationship of selected groups of active pharmaceutical ingredients. Pharmacopoeal analysis of selected inorganic substances.


The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. The student has to write a notebook about the performed practice. 70 % of the performed quantitative determinations should be accepted. The students have to write two midterm tests. One re-take chance is allowed after both tests. Both midterm tests results should be above 60 %. The students have to write mini-tests at least four times on the practice. The average of the results must exceed 50%.



Reading material

European Pharmacopoeia, EDQM Publication. Pharmaceutical Chemistry Practice I, laboratory manual, University of Pécs. D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams & Wilkins,

Philadelphia, 2002 Lecture notes

Lectures

1 Antidepressants. Dr. Perjési Pál 2 Antidepressants. Dr. Perjési Pál 3 Antiparkinson agents Dr. Huber Imre 4 Antiparkinson agents Dr. Huber Imre 5 Nootropics. Analeptics Dr. Huber Imre 6 Nootropics. Analeptics Dr. Huber Imre 7 Non-opioid analgesics and antipyretics. Dr. Perjési Pál 8 Non-opioid analgesics and antipyretics. Dr. Perjési Pál 9 Non-steroid anti-inflammatory agents I Dr. Perjési Pál 10 Non-steroid anti-inflammatory agents I Dr. Perjési Pál 11 Non-steroid anti-inflammatory agents II Dr. Perjési Pál 12 Non-steroid anti-inflammatory agents II Dr. Perjési Pál


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13 Antiallergic antihistamines. Drugs for rheumatic gout Dr. Perjési Pál 14 Antiallergic antihistamines. Drugs for rheumatic gout Dr. Perjési Pál 15 Parasympathomimetics Dr. Perjési Pál 16 Parasympathomimetics Dr. Perjési Pál 17 Parasympatholytics Dr. Perjési Pál 18 Parasympatholytics Dr. Perjési Pál 19 Sympathomimetics Dr. Perjési Pál 20 Sympathomimetics Dr. Perjési Pál 21 Sympatholytics Dr. Perjési Pál 22 Sympatholytics Dr. Perjési Pál 23 Local anesthetic agents Dr. Huber Imre 24 Local anesthetic agents Dr. Huber Imre 25 Spasmolytics. Muscle relactants. Antitussiv agents. Mucolytics. Dr. Huber Imre 26 Spasmolytics. Muscle relactants. Antitussiv agents. Mucolytics. Dr. Huber Imre 27 Drugs of gastrointestinal disorders Dr. Huber Imre 28 Drugs of gastrointestinal disorders Dr. Huber Imre

Practices

1 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum, Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isopropylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum (Ph.Hg.VII.)




5 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 6 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 7 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 8 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 9 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 10 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 11 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 12 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 13 Aldehydes and ketones. Carbohydrates. Formaldehydi solutio (35 per centum), Fructosum, Glucosum anhydricum,

Lactosum, Saccharum. 14 Aldehydes and ketones. Carbohydrates. Formaldehydi solutio (35 per centum), Fructosum, Glucosum anhydricum,



Lactosum, Saccharum.


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17 Carboxylic acids. Amino acids. Acidum benzoicum. Acidum lacticum, Acidum tartaricum, Acidum sorbicum, Acidum citricum, Natrii citras, Acidum asparticum.




21 Sedative-hypnotics I. Carbonic acid derivatives. Chloroformium (Ph.Hg.VII.) Chlorali hydras, Chlorobutanolum, Ureum, Urethanum (Ph.Hg.VII.).




25 Sedative-hypnotics II. Barbituric acid derivatives. Tautomerism. Barbitalum, Barbitalum natricum, Phenobarbitalum, Phenytoinum.




29 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 30 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 31 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 32 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 33 Non-steroid analgesics and antipyretics. . Acidum salicylicum, Acidum acetylsalicylicum, Natrii salicylas, Salicylamidum

(Ph. Hg. VII.), Paracetamolum, Phenacetinum (Ph. Hg. VII.). 34 Non-steroid analgesics and antipyretics. . Acidum salicylicum, Acidum acetylsalicylicum, Natrii salicylas, Salicylamidum



(Ph. Hg. VII.), Paracetamolum, Phenacetinum (Ph. Hg. VII.). 37 Non-steroid anti-inflammatory agents. Phenazonum, Aminophenazonum (Ph.Hg.VII.), Metamizolum natricum,

Diclofenacum natricum, Indometacinum. 38 Non-steroid anti-inflammatory agents. Phenazonum, Aminophenazonum (Ph.Hg.VII.), Metamizolum natricum,



Diclofenacum natricum, Indometacinum. 41 Autonomic nervous system drugs. Pilocarpini hydrochloridum, Atropini sulfas, Homatropini methylbromidum, Homatropini

hydrobromidum, Naphazolini hydrochloridum. 42 Autonomic nervous system drugs. Pilocarpini hydrochloridum, Atropini sulfas, Homatropini methylbromidum, Homatropini



hydrobromidum, Naphazolini hydrochloridum. 45 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 46 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 47 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 48 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 49 Complete pharmacopoeial analysis of one substance 50 Complete pharmacopoeial analysis of one substance 51 Complete pharmacopoeial analysis of one substance 52 Complete pharmacopoeial analysis of one substance


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53 The correlation between structure, the configuration and the conformation of molecules 54 The correlation between structure, the configuration and the conformation of molecules 55 The correlation between structure, the configuration and the conformation of molecules 56 The correlation between structure, the configuration and the conformation of molecules

Seminars


Oral exam covering the topics of Pharmaceutical Chemistry II and selected topics of Pharmaceutical Chemistry I. Before the exam each student should have a Minimum Requirement Test of which result should be at least 80%.

Further details: www.gytsz.pte.hu

Participants

Kulcsár Győző (KUGDAA.T.JPTE)


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7 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 70 practices + 0 seminars = total of 98 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPA-FI2 completed + OPG-GK1 completed + OPG-GT1 completed Prerequisites: OPG-GT1 completed

Topic

This semester include practice with ocular dosage forms. Special formulations of ocular dosage forms are eye ointments and oily and viscous eye drops. Other formulations such as emulsion, suspension and semisolid dosage forms (ointment, cream, gel, paste) are also discussed.


Accepted preparations made on practices Accepted work reports Accepted practical and theoretical assessment



Reading material


Lectures

1 Dispers systems (emulsions, amulgents) Dr. Dévay Attila 2 Dispers systems (emulsions, amulgents) Dr. Dévay Attila 3 Dispers systems (suspension) Dr. Dévay Attila 4 Dispers systems (suspension) Dr. Dévay Attila 5 Importance and determination of particle size Dr. Dévay Attila 6 Importance and determination of particle size Dr. Dévay Attila 7 Filtration, sedimentation, centrifugation Dr. Dévay Attila 8 Filtration, sedimentation, centrifugation Dr. Dévay Attila 9 Extraction and pressing Dr. Dévay Attila 10 Extraction and pressing Dr. Dévay Attila


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11 Written test Dr. Dévay Attila 12 Written test Dr. Dévay Attila 13 Reologic properties of ointments, Excipients for preparation of ointments Dr. Dévay Attila 14 Reologic properties of ointments, Excipients for preparation of ointments Dr. Dévay Attila 15 Structural properties of ointments and their preparation Dr. Dévay Attila 16 Structural properties of ointments and their preparation Dr. Dévay Attila 17 Examinations of ointments Dr. Dévay Attila 18 Examinations of ointments Dr. Dévay Attila 19 Excipients of liquid and semi-solid dosage forms Dr. Dévay Attila 20 Excipients of liquid and semi-solid dosage forms Dr. Dévay Attila 21 Suppositories, pessaries, medicated sticks Dr. Dévay Attila 22 Suppositories, pessaries, medicated sticks Dr. Dévay Attila 23 Written test Dr. Dévay Attila 24 Written test Dr. Dévay Attila 25 Technology of medications for veterinary use Dr. Dévay Attila 26 Technology of medications for veterinary use Dr. Dévay Attila 27 Tools for medical aids and surgical dressing Dr. Dévay Attila 28 Tools for medical aids and surgical dressing Dr. Dévay Attila

Practices

General instructions, rules and regulations on practices, introduction to emulsions, suspensions and oinments

Preparation and examination of suspensions

Preparation and examination of magistral emulsions and ointments I.

Preparation and examination of magistral emulsions and ointments II.

Magistral ointments/creams/pastes/gels

Preparation and examination of ointments and creams

Preparation and examination of gels and pastes

Assessment

Preparation and examination of suppositories, calibration

Preparation and examination of rectal suppositories

Preparation and examination of vaginal suppositories

Examination of packaging materials

Visiting pharmaceutical company


Seminars


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The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute. At the end of semester, students take written exam. The date of „A” chance exam is in determined date for students finishing the course. Chance „B” and „C” are oral exams, which is preceded by the „Minimum Test” (MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam. Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to unsatisfactory grade.

Participants

Dr. Diós Péter (DIPOAAO.PTE), Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


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OPO-KTN PATHOPHYSIOLOGY Course director: DR. JÁNOS GARAI, associate professor Department of Pathophysiology and Gerontology

5 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 42 lectures + 0 practices + 28 seminars = total of 70 hours Course headcount limitations (min-max.): min. 5 – Prerequisites: OPO-EN2 completed

Topic

The main goal of the curriculum is to introduce the students on a preclinical level to the basic dysfunctions of individual organs and organ systems, to make them acquainted with the inherited and acquired etiological factors, with the pathogenesis and pathomechanism of diseases, and with the possible compensatory or adaptive mechanisms and system interactions. The topics covered (among others) include pathophysiologic aspects of circulation, respiration, energy homeostasis, thermoregulation, renal-, endocrine-, gastrointestinal functions, acid-base and salt-water balance with special focus on pathomechanisms fundamentally linked to target sites of the most prescribed drugs as well as on iatrogenic risks in connection with the main- and side-effects of drugs. Since the mean age of the patients is growing higher in most parts of the world, the gerontological aspects of functional changes are embedded into the curriculum throughout the course. The course is important to understand the clinical symptoms, as well as the possible pharmacological or other interventions and steps of prevention.


Max. 3 misses from seminars (15%/28) can be tolerated. On the interim written test (ZH) a 50% achievement is the precondition for entering the oral exam. The person(s) not achieving 50% or not participating at the interim test must answer 10 Minimum Questions within 10 minutes in writing just prior to the oral exam. 80% achievement is the precondition for entering the exam. Passing the minimum questions in this case, however, is only a prerequisite, but is not sufficient on its own for a successful exam.


Writing an essay from the topic of the missed seminar

Reading material

Basically the knowledge of topics dealt with at the lectures and seminars is the requirement at the exams. - Prof. Miklós Székely (ed.): Basic Principles of Pathophysiology, department notes for medical students, 2006, - S. Silbernagl, F. Lang: Color Atlas of Pathophysiology, Thieme Stuttgart; New York, 2000 (useful for final preparation) - Martin M. Zdanowicz: Essentials of Pathophysiology for Pharmacy, CRC Press 2002 Handouts on http://www.pote.hu/index.php?page=egyseg&egy_id=150&menu=okt_anyag&nyelv=eng

Lectures

1 Inflammation & injury I Dr. Garai János 2 Inflammation & injury II Dr. Garai János 3 Pathophysiology of coronary circulation I Dr. Garai János 4 Pathophysiology of coronary circulation II Dr. Garai János 5 Disorders of cerebral circulation Dr. Garai János 6 Disorders of cerebral circulation Dr. Garai János 7 Abnormalities of blood pressure, hypertension Dr. Garai János 8 Consequences of hypertension, and prevention thereof Dr. Garai János 9 Circulatory failure, definition, forms Dr. Garai János 10 Chronic heart failure Dr. Garai János


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11 Disorders of the control of breathing, sleep apnea sy. Dr. Garai János 12 Abnormalities of gas exchange Dr. Garai János 13 Dyspnea, respiratory failure, tissue hypoxia Dr. Garai János 14 Role of buffers in acid-base balance Dr. Garai János 15 Role of breathing and the kidney in pH-homeostasis Dr. Garai János 16 Anomalies in glomerular és tubular functions Dr. Garai János 17 Acute and chronic renal failure, uraemia Dr. Garai János 18 Disorders of thermoregulation: introduction / fever Dr. Garai János 19 Disorders of thermoregulation: fever / hypo- & hyperthermia Dr. Garai János 20 Energetic balance, nutritional status Dr. Garai János 21 Obesity, metabolic syndrome Dr. Garai János 22 Diabetes mellitus (DM) syndrome: definition, classification Dr. Garai János 23 Pathogenesis of DM syndromes Dr. Garai János 24 Acute complications of DM Dr. Garai János 25 Chronic complications of DM Dr. Garai János 26 Pancreatic disorders. Dr. Garai János 27 Pathophysiology of liver function, liver damage, icterus Dr. Garai János 28 Portal hypertension, ascites, hepatic coma Dr. Garai János 29..42

Practices

Seminars

1 The contextual position of Pathophysiology in pharmacists’ curriculum 2 Health and disease. Pathogens, disease course, signs & symptoms, therapy, prevention 3 ECG analysis, basic aspects 4 Common anomalies of repolarisation 5 ECG of acute myocardial infarct 6 Abnormal impulse formation 7 Abnormal impulse conduction 8 Complex ECG-abnormalities 9 Theory of respiratory function tests 10 Demonstration of respiratory function tests in practice 11 Acid-base balance, functionality of defense systems, major challenges 12 Acid-base disorders 13 Salt-water balance (Osmo- & volume homeostasis), the regulators and effectors 14 Disorders of salt-water balance 15 Disorders of metabolism I: Lipoproteins, hyperlipidemias, atherosclerosis


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16 Disorders of metabolism II: Abnormal aminoacid metabolism, hyperuricemia, gout 17 Potassium homeostasis 18 Hyperkalemias, hypokalemias 19 Pathophysiology of vitamins and trace elements 20 Hypo- & hypervitaminoses 21 Disorders of Ca, P homeostasis, osteoporosis, osteomalacia 22 Vitamin-D, parathormone, hypo- & hypercalcemia 23 Anaemia, polycythemia 24 Disorders of hemostasis, DIC 25 Disorders of swallowing, filling- and emptying of the stomach, vomiting. 26 GI tract motility problems I: Diarrhea, constipation 27 GI tract motility problems II: ileus / Malabsorption syndromes 28 Pre-exam discussion of particular questions requested by the students.


„A” exam is absolved by filling out a test based on the exam questions. „B” and „C” exams are absolved orally with answering three questions drawn.

Pathophysiology of water-soluble vitamins and trace elements Pathophysiology of fat-soluble vitamins Complete starvation Partial starvation, accelerated forms of energetic insufficiency, anorexia nervosa Obesity: criteria, classification, epidemiology, etiology and pathogenesis. Metabolic syndrome Protein deficiency, protein-calorie malnutrition, senile sarcopenia Pathobiochemistry of LDL-metabolism, hyperlipoproteinemias Hypoglycemias Etiology and pathogenesis of DM1. Etiology and pathogenesis of DM2. Diabetic coma (ketoacidotic & hyperosmolar forms) Late complications of diabetes mellitus (including pathobiochemistry thereof) Pathophysiology of the pituitary, anomalies of growth Hyperthyroidism Hypothyroidism Glucocorticoid hyperfunctional states Pathophysiological aspects of glucocorticoid therapy Adrenal (cortex) insufficiency Hyperaldosteronisms Hyper- and hypocalcemia Osteoporosis, osteomalacia General pathophysiology and consequences of anemias and polycythemia Deficiency anemias Aplastic anemias Hemolytic anemias Congenital and acquired coagulopathies Bleeding abnormalities due to vascular factors Disorders of platelet functions Disseminated intravascular coagulation Thrombophilia, thrombosis: causes and consequences Pathophysiology of peptic ulcer Disorders of gastric filling and emptying, vomiting Malabsorption syndromes Diarrhea: causes, pathophysiological forms, consequences Bowel obstruction (ileus) Obstipation, diverticulosis Jaundice (conjugated & non-conjugated hyperbilirubinemias) Pathophysiological aspects of hepatic detoxifying system Toxic- and idiosynchratic liver damage


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Hepatic coma Liver cirrhosis, portal hypertension, ascites Pancreatitis (acute & chronic): pathophysiology and consequences. Hypothermia Heat stroke, malignant hyperthermia Pathophysiology of fever, its biological value, basic aspects of antifebrile strategies Inflammation, forms of manifestation, basic pathomechanisms Main groups and important representatives of inflammatory mediators Systemic inflammatory response syndrome (SIRS), multiple organ failure (MOF) Metabolic acidosis and alkalosis: causes, compensation, consequences Respiratory acidosis and alkalosis: causes, compensation, consequences Hyperkalaemia Hypokalaemia Mechanisms and disorders of volume regulation, abnormal distribution of extracellular fluid (edema) Mechanisms and disorders of osmoregulation, states with hypo- and hypertonicity Cardiovascular adaptation to physical exercise in healthy persons and patients with heart disease Pathophysiology of coronary insufficiency, risk factors Pathomechanism and consequences of acute myocardial infarction (AMI) Pathophysiology of heart failure Cardiomyopathies Cerebral hypoxia, ischemia, stroke Pulmonary hypertension. General pathophysiology and classification of systemic hypertension Primary (essential) hypertension: characteristics, etiological factors, consequences Hypertension and the kidneys (reciprocal connection) Hypertension and the adrenal gland Vasovagal syncope and other states with hypotension Circulatory shock: definition, classification, pathophysiology, phases and characteristics of microcirculation Hypovolemic shock Distributive shock Cardiogenic shock Forms of extrasystole (premature beats) Pre-excitation syndromes, forms and consequences of paroxysmal tachycardia Flutter and fibrillation: atrial and ventricular Nomotopic and passive heterotopic abnormalities of impulse formation Abnormalities of atrioventricular conduction (AV blocks) Intraventricular conduction abnormalities (bundle branch blocks) Atrial and ventricular axis deviations Primary repolarization abnormalities in the ECG: ECG in angina pectoris and acute myocardial infarction Disorders of the control of breathing. Sleep-apnea syndrome (OSAS, CSAS) Causes and consequences of increased airway resistance, chronic obstructive pulmonary disease (COPD) Alveolar hypoventilation and hyperventilation, causes and consequences Forms and mechanisms of hypoxia, ways of compensation, cyanosis Disorders of oxygen transport (abnormal hemoglobin, CO-poisoning, methemoglobinemia) Partial and complete respiratory failure, dyspnea Principles of basic respiratory function tests, parameters of restrictive and obstructive breathing mechanics Pathophysiology of glomerular filtration Disorders of tubular functions Acute renal failure: causes, forms, general and specific features Chronic renal failure: causes, characteristics and progression Uraemia Hyperuricemia, gout Disturbances of amino acid metabolism, (phenylketonuria, hyperhomocysteinaemia etc)

Participants

Dr. Soós Szilvia (SOSSAAI.PTE), Dr. Garai János (GAJMAAO.PTE), Dr. Garami András (GAAFAEO.PTE), Dr. Szekeres-Solymár Margit (SOMFAAO.PTE)


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OPO-MA2 MICROBIOLOGY 2 Course director: DR. JÚLIA SZEKERES, professor Department of Medical Microbiology and Immunology

4 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 28 practices + 0 seminars = total of 56 hours Course headcount limitations (min-max.): min. 1 – max. 100 Prerequisites: OPO-MI1 completed

Topic

Systematic bacteriology, virology, mycology and parasitology are the main subjects of the second semester. The course is completed by a block of lectures integrating the knowledge using a clinical microbiological approach.. The objective is to provide solid knowledge on the prevention and therapy of infectious diseases.


At the end of second semesters the students will sit for written examinations (MCQ) in microbiology. The subject of the examinations is the information provided on the lectures and practices during the first and second semesters.


-

Reading material

Stephen P. Denyer, Norman Hodges, Sean P. Gorman, Brendan F. Gilmore (eds.): Hugo and Russell’s Pharmaceutical Microbiology, 8th edition 2011, Wiley-Blackwell ISBN : 978-1-4443-3063-2

Lectures

1 Pathogens in respiratory tract Dr. Mestyán Gyula 2 Pathogens in respiratory tract Dr. Mestyán Gyula 3 Aerobic and anaerobic spore-forming bacteria Dr. Kocsis Béla 4 Aerobic and anaerobic spore-forming bacteria Dr. Kocsis Béla 5 Gram-negative nonfermenters Dr. Emődy Levente 6 Mycobacteria Dr. Emődy Levente 7 Anti-mycobacterial drugs Dr. Mestyán Gyula 8 Spirochaetes Dr. Kocsis Béla 9 Rickettsia, Chlamydia Dr. Bátai Istvánné 10 Zoonosis Dr. Bátai Istvánné 11 Characterization of viruses (basic concepts, structure, chemical composition,calssification). Multiplication of viruses (modes

of replication, mutants, interaction between viruses) Dr. Szereday László 12 Pathogenesis of virus infections (modes and types of infection, immunity) Dr. Szereday László 13 Adenovirus, Parvovirus (Erythrovirus B19) Dr. Szereday László 14 Herpesviruses, Hepatitis viruses Dr. Szereday László 15 Papovaviruses, Polyomaviruses, Poxviruses, Slow virus infections, Prions Dr. Szereday László


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16 Arboviruses, Roboviruses, Rhabdoviruses Dr. Szereday László 17 Respiratory viruses (orthomyxo-,Paramyxovitruses, Coronaviruses, RSV, Rhinoviruses) Dr. Szereday László 18 Enteric viruses Dr. Szereday László 19 Retroviruses (HTLV-I, HTLV-II., HIV and AIDS) Dr. Szereday László 20 Prophylaxis of virus infections, chemotherapy (conventional and new vaccines, antiviral compounds, interferon) Dr. Szereday László 21 Mycology I. Dr. Mestyán Gyula 22 Mycology II. Dr. Mestyán Gyula 23 Antimycotics Dr. Mestyán Gyula 24 Parasitology I. Dr. Kocsis Béla 25 Parasitology II. Dr. Kocsis Béla 26 Antiparasitic drugs Dr. Mestyán Gyula 27 Nosocomial or iatrogenic infections I. Dr. Kocsis Béla 28 Nosocomial or iatrogenic infections II. Dr. Kocsis Béla

Practices

1 Introduction, safety regulations. The microscope, native and stained preparations 2 Introduction, safety regulations. The microscope, native and stained preparations 3 Cultivation of bacteria, media and techniques. Bacterial diagnosis.(Biochemical reactions in the identification) 4 Cultivation of bacteria, media and techniques. Bacterial diagnosis.(Biochemical reactions in the identification) 5 Serology. Molecular diagnostics. Immunotherapy. 6 Serology. Molecular diagnostics. Immunotherapy 7 Sterilisation and disinfection, Sterility and pyrogen testing. Demonstration of the effect of disinfectants on skin flora 8 Sterilisation and disinfection, Sterility and pyrogen testing. Demonstration of the effect of disinfectants on skin flora 9 Antibiotic sensitivity (Kirby-Bauer method, MIC, MBC, E-test) 10 Antibiotic sensitivity (Kirby-Bauer method, MIC, MBC, E-test) 11 Antibiotic concentration in body fluids. Detection of enzyme and compounds which neutralize antibiotics.Interactions of

antibiotics 12 Antibiotic concentration in body fluids. Detection of enzyme and compounds which neutralize antibiotics.Interactions of

antibiotics 13 Diagnostic virology, mycology and parasitology 14 Diagnostic virology, mycology and parasitology 15-28 …

Seminars


Written exam consists of multiple choice questions

Participants

Dr. Bátai Istvánné (KEMHAAP.PTE), Dr. Kocsis Béla (KOBHACE.PTE), Dr. Mestyán Gyula (MELPAAP.PTE), Dr. Polgár Beáta (POBPAAP.PTE), Dr. Szereday László (SZLPAAP.PTE), Dr. Tigyi Zoltán (TIZHAAE.PTE)


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OPR-SG2 PROFESSIONAL PRACTICE 2 Course director: DR. KLÁRA MAYER, assistant professor Department of Pharmacotechnology

0 credit ▪ signature ▪ Criterion requirement module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 0 lectures + 160 practices + 0 seminars = total of 160 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GK1 completed + OPG-GT1 completed + OPR-SG1 completed

Topic

Aim of summer pharmacy practice after the 6th semester is to expand the practical and theoretical knowledge and adaptation into pharmaceutical practice. Student is allowed to execute the practice in a pharmacy or in a clinical/hospital pharmacy or pharmaceutical factory. It is also allowed to split the four week practice into 2-2 weeks in order to spend the practice at both places. Proposal in the Hungarian pharmacy practice with Hungarian Student together.


Student can only work under the supervision of the tutor pharmacist or other assigned person. Brief daily report must be done during the practice which has to be presented on course of Pharmaceutical Technology 3.


4 weeks of practice can be split into two parts due to illness.

Reading material

European Pharmacopoeia Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices

1 Knowing duties of pharmacy 2 Evaluation of prescriptions 3 Practicing preparation of liquid and semisolid dosage forms under supervision 4 Examination of incoming active pharmaceutical ingredients, rules of impleation 5 Practicing usage of pharmaceutical appliances, scales 6 Basics of aseptic work 7 Observing expenditure 8 Pharmaceutical elaboration, documentation, storage 9 Practicing synonyms, pharmaceutical nomenclature, abbreviations, formulas 10 Observing preparations of Hungarian National Formulary (Formulae Normales VII.) 11 Observing pharmaceutical interactions and incompatibility, solving incompatibility 12 Pharmaceutical documentation (book for elaboration, log of sterilizing, etc.) 13 Studying pharmaceutical literature 14 Knowing medical aids, surgical bandages 15 Knowing and practicing work of assistants 16 ... 17 Pharmaceutical factory 18 Pharmacetical industry works 19 Good Manufactory Practice (GMP) 20 The key persons in the factory 21 Quality Assurans, Qualify Person, responsibility 22 Production area, production process 23 Microbiology in the pharmaceutical industry

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice.


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Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)


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OPG-GH1 PHARMACODYNAMICS 1 Course director: DR. GÁBOR PETHŐ, professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Course headcount limitations (min-max.): min. 5 – Prerequisites: OPG-GK2 completed + OPA-BA2 completed + OPO-EL2 completed

Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic nervous system and the cardiovascular system. It must be emphasized the knowledge of the physiological principles is absolutely needed for the study of this subject.


Maximum of 25 % absence allowed


There is no way to make up for missed lectures or seminars.

Reading material

Rang, Dale, Ritter, Moore: Pharmacology, 7th edition, Elsevier Churchill Livingstone, 2012 B. G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012

Lectures

1 General aspects of neuropharmacology. General characterization of the autonomic nervous system Dr. Barthó Loránd 2 Cholinergic agonists Dr. Barthó Loránd 3 Cholinesterase inhibitors I Dr. Barthó Loránd 4 Cholinesterase inhibitors II Dr. Barthó Loránd 5 Muscarinic receptor antagonists I Dr. Barthó Loránd 6 Muscarinic receptor antagonists II Dr. Barthó Loránd 7 Neuromuscular blocking agents I Dr. Pethő Gábor 8 Neuromuscular blocking agents II Dr. Pethő Gábor 9 Agents acting on biosynthesis, storage, release and elimination of catecholamines I Dr. Pethő Gábor 10 Agents acting on biosynthesis, storage, release and elimination of catecholamines II Dr. Pethő Gábor 11 Adrenergic receptor agonists I Dr. Barthó Loránd 12 Adrenergic receptor agonists II Dr. Barthó Loránd 13 Adrenergic receptor antagonists I Dr. Barthó Loránd 14 Adrenergic receptor antagonists II Dr. Barthó Loránd


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15 Pharmacology of calcium channels I Dr. Pethő Gábor 16 Pharmacology of calcium channels II Dr. Pethő Gábor 17 Drugs acting on the renin-angiotensin-aldosterone system I Dr. Pethő Gábor 18 Drugs acting on the renin-angiotensin-aldosterone system II Dr. Pethő Gábor 19 Diuretics I Dr. Pethő Gábor 20 Diuretics II Dr. Pethő Gábor 21 Drugs used to treat congestive heart failure I Dr. Barthó Loránd 22 Drugs used to treat congestive heart failure II Dr. Barthó Loránd 23 Antianginal drugs I Dr. Barthó Loránd 24 Antianginal drugs II. Drugs that increase regional blood flow Dr. Barthó Loránd 25 Antihypertensive drugs I Dr. Pethő Gábor 26 Antihypertensive drugs II Dr. Pethő Gábor 27 Antiarrhythmic drugs I Dr. Pethő Gábor 28 Antiarrhythmic drugs II Dr. Pethő Gábor

Practices

Seminars

1 Introduction to pharmacodynamics I 2 Introduction to pharmacodynamics II 3 Basic mechanisms of drug actions 4 Characterization of agonist-receptor interaction I 5 Characterization of agonist-receptor interaction II 6 Characterization of agonist-receptor interaction III 7 Signal transduction mechanisms of drug receptors 8 Tachyphylaxis and tolerance to drugs 9 Mechanisms of drug antagonisms I 10 Mechanisms of drug antagonisms II 11 Transport of drugs across membranes I 12 Transport of drugs across membranes II 13 Absorption of drugs 14 Distribution of drugs 15 Biotransformation of drugs I 16 Biotransformation of drugs II 17 Excretion of drugs I 18 Excretion of drugs II 19 Pharmacokinetic parameters I 20 Pharmacokinetic parameters II 21 Pharmacokinetic parameters III 22 Pharmacokinetic parameters IV 23 Drug development 24 Drugs acting on autonomic ganglia


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25 Local anaesthetics I 26 Local anaesthetics II 27 Computer program demonstrating the cardiovascular effects of agents acting on the autonomic nervous system I 28 Computer program demonstrating the cardiovascular effects of agents acting on the autonomic nervous system II


1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated by physicochemical interactions)

2. Characterisation of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy 3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs 4. Mechanisms of drug antagonisms 5. Transport of drugs across membranes 6. Absorption of drugs, oral bioavailability and presystemic elimination 7. Plasma protein binding and tissue distribution of drugs 8. Biotransformation of drugs 9. Excretion of drugs 10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses 11. Drug development 12. Cholinergic agonists and cholinesterase inhibitors 13. Muscarinic receptor antagonists 14. Neuromuscular blocking agents. Drugs acting on autonomic ganglia 15. Agents acting on the biosynthesis, storage, release and elimination of catecholamines 16. Adrenergic receptor agonists 17. Adrenergic receptor antagonists 18. Local anaesthetics 19. Calcium channel blockers 20. Drugs acting on the renin-angiotensin-aldosterone system 21. Diuretic drugs 22. Positive inotropic and other drugs used to treat congestive heart failure 23. Antianginal drugs. Drugs that increase regional blood flow 24. Antihypertensive drugs 25. Antiarrhythmic drugs In addition to the exam topics, an important part of the exam are questions that aim at assessing the general knowledge of the student.

Participants

Dr. Barthó Loránd (BALIAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Sághy Éva (SAEPABO.PTE)


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OPG-GI2 PHARMACEUTICAL PRACTICE AND MANAGEMENT 1 Course director: DR. LAJOS BOTZ, professor Dept. of Pharmaceutics and University Pharmacy

3 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 0 practices + 14 seminars = total of 42 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GI1 completed + OPG-GK1 completed + OPG-GT1 completed

Topic

The undergraduates acquire knowledge of the innovation of a new drug from a drug candidate, the formation of the legal validity of official indications, as well as grouping and professional explanation of unwanted effects. The topics of the semester introduce the basic functioning of medical market, the fundamentals and specifications of economic relations. Methods of comprehensive analysis, evaluation and development of drug therapy, healthcare systems, the framework and regulation of pharmaceutical supply will be covered throughout the semester. Interactive discussions will cover essential topics regarding self-medication and over the counter products used in minor diseases. Students will improve their communicational skills in order to counsel patients more efficiently and improve adherence to medications. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures in pharmaceutical studies: Basic aim of these studies is to solidify pharmacy practice and related economic, communicational, drug development and authorization knowledge in order to understand pharmacoeconomics, drug allocation, pharmaceutical management, health economics, evidence based medicine and in general pharmaceutics. This knowledge will support later studies in these fields. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional studies. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills. Topics discussed during the lectures, but not included in the notes/books will also be included in the exams. Students can access the slides of the lectures and further reading material on a designated web based interface (CooSpace).


Acceptance of term/semester (provisions of casting to examination): A. Regular attendance of classes (maximum 30 % of absence is accepted), B. Assignments given in class should be carried out during term-time and, C. The end-of-the-term test should be passed (minimum grade 2).


Compensation is possible following personal discussion.

Reading material

All presentations can be downloaded from CooSpace. J.L. Bootman, R. J. Townsend, W. F. McGhan (eds.): Principles of Pharmacoeconomics, Harvey Whitney Book Company, 2002. Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, 6th edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 16th edition, American Pharmacists Association,

2009.

Lectures

1 Drug authorization process, Patent of drugs 1. Dr. Fittler András Tamás 2 Drug authorization process, Patent of drugs 2. Dr. Fittler András Tamás 3 Variations of authorization processes (orphan drugs, generic, etc.) Dr. Fittler András Tamás 4 Drug Research and Development 1. Dr. Fittler András Tamás 5 Drug Research and Development 2. Dr. Fittler András Tamás 6 Nonclinical studies, preclinical development, Design and methodology in clinical trials Dr. Fittler András Tamás 7 Simulation of a small, pilot clinical study Dr. Fittler András Tamás 8 Clinical trials 1. Dr. Fittler András Tamás 9 Clinical trials 2. Dr. Fittler András Tamás


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10 Clinical trials 3. Dr. Fittler András Tamás 11 Monitoring clinical trials Dr. Fittler András Tamás 12 Equivalencies of drugs 1. Dr. Fittler András Tamás 13 Equivalencies of drugs 2. Dr. Fittler András Tamás 14 Pharmacovigilance 1. Dr. Fittler András Tamás 15 Pharmacovigilance 2. Dr. Fittler András Tamás 16 Organisation of Hungarian health system Dr. Vida Róbert György 17 Principles and basic terms of economics Dr. Fittler András Tamás 18 The drug supply chain, participants of the drug market Dr. Fittler András Tamás 19 Market mechanisms Dr. Fittler András Tamás 20 Social insurance systems Dr. Takács Gábor 21 Economic actors, sectors of economy Dr. Fittler András Tamás 22 Social insurance in Hungary Dr. Vida Róbert György 23 Money, incomes, investments, taxation, redistribution Dr. Fittler András Tamás 24 Requirements of opening and operation of pharmacies. Regulation of public drug supply Dr. Fittler András Tamás 25 Inflation, national production, GDP Dr. Fittler András Tamás 26 Regulation regarding prescribing and dispensing of medicines in Hungary. Limitation of distribution of medicines in the EU Dr. Fittler András Tamás 27 The imperfect market of healthcare Dr. Fittler András Tamás 28 Test Dr. Botz Lajos

Practices

Seminars

1 Basics of communication 1. 2 Basics of communication 2. 3 Communication skills in pharmacy practice 1. 4 Communication skills in pharmacy practice 2. 5 Medication safety and communication 6 Introduction - self-care, legal issues 7 Introduction - patient assessment and consultation 8 Sample presentation, PowerPoint presentation scheme 9 Nutrition, mineral replacement and vitamins 10 Dry skin, atopic dermatitis 11 Acne, prevention of sunburn, skin hyperpigmentation 12 Minor burns, wounds 13 Smoking cessation 14 Test


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Based on the topics of the lectures and seminars.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Takács Gábor (TAGSAAP.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


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7 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 42 lectures + 56 practices + 0 seminars = total of 98 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GK2 completed + OPG-GT2 completed

Topic

Introduction to the most important analytical methods and their applications to pharmacopoeal qualification of active pharmaceutical ingredients and experiments. introduction to molecular aspect and structure-activity relationship of selected group of active pharmaceutical ingredients.


The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. The students have to write two midterm tests. One re-take chance is allowed after both tests. The student has to write a notebook about the performed practice. Both midterm tests results should be above 60%. The students have to write mini-tests at least four times on the practice. The average of the results must exceed 50%.



Reading material

European Pharmacopoeia, EDQM Publication. Pharmaceutical Chemistry Practice I, laboratory manual, University of Pécs. D.A. Williams, T.L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams & Wilkins, Philadelphia,

2002.

Lectures

1 Application of CD and ORD spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 2 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 3 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 4 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 5 Application of fluorimetry in pharmaceutical analysis. Dr. Kőszegi Tamás Antal 6 Application of fluorimetry in pharmaceutical analysis. Dr. Kőszegi Tamás Antal 7 Application of atomic absorption spectrometry and flame photometry in pharmaceutical analysis. Dr. Perjési Pál 8 Application of IR spectroscopy in pharmaceutical analysis. Dr. Lóránd Tamás 9 Application of IR spectroscopy in pharmaceutical analysis. Dr. Lóránd Tamás 10 Application of thermoanalytic methods in pharmaceutical analysis. Dr. Perjési Pál 11 Agents of cardiac failure. Dr. Perjési Pál 12 Agents of cardiac failure. Dr. Perjési Pál


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13 Agents of antiarythmic agents. Dr. Perjési Pál 14 Agents of antiarythmic agents. Dr. Perjési Pál 15 Antihipertensire agents. Dr. Perjési Pál 16 Antihipertensire agents. Dr. Perjési Pál 17 Diuretics. Dr. Perjési Pál 18 Diuretics. Dr. Perjési Pál 19 Antianginal drugs. Dr. Perjési Pál 20 Antianginal drugs. Dr. Perjési Pál 21 Antihiperlidemic agents. Dr. Perjési Pál 22 Antihiperlidemic agents. Dr. Perjési Pál 23 Antithrombotics, Thrombolytics, Coagulants. Dr. Perjési Pál 24 Antithrombotics, Thrombolytics, Coagulants. Dr. Perjési Pál 25 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 26 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 27 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 28 Application of mass spectrometry in pharmaceutical analysis. Dr. Perjési Pál 29 Application of NMR spectroscopy in pharmaceutical analysis. Dr. Berente Zoltán 30 Application of NMR spectroscopy in pharmaceutical analysis. Dr. Berente Zoltán 31 Introduction to separation techniques. Dr. Perjési Pál 32 Introduction to separation techniques. Dr. Perjési Pál 33 Application of TLC in pharmaceutical analysis. Dr. Perjési Pál 34 Application of TLC in pharmaceutical analysis. Dr. Perjési Pál 35 Application of HPLC in pharmaceutical analysis. Dr. Perjési Pál 36 Application of HPLC in pharmaceutical analysis. Dr. Perjési Pál 37 Application of GC in pharmaceutical analysis. Dr. Perjési Pál 38 Application of GC in pharmaceutical analysis. Dr. Perjési Pál 39 Application of gel chromatography in pharmaceutical analysis. Dr. Perjési Pál 40 Application of capillary electrophoresis in pharmaceutical analysis. Dr. Perjési Pál


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41 Application of capillary electrophoresis in pharmaceutical analysis. Dr. Perjési Pál 42 Application of immunoassay techniques in pharmaceutical analysis. Dr. Perjési Pál

Practices

1 Laboratory safety, accident protection, equipping. 2 Preliminary testing and classification of inorganic and organic compounds I. Identification of 20 inorganic and organic

substances I. 5 Preliminary testing and classification of inorganic and organic compounds II. Identification reactions of inorganic cations and

anions. Identification of 20 inorganic and organic substances II. 9 Preliminary testing and classification of inorganic and organic compounds III. Identification reactions of organic functional

groups. Identification of 20 inorganic and organic substances II. 13 Validation of analytical methods. Important performance characteristics. Validation of a titrimetric method. Comparison of

different methods, calculatuon of some performance characteristics. 17 Spectrophotometry I. Lambert-Beer’s law definition. Determination of specific absorbance. Spectrophotometric

determination of drug mixtures containing two components 21 Spectrophotometry II. Determination of drug mixtures containing salicylic acid and acetylsalicylic acid by

spectrophotometric and alkalimetric methods. 25 Spectrophotometry III. Determination of isoniazid drug by spectrophotometric and bromatometric methods. 29 Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Calibration of pH-meter.

Determination of a mixture containing a strong and a weak acid. 33 Potentiometry II. Electrodes used in potentiometry. Determination of the pKa os ascorbic acid by direct potentiometric

titration. 37 Potentiometry III. Polarography, amperometry. determination of water by the Karl Fischer method. Determination of

protonation constants of paracetamol by difference titration. 41 Spectrophotometry IV. Buffer solutions. Determination of the pKa of benzocaine by spectrophotometry. 45 The principles of thin-layer chromatography and denzitometry. The characterization of gel chromatography. TLC

investigation of C1-C5 alcohols. The separation of serum albumine and sodium chloride by gel chromatographic method. 49 The principles of high pressure liquid chromatography. Detremination of 4-nitrophenol, 4-nitrophenyl-glucuronide and 4-

nitrophenol-sulphate by HPLC method. 53 The principles of gas chromatography. Determination of salicylic acid and metabolites by GC method

Seminars


Written the topics of the lectures and the laboratory practices. Written exam covering the topics of the lectures and the laboratory practices. The result of written exam must exceed 60%. According to the results of midterm tests, practical work and written exam final grade will be determined. The result of the midterm tests may imply maximum 20%, the practical work maximum 5% and the result of the written exam maximum 75%. Participation on the exam on the first exam date is obligatory.

Participants

Dr. Rozmer Zsuzsanna (ROZQAAP.PTE)


50


7 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 70 practices + 0 seminars = total of 98 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GK2 completed + OPG-GT2 completed + OPG-GH1 parallel

Topic

Mainly semisolid dosage forms are prepared in this semester: suppositories and vaginal suppositories. Powders and capsules as solid dosage forms are also prepared and discussed.





Reading material

International Pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII.) James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, , Marcel Dekker Inc., New York- Basel Mansoor A. Khan, Indra K. Reddy: Pharmaceutical and Clinical Calculations, CRC Press Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press www.gytsz.pte.hu www.sciencedirect.com Attila Dévay: The Theory and Practice of Pharmaceutical Technology, PTE-Pécs (electronic book)

Lectures

1 Cristallisation, polymorphism, and their technological aspects Dr. Dévay Attila 2 Cristallisation, polymorphism, and their technological aspects Dr. Dévay Attila 3 Drying, freeze-drying Dr. Dévay Attila 4 Drying, freeze-drying Dr. Dévay Attila 5 Grinding and shieving Dr. Dévay Attila 6 Grinding and shieving Dr. Dévay Attila 7 Preparation of granules I. Dr. Dévay Attila 8 Preparation of granules I. Dr. Dévay Attila 9 Preparation of granules II. Dr. Dévay Attila 10 Preparation of granules II. Dr. Dévay Attila


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11 Fluidization and its application Dr. Dévay Attila 12 Fluidization and its application Dr. Dévay Attila 13 Written test Dr. Dévay Attila 14 Written test Dr. Dévay Attila 15 Tabletting I. Dr. Dévay Attila 16 Tabletting I. Dr. Dévay Attila 17 Tabletting II. (excipients, examinations) Dr. Dévay Attila 18 Tabletting II. (excipients, examinations) Dr. Dévay Attila 19 Excipients for the preparation of tablets and granules Dr. Dévay Attila 20 Excipients for the preparation of tablets and granules Dr. Dévay Attila 21 Coating of preparations Dr. Dévay Attila 22 Coating of preparations Dr. Dévay Attila 23 Pharmaceutical capsules Dr. Dévay Attila 24 Pharmaceutical capsules Dr. Dévay Attila 25 Written test Dr. Dévay Attila 26 Written test Dr. Dévay Attila 27 Inhaled drug delivery systems Dr. Dévay Attila 28 Inhaled drug delivery systems Dr. Dévay Attila

Practices

General instructions, rules and regulations on practices, introduction to solid forms

Undivided (bulk) powders, dusting powders, species I.

Undivided (bulk) powders, dusting powders, species II.

Divided powders I.

Divided powders II.

Dusting powders

Pills, hard gelatin capsules

Assessment

Preparation of garnules I., drying

Preparation of garnules II., examinations

Tabletting I., Machines

Tabletting II., Direct compression

Sugar and film coating process


Seminars


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The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute. At the end of semesters, students take oral exam. The criterion of starting the oral exam is to pass a written „Minimum Test” (MT). To

write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to unsatisfactory grade.

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Nagy Sándor (NASMAAO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


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OPO-KE1 PUBLIC HEALTH 1 Course director: DR. ISTVÁN KISS, professor Department of Public Health Medicine

2 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min-max.): min. 1 – Prerequisites: OPO-EL2 completed + OGO-MK2 completed

Topic

Public Health represents the preventive side of medicine. The subject deals with primary, secondary and tertiary prevention of the most challenging diseases of public health. The aims are to exam the process of disease development and demonstrate the possibilities of prevention on individual and community levels.


-


-

Reading material

PPT-presentations (Coospace) Edit Paulik: Public Health and Preventive Medicine, Medicina Publishing House, Budapest 2013.

Lectures

0 Global overview of health status. Dr. Gombos Katalin 0 Definition of health and disease. Health determinants. Dr. Gombos Katalin 0 History of public health. Scope of preventive medicine. Dr. Kiss István 0 Basics of disease prevention. Levels of prevention. Dr. Kiss István 0 Demography. Dr. Szabó István 0 Descriptive epidemiology. Dr. Szabó István 0 Basics of epidemiology, epidemiological indicators. Dr. Szabó István 0 Main types of epidemiological studies. Dr. Szabó István 0 Observational and experimental epidemiological studies I. Dr. Szabó István 0 Observational and experimental epidemiological studies II. Dr. Szabó István 0 Nutritional epidemiology: Basics of nutrition. Raposa László Bence 0 Nutritional habits. Raposa László Bence 0 Nutrition related diseases. Raposa László Bence 0 Healthy nutrition, dietary recommendations. Raposa László Bence 0 Nutritional epidemiology: Role of diet in the development of major chronic non infectious diseases I. Dr. Kiss István 0 Nutritional epidemiology: Role of diet in the development of major chronic non infectious diseases II. Dr. Kiss István


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0 Screening I. Dr. Szabó István 0 Screening II. Dr. Szabó István 0 Epidemiology of cardiovascular diseases I. Dr. Kiss István 0 Epidemiology of cardiovascular diseases II. Dr. Kiss István 0 Cancer epidemiology I. Dr. Kiss István 0 Cancer epidemiology II. Dr. Kiss István 0 Epidemiology of diabetes and obesity. Dr. Gombos Katalin 0 Epidemiology of osteoporosis. Dr. Gombos Katalin 0 Epidemiology of respiratory and gastrointestinal diseases I. Dr. Gombos Katalin 0 Epidemiology of respiratory and gastrointestinal diseases II. Dr. Gombos Katalin 0 Epidemiology of suicide, epidemiology of mental disorders I. Dr. Gyöngyi Zoltán 0 Epidemiology of suicide, epidemiology of mental disorders. Dr. Gyöngyi Zoltán

Practices

Seminars


Questions of choice Public Health 1. 1. Global overview of health status. 2. Definition of health and disease. Health determinants. 3. History of public health. Scope of preventive medicine. 4. Basics of disease prevention. Levels of prevention. 5. Demography. Descriptive epidemiology. 6. Basics of epidemiology, epidemiological indicators. 7. Main types of epidemiological studies. 8. Observationalepidemiological studies. 9. Experimental epidemiological studies. 10. Basics of nutrition. Nutritional habits. 11. Nutrition related diseases. 12. Healthy nutrition, dietary recommendations. 13. Role of diet in the development of major chronic non infectious diseases. 14. Screening. 15. Epidemiology of cardiovascular diseases. 16. Cancer epidemiology. 17. Epidemiology of diabetes. 18. Epidemiology of obesity. 19. Epidemiology of osteoporosis. 20. Epidemiology of respiratorydiseases. 21. Epidemiology of gastrointestinal diseases. 22. Epidemiology of suicide, epidemiology of mental disorders.

Participants


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OPG-GH2 PHARMACODYNAMICS 2 Course director: DR. GÁBOR PETHŐ, professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Course headcount limitations (min-max.): min. 5 – Prerequisites: OPG-GH1 completed + OPG-GK3 completed + OPG-GT3 completed

Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the blood, pharmacology of histamine, serotonin and eicosanoids, pharmacology of the respiratory tract and the gastrointestinal tract, pharmacology of the central nervous system. Drug abuse and dependence as well as non-steroidal anti-inflammatory drugs will also be discussed.





Reading material


Lectures

1 Drugs used to treat hyperlipoproteinaemias I Dr. Sághy Éva 2 Drugs used to treat hyperlipoproteinaemias II Dr. Sághy Éva 3 Drugs affecting haemostasis I Dr. Pethő Gábor 4 Drugs affecting haemostasis II Dr. Pethő Gábor 5 Drugs affecting haemostasis III Dr. Pethő Gábor 6 Drugs affecting haemostasis IV Dr. Pethő Gábor 7 Drugs affecting haematopoiesis I Dr. Sághy Éva 8 Drugs affecting haematopoiesis II Dr. Sághy Éva 9 Introduction into the pharmacology of the central nervous system I Dr. Barthó Loránd 10 Introduction into the pharmacology of the central nervous system II Dr. Barthó Loránd 11 Antianxiety and hypnotic drugs I Dr. Barthó Loránd 12 Antianxiety and hypnotic drugs II Dr. Barthó Loránd 13 Pharmacology of alcohols I Dr. Barthó Loránd 14 Pharmacology of alcohols II Dr. Barthó Loránd


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15 Antipsychotic drugs I Dr. Barthó Loránd 16 Antipsychotic drugs II Dr. Barthó Loránd 17 Antidepressants I Dr. Barthó Loránd 18 Antidepressants II Dr. Barthó Loránd 19 Antiepileptic drugs I Dr. Pethő Gábor 20 Antiepileptic drugs II. Centrally-acting muscle relaxants Dr. Pethő Gábor 21 Opioid analgesic drugs I Dr. Barthó Loránd 22 Opioid analgesic drugs II Dr. Barthó Loránd 23 Opioid analgesic drugs III Dr. Barthó Loránd 24 Opioid analgesic drugs IV Dr. Barthó Loránd 25 Non-steroidal antiinflammatory drugs I Dr. Pethő Gábor 26 Non-steroidal antiinflammatory drugs II Dr. Pethő Gábor 27 Non-steroidal antiinflammatory drugs III Dr. Pethő Gábor 28 Adjuvant analgesics. Drugs used to treat gout Dr. Pethő Gábor

Practices

Seminars

1 Histamine, H1 receptor antagonists 2 H2 receptor antagonists 3 Serotonin, serotonin receptor agonists 4 Serotonin receptor antagonists 5 Pharmacology of eicosanoids 6 Drugs acting on the smooth muscle including uterine muscle 7 Pharmacology of the respiratory tract I 8 Pharmacology of the respiratory tract II 9 Pharmacology of the respiratory tract III 10 Pharmacology of the respiratory tract IV 11 Pharmacology of the gastrointestinal tract I 12 Pharmacology of the gastrointestinal tract II 13 Pharmacology of the gastrointestinal tract III 14 Pharmacology of the gastrointestinal tract IV 15 Pharmacology of the gastrointestinal tract V 16 Pharmacology of the gastrointestinal tract VI 17 General anaesthetics I 18 General anaesthetics II 19 Drug treatment of neurodegenerative disorders I 20 Drug treatment of neurodegenerative disorders II 21 Central nervous system stimulants I 22 Central nervous system stimulants II. Nootropic drugs


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23 Drug abuse I 24 Drug abuse II 25 Drug abuse III 26 Drug abuse IV 27 Harmful effects of drugs and their mechanisms I 28 Harmful effects of drugs and their mechanisms II


1. Antianxiety and hypnotic drugs 2. Alcohols: pharmacology, toxicology 3. Antipsychotic drugs 4. Antidepressants 5. Central nervous system stimulants. Nootropic drugs 6. Drug treatment of neurodegenerative disorders 7. General anaesthetics 8. Antiepileptic drugs 9. Opioid analgesic drugs: morphine and codeine 10. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists 11. Non-steroidal antiinflammatory drugs: aspirin, paracetamol 12. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol 13. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants 14. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants 15. Drugs used to treat hyperlipoproteinaemias 16. Drugs affecting haemostasis 17. Drugs affecting haematopoiesis 18. Histamine, H1 and H2 receptor antagonists 19. Serotonin, serotonin receptor agonists and antagonists 20. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle 21. Drugs used in bronchial asthma 22. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents 23. Drugs used in the treatment of peptic ulcer 24. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis 25. Laxatives, antidiarrhoeal agents, drug treatment of inflammatory bowel diseases 26. Harmful effects of drugs and their mechanisms In addition to the exam topics, an important part of the exam is questions that aim at assessing the general knowledge of the student.

Participants

Dr. Barthó Loránd (BALIAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Sághy Éva (SAEPABO.PTE)


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OPG-GI3 PHARMACEUTICAL PRACTICE AND MANAGEMENT 2 Course director: DR. LAJOS BOTZ, professor Dept. of Pharmaceutics and University Pharmacy

5 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 18 practices + 24 seminars = total of 70 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GI2 completed + OPG-GH1 completed + OPG-GT3 completed

Topic

The topic of the semester primarily is to introduce the basic function of the health care system and pharmaceutical supply chain; in respect of general legal, pharmaceutical, economical, marketing relations and specialties. Fundamentals of health economics and pharmaeconomics essential for pharmacists are core elements of the semester. Basic and specific concepts of pharmaceutical care are discussed in detail. Introduction to the basic tasks and services in hospital and clinical pharmacy are covered to support pharmacists; clinical knowledge. Development of legal norms, hierarchy of norms, patients rights, claim for damages and other legislative aspects of pharmacy practice are introduced in this semester. Lectures will cover basic knowledge regarding marketing and specific issues in marketing for pharmacists. Interactive discussions will cover further topics regarding self-medication and over the counter medications used in minor diseases. Students will improve pharmaceutical communication skills in order to counsel patients more efficiently, collaborate with healthcare professionals and improve medication adherence. Methods of comprehensive analysis, evaluation and development of drug therapy, the framework and regulation of pharmaceutical supply system will be covered throughout the semester. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures are to consolidate students; legal, marketing and pharmacoeconomical knowledge (pharmaceutical management, health economy, pharmaceutical supply, pharmacoeconomy, evidence based medicine and pharmaceutics), and to lay the foundations of practical pharmaceutical work and further professional development. Interactive group work during the seminars will encourage problem solving skills and creative thinking. Aims of lectures in pharmaceutical studies: Basic aim of these studies is to solidify pharmacy practice and related economic, clinical, pharmaceutical care, communicational, marketing knowledge in order to understand pharmacoeconomics, drug allocation, pharmaceutical management, health economics, evidence based medicine and in general pharmaceutics. This knowledge will support later studies in these fields. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional studies. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills. Topics discussed during the lectures, but not included in the notes/books will also be included in the exams. Students can access the slides of the lectures and further reading material on a designated web based interface (CooSpace).





Reading material

All presentations can be downloaded from CooSpace. Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, 6th edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 16th edition, American Pharmacists Association,

2009. Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

Lectures

1 Communication: Strategies to meet specific needs 1. Dr. Fittler András Tamás 2 Communication: Strategies to meet specific needs 2. Dr. Fittler András Tamás 3 Introduction to the hospital and clinical pharmacy 1. Dr. Takács Gábor 4 Introduction to the hospital and clinical pharmacy 2. Dr. Vida Róbert György 5 Communication skills in hospital practice Dr. Fittler András Tamás


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6 Electronic communication is healthcare, pharmacists in the social media Dr. Fittler András Tamás 7 Hospital pharmacy services I. Dr. Takács Gábor 8 Hospital pharmacy services II. Dr. Takács Gábor 9 Helping patients manage therapeutic regimens. Supporting behaviour change. Dr. Fittler András Tamás 10 Ethical behaviour and assertiveness in communication. Dr. Fittler András Tamás 11 Adherence 1. Dr. Fittler András Tamás 12 Adherence 2. Dr. Fittler András Tamás 13 Interactive discussion and comparative evaluation of different Health Care Systems 1. Dr. Fittler András Tamás 14 Interactive discussion and comparative evaluation of different Health Care Systems 2. Dr. Takács Gábor 15 International Health Organizations Dr. Vida Róbert György 16 Hungarian and International Pharmaceutical Organizations. Dr. Vida Róbert György 17 Fundamentals of Health Economics, Health Policy. Dr. Takács Gábor 18 Fundamentals and legal basic terms. Dr. Mohay Ágoston Csanád 19 Constitution, Acts, Laws, Regulations, Directives. Dr. Mohay Ágoston Csanád 20 Patient rights, obligations. Dr. Mohay Ágoston Csanád 21 Health care professional rights and obligations. Dr. Mohay Ágoston Csanád 22 Claim for damages. Dr. Mohay Ágoston Csanád 23 European Union. Dr. Mohay Ágoston Csanád 24 Impact of regulation of Community Pharmacies on efficiency, access and equity. Dr. Fittler András Tamás 25 The Costs of Health Care, the Benefits of Health Care. Dr. Fittler András Tamás 26 Health Expenditures, Prices of Drugs/Health Care Services, Cost Control Techniques. Dr. Vida Róbert György 27 Placebo 1. Dr. Takács Gábor 28 Test Dr. Botz Lajos

Practices

1 Pharmaceutical Care: evolution, principles. 2 Pharmaceutical Care: feasibility and technique, legal framework, levels. 3 Pharmaceutical Care: Special populations. 4 Pharmaceutical Care: Asthma. Allergic rhinitis, COPD 1. 5 Pharmaceutical Care: Asthma. Allergic rhinitis, COPD 2. 6 Definition and history of marketing. 7 The pharmaceutical and healthcare market. 8 Decision Analysis. 9 Decision Tree.


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10 Drug Utilization Studies. 11 Quality of Life. 12 Marketing mix, Motivation of the customer. 13 Trademarks, brand building. 14 Life cycle management, Product strategies. 15 Price strategies, Distribution. 16 Advertising medicines. 17 Placebo 2. 18 Test

Seminars

1 Insect bites, stings, Tics, Scabies, Pediculosis 2 Oral pain and discomfort, herpes labialis, aphthous stomatitis 3 Ophthalmic disorders, contact lenses. 4 Otic disorders, vertigo. 5 Prevention of pregnancy, pregnancy tests and STD-s. 6 Vitamins, nutrition and drug therapy during pregnancy. 7 Diaper dermatitis, Basic medications for infants. 8 Musculoskeletal injuries and disorders. 9 Menstruation, biliary and urinary stones. 10 Drowsiness and fatigue. 11 Benign Prostatic Hyperplasia. 12 Scaly dermatosis, dandruff. 13 Pharmaceutical Care: Metabolic syndrome. 14 Pharmaceutical Care: Hypertension. 15 Pharmaceutical Care: Diabetes mellitus. 16 Pharmaceutical Care: Dyslipidemia 17 Pharmaceutical Care: Devices. 18 Main Pharmacoeconomic Evaluations 1. Theoretical. 19 Main Pharmacoeconomic Evaluations 2. Practical. 20 Decision Tree. Practical. 21 Quality of Life. Practical. 22 SOJA. 23 SWOT analysis, BCG matrix. 24 Test



Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Takács Gábor (TAGSAAP.PTE), Dr. Télessy István (TEIQAAP.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


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6 credit ▪ final exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GK3 completed + OPG-GT3 completed

Topic

Introduction to quality control of compounded preparations. Application of instrumental methods in pharmacopoeal quality control of pharmaceutical preparations. Introduction of molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients.


The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. The student has to write a notebook about the performed practice. The students have to write two midterm tests. One re-take chance is allowed after both tests. Both semester tests results should be above 60 %. The students have to write mini-tests at least four times on the practice. The average of the results must exceed 50%.



Reading material

European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I, laboratory manual, University of Pécs. D.A. Williams, T.L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams & Wilkins, Philadelphia,

2002.

Lectures

1 Adrenocorticoids. Dr. Perjési Pál 2 Adrenocorticoids. Dr. Perjési Pál 3 Estrogens, Androgens, Progestins. Dr. Perjési Pál 4 Estrogens, Androgens, Progestins. Dr. Perjési Pál 5 Drugs affecting calcium homeostatis. Dr. Perjési Pál 6 Drugs affecting calcium homeostatis. Dr. Perjési Pál 7 Insulin and oral hypoglycemic drugs. Dr. Perjési Pál 8 Insulin and oral hypoglycemic drugs. Dr. Perjési Pál 9 Drug affecting thyroid functions. Dr. Perjési Pál 10 Drug affecting thyroid functions. Dr. Perjési Pál 11 Vitamins. Dr. Perjési Pál 12 Vitamins. Dr. Perjési Pál


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13 Antiparasitic agents. Dr. Perjési Pál 14 Antiparasitic agents. Dr. Perjési Pál 15 Antifungal drugs. Dr. Perjési Pál 16 Antifungal drugs. Dr. Perjési Pál 17 Antimicrobial agents. Dr. Perjési Pál 18 Antimicrobial agents. Dr. Perjési Pál 19 Antibiotics I. Dr. Lóránd Tamás 20 Antibiotics I. Dr. Lóránd Tamás 21 Antibiotics II. Dr. Lóránd Tamás 22 Antibiotics II. Dr. Lóránd Tamás 23 Antibiotics III. Dr. Lóránd Tamás 24 Antibiotics III. Dr. Lóránd Tamás 25 Anticancer agents. Dr. Perjési Pál 26 Anticancer agents. Dr. Perjési Pál 27 Antiviral agents. Dr. Perjési Pál 28 Antiviral agents. Dr. Perjési Pál

Practices

1 The bases of reaction kinetics. The dependence of drug degradation rate of temperature and pH. Analysis of degradation of acetylsalicylic acid.

5 Determination methods of partition coefficients. Determination of logP steroids by thin-layer chromatographic technique. 9 The structure, the configuration and the conformation of molecules. (Hyperchem) 11 The analytics of steroid hormones. TLC identification of steroid hormones. Determination of hydrocortisone content using

spectrophotometric method. 13 Identification of multi-component drug mixtures I. General principles. Pulvis antispasticus: chemical identification,

chromatographic identification, assay. 17 Identification of multi-component drug mixtures II. Determination of bases I. Pulvis chinacisalis cum vitamino C, Pulvis

somniferens. 21 Identification of multi-component drug mixtures III. Determination of bases II. Pulvis analgeticus, Tabletta Meristin. 25 Identification of multi-component drug mixtures IV. Determination of acids I. Spiritus iodosalicylatus, Spiritus salicylatus

cum resorcino. 29 Identification of multi-component drug mixtures V. Unguentum haemorrhoidale, Suppositorium analgeticum. 33 Identification of multi-component drug mixtures VI. 37 Visit at the Quality Control Laboratory of Hungaropharma Ltd 41 Vitamines. Acidum ascorbicum, Acidum folicum, Pyridoxinii ydrochloridum, Riboflavinum, Thiamini hydrochloridum.

Detremination of cyanocobalaminum by spectrophotometric and HPLC method. 45 Chemotherapeutic agents. Chinini hydrochloridum, Sulfadimidinum, Sulfaguanidinum, Sulfathiazolum, Chloramphenicolum 49 Spectrum analysis of infrared and nuclear magnetic resonance spectrumes. The nomenclature and plotting of heterocycles. 53 Summary. Repetition.


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Seminars


Oral exam covering the topics of Pharmaceutical Chemistry I-IV. Before the exam each student should have a Minimum Requirement Test of which result should be at least 80%.

Further details: www.gytsz.pte.hu

Participants

Dr. Rozmer Zsuzsanna (ROZQAAP.PTE)


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6 credit ▪ final exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GT3 completed

Topic

In this semester solid dosage forms, theoretical introduction of granulation, tabletting and tablet coating is discussed. Quality control of prepared dosage forms are also carried out such as disintegration, dissolution, tablet hardness test, etc. Aspects and work in industrial pharmacy is also presented during this semester.





Reading material


Lectures

1 Drug Delivery Systems 1. Dr. Dévay Attila 2 Drug Delivery Systems 1. Dr. Dévay Attila 3 Drug Delivery Systems 2. Dr. Dévay Attila 4 Drug Delivery Systems 2. Dr. Dévay Attila 5 Drug Delivery Systems 3. Dr. Dévay Attila 6 Drug Delivery Systems 3. Dr. Dévay Attila 7 Drug Delivery Systems 4. Dr. Dévay Attila 8 Drug Delivery Systems 4. Dr. Dévay Attila 9 Written test Dr. Dévay Attila 10 Written test Dr. Dévay Attila


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11 Multiparticulate systems I. (microcapsules, micropellets) Dr. Dévay Attila 12 Multiparticulate systems I. (microcapsules, micropellets) Dr. Dévay Attila 13 Multiparticulate systems II. (molecular dispersion, liposomes, dendrimers, kohleats, kvantum dots, nanotubes) Dr. Dévay Attila 14 Multiparticulate systems II. (molecular dispersion, liposomes, dendrimers, kohleats, kvantum dots, nanotubes) Dr. Dévay Attila 15 Development of pharmaceutical dosage forms I. Dr. Dévay Attila 16 Development of pharmaceutical dosage forms I. Dr. Dévay Attila 17 Development of pharmaceutical dosage forms II. Dr. Dévay Attila 18 Development of pharmaceutical dosage forms II. Dr. Dévay Attila 19 Written test Dr. Dévay Attila 20 Written test Dr. Dévay Attila 21 Stability of preparations Dr. Dévay Attila 22 Stability of preparations Dr. Dévay Attila 23 Wrapping of pharmaceutical preparations Dr. Dévay Attila 24 Wrapping of pharmaceutical preparations Dr. Dévay Attila 25 Quality Assurance, GMP Dr. Dévay Attila 26 Quality Assurance, GMP Dr. Dévay Attila 27 Official approval, validation, reproducibility, process control Dr. Dévay Attila 28 Official approval, validation, reproducibility, process control Dr. Dévay Attila

Practices

General instructions, rules and regulations on practices, solutions, nasal drops, ear drops

Emulsions, suspensions

Eye oinments, eyes drops, tea mixtures, decoctum, infusum

Ointments/creams/pastes/gels

Vaginal, rectal suppositories

Powders, pills, hard gelatin capsules

Personal assessment 1.







End-subject assessment of practice

Seminars


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The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute. At the end of semester, students take final exam. Final exam consists of practice and theoretical parts. Based on practice results of the

previous four semesters and final practice exam, students get a summarized practice grade. The oral/theoretical part of the exam has two topics, but any part done with insufficient knowledge will result in assessment of the exam to unsatisfactory grade. The grade of final exam is influenced by 1/3 proportion from practice grade and 2/3 proportion from oral/theoretical part.

The criterion of starting the oral exam is to pass a written „Minimum Test” (MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to unsatisfactory grade.

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


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OPO-KE2 PUBLIC HEALTH 2 Course director: DR. ISTVÁN KISS, professor Department of Public Health Medicine

3 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 14 practices + 0 seminars = total of 42 hours Course headcount limitations (min-max.): min. 1 – Prerequisites: OPO-KE1 completed

Topic

Public Health represents the preventive side of medicine. The subject deals with primary, secondary and tertiary prevention of the most challenging diseases of public health. The aims are to exam the process of disease development and demonstrate the possibilities of prevention on individual and community levels.


Participation in practicals is obligatory which is registered. Absences should not exceed 15% of practicals (2x45 min). Otherwise signature of grade book is denied.


There are no make-up classes.

Reading material

PPT-presentations (Coospace) Edit Paulik: Public Health and Preventive Medicine, Medicina Publishing House, Budapest 2013.

Lectures

0 Health effects of alcohol consumption and smoking I. Dr. Berényi Károly 0 Health effects of alcohol consumption and smoking II. Dr. Berényi Károly 0 Global drug trends. Drug trends in Hungary I. Dr. Szabó István 0 Global drug trends. Drug trends in Hungary II. Dr. Szabó István 0 Basics of toxicology. Dr. Szabó István 0 Epidemiology of poisoning; global trends. Dr. Szabó István 0 Basics of occupational health. Dr. Tibold Antal 0 Health effects of mechanical, ergonomic and psychological factors. Dr. Tibold Antal 0 Occupational carcinogens I. Dr. Kiss István 0 Occupational carcinogens II. Dr. Kiss István 0 Basics of environmental health. Dr. Varga Csaba 0 Environmental health; global trends. Dr. Varga Csaba 0 Air pollution. Dr. Szabó István 0 Health effects of dust exposure. Dr. Szabó István


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0 Water hygiene, soil pollution I. Dr. Varga Csaba 0 Water hygiene, soil pollution II. Dr. Varga Csaba 0 Basics of infectious diseases. Dr. Patczainé Dr. Gőcze Katalin Réka 0 Epidemiology of infectious diseases: global situation. Dr. Patczainé Dr. Gőcze Katalin Réka 0 Epidemiology of airborne diseases I. Dr. Gombos Katalin 0 Epidemiology of airborne diseases II. Dr. Gombos Katalin 0 Epidemiology of infectious diseases transmitted by food and water I. Dr. Patczainé Dr. Gőcze Katalin Réka 0 Epidemiology of infectious diseases transmitted by food and water II. Dr. Patczainé Dr. Gőcze Katalin Réka 0 Epidemiology of sexually transmitted diseases. Dr. Kiss István 0 Hepatitis Dr. Kiss István 0 Haematogenic and lymphogenic infections. Epidemiology of infections transmitted through the skin. Dr. Gombos Katalin 0 Epidemiology of zoonoses. Dr. Gombos Katalin 0 Prion diseases. New infectious diseases. Dr. Varga Csaba 0 Public health methods in disasters. Chemical and biological weapons, (bio)terrorism. Dr. Szabó István

Practices

0 General epidemiology; meta-analysis, systematic review, databases I. 0 General epidemiology; meta-analysis, systematic review, databases II. 0 Chemical and microbiological qualification of drinking water I. 0 Chemical and microbiological qualification of drinking water II. 0 Genotoxicity laboratory practical I. 0 Genotoxicity laboratory practical II. 0 Chemical safety, risk assessment I. 0 Chemical safety, risk assessment II. 0 Vaccination, vaccination schedule I. 0 Vaccination, vaccination schedule II. 0 Nosocomial infections; Disinfection and sterilization I. 0 Nosocomial infections; Disinfection and sterilization II. 0 Physical exposures I. 0 Physical exposures II.

Seminars


1. History and objectives of public health 2. Definition of health and disease 3. Determinants of health 4. Social risk factors 5. Levels of prevention 6. Health promotion 7. Health politics 8. Maternal and newborn health 9. Child and adolescent health 10. Health concerns of elderly. Aging societies


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11. Minorities: Health issues and disparities 12. Health issues and disparities of people living with disabilities 13. Evidence-based medicine and prevention 14. History and objectives of epidemiology 15. Causation in epidemiology: association and causation 16. Epidemiological indicators I.: indicators of disease frequency and populational impact of a disease Epidemiological indicators II.: definition and measures of relative risk and odds ratio 17. Standardization 18. Epidemiological studies: parameters, design 19. Descriptive epidemiological studies, cross-sectional studies 20. Ecological studies. Immigrant studies 21. Case-control studies 22. Cohort studies 23. Experimental (interventional) epidemiological studies 24. Meta-analysis, systematic review 25. Errors and bias in epidemiological studies 26. Confounders, effect modifiers and possibilities for elimination 27. Molecular epidemiology 28. Basic principles of screening 29. Optional and mandatory screening 30. Demography: definition, methods, data sources 31. Demographic indicators: measures of mortality 32. Demographic indicators: measures describing population groups. Population pyramids 33. Demographic indicators: measures of birth and fertility 34. Role of nutrition in prevention of cardiovascular diseases 35. Role of nutrition in prevention of cancers 36. Principles of healthy diet 37. Epidemiology of malnutrition and nutritional deficiencies 38. Dietary guidelines 39. Special nutritional considerations: vegetarianism 40. Special nutritional considerations: Mediterranean diet, DASH- (Dietary Approaches to Stop Hypertension) diet 41. Special nutritional considerations: trendy diets 42. Assessment of nutritional status, nutritional screening 43. Dietary supplements and functional foods 44. Food additives 45. Food safety, food safety testing 46. Chemoprevention 47. Genetically modified organisms 48. Interaction of environmental and genetical factors in disease development 49. Genomics and epigenetics in public health. Nutrigenomics 50. Molecular basics of carcinogenesis 51. Primary and secondary factors of epidemic process (virulence, source of infection, means of transmission, susceptible host) 52. Nosocomial infections. Sterilization, disinfection 53. Infectious diseases worldwide 54. Prevention of infectious diseases: vaccination, chemoprophylaxis 55. Epidemiology and prevention of vaccine-preventable diseases, mandatory immunisation for children 56. Epidemiology and prevention of airborne bacterial infections 57. Epidemiology and prevention of airborne viral infections 58. Characteristics, types, occurrence and prevention of enteric infections 59. Epidemiology and prevention of enteric bacterial infections 60. Epidemiology and prevention of enteric viral infections 61. Epidemiology and prevention of enteric helminth and protozoon infections 62. Epidemiology and prevention of viral hepatitides 63. Epidemiology and prevention of haematogenic and lymphogenic infections 64. Epidemiology and prevention of infections transmitted through the skin 65. Epidemiology and prevention of zoonotic helminth and bacterial infections


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66. Epidemiology and prevention of zoonotic protozoon and viral infections 67. Epidemiology and prevention of sexually transmitted diseases (excluding AIDS) 68. Epidemiology and prevention of AIDS 69. Epidemiology and prevention of prion diseases 70. New infectious diseases. Bioterrorism 71. Importance of non-communicable diseases in developed countries (mortality, morbidity, trends) 72. Epidemiology of ischaemic heart disease 73. Main modifiable risk factors of coronary heart disease 74. Other modifiable risk factors of coronary heart disease 75. Risk factors of coronary heart disease (excluding main and other modifiable risk factors) 76. Epidemiology and prevention of cerebrovascular diseases 77. Epidemiology and prevention of hypertension 78. Cardiovascular diseases: risk assessment and prevention 79. Morbidity and mortality of malignant diseases 80. Role of infectious diseases in tumour development 81. Risk factors of malignant diseases 82. Screening of malignant diseases 83. Epidemiology and prevention of lung cancer 84. Epidemiology and prevention of colorectal cancer 85. Epidemiology and prevention of breast cancer 86. Epidemiology and prevention of prostate and cervix cancer 87. Epidemiology and prevention of liver-, pancreas- and gastric cancer 88. Epidemiology and prevention of head and neck cancers and skin cancers 89. Epidemiology and prevention of diabetes 90. Epidemiology and prevention of obesity 91. Epidemiology and prevention of osteoporosis 92. Epidemiology and prevention of chronic obstructive pulmonary disease 93. Epidemiology and prevention of asthma 94. Epidemiology and prevention of allergic rhinitis 95. Epidemiology and prevention of hepatic cirrhosis 96. Epidemiology and prevention of ulcer disease 97. Epidemiology and prevention of inflammatory bowel diseases 98. Epidemiology and prevention of suicide 99. Epidemiology and prevention of depression and mood disorders 100. Epidemiology and prevention of anxiety disorders 101. Epidemiology and prevention of schizophrenia and dementias 102. Epidemiology and prevention of addictions 103. Recommended and compulsory screening methods for non-communicable diseases (excluding cancers) 104. Basic principles of ecology. Human environment, human ecology. 105. Settlement health, transportation and health. Health effects of interiors, health and the built environment 106. Environmental monitoring and protection. Health effects of global environmental issues 107. Air pollutants and their health effects 108. Health effects of microbiological and chemical water pollutants, water quality testing 109. Health effects of soil contamination. Health effects and management of waste water, wastes and hazardous wastes 110. History of occupational health. Organization and levels of occupational health services. 111. Work safety. 112. Risk assessment, management and communication 113. Occupational toxicology – chemical safety 114. Occupational cancers 115. Physical hazards: health effects of low and high temperature 116. Physical hazards: disorders caused by noise and vibration and their prevention 117. Chemical hazards: Industrial and agricultural toxicology of organic compounds 118. Chemical hazards: Industrial and agricultural toxicology of inorganic compounds 119. Psychosocial and biological hazards 120. Health effects of ionizing and non-ionizing radiations 121. Ergonomic factors. Health effects of inorganic and organic dusts and their prevention


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122. New and emerging risks in occupational medicine 123. Occupational diseases of health care workers and prevention. Occupational accidents. 124. Migration and catastrophes, medical and occupational health considerations

Participants

Dr. Patczainé Dr. Gőcze Katalin Réka (GOKFACO.PTE), Dr. Szabó István (SZIGABO.PTE), Dr. Szendi Katalin (SZKFAPO.PTE)


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OPO-KL1 CLINICAL STUDIES 1 Course director: DR. ERIKA PINTÉR, professor Department of Pharmacognosy

2 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min-max.): min. 2 – max. 40 Prerequisites: OPA-BA2 completed + OPO-EL2 completed

Topic

The task of the subject is the transmission of the most fundamental knowledge of the clinical studies for the pharmacy students. The curriculum covers the most important diseases focusing on their pharmacotherapy. The task of this subject to promote the accurate knowledge pharmacotherapy in the clinical practise.




None

Reading material

Lecture notes

Lectures

1 Basic principles of medication of internal diseases Dr. Cziráki Attila 2 Basic principles of medication of internal diseases Dr. Cziráki Attila 3 Cardiology Dr. Czopf László József 4 Cardiology Dr. Czopf László József 5 Gastroenterology Dr. Fábián György 6 Gastroenterology Dr. Fábián György 7 Hepatology Dr. Pár Alajos 8 Hepatology Dr. Pár Alajos 9 Nephrology Dr. Kelényi Gáborné 10 Nephrology Dr. Kelényi Gáborné 11 Metabolism - Diabetology Dr. Wittmann István 12 Hypertension Dr. Kovács Tibor József 13 Hematology Dr. Kosztolányi Szabolcs 14 Hematology Dr. Kosztolányi Szabolcs 15 Pulmonology Dr. Illés Miklós Balázs 16 Pulmonology Dr. Illés Miklós Balázs


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17 Survey of the endocronological diseases Dr. Mezősi Emese 18 Survey of the endocronological diseases Dr. Mezősi Emese 19 Infectology Dr. Péterfi Zoltán 20 Infectology Dr. Péterfi Zoltán 21 Surgery of the esophagus and the stomach Dr. Papp András 22 Surgery of the esophagus and the stomach Dr. Papp András 23 Transplantation Dr. Szakály Péter 24 Transplantation Dr. Szakály Péter 25 Thoracic surgery Dr. Szántó Zalán János 26 Coloproctological surgery Dr. Baracs József 27 Surgery of the pancreas Dr. Kelemen Dezső Tamás 28 Surgery of the liver Dr. Papp András

Practices

Seminars


Written exam based on the lectures.

Participants


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OPG-FID HERBAL MEDICINE AND HERBS IN NUTRITION Course director: DR. TAMÁS ANTAL KŐSZEGI, associate professor Department of Pharmacognosy

2 credit ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Course headcount limitations (min-max.): min. 1 – Prerequisites: OPG-FG2 completed + OPG-GH2 completed

Topic

Aims of the subject: To give an overview for the students on the biological effects of generally used herbs, drugs and herbal nutrients on the human body (beneficial and hazardous as well). To demonstrate the mode of action, indications and applications of herbal drugs in the most important disease groups by showing practical examples and case reports. To make emphasis on the interactions of herbal constituents with allopathic drugs used in modern medicine. The curriculum helps proper orientation among today’s frequent misbelieves and myths by the methods of evidence based medicine.




An absence rate of less than 25% is acceptable, no medical or other certificate is necessary. Management of catch up for absences is possible by personal consultation with the tutor.

Reading material

Aronson J.K. (ed.): Meyler’s Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009 Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002 ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Thieme, Exeter; Stuttgart; New York, 2003 European Medicines Agency guidelines; www.ema.europa.eu

Lectures

1 Major biological effects of herbs used in the human diet Dr. Kőszegi Tamás Antal 2 Characteristics of an optimal nutritional regime for maintenance of health in regard of herbal constituents of different diets Dr. Kőszegi Tamás Antal 3 Biochemical testing methods for the assessment of biological effects of herbal extracts in cellular model systems Dr. Kőszegi Tamás Antal 4 Effects of antioxidants and other cytoprotective molecules of plant origin on cell energetics and free radical levels Dr. Kőszegi Tamás Antal 5 Application of plant extracts and monitoring procedures of their action at the body level Dr. Kőszegi Tamás Antal 6 Herbal formulations with immuno-modulant activity; case discussion Dr. Kőszegi Tamás Antal 7 Application of herbal medicine based on ethnopharmacobotany and evidence based medicine Dr. Papp Nóra 8 Application of herbal medicine based on ethnopharmacobotany and evidence based medicine Dr. Papp Nóra 9 Authentic judgement of plant based dietary supplements using the conception of evidence based medicine Dr. Kőszegi Tamás Antal 10 The problematic of plant based dietary supplements: evidences, myths and disbelieves Dr. Kőszegi Tamás Antal 11 Role of herbal medicine in common cold (diseases of the upper respiratory tract: flue like symptoms); application of methods

based on traditions and on scientific evidences Dr. Farkas Ágnes 12 Herbal remedies in lowering blood cholesterol levels; plants with antidiabetic activity Dr. Farkas Ágnes 13 Major aspects of prevention and therapy of cardiovascular diseases (nutrition and medicinal herbs) Dr. Kőszegi Tamás Antal 14 Cardiovascular diseases; case discussion Dr. Kőszegi Tamás Antal


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15 Complementary therapy of chronic bone and joint diseases Dr. Kőszegi Tamás Antal 16 Rheumatoid arthritis; case discussion Dr. Kőszegi Tamás Antal 17 Medicinal plant drug nutrient interactions Dr. Horváth Györgyi 18 Medicinal plant drug nutrient interactions Dr. Horváth Györgyi 19 Nutritional and herbal medicine approaches in malignant diseases Dr. Kőszegi Tamás Antal 20 Complementary therapy of malignant diseases; case discussion Dr. Kőszegi Tamás Antal 21 Restoration of the various balances in the gastrointestinal tract by phytotherapy and microbiological therapy Dr. Kőszegi Tamás Antal 22 Useful complementary methods in the diseases of the gastrointestinal tract; case discussion Dr. Kőszegi Tamás Antal 23 Body care with roborant; vitamin and antioxidant containing phytotherapeutic agents and lotions Dr. Kőszegi Tamás Antal 24 Body care with roborant; vitamin and antioxidant containing phytotherapeutic agents and lotions; critical evaluation Dr. Kőszegi Tamás Antal

Practices

Seminars


1. Why plants used in human nutrition may be considered to function as medicinal herbs? Give examples. 2. What types of cytoprotective factors can be found in fruits and vegetables? 3. What are the most important constituents of plant origin in the human diet for maintenance of health? 4. Give a few examples for in vitro assessment of biological effects of plant extracts in cellular models. 5. How antioxidant capacity can be measured using in vitro cellular models? How cell energetics can be characterized by laboratory

approaches? 6. Give a few clinical laboratory tests for estimation of biological effects of plant extracts at the body level (e.g. antioxidant,

antiinflammatory, antidiabetic, influencing lipid metabolism, etc). 7. What does immune modulation mean? List a few practical examples with the mention of active ingredients. 8. Plants, herbal drugs and traditional names of them. Different examples for confusing and mismatching herbal names in

phytotherapy. 9. Evaluation of traditional medicine in view of evidence based medicine (give examples). 10. What are the major rules in proper application of dietary supplements? 11. What are the contraindications in application of dietary supplements (give examples)? 12. List the most important medicinal herbs applied in the complementary therapy of common cold and name their active ingredients. 13. Herbal drugs influencing lipid metabolism and their proper application. 14. Safe application of medicinal herbs in diabetes mellitus (active agents, complex herbal formulations). 15. Complementary therapies with indications and contraindications in cardiovascular diseases (give examples). 16. Mineral supplementation in metabolic bone diseases (including microbiological therapy). 17. Different immune modulation therapies in rheumatoid arthritis. 18. Give some examples in detail on modern drug-herbal medicine interactions with serious outcome (with reference of active

ingredients). 19. Give some examples of important food-drug interactions with reference of active ingredients. 20. List those complementary therapeutically acceptable modalities which can be interpreted by the principles of evidence based

medicine. 21. Name those complementary therapies or processes that are contraindicated in malignant diseases (active agents, ingredients). 22. Explain why restoration of function, bacterial micro flora and permeability of the gastrointestinal tract is of vital importance? 23. Major indication of phytotherapeutical treatments in certain diseases of the gastrointestinal tract (name the active agents as well). 24. Explain the proper administration routes of vitamins, antioxidants and roborants and their indications. 25. Give description on professional compliance for formulations of external use and of cosmetics containing natural ingredients.

Participants


76

OPG-GS3 PHARMACODYNAMICS 3 Course director: DR. GÁBOR PETHŐ, professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ final exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 24 seminars = total of 48 hours Course headcount limitations (min-max.): min. 5 – Prerequisites: OPG-GH2 completed + OPG-GK4 completed + OPG-GT4 completed

Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the endocrine system; chemotherapy of microbial diseases including antibacterial, antifungal drugs, antiviral antiprotozoal, antihelminthic agents, antiseptics and disinfectants; drugs used in chemotherapy of neoplastic diseases; immunosuppressants, immunomodulators, drug treatment of rheumatoid arthritis. Further topics are pharmacogenetics; effects of age, diet and diseases on drug action; drug interactions.





Reading material


Lectures

1 Corticosteroids I Dr. Pethő Gábor 2 Corticosteroids II Dr. Pethő Gábor 3 Corticosteroids III Dr. Pethő Gábor 4 Oestrogens and anti-oestrogens Dr. Pethő Gábor 5 Progestins and anti-progestins Dr. Pethő Gábor 6 Postmenopausal hormone therapy. Hormonal contraceptives Dr. Pethő Gábor 7 Androgens, anabolic steroids and anti-androgens I Dr. Pethő Gábor 8 Androgens, anabolic steroids and anti-androgens II Dr. Pethő Gábor 9 Thyroid hormones, antithyroid drugs I Dr. Sághy Éva 10 Thyroid hormones, antithyroid drugs II Dr. Sághy Éva 11 Hypothalamic and pituitary hormones I Dr. Pethő Gábor 12 Hypothalamic and pituitary hormones II Dr. Pethő Gábor 13 Hypothalamic and pituitary hormones III Dr. Pethő Gábor 14 Insulin, oral hypoglycaemic agents I Dr. Pethő Gábor 15 Insulin, oral hypoglycaemic agents II Dr. Pethő Gábor


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16 Insulin, oral hypoglycaemic agents III. Glucagon Dr. Pethő Gábor 17 Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteoporosis I Dr. Sághy Éva 18 Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteoporosis I Dr. Sághy Éva 19 Drugs used in neoplastic diseases I Dr. Pethő Gábor 20 Drugs used in neoplastic diseases II Dr. Pethő Gábor 21 Drugs used in neoplastic diseases III Dr. Pethő Gábor 22 Drugs used in neoplastic diseases IV Dr. Pethő Gábor 23 Immunosuppressants and immunomodulators Sánticsné Dr. Pintér Erika 24 Drugs used to treat rheumatoid arthritis Sánticsné Dr. Pintér Erika

Practices

Seminars

1 Basic principles of antimicrobial chemotherapy 2 Sulphonamides and trimethoprim 3 Fluoroquinolones 4 Beta-lactam antibiotics I 5 Beta-lactam antibiotics II 6 Beta-lactam antibiotics III. Glycopeptide antibiotics 7 Aminoglycosides 8 Macrolide antibiotics 9 Tetracyclines, chloramphenicol 10 Linezolid, clindamycin, metronidazol 11 Antituberculotic drugs 12 Anti-leprosy drugs 13 Antifungal drugs I 14 Antifungal drugs II 15 Antiviral drugs I 16 Antiviral drugs II 17 Antiprotozoal drugs I 18 Antiprotozoal drugs II 19 Anthelminthic drugs I 20 Anthelminthic drugs II 21 Antiseptics and disinfectants I 22 Antiseptics and disinfectants II 23 Pharmacogenetics, pharmacogenomics 24 Effects of age, diet and disease on drug action. Drug interactions


1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated by physicochemical interactions)

2. Characterisation of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy 3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs 4. Mechanisms of drug antagonisms 5. Transport of drugs across membranes 6. Absorption of drugs, oral bioavailability and presystemic elimination 7. Plasma protein binding and tissue distribution of drugs 8. Biotransformation of drugs 9. Excretion of drugs


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10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses

11. Drug development 12. Harmful effects of drugs and their mechanisms 13. Factors influencing drug effects: genetic constitution, age, diet, disease 14. Drug interactions 15. Cholinergic agonists and cholinesterase inhibitors 16. Muscarinic receptor antagonists 17. Neuromuscular blocking agents. Drugs acting on autonomic ganglia 18. Agents acting on the biosynthesis, storage, release and elimination of catecholamines 19. Adrenergic receptor agonists 20. Adrenergic receptor antagonists 21. Local anaesthetics 22. Calcium channel blockers 23. Drugs acting on the renin-angiotensin-aldosterone system 24. Diuretic drugs 25. Positive inotropic and other drugs used to treat congestive heart failure 26. Antianginal drugs. Drugs that increase regional blood flow 27. Antihypertensive drugs 28. Antiarrhythmic drugs 29. Antianxiety and hypnotic drugs 30. Alcohols: pharmacology, toxicology 31. Antipsychotic drugs 32. Antidepressants 33. Central nervous system stimulants. Nootropic drugs 34. Drug treatment of neurodegenerative disorders 35. General anaesthetics 36. Antiepileptic drugs 37. Opioid analgesic drugs: morphine and codeine 38. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists 39. Non-steroidal antiinflammatory drugs: aspirin, paracetamol 40. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol 41. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants 42. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants 43. Drugs used to treat hyperlipoproteinaemias 44. Drugs affecting haemostasis 45. Drugs affecting haematopoiesis 46. Histamine, H1 and H2 receptor antagonists 47. Serotonin, serotonin receptor agonists and antagonists 48. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle 49. Drugs used in bronchial asthma 50. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents 51. Drugs used in the treatment of peptic ulcer 52. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis 53. Laxatives, antidiarrhoeal agents, drug treatment of inflammatory bowel diseases 54. Corticosteroids 55. Oestrogens, antioestrogens, progestins, antiprogestins 56. Postmenopausal hormone therapy and hormonal contraceptives 57. Androgens, anabolic steroids, antiandrogens 58. Thyroid hormones, antithyroid drugs 59. Hypothalamic and pituitary hormones 60. Insulin and oral hypoglycaemic agents. Glucagon 61. Parathyroid hormone, calcitonin and vitamin D, drugs used to treat osteoporosis 62. Sulphonamides and trimethoprim. Fluoroquinolones 63. Beta-lactam antibiotics 64. Glycopeptide antibiotics, aminoglycosides, macrolide antibiotics 65. Tetracyclines, chloramphenicol, linezolid, clindamycin, metronidazol


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66. Antituberculotic drugs. Anti-leprosy drugs 67. Antifungal drugs 68. Antiviral drugs 69. Antiprotozoal drugs 70. Anthelminthic drugs 71. Antiseptics and disinfectants 72. Drugs used in the chemotherapy of neoplastic diseases: alkylating agents, antimetabolites 73. Drugs used in the chemotherapy of neoplastic diseases: alkaloids, antibiotics, hormonal agents, biological therapy 74. Immunosuppressants and immunomodulators. Drug used to treat rheumatoid arthritis In addition to the exam topics, an important part of the exam is questions that aim at assessing the general knowledge of the student.

Participants

Dr. Barthó Loránd (BALIAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Sághy Éva (SAEPABO.PTE), Dr. Sándor Zsolt István (SAZFABO.PTE), Dr. Szitter István (SZIHACO.PTE)


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OPG-KLF CLINICAL PHARMACOLOGY Course director: DR. ERIKA PINTÉR, professor Department of Pharmacology and Pharmacotherapy

1 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 15 lectures + 0 practices + 0 seminars = total of 15 hours Course headcount limitations (min-max.): min. 2 – max. 40 Prerequisites: OPO-KL2 parallel + OPG-HT3 parallel

Topic

In the frame of this one semester subject (15 lectures) students get acquainted with the next clinical pharmacological terms and sections: history of the drug research, rational drug design, preclinical development, safety pharmacology, clinical studies (Phase I-II-III-IV), Good Clinical Practice. Documentation of clinical trials. Practical aspects of clinical studies. Evidence-based medicine.




None

Reading material

Lecture notes made available on Intranet. Atkinson-Abernethy-Daniels-Dedrick-Markey: Principles of Clinical Pharmacology, Elsevier, 2007

Lectures

1 History of drugs Sánticsné Dr. Pintér Erika 2 History of drugs Sánticsné Dr. Pintér Erika 3 Drug discovery and development Dr. Bölcskei Kata 4 Drug discovery and development Dr. Bölcskei Kata 5 Drug discovery and development Dr. Bölcskei Kata 6 Preclinical testing Dr. Bölcskei Kata 7 Preclinical testing Dr. Bölcskei Kata 8 Preclinical testing Dr. Bölcskei Kata 9 Design and conduct of clinical trials Dr. Bölcskei Kata 10 Design and conduct of clinical trials Dr. Bölcskei Kata 11 Design and conduct of clinical trials Dr. Bölcskei Kata 12 GMP, GLP, GCP Dr. Bölcskei Kata 13 GMP, GLP, GCP Dr. Bölcskei Kata 14 Documentation of the clinical studies Dr. Bölcskei Kata 15 Documentation of the clinical studies Dr. Bölcskei Kata


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Practices

Seminars


Written exam based on the lectures

Participants


82

OPG-PMG PROBLEMSOLVING PHARMACY Course director: DR. ERIKA PINTÉR, professor Department of Pharmacology and Pharmacotherapy

2 credit ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 21 lectures + 0 practices + 0 seminars = total of 21 hours Course headcount limitations (min-max.): min. 2 – max. 40 Prerequisites: OPG-GH2 completed + OPG-BFR completed

Topic

Training for the practical aspects of the pharmacist praxis. Discussions of the case reports.




None

Reading material

Lecture notes made available on Intranet

Lectures

1 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Sánticsné Dr. Pintér Erika 2 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Sánticsné Dr. Pintér Erika 3 Tasks of the pharmacist in the treatment of diabetes Sánticsné Dr. Pintér Erika 4 Drug treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Dr. Bölcskei Kata 5 Drug treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Dr. Bölcskei Kata 6 Pharmacotherapeutic problems of respiratory diseases (cough, runny nose, shortness of breath, wheezing, chest pain) Dr. Szitter István 7 Pharmaceutical problems of coagulation disorders (warfarin, heparin therapy, interactions, bleeding) Dr. Szitter István 8 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) Dr. Bölcskei Kata 9 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) Dr. Bölcskei Kata 10 The specific pharmacological problems of pediatrics -1 Sánticsné Dr. Pintér Erika 11 The specific pharmacological problems of pediatrics -2 Sánticsné Dr. Pintér Erika 12 Inflammatory, allergic diseases Sánticsné Dr. Pintér Erika 13 Anxiety, depression, drug abuse Sánticsné Dr. Pintér Erika 14 Support of the antidepressant therapy by the pharmacist Sánticsné Dr. Pintér Erika 15 Pharmacological problems of pain management-1 Dr. Szitter István 16 Pharmacological problems of pain management-2 Dr. Szitter István


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17 Problem solving in the current scope of antimicrobial therapy-1 Dr. Botz Lajos 18 Problem solving in the current scope of antimicrobial therapy-2 Dr. Botz Lajos 19 Medication problems during pregnancy and lactation Dr. Fittler András Tamás 20 Contraception, therapeutic use of drugs for treatment of genitals. Dr. Fittler András Tamás 21 Drugs used for treatment of sensory organs. Dr. Fittler András Tamás

Practices

Seminars


Written exam based on the lectures. Lecture notes made available on Intranet Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Medical treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Pharmacotherapeutic problems of respiratory disease (cough, runny nose, shortness of breath, wheezing, chest pain) Pharmaceutical problems affecting coagulation disorders (warfarin, heparin therapy, interactions, bleeding) Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) The specific pharmacological problems of pediatrics Inflammatory, allergic diseases Anxiety, depression, drug abuse Problems of pharmacological pain management Problem solving in the current scope of antimicrobial therapy Applications of dermatological preparations (rash, itching, peeling, dermatitis, wound care, dry skin) Arising medication problems during pregnancy and lactation Contraception, therapeutic use of drugs for treatment of genitals. Drugs used for treatment of sensory organs.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Bölcskei Kata (BOKFABO.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Szitter István (SZIHACO.PTE), Sánticsné Dr. Pintér Erika (PIEMAAO.PTE)


84

OPG-TOX TOXICOLOGY Course director: DR. BALÁZS FERENC NÉMETI, associate professor Department of Pharmacology and Pharmacotherapy

2 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Course headcount limitations (min-max.): min. 2 – max. 60 Prerequisites: OGG-HT3 parallel + OPG-GK4 completed

Topic

Toxicology as a subject deals with the adverse health effects, including developmental adverse effects and carcinogenic effects, of drugs and other xenobiotics (e.g., pesticides, solvents, metal compounds, toxic gases, chemical warfare agents, mushroom- and plant-derived toxins) caused by overdose or excessive exposure. It describes the manifestations of the harmful effects, the mechanisms involved in the adverse outcome, the major factors influencing the development of toxic injury, the diagnostics of the adverse health effects, as well as their prevention and treatment. The principles and practice of safety evaluation of drugs (toxicity testing) and risk assessment of chemicals are also discussed.


Students are requested to take two multiple choice tests during the semester, and a final test at the end of the semester in the examination period. Their grades will be calculated from their performance (expressed as %) on these three tests. They can acquire 15-15% from the two tests during the teaching period and 70% from the final test. The cumulative score of the three tests should be at least 60% for the passing grade. The student who fails to take one or both tests during the teaching period can collect only 85 and 70%, respectively.


Students missing a lecture can download the teaching material from the website of Department of Pharmacology and Pharmacotherapy. Alternatively, they can use the notes of fellow students who attended the lecture, or may consult with the teacher giving the lecture.

Reading material

1. Teaching material from the CooSpace. 2. Recommended literature: a. Toxicology chapters of Pharmacology textbooks, e.g., Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th edition, 2011: Drug toxicity and Poisoning;

Environmental Toxicology; Rang and Dale’s Pharmacology, 7th edition, 2012: Harmful effects of drugs. b. Casarett & Doulls’ Toxicology, 8th edition, McGraw and Hill, New York, 2013. (A copy of the chapter on „Mechanisms of

Toxicity” by Z. Gregus may be requested from the author.) c. Timbrell, J.A.: Principles of Biochemical Toxicology,. 4th edition. Taylor & Francis, Inc., London, 2008.

Lectures

1 The scope of toxicology. Human intoxications - Occurrence and classification. Causes of poisoning-related death. Dr. Gregus Zoltán 2 Management of the poisoned patients - I. (emergency care, diagnostic procedures) Dr. Gregus Zoltán 3 Management of the poisoned patients - II. (decontamination, antidotes) Dr. Gregus Zoltán 4 Management of the poisoned patients - III. (enhancement of the elimination of toxicants, supportive treatment) Dr. Gregus Zoltán 5 Drug intoxications - I. Dr. Gregus Zoltán 6 Drug intoxications - II. Dr. Gregus Zoltán 7 Drug intoxications - III. Dr. Gregus Zoltán 8 Intoxication with metals - I. Mechanisms of metal toxicity. Protective mechanisms. Metal chelators. Dr. Németi Balázs Ferenc 9 Intoxication with metals - II. Lead, mercury, cadmium. Dr. Németi Balázs Ferenc


85

10 Intoxication with metals - III. Arsenic, chromium, cobalt, nickel, manganese. Dr. Németi Balázs Ferenc 11 Intoxication with pesticides - I. General properties. Insecticides: halogenated hydrocarbons. Dr. Németi Balázs Ferenc 12 Intoxication with pesticides - II. Insecticides: Organophosphates and carbamates. Herbicides. Dr. Gregus Zoltán 13 Intoxication with pesticides - III. Fungicides. Rodenticides. Fumigants. Dr. Gregus Zoltán 14 Intoxication with solvents - I. Benzol, aliphatic hydrocarbons, carbon disulfide. Dr. Németi Balázs Ferenc 15 Intoxication with solvents - II. Alcohols, glycols, halogenated hydrocarbons. Dr. Németi Balázs Ferenc 16 Toxic gases (CO, HCN and cyanogenic compounds, H2S). Dr. Gregus Zoltán 17 Hemolytic chemicals, methaemoglobin-forming chemicals. Dr. Gregus Zoltán 18 Chemical warfare agents - I. Dr. Németi Balázs Ferenc 19 Chemical warfare agents - II. Chemical teratogenesis - I. Dr. Németi Balázs Ferenc 20 Chemical teratogenesis - II. Dr. Németi Balázs Ferenc 21 Chemical carcinogenesis - I. Dr. Gregus Zoltán 22 Chemical carcinogenesis - II. Dr. Gregus Zoltán 23 Toxicity testing and risk assessment - Principles and practices - I. Dr. Gregus Zoltán 24 Toxicity testing and risk assessment - Principles and practices - II. Dr. Gregus Zoltán

Practices

Seminars


All tests will consist of 50-70 multiple choice type questions and a few assay type questions, which are covered by the teaching materials attainable on the CooSpace and/or the oral lectures.

Participants


86

OPG-UI4 PHARMACEUTICAL PRACTICE AND MANAGEMENT 3 Course director: DR. LAJOS BOTZ, professor Dept. of Pharmaceutics and University Pharmacy

5 credit ▪ final exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 24 practices + 12 seminars = total of 60 hours Course headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GI3 completed + OPG-GH2 completed + OPG-GT4 completed

Topic

The lectures of the semester will further outline the pharmaceutical supply system, specific pharmacy practice knowledge in community and clinical professional pharmaceutical practice and care. Students will acquire skills inclunding, evaluating and interpreting reliable pharmaceutical information by getting familiar with the concepts of evidence based medicine and pharmacy informatics. In this semester also interactive discussions will cover essential topics regarding self-medication, patient counselling and over the counter products used in minor diseases. Detailed discussion of pharmacy practice will cover personal and objective criteria of pharmacies, prescribing and dispensing regulations, controlled drugs, ordering and stockpiling drugs. Ensuring medication safety in community and hospital pharmacy setting is a key element of modern pharmaceutical practice, thus the lectures focus on relevant issues. Students will discuss elements of ethical behavior and pharmacy ethics in practice. During the semester the students will become familiar with the basics of personal computer and network systems is general and with the specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy software. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course. Aims of lectures in pharmaceutical studies: The aims of the lectures in pharmaceutical studies are to broaden the pharmaceutical practice and management skills of students, and to generate interest in pharmacy as a profession. Main aim of these studies is to solidify pharmacy practice and related economic, clinical, pharmaceutical care, information technology, ethics knowledge in order to understand pharmacoeconomics, drug allocation, pharmaceutical management, health economics, evidence based medicine, clinical pharmacy services and general pharmaceutics.. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional knowledge. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills. Topics discussed during the lectures, but not included in the notes/books will also be included in the exams. Students can access the slides of the lectures and further reading material on a designated web based interface (CooSpace).





Reading material

All presentations can be downloaded from CooSpace. C. Bond (ed.): Evidence-based Pharmacy, Pharmaceutical Press, London, 2002. A. J. Winfield, R. M. E. Richards (eds.): Pharmaceutical Practice, Churchill Livingstone C. H. Knowlton, R. P. Penna (eds.): Pharmaceutical Care, ASHSP M. Stephens (ed.): Hospital Pharmacy, Pharmaceutical Press, London, 2006. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 16th edition, American Pharmacists Association,

2009. Walker, Roger: Clinical Pharmacy and Therapeutics, 2011. Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional

Supplementation, Section XI: Complementary and Alternative Medicine. Edzard Ernst, Simon Singh: Trick or Treatment? Alternative Medicine on Trial Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists

Association, 2010


87

Lectures

1 Hospital pharmacy services Dr. Takács Gábor 2 Clinical pharmacy services 1. Dr. Takács Gábor 3 Clinical pharmacy services 2. Dr. Vida Róbert György 4 Drugs in pregnancy and lactation Dr. Takács Gábor 5 Pharmaceutical Care: Geriatrics Dr. Takács Gábor 6 Pharmaceutical Care: Neonates and paediatrics Dr. Takács Gábor 7 Antidotes for toxicological emergencies Dr. Vida Róbert György 8 Oncology pharmacy Dr. Takács Gábor 9 Patient safety in clinical practice Dr. Fittler András Tamás 10 Volume therapy Dr. Takács Gábor 11 Pharmaceutical care in infectology Dr. Takács Gábor 12 Assuring medication safety in community pharmacy practice Dr. Fittler András Tamás 13 Controlled drugs - prescribing and dispensing regulations, international treaties. Dr. Vida Róbert György 14 Monitoring medication safety. Dr. Fittler András Tamás 15 Ordering, procurement, stockpiling and storing. Dr. Vida Róbert György 16 Personal and objective criteria for pharmacies. Dr. Fittler András Tamás 17 Detailed introduction to the dispensing practice. Dr. Fittler András Tamás 18 Evaluating Clinical Trials from the aspect of EBM. Dr. Takács Gábor 19 Fundamentals of EBM and Clinical Epidemiology I. Dr. Takács Gábor 20 Evidence-based Practice. Most important internet databases Dr. Takács Gábor 21 How to formulate a question, searching strategy, evaluate methods, evaluate results, conclusions Dr. Fittler András Tamás 22 Principles of critical appraisal Dr. Fittler András Tamás 23 Interpreting results Dr. Fittler András Tamás 24 Test Dr. Botz Lajos


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Practices

1 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 1. 2 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 2. 3 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 3. 4 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 4. 5 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 5 . 6 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 6. 7 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 7. 8 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 8. 9 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 9. 10 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 10. 11 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 11. 12 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 12. 13 Drug interactions 1. 14 Drug interactions 2. 15 Drug interactions 3. 16 Drug interactions 4. 17 Practical use of Evidence-based Practice 1. 18 Practical use of Evidence-based Practice: Answering therapeutic questions 1. 19 Pharmaceutical Ethics 1. 20 Pharmaceutical Ethics 2. 21 Personal computer and network systems fundamentals. 22 Pharmacy information management systems. 23 Drug marketing on the web. Finding pharmaceutical information. 24 Development and stages of pharmacy informatics. Principles of pharmacy software. Different software types used in

pharmacies, drug dispensing rules.

Seminars

1 Seborrheic dermatitis, psoriasis 2 Allergy and contact dermatitis 3 Vaginal and vulvovaginal disorders 4 Fungal skin infections, Athlete’s foot 5 Headache and migraine 6 Disorders related to colds 7 Cough and expectorants 8 Fever 9 Dyspepsia, heartburn and intestinal gas 10 Diarrhoea and constipation 11 Practical use of Evidence-based Practice: Answering therapeutic questions 2. 12 Practical use of Evidence-based Practice 2.



Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Takács Gábor (TAGSAAP.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


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OPO-KL2 CLINICAL STUDIES 2 Course director: DR. ERIKA PINTÉR, professor Department of Pharmacognosy

5 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 60 lectures + 0 practices + 0 seminars = total of 60 hours Course headcount limitations (min-max.): min. 2 – Prerequisites: OPO-KL1 completed

Topic

The task of the subject is the transmission of the most fundamental knowledge of the clinical studies for the pharmacy students. The curriculum covers the most important diseases focusing on their pharmacotherapy. The task of this subject to promote the accurate knowledge pharmacotherapy in the clinical practise.




None

Reading material

Lecture notes

Lectures

1 Gestation time, pregnancy diagnosis, growth of the uterus during pregnancy. Uncomplicated spontaneous labor. Disorders of pregnancy: hyperemesis gravidarum, abortion.

Dr. Kovács Kálmán András 2 Ultrasound examinations during pregnancy. Procedures for assessment of the status of the fetus in utero. Location of the fetus

in utero and its diagnosis. Dr. Kovács Kálmán András 3 Laying, holding, rotational and integration abnormalities. Natal complications: breech, vacuum forceps, sectio Caesara,

preterm birth, preeclampsia, diabetes and pregnancy, placenta praevia, abruptio placenta, preterm rupture. Dr. Kovács Kálmán András 4 Contraception. Gynecological inflammations. Sterility testing and management. Dr. Kovács Kálmán András 5 Cancer screening, gynecologic cancers (cervical and endometrial cancer, ovarian cancer). Benign tumors of the uterus

(myoma). Dr. Kovács Kálmán András 6 Growth and development during childhood. Dr. Györgyi Csábi Dr. Csábi Györgyi 7 Infant nutrition. Dr. Györgyi Csábi Dr. Csábi Györgyi 8 The bacterial infections in pediatric care practice. Dr. Györgyi Csábi Dr. Csábi Györgyi 9 Exsiccatio, fluid replacement, oral rehydration. Antifebrile therapy, treatment of convulsion. Dr. Györgyi Csábi Dr. Csábi Györgyi 10 Neurological disease symptoms, peripheral and central nervous system disorders. Dr. Pál Endre 11 Stroke. Dr. Pál Endre 12 Encephalitis and meningitis, intracranial and spinal tumors. Dr. Pál Endre 13 Multiple sclerosis, Parkinson’s disease, epilepsy. Dr. Pál Endre 14 Peripheral nervous system diseases, myopathies. Dr. Pál Endre 15 Examination of psychiatric patient. Dr. Tényi Tamás


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16 Organic mental disorders. Dr. Tényi Tamás 17 Endogenous psychoses. Dr. Tényi Tamás 18 Non-psychotic psychiatric disorders. Psychiatric therapies. Dr. Tényi Tamás 19 Ear, nose, laryngology. The outer and middle ear. Dr. Bauer Miklós 20 The inner ear. Audiological and vestibular basics. Dr. Bauer Miklós 21 The nose. Dr. Bauer Miklós 22 The pharynx. Dr. Bauer Miklós 23 The larynx, trachea, esophagus and neck. Dr. Bauer Miklós 24 Basics of preventive dentistry, pediatric dentistry. Dr. Balásné Dr. Szántó Ildikó 25 Oral surgery treatments, pain relief. Dr. Balásné Dr. Szántó Ildikó 26 Restorative dental treatments. Dr. Balásné Dr. Szántó Ildikó 27 Basics of prosthodontics. Dr. Balásné Dr. Szántó Ildikó 28 Dental development, orthodontic anomalies, drug-induced dental lesions. Dr. Balásné Dr. Szántó Ildikó 29 Orthopedic examination possibilities, orthopedic screenings, pediatric orthopedic disorders. Dr. Tunyogi Csapó Miklós 30 Large joint diseases and their medical and surgical management Dr. Tunyogi Csapó Miklós 31 Spinal diseases and their conservative and surgical treatment. Dr. Tunyogi Csapó Miklós 32 Joint injuries and their pharmacological and surgical treatment. Dr. Tunyogi Csapó Miklós 33 Orthopedic surgery perioperative complications, prevention, and treatment. Dr. Tunyogi Csapó Miklós 34 Drugs for treatment of urine storage and emptying disorders. Dr. Damásdi Miklós 35 Medical treatment of uro-oncological diseases. Dr. Damásdi Miklós 36 Medical treatment of erectile dysfunction. Dr. Damásdi Miklós 37 Medical aids in urological practice. Dr. Damásdi Miklós 38 Urologic clinics of stone diseases and its drugs. Dr. Damásdi Miklós 39 The structure of skin, essential phenomena. Dr. Kinyó Ágnes 40 Infectious skin disease, pyoderma, bacterial, viral and fungal diseases. Dr. Kinyó Ágnes 41 STD diseases and sexual health care. Dr. Kinyó Ágnes 42 Dermatological tumors. Immunpathological disorders in dermatology. Dr. Kinyó Ágnes 43 Eye examination of the patient. (The functional anatomy of the organ of vision, functional and morphological methods of

analysis.) Dr. Varsányi László Balázs


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44 Chronic eye diseases (glaucoma, cataracts, age-related macular degeneration, symptomatology, basic examinations, interpretation of findings, therapy).

Dr. Varsányi László Balázs 45 Acute ocular diseases. (Symptomatology, basic examinations, interpretation of findings, therapy). Dr. Varsányi László Balázs 46 Childhood eye diseases. Ocular symptoms of general disorders. Neuroophthalmology. Dr. Varsányi László Balázs 47 Traumatology in ophthalmology and intraocular tumors. Dr. Varsányi László Balázs 48 Treatment of spondylarthritis. Treatment of gout. Treatment of infection-triggered arthritis. Dr. Sütő Gábor 49 Non-biological and biological base therapeutic drugs in rheumatoid arthritis. Dr. Sütő Gábor 50 Rules of the utilization of non steroidal antiinflammatory drugs in rheumatology and clinical immunology. Management of

acute and chronical pain in rheumatology. Dr. Sarlós Gézáné 51 Pharmacological treatment of osteoporosis. Dr. Sarlós Gézáné 52 Treatment with corticosteroids and cytostatic agents in autoimmun diseases. Dr. Czirják László István 53 The primary care of cancer patients, the TNM system, prognostic factors and onkoteam decision. Dr. Mangel László 54 The principles and practice of radiochemotherapy. Dr. Bellyei Szabolcs 55 The clinical implications of chemotherapy and Dr. Karádi Oszkár 56 Modern targeted therapies and basics of hormone replacement therapy. Dr. Karádi Oszkár 57 The practice of supportive therapy in oncology. Dr. Boronkai Árpád 58 Specificity of General Practice, the holistic approach. Dr. Bán Ildikó 59 Physician-pharmacist relationship. Team work. Role-playing. Dr. Ágnes Csikós Dr. Bán Ildikó 60 GP office and staff. Pharmacist-patient relationship. Dr. Bán Ildikó

Practices

Seminars


Written exam based on the lectures.

Participants


92

OPO-KLV CLINICAL LABORATORY INVESTIGATIONS Course director: DR. TAMÁS ANTAL KŐSZEGI, associate professor Institute of Laboratory Medicine

2 credit ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Course headcount limitations (min-max.): min. 1 – Prerequisites: OPO-KL2 parallel + OPO-IMM completed + OPO-KOT completed

Topic

Clinical Laboratory Investigations is a subject based on a solid knowledge in chemistry, biochemistry and physiology. It gives a practical guide to understand and interpret a wide variety of modern laboratory tests by showing the molecular basis of them. The subject includes classic chemical and biochemical methods, immunochemistry, hematology, blood coagulation, toxicology and molecular biology. The major methodological aspects and applications are discussed during the lectures.




An absence rate of less than 25% is acceptable, no medical or other certificate is necessary.

Reading material

W.J. Marshall, S.K. Bangert: Clinical Chemistry, 5th ed., Mosby Co, 2004, ISBN 0723433283 G.J. Beckett, S.W. Walker, P. Rae, P. Ashby: Lecture Notes on Clinical Biochemistry, 7th ed., Blackwell Co., 2005 W.J. Marshall, S.K. Bangert: Clinical Chemistry 6th ed., Mosby Co, 2008 ISBN 9780723434559

Lectures

1 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. Different factors influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches).

Dr. Kőszegi Tamás Antal 2 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. Different factors

influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches). Dr. Kőszegi Tamás Antal 3 Different laboratory approaches in water and electrolyte disorders. Internal and external quality controls. Dr. Kőszegi Tamás Antal 4 Different laboratory approaches in water and electrolyte disorders. Internal and external quality controls. Dr. Kőszegi Tamás Antal 5 Analysis of plasma proteins. Separation techniques and basis of immunochemical methods. Dr. Kőszegi Tamás Antal 6 Analysis of plasma proteins. Separation techniques and basis of immunochemical methods. Dr. Kőszegi Tamás Antal 7 Analysis of plasma enzymes. Routes of release of enzymes into the extracellular space. Enzymes as tissue markers. Dr. Kőszegi Tamás Antal 8 Analysis of plasma enzymes. Routes of release of enzymes into the extracellular space. Enzymes as tissue markers. Dr. Kőszegi Tamás Antal 9 Carbohydrate metabolism and laboratory tests in endocrine diseases. Dr. Kőszegi Tamás Antal 10 Carbohydrate metabolism and laboratory tests in endocrine diseases. Dr. Kőszegi Tamás Antal 11 Laboratory diagnostics of cardiac and skeletal muscle diseases. Inherited and acquired disorders. Importance of the half-life

of tested parameters. Dr. Kőszegi Tamás Antal 12 Laboratory diagnostics of cardiac and skeletal muscle diseases. Inherited and acquired disorders. Importance of the half-life

of tested parameters. Dr. Kőszegi Tamás Antal


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13 Iron, porphyrin and hemoglobin metabolism. Automated immunochemical measurements. Dr. Kőszegi Tamás Antal 14 Iron, porphyrin and hemoglobin metabolism. Automated immunochemical measurements. Dr. Kőszegi Tamás Antal 15 Disorders of lipid metabolism. Automated hematological analyses. Dr. Kőszegi Tamás Antal 16 Disorders of lipid metabolism. Automated hematological analyses. Dr. Kőszegi Tamás Antal 17 Acid-base balance. Methods and interpretation of test results. Dr. Kőszegi Tamás Antal 18 Acid-base balance. Methods and interpretation of test results. Dr. Kőszegi Tamás Antal 19 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases. Dr. Kőszegi Tamás Antal 20 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases. Dr. Kőszegi Tamás Antal 21 Laboratory tests in kidney diseases. Tumors and tumor markers. Dr. Kőszegi Tamás Antal 22 Laboratory tests in kidney diseases. Tumors and tumor markers. Dr. Kőszegi Tamás Antal 23 Different approaches in liver and gastrointestinal diseases. Basic methods in investigation of disorders in hemostasis. Dr. Kőszegi Tamás Antal 24 Different approaches in liver and gastrointestinal diseases. Basic methods in toxicology and interpretation of results. Dr. Kőszegi Tamás Antal

Practices

Seminars


In every new semester new multiple choice questions are to be worked out.

Participants


94

OPS-SG3 PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 1 Course director: DR. KLÁRA MAYER, assistant professor Department of Pharmacotechnology

4 credit ▪ midsemester grade ▪ Final/Rotational (year) module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 0 lectures + 320 practices + 0 seminars = total of 320 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GH1 completed + OPG-GI2 completed + OPR-SG2 completed

Topic

Two month of course Pharmacy Practice 3 is the first part of the 6 month of practice in the rigorous year. Aim of the first part of rigorous year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing the aspects of pharmaceutical care, economy and preparing magistral medicines in the pharmacy. The 6 months are the 6 thematic, from this 1-3 parts must in the 2 months 2 part in the Professional Practice Before state Examination I. The practice 2 months can be homeland or Hungarian or foreign countries pharmacy.


Brief daily report must be done during the practice which has to be presented. Tutor pharmacist and chief pharmacist has to evaluate students work and confirm the pharmacy practice with their signature. Student must work daily 8 hours during two month of practice. Proposal in the Hungarian pharmacy practice with Hungarian Student together.


During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented.

Reading material

European Pharmacopoeia International pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices

1.a) Clinical pharmacy 1.parts Knowing the structure of hospital/clinic Studying the relationship between the pharmacy and other wards Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy under the supervision of the tutor pharmacist Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Pharmaceutical economy, ordering medicines Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory continuation „Clinical pharmacy 2.parts” ..


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2. Public pharmacy operation Public pharmacies’ measures concerning drug supply In the pharmacy’s farming tasks truth participation The acquisition of management, technical knowledge Medicine farming: the procession of the medicine order The preparation of medicine orders Contacts, information, the examination of orders, complaints lasted with the medicine wholesalers With the implements to be checked increased related knowledge and tasks In the course of the waste product, the returns, a damage truth tasks It is related to changes in price tasks The closings: daily, weekly, snow end ill. OEP meanings The knowledge of measures, bulletins A drawer pharmacy’s, „kézigyógyszertár” concepts, knowledge, tasks The knowledge of the officinal literature The acquisition of the officinal computer program with a skill level ..

3. Pharmaceutical practice, receipt, preparate

The accomplishment of the medicine making processes turning up in the pharmacy with the management of a teaching chemist The pharmacy’s inner cheque activity in the process of the medicine making Unique praescriptions his cognition, his completion, their comparison the official one with praescriptions Pharmacopoeia, FoNo Laboration concept, the differences of processes, completions the unique one prescriptions his making, documentation His Manual cognition, his application and prescription his editing The nomenclature of the stocks, regular pharmacopoeia full Latin ill. his abridged name Medicine cheque: the incoming medicines, stocks, basis artefacts, vegetal drugs, bandages, etc. his regular receipt The the examination of stocks and his documentation arrived The laboured the cheque of artefacts (pl. 70% Ethanolum, Sirup. simplex) The aseptic working in the pharmacy, a principle, practice Sterile, documentation, sterile apparatus cheque The recognition of incompatibilities, correct completions, physical, chemistry, kolloidikai the reasons of incompatibilities and technological solutions

1.b)”Clinical pharmacy 2.parts”

Directives of the pharmacy Studying pharmaceutical literature Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Knowing basic databases used in clinical pharmacy Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Participating in works on different divisions of the pharmacy (labelling, packaging, etc.) Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy under the supervision of the tutor pharmacist Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions) Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale Pharmaceuticum Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Participating in ordering of drugs on-line and off-line Studying relationship with pharmaceutical manufacturers and distributors


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Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Studying pharmaceutical literature Knowing basic databases used in clinical pharmacy Knowing the system of quality assurance Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.

Participants



97

OPS-SG4 PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 2 Course director: DR. KLÁRA MAYER, assistant professor Department of Pharmacotechnology

14 credit ▪ midsemester grade ▪ Final/Rotational (year) module ▪ spring semester ▪ recommended semester: 10 Number of hours/semester: 0 lectures + 640 practices + 0 seminars = total of 640 hours Course headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OGG-HT3 completed + OP-GUI4 completed + OPG-GT4 completed

Topic

Aim of the first part of rigorous year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing the aspects of pharmaceutical care, economy and preparing medicines both in the public pharmacy (3 months)and in clinical/hospital (1 months)pharmacies. This course is expanded with practice in clinical/hospital pharmacies in order to learn the tasks and connections of the pharmacy with other wards of the hospital. The 6 months have 6 thematik, one thematik 1-1 months time. Proposal in the Hungarian pharmacy practice with Hungarian Student together.


Brief daily report must be done during the practice which has to be presented. Tutor pharmacist and chief pharmacist has to evaluate students work and confirm the pharmacy practice with their signature. Student must work daily 8 hours during two month of practice. The practice 4 months must in the Hungarian pharmacy.


During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented.

Reading material

European Pharmacopoeia International pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices

1. Clinical pharmacy Knowing the structure of hospital/clinic Studying the relationship between the pharmacy and other wards Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Participating in works on different divisions of the pharmacy (labelling, packaging, etc.) Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy under the supervision of the tutor pharmacist Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Pharmaceutical economy, ordering medicines Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Participating in ordering of drugs on-line and off-line Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory Directives of the pharmacy


98

Studying pharmaceutical literature Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Knowing basic databases used in clinical pharmacy Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Participating in works on different divisions of the pharmacy (labelling, packaging, etc.) Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy under the supervision of the tutor pharmacist Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions) Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale Pharmaceuticum Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Participating in ordering of drugs on-line and off-line Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Studying pharmaceutical literature Knowing basic databases used in clinical pharmacy Knowing the system of quality assurance Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy ..

2. Public pharmacy operation Public pharmacies’ measures concerning drug supply In the pharmacy’s farming tasks truth participation The acquisition of management, technical knowledges Medicine farming: the procession of the medicine order The preparation of medicine orders, Contacts, informations, the examination of orders, complaints lasted with the medicine wholesalers With the implements to be checked increased related knowledge and tasks In the course of the waste product, the returns, a damage truth tasks It is related to changes in price tasks The closings: daily, weekly, snow end ill. OEP meanings The knowledge of measures, bulletins A drawer pharmacy’s, „kézigyógyszertár” concepts, knowledge, tasks The knowledge of the officinal literature The acquisition of the officinal computer program with a skill level ...


99

3. Pharmaceutical practice, receipt, preparate The accomplishment of the medicine making processes turning up in the pharmacy with the management of a teaching chemist The pharmacy’s inner cheque activity in the process of the medicine making Unique praescriptions his cognition, his completion, their comparison the official one with praescriptions (Pharmacopoeia, FoNo) Laboration concept, the differences of processes, completions the unique one prescription his making, documentation His Manual cognition, his application and előirat his editing The nomenclature of the stocks, regular pharmacopoeia full Latin ill. his abridged name Medicine cheque: the incoming medicines, stocks, basis artefacts, vegetal drugs, bandages, etc. his regular receipt The examination of stocks and his documentation arrived The laboured the cheque of artefacts (pl. 70% Ethanolum, Sirup. simplex) The aseptic working in the pharmacy, a principle, practice Sterile, documentation, sterile apparatus cheque The recognition of incompatibilities, correct completions, physical, chemistry, kolloid reasons of incompatibilities and technological solutions ..

4. Medicine wholesale (expedition), officinal quality assurance

The pharmacy’s inner cheque activity in the processes of the medicine wholesale The acquisition of the officinal computer program with a skill level The categories of storage, storage, his documentations, the cold chain chekd his process The cognition of the medicines, replaceabilities, strength / cross marks The prescription in the case of his regularity, formal deficiencies the tasks The treatment of veterinary science prescriptions The artefacts which can be received without the prescription (OTC) his concept, knowledge, dispatching The groups of products which can be distributed in a pharmacy, his knowledge The recognition of incompatibilities, on emphasized one the pharmacology incompatibilities, tasks, solution opportunities Solutions according to Polipragmazia cognition, hygienic viewpoints – contact with doctors, patients The expense of artefacts to be checked increased, his documentations The significance of the retaxa and his practice Correct communication towards the patients in a principle and the practice The knowledge of the officinal quality assurance system ...

5. Medicine- pharmaceutical review

Officinal literature, technical books the knowledge of journals, his availability Correct communication towards the hygienic specialists Hygienic counsel towards different age groups (school, caretaker at home) Pedigreed medicines, nutritions, bandages, therapeutic equipment, his knowledge The artefacts which can be received without the prescription (OTC) his concept, knowledge, dispatching The groups of products which can be distributed in a pharmacy, his knowledge For the officinal employees medicine review from an actual artefact (recording, in the framework of inner professional development) The correct assessment of homoeopathic prescriptions, products, his conceptual and practical knowledge ..

6. Pharmacist nurture

The cognition of the legal regulation being attached to the chemist nurture The levels of the chemist nurture, the conditions of his order Pharmaceutical Nurture Committee characters, his tasks Good Pharmacy Practice (GPP) the knowledge of his governing principles Elementary level chemist medicine safety cheque made in the framework of nurture vocational governing principle applying his knowledge and practical one For the International Classification of the illnesses (in Hungarian BNO) his knowledge


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BNO being found the most mostly the cognition of codes The resuscitation of the pathologic and clinical knowledge of illnesses Self-therapy the information of his concept, his practice, patients Officinal literature, technical books the knowledge of journals, his availability ..

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.

Participants


study program 2014/2015 subjects of the 5-10. semesters ...€¦ · up ms pharmacy major – 5-10th...

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