Subject Index

abscess 280 acetyl salicylic acid

386, 387 233, 377,

acute febrile mucocutaneous lymph node syndrome 152

acute phase protein 127 adeno virus 191, 438 adenyl cyclase 291, 385 adjuvant 108, 183

see also Freund's adjuvant adjuvant arthritis 220, 290, 372,

400 adrenalectomy 396 adrenalitis 437 agammaglobulinaemia 18 agglutinator 164

see also antibody agonists

autonomic - 20 autopharmacological 20

albumin albumin/globulin ratio 252 bovine serum - 28, 34, 86,

94, 124, 158 125J-labelled 29, 95

egg white - 141, 165 human serum - 107, 132, 165,

182, 198 125J -labelled 107, 182

in mycoplasma infection 251 aldosterone 259, 288 Aleutian mink disease 152

- virus 191 ALG

see anti-lymphocyte serum alkylation 395 allantoic fluid 241 allergic response

antibody-mediated 6, 34, 44 auto-allergic - 123, 141 cell-mediated 6, 17, 34, 44, 53,

118, 140 detection of auto-allergic - 141

to drugs site of -type I -

82 391

439 allergic rhinitis 82 Allison-Ghormley bodies 278 allogeneic cells 193, 395 allogeneic effect 53, 432 allogeneic factor 432 amino acid

- transport 399 - tRNA binding 411

£-aminocaproic acid 138, 321 amniotic fluid 241 amyloid 74, 338

birefringence 342 deposi ts 339 - fibrils 74

anaphylactoid reactions 229 anaphylatoxin 100 anaphylaxis 96, 97, 122

shock 97 trigger 96

anemia 212, 243 autoimmune hemolytic - 52, 59,

71, 109, 402 anergy 397 aneurysma 154 angiitis

leucocytoclastic - 97 angioneurotic oedema 156 ankylosis 216, 293 antibiotics 233, 239, 259, 279, 304,

379, 400 antibody

affini ty 107 antibacter ial 119 anti Clq 129 anti C3 95, 198, 215 anti C4 198 anti HBs 198 anti-IgA 173 anti-IgG 85, 121, 167 anti-IgM 173

444

antibody anti-glomerular basement membrane

99 anti-immunoglobulin 118, 156,

197, 431 anti-macrophage 263 anti-microsomal 438 anti-nuclear 52, 71, 109, 197,

202, 423 anti-nucleic acid 191, 434 anti-salivary duct 346 anti-streptococcal 259, 440 anti-thyroglobulin 156, 438 anti-tissue - 422 autoantibody 49, 59, 200, 291,

345 autologous 265 avidity 111 BSA 95 chondroitin-sulfate 284 circulating - 49, 283 cold-reactive 153 collagen 216, 218, 437 complement-fixing - 281 C-polysaccharide 259, 263 cross-reacting - 200 DNA 55, 110, 433 DNAse B 259 double stranded DNA 55, 109 erysipelothrix bacteria 216, 238 erythrocytes 52, 203 fibrin 33 fluorescein-labelled - 95, 215,

238, 278 gelatin 437 y-chain 55 heterophil - 432 high affinity - 108, 433 HSA 182 125J-labelled - 278 local production 98 low affinity - 107, 108, 433 lymphocytes 52, 434 lymphocytotoxic - 204 ]..I-chain 55 native DNA 72, 109 natural - 164 neutralising - 439 N. meningitidis 182 non-precipitating - 164 P30 (feline) 74 peroxidase-labelled - 215 poly A 56 production 395 RF-like - 178 RNA 53, 433 RNA viral envelope antigen 74

7S- 53, 54, 250 19S- 53, 54, 250 SP 104 virions 74 stabilizing - 281 streptolysine 0 259 streptozyme 259 thymocytes 52 transferrin 110, 202

antigammaglobulins see rheumatoid factor

antigen -aggregated - 158 auto-antigen 124, 136, 143, 384,

437 bacterial - 118, 146, 384 bacterial somatic - 122 C-type viral - 60, 75 cross-reacting - 212 endogenous - 373, 423, 436 exogenous - 202, 422 foreign - 373 group-specific - 60, 212 HBs - 198 histocompatibility - 65, 66 host-coded - 189 interspecies-specific - 60 iodination 42 KB cell DNA - 55 local - 33 mesangial localization 158 mycoplasma - 241 non-biodegradable - 422 persistence of - 4, 114, 269,

278, 291, 373, 384, 422, 423 phagocytosis of - 373 reovirus - 212 - residues 425 rho- 200 seggregated - 200 "self" - 424 sequestration of - 374 soluble - 28 streptococcal - 119 systemic distribution 43 thymus-dependent 57 tissue - 422 transformation of lymphocytes 334 transport 43 trapping 4 type-specific - 60 ubiquitous 425 vascular localization 158 viral 53, 189, 424 virus-coded 189, 201 virus-induced 189, 201

antigen-antibody complexes see immune complexes

antigen elimination see immune elimination

antigenic stimulation, local -34

anti globulins see rheumatoid factor

antiinflammatory drugs see also drugs effect on connective tissue

metabolism 441 side-effects 419

anti lymphocyte serum 52, 84, 204, 397, 434

antimetabolites 401 antinuclear factor

see an tibody antitrypsin 198 arachidonic acid 259, 289, 381 arboviruses 196 Arteparon 411 arterioles 196 arteriolitis 119 arteritis 95

complement- and neutrophil-dependent 100

equine viral - 152 granulomatous - 119 immune complex-induced - 98, 100

arthritis allergic - 10 chlamydial - 425 chronic erosive - 12 chronic proliferative - 238 experimental - 243, 265 erysipelothrix - 221, 238, 425 immune complex-induced - 100,

182, 183, 196 arthritogenicity 238 Arthus reaction 5, 98, 100, 117,

146, 158 articular index 370 asparaginase 398 aspirin 377, 387

reduction of lymphocyte activity 387

athymic mouse 57 aurothiomalate 193 auto-immunity 52, 67, 98, 109, 178,

239, 258, 391, 430, 436 expression of - 435 predisposition to - 433 reversible - 431 short-lived - 431

autoradiography 42, 183, 305, 327 autosensitization 143 azathioprine 305, 316, 370, 392

413

445

bacterial cell wall fragments 238, 258, 290, 384 persistence of - 422

bacterial remnants 426 non-digestible 427

bacteriemia 220, 261 basement membrane 74, 154, 196, 437

deposits of Ig and C3 154 vascular - 131

see complement components B-cell

see also lymphocytes antibody forming precursor 431 antibody-releasing - 431 extravascular - 392 immunocompetent - 346 infected - 432 - nitrogens 64 transformed - 346

BCG 329 see also Mycobacteria

Behcets disease 82 biodegradation 353 bis-diazo-benzidine 132 blood cells 391 body weight

reduction of - 233 bone

destruction of - 261 erosion of - 11, 198, 245 - resorption 376

bone marrow 331, 430 - cells 398

Bordetella pertussis 372, 427 bowel disease 425 Boyden chamber 132 5-bromo-deoxyuridine 64, 195 bronchi tis 343 B-type virus 59 buffy coat leucocytes 142, 249 Burkitt's lymphoma 431 bursectomy 18 butazolidin 370

see also phenylbutazone

candida 121 carbon 427 cardiotoxin 292 carrageenan 42?, 429

- induced oedema 372, 386 cartilage

articular - 28, 183, 244, 269 degradation of polysaccharide 280 destruction 32, 169, 216, 352 energy metabolism 408

446

cartilage enzyme digestion 196 erosion 11, 198, 257 fibro - 213 fibrous structure 352 hyaline - 263 proliferating 269

cathepsin D 164, 287, 293, 377, 413 digestion of IgG by - 165 isolation of - 165

C2 - deficiency 157 cell culture 188 cell cycle

determ. of time 306 G2 -phase 317 Go-phase 330 metaphase 328 S-phase 317

cell debris 80, 264, 302 cell fusion 329 cell kinetics 328

- of chronic inflammation 329 - of macrophages 328

cell lines Chang liver - 196 D17 (Dog sarcoma -) 195 HeLa - 111, 196 HTI (Hamster transformed -) KB - 54 LLC-MK2 - 195 118 MGEH (human glioma -) SP104 - 73, 204 V3A - 80 vero - 78 XC - 195

cell-mediated immunity 17, 34, 53, 189, 249, 265, 290, 372, 376, 428

chemotaxis 133, 371, 376 chemotactic factor 100, 140, 321,

428 C5a 100 C567 100 generation of - 290 mononuclear - 282 - neutrophil granulocytes 100,

133, 376 chloramine - T method 42, 86 chloramphenicol 400 chloroquine 418 cholera toxin 396 chondrocytes 196, 257

fusion of - 196 rabbit embryo - 196

chondroitin 406 antibodies to - 284

hybrids with keratan sulfate 406 - sulfate 284, 406, 408

chondroitin sulfotransferase 408 chondrolysis 261 chorea 256 chorio-allantoic membrane 241 chromatin 303, 332 chromosome 328 clotrimazole 370 coacervates

polylysine/hyaluronate 354 resistance to enzymic digestion

360 coagulation 155

intravascular - 152 - factors 216, 230, 321 assays of - 216 - crisis 233

coagulopathy 221 fibrin-rich - 222 hyaline - 222, 224

colcemid 36 colchicine 328 colitis

arthri tic - 425 ulcerative - 392, 402

collagen 437 biosynthesis 370 degradation 123, 377, 384 distribution 407 - fibres 407 interaction with proteoglycan

409 type I 408 type II 408

collagenase 290, 292, 302, 330, 377, 428 secretion from macrophage 330

colony stimulating factor 321 complement 52, 96, 118, 155, 189,

215, 222 - activated 117, 131 - activation 156, 290 altered - 156 anaphylatoxin 100 canine - 74 chemotactic factors 100 classical pathway 128 - depletion 97 - deposition 130 - fixation 60

complement components 20, 109, 153, 192, 265, 279, 302, 321 ilIA 156 ill C 74, 153, 156, 184 CI 129, 154 Clq 153, 157, 182, 198

complement components C3 100,156,182,198,367,440 C3a 100 C3b 96 C3c 120, 129, 157 C3d 120, 157 C4 120, 182 Cs 157, 367 CS a 100 CS67 96, 440 Cs 96 Cg 96 cleavage of C3 30, 182 cleavage of Cs 30, 182

congo red 353 connective tissue 406, 429

- cells 349 composition 407 depolymerisation 279 matrix 411 metabolism 441 proliferation 349

corticosteroids 191, 193, 233, 259, 284, 288, 292, 302, 305, 315, 364, 386, 391, 415

corynebacteria 188, 269 coryza 240 C-reactive protein 118, 119, 127 Crohn's disease 82, 425 SlCr-release technique 192 cryoglobulins 123, 158 cryoprecipitates 153, 195

intravasal - 154 C-type particle

see C-type virus C-type virus 53, 59, 73, 189

activation 64 defective 61, 62 group-specific antigen 60 helper virus 61 human 66 inter species-specific antigen

60 isolation 59 latency 61, 73 persistence 65 replication 59 type-specific antigen 60

cyclic AMP (cAMP) 259, 287, 371, 395 dibutyryl - 396

cyclic GMP 371 cycloheximide 195 cyclophosphamide 233, 392, 418 cytoplasmic membrane 264 cytosine arabinoside 399 cytospectrophotometry 317

cytotoxic chemotherapy 84, 391 cytotoxicity 265, 367

~egeneration 171 bone marrow 213 fibrinoid - 119, 268

dehydration 243 delayed hypersensitivfty

447

see cell-mediated immunity density gradient analysis 80, 193 dermatan sulfate 406 dermatomyositis 82 dextran sulphate 397 diapedesis

- of blood plasma 215 diphtheria toxoid 86 disseminated lupus

see systemic lupus erythematosus DNA

content in promonocytes double stranded - 111 - precursors 192 - repair 395

317

- synthesis - synthesis

196, 366, 376, 418 time 306

- template DNAse 281

- B 259 DPNase 281 drugs

401

alkylating - 329, 418 anti-inflammatory 230, 285, 302,

315, 370, 385, 406, 441 aspirin-like - 292, 370 non-steroidal - 258, 370, 377 steroidal - 258, 315

anti-rheumatic - 441 compartmentalization of - 398

drug-induced lupus-like syndrome 431 dye exclusion 378

E. coli 233 elastase 428 electrocardiogramm 215, 222 electromicroscopy 154, 189, 192,

215, 224, 259 electrophoresis

cellulose acetate - 251 crossed - 182

encephalitis 437 experimental allergic - 387

endocardiosis 226 endocarditis 431 endogenous virus of baboons (BaEV)

66

448

endoplasmatic reticulum 216, 264 endotoxin 137, 281, 425, 439 enzymes

bacterial - 155, 437 lysosomal - 117, 131, 186,

352, 371, 376, 412, 428 proteolytic - 30, 101

spectrum of tissue - 226 enzyme inhibitors 400

inhibition of plasmin 137 epichlorhydrin 128 epimyoepithelial islands 344 epitheloid cells 195, 279, 428

280,

formation from macrophages 328 life span 329

epizootics 260 Epstein-Barr virus 77, 191, 205

- genome 204 - infection 431

erosion - articular cartilage 11, 198,

213, 244 - bone 11, 198, 245

erysipelothrix bacteria 215 agglutinating antibody 216, 238 arthritis 221, 238 arthritogenicity 238 chronic polyarthritis 216 E. insidiosa 215, 238, 422 E. rhusiopathiae 215, 265, 292 - induction of autoimmunological

processes 239 - infection 215, 238, 422

erythema 376 - multiforme 82

- nodosum 119, 137 erythrocytes

aggregation 222 human group ORIR2 167 phagocytized 339 sheep - 167, 397

Evans blue 98

!actor increasing monocytosis (FIM) 307, 318

Farr technique 153 Felty's syndrome 342 feprazone 386 a-fetoprotein 200, 397 Feulgen stain 197 fibrin 101,117,118,215,256

antibody 33, 221 auto-allergy to - 136 auto-antigen 136, 143 autologous 148 consumption 221

delayed hypersensitivity to -148

deposits of - 157, 168, 222 - exudation 221 - fibers 226

fibrin degradation products 136, 397 autoantigen 136 detection 138 fibrinopeptide B 140 Hodgkin's disease 137 immunosuppression 397 leucocyte attraction 136, 140 persistence of - 136 pregnancy 137

fibrinogen 20, 198 extravasation of - 20 determination 216 local polymerization 20 overproduction 228

fibrinoid 117 - degeneration 268 - deposits 169, 264 - foci 257 - necrosis 34, 136, 216, 263

fibrinolysis 136, 137 fibroblast 101, 352, 371, 385

granuloma - 327 human foetal - 193, 195 interaction with lymphocytes 352 proliferation 261, 327, 352 release of lysosomal enzymes 352 synovial (see also type B lining

cells) 191, 226, 256 fibrosarcoma 193 fibrosis 11, 221

- myocardial - 227 - of synovia 257 - of tendon sheaths 244

flufenamic acid 413 fluorouracil 397 Freund's adjuvant 328, 437

complete - 5, 6, 28, 141, 183, 291, 379

incomplete - 5, 6, 28, 291, 372

S-~alactosidase 358, 366, 413 galactosyl transferase 410 gamma globulin

al tered - 284 bovine - 6, DNP-bovine -

gammopa thy 203 gengrene 231

7, 242, 379 398

genetic recombination 65 giant cell 279

cell fusion 329

giant cell - formation 328 hyperdiploid nuclei 329 life span 329 multinucleated - 256, 329, 357

gibbon ape lymphoma virus (GALV) 66

glomerulonephritis 52, 59, 64, 101, 154, 424 complement and neutrophil

dependent - 101 complement and neutrophil in-

dependent - 99 chronic - 102, 109 immune complex-induced - 74, 112 membranous - 74 post-streptococcal - 256

a-glucosidase 413 6- glucuronidase 134, 293, 358

lysosomal - 366 glucuronyl transferase 410 glycoprotein 406

glycine-rich-6 - 157 inhibition of biosynthesis 419 viral - 201

glycosaminoglycan 406 - polysulfate 411 protein-polysaccharide linkage

408 glycosidases 320

endo - 414 exo - 414

gold 370 Golgi apparatus 216, 264

gonococcus 292 graft rejection 395

homograft - 64 graft-versus-host reaction 53, 64 gram stain 295 granulation tissue 222, 357 granuloma

allergic - 20 chronic - 353 experimental - 34, 427 high-turnover - 327, 428 - induction 353 leprosy 327 low-turnover - 327 mixed - 5, 18 sarcoidosis 327 subcutaneous - 19, 33

granulomagens 425

haptoglobin 198 Hashimoto's disease 428 HEL-12 virus 66

449

hemagglutination - inhibition 246 - passive hemagglutination test

164, 215 hematocrit 216 hematoxylin bodies 340 hemolysin 257, 280 hemolysis 128 hemoptysis 154 hemosiderin 342 hemostasis 215 Henoch-Schonlein purpura 152, 156,

157 hepar an sulfate 406 heparin 249, 303, 366, 412, 416 hepatitis

acute - 198 - A virus 188 - B 154 - B virus 188, 197 lupoid - 198

hepatomegaly 198 hepatosplenomegaly 198, 345 herpes viruses 191

herpes simplex - 78, 80 histamine 96, 427

hypersensitivity to - 427 histiocytes 256, 338

neoplasm of - 346 HLA

typing 432 minor systems 432

HL23V - 1 virus 66 Hodgkin's disease 137 Homeostasis 322, 429 homoreactant 164 "hot antigen suicide" model 42 human respiratory syncytial (RS)

virus 65 hyaline bodies 213 hyaluronate 353, 406

complex with polylysine 353 degradation 415 depolymerization 413 preparation 354 - protein 191 radiolabelled - 360 synthesis 191

hyaluronidase 81, 167, 182 hybridization of nucleic acids 67 hydrolases

acid - 358 leucocyte - 265 lysosomal - 265, 302

hydroxychloroquine 418 hypergammaglobulinaemia 41, 198, 345 hyperimmunisation 41

450

hypersensitivity 4 delayed - 117 (see also allergic response)

hyperviscosity 154 - syndrome 154

hypoalbuminaemia 400 hypocomplementaemia 154 hypoglobulinaemia 199 hysterectomy 222

immune adherence 122 immune complex disease 81, 94, 107,

117, 152, 182, 196 chronic - 102 experimental - 94, 152 viral 191

immune complexes 5, 28, 117, 140, 168, 182, 190, 257, 264, 290, 302, 366, 430 anaphylactic trigger for deposi­

tion of - 96 circulating 95, 152 containing viral antigens 53,

114 cryoglobulins 153, 158 deposition 95, 114, 182, 197 DNA/anti-DNA 109 formation 95 IgG/lgG - 202 induction of arteritis 98 ingestion of - 195 intermediate 158 local formation 178 MuLV/anti-MuLV - 109 nucleic acid/anti-nucleic acid -

197 persistence 114 phagocytosis of - 178 preformed - 108 retention of 185 size 95 soluble - 107 tissue localization - 94 trapping of - 30, 102, 196

immune deviation 17 immune elimination 108 immune response

anamnestic - 35 - gene 432 ontogeny of - 112 self-limiting - 39

immunoadsorption 85 - column 124

immunoblasts see lymphoblasts

immunoblast-like cells 336

immunoblastic sarcoma see lymphoma

immuno-conglutinin 121, 156, 198 immunodeficiency 107 immunodiffusion 153, 212

OUchterlony - 55, 165 Mancini radial - 130, 182

immunoelectrophoresis 153, 282 immunofluorescence 60, 74, 134, 157,

167, 182, 192, 215, 238, 264 detection of

- bacterial antigen 215 complement compounds 134,

182 - CRP 134

- fibrin 157 - immunoglobulin 74, 120, 134,

167, 182, 238 indirect assay 75

immunoglobulin 109, 118, 331 aggregated 123, 124 autologous 424 canine - 74 - class 112 conjugate with peroxidase 215 fragments see immunoglobulin

fragments y-chain 55 IgA 119, 157, 173, 202

- mesangiopathy 158 IgD 119, 202 IgE 96, 97, 119, 130 IgG 112, 119, 173, 184, 191,

202, 215, 218, 424, 430 IgGl 112 IgG2a 112 IgG2b 112 IgG3 123 IgM 112, 119, 159, 191, 202, 218,

250, 340 IgY 250 insoluble 124 isolation of IgG 165 isologous - 424 Il-chain 55 membrane 48 production 431 proteolysis of secretion of -subclass 112

IgG 430

127, 164, 431

synthesis 80, 85, 419 immunoglobulin fragments

autologous IgG - 164 IgG - Fab 164 - F(ab') 2 124, 164, 165 - Fc 124, 168, 202

immunoglobulin fragments preparation 165 purification 165

immunological surveillance 65 immunostimulation 25, 64, 370 immunosuppression 25, 89

drugs 352, 370, 387, 391, 441 a-globulins 397 a-fetoprotein 397 fibrin-degradation products 397

indicator cells 90 indomethacin 233, 260, 286, 370,

377, 386, 413 infection 212, 215, 238, 240, 292,

391, 422, 430 bacterial - 82 endogenous - 436 erysipelothrix - 215, 238, 422 exogenous - 436 mixed - 65 multiplicity of - 80 natural 245, 422 persistent - 77, 423 transmission of mycoplasma - 241 viral - 109, 430, 438

infectious mononucleosis 82, 200, 334, 431 autoantibodies in - 200

inflammation acute - 314 allergic - 11 chronic - 4, 30, 64

cellular kinetics of chronic -327, 329

granulomatous - 257 immuno - 331, 391 influx of cells 328 - of joints 6, 49 local - 227 mediators of - 29, 155, 222 persistence of - 238, 366 proliferating - 221 purulen t - 240 turpentine-induced - 227

inflammatory injury cardiovascular - 94 chronic, self-perpetuating - 103 glomerular - 94

influenza 82 - virus 78, 80

innocent bystander lysis 97, 98 interferon 78, 80, 376

induction of - 84 intraarticular injection 166 5-iodo-deoxyuridine 64, 111, 195,

397 Ir-gene 432

- products 57 irradiation

whole body - 328 ionizing - 64, 328, 395

isolator 222

i Oint experimental - disease 353 - fluid 182, 366

451

- inflammation 6, 49, 212, 215, 240, 256

pathology 11, 349

~aryotype 328 keratan sulfate 406

- glycanohydrolase 413 keratoconjunctivitis sicca 156, 343 ketoprofen 386 keyhole limpethaemocyanin 42, 282 kinin 155

- system 222 Klinefelter's syndrome 433 Kupffer cell blockade 397

lactiC dehydrogenase 133 - virus 191

Langmuir plot 107 latex agglutination test 215, 242,

252 lectins 38, 79, 80, 191, 204, 430,

436 LE cells 52, 71, 198 leprosy 327 lesions

active - 376 arthritic - 238, 241 chronic inflammatory - 358 endothelial - 230 extra-articular - 19, 199 granulomatous - 265, 353 hemorrhagic - 155 indolent - 119 rheumatoid - 428 rheumatoid -, models 4 spontaneous - 118 tumor-like - 213 vascular - 19, 95

leucine-2-naphthylamidase 293 leucocyte migration inhibition test

142, 249 leucocytes

basophil 97 - degranulation 97

452

leucocytes eosinophil 123 neutrophil (polymorphnuclear)

96, 117, 122, 155, 169, 216, 244, 249, 263, 302, 312, 338, 356, 378, 428 - accumulation 100, 264 - activation of lysosomes 191 - attraction test 132 - bactericidal system 265 chemotaxis 100, 376 C3b-receptor 101 degenerate 123, 256 depletion 99, 118 exocytosis of granules 101 extracts 440 Fc-receptor 101 imma ture 244 infiltration 117, 213 proteolytic enzymes 101, 122 release of lysosomal enzymes

131, 366 leukemia 59

erythroid - 61 human - 66 lymphoblastic - 59, 67, 75,

155, 156, 203 myeloblastic - 61, 67

leukemia virus 53 avian - (ALV) 60 avian myeloblastic - (AMV) 62 endogenous 203 feline 194 murine - (MuLV) 60, 73, 109

levamisole 370 lining cells 216, 353

type A - 188, 195 - phagocytic ability 195 type B - 188, 191, 226, 256 - proliferation 192 type C - 188

lining layer 168 - hyperplasia 169

lipopolysaccharide (LP8) 64, 283, 292, 426, 440 - shock 98

lipoteichoic acids 257, 292 sensitization with - 283

liquemin 167 Listeria-like organisms 188 L-phase organisms 188 lymphadenitis

hyperplastic - 23 postvaccineal - 334

lymphadenopathy 331 benigne - 340 generalized - 345

- in lupus erythematodes 340 lymph follicles

extopic - 5, 18, 41, 213 extension into perinodal fat 332 formation 249 fusion 334 hyperplasia 332 lining layer 169 pseudolymphatic - 263 starry sky pattern 333, 334

lymph node 382, 396 - biopsy 332 - enlargement 331, 339 - hyperplasia 41, 49, 331 opliteration of sinus 340 pathology 331 retroperitoneal - 339 rheumatoid - 20, 331 - sinus 336 vascular proliferation 338

lymph node cells 35, 37, 72, 112, 383 lymphoblast 192, 346 - proliferation 48 - transformation 193

lymphochoriomeningitis 152 lymphocyte 101, 192, 216, 244, 249,

256, 312, 327, 376, 428 activation 24, 38, 381, 435 aggregations of - 354 allogenic 432 altered 424 B - 35, 52, 53, 64, 80, 190, 203,

334, 346, 391, 430 B-cell proliferation 192 blast cell proliferation blast cell transformation

376 blood - 85 competent - 190 circulating - 429 culture 91 cytoplasmic membrane 75 defective function 83 depletion 203 DNA-synthesis 376 effector 392

44, 48 193,

emigration 23, 430, 439, 440 Fc-rosetting - 48 foetal thymic - 204 helper 392, 396 homing properties 397 Ig-synthesis - 85 inappropriate activation 435,

436 infiltration 52, 349, 429, 438 lymphotoxic agents 397

lynphocyte memory - 334 migratory properties 397 - modulation 334 non-sensitized 377, 428 peripheral 193 perivascular infiltration 213 permissiveness to viral infection

84 PHA-induced activation 38, 381 production of macrophage mitogens

330 recirculatory 24, 35, 75, 398 receptor for myxo- and para-

myxov irus 81 recruitement 38 sensitized 279, 422 subpopulations 80, 92 suppressor 396 surface markers 80 surface membrane 57 susceptibility to viral infec-

tion 77 synovial membrane - 202 T- 35, 48, 49, 52, 53, 57, 80,

112, 190, 203, 391, 430 thoracic duct - 398 transformation 142, 291, 334,

371 transmural passage 19 virocidal - 84 virus particles in - 195 virus receptors on - 80

lymphocyte-macrophage axis 378 lymphocytic choriomeningitis virus

73, 107, 191 lymphocytotoxin 204 lymphoendothelial system 24 lymphoid malignancy 52 lymphoid proliferation 331 lymphoid system 35, 373 lymphoid tissue 391

hyperplasia of - 47 lymphokin 6, 17, 19, 48, 201, 279,

282, 352, 373, 376, 430 mediator of cell-mediated

immuni ty 376 properties 380 release 291 secretion 383

lymphoma 59, 67, 75, 155, 156, 203 Burki tt' s - 431 histiocytic - 346 lymphocytic - 340 malignant - 331, 340, 431 - in Sjogren's syndrome 344

lymphopenia 213, 395

lymphoproliferation benigne - 331 generalized - 344

lymphoreticular cells 77 lymphoreticular system 331 lymphosarcoma 203

453

lysosomal enzymes 117, 280, 352, 376, 412 - of polymorphnuclear leucocytes

186 - secretion 131, 371, 428

lysosome 216, 329, 413 enzymes 117, 131, 186, 280, 352,

371, 376, 412, 428 intralysosomal structures 266 labilizing toxins 280 myelin-like figures adjacent to -

269 stabilizing antibodies 281

lysozyme 413, 428 cleavage of peptidoglycan 265 secretion by macrophages 302, 330

~croglobulinemia

monoclonal - 53 Waldenstrom's - 52, 346

macrophage 57, 101, 118, 140, 249, 302, 327, 338, 366, 376, 428 activation 18, 376 activation of lysosomes 191 alveolar 309, 382 blockade of - 374 cellular kinetics 328 clearance function 109, 112 DNA synthesis 327 epitheloid cell formation 328 Go-phase - 330 granuloma 118, 327 helical tubular structures in RA -

195 inactivation 428 inflammatory 327 labelling of - 327 liver - 309 lymphokine generation 383 migration inhibition 376, 382 mitogen 330 mitotic division 327, 329 myelin figures in - 269 peritoneal - 108, 303, 309, 366,

427 perivascular infiltration 213 persistence of streptococcal com­

pounds 265 phagocytosis 302, 377 pinocytosis 302

454

329 macrophage

polykaryon production

pounds of complement com-302

proliferation 328, 366, 367 prostaglandin production 381,

386 recrui tment 18 red pulp - 334 release of lysosomal enzymes

293, 302 secretion of enzymes 330 stromal - 353 synovial - 196 tissue - 176 turnover 327, 427, 428 type A lining cells 189, 195 virus infection of - 87

macrophage migration inhibition factor (MIF) 6, 282

malaria 432 tertiary - 436

Mancini radial immunodiffusion see immunodiffusion

Mantoux reaction 397 Marbrook chamber 85, 90 mast cell 97, 101 Masugi nephritis 99, 101 MAV 62 measles virus 65, 78, 84, 191 mediators 99, 221

autopharmacological - 20 - of cell mediated immunity 376 - of inflammation 29, 155, 222,

377 peptide - 30 - release 370

meningi tis 183 meniscus 28 6-mercaptopurine 392 mesangiopathy 157

IgA - 158 mesenchymal reaction 233 mesenchymoid transformation methotrexate 399 MHC gene products 57 micrococcus 121 microsomes 400 mitochondria 216 mi togen 78, 83

352

lymphocyte transformation by -334

streptococcal - 257, 282 mitomycin C 195 mitosis 328, 401

- in follicle centers 339 - of macrophages 328

mixed lymphocyte cultures 64, 434 monoarthritis

allergic - 5, 6, 18 models 5, 28

monoblast 308 monocyte 224, 302, 327, 391, 429

blood - 303, 366 bone marrow - 304 circulating 311, 313 electron microscopy 224 in inflammation 314 influx of - 314 labelling 305 migration 374 - precursor 327 - production 306 - production inhibitor (MPI) 323

monocytopenia 315 monocytopoiesis 302

- inhibiting factor 323 humoral control 318 stimulators of - 322

mononuclear cells 5, 77, 169, 366, 372, 376 accumulation 118 blood - 79 function 79 infiltration 171, 376 separation 80 susceptibility to virus infection

84 synovial exudate 193 transit 315

mouse strains A/jax 108 AKR 59, 64 Balb/c 64 CAf 1 72 CBA/H 36 CBA/H"T6T6 36 C3H 108 CRF 303 high affinity -low affinity -New Zealand 59,

- black (NZB) 203

108 108 64, 71, 434

52, 108, 191,

hybrids (NZB/W) 52, 109 - white (NZW) 52, 64, 108

non-responder - 432 responder - 432 Swiss 63, 303

mucopeptide-polysaccharide complex 269, 278

mucopolysaccharide 290 multiple sclerosis 82, 189, 433 multiplicity of infection 80

Mumps virus 191 mutagens 64 myasthenia gravis 433 Mycobacteria 269, 292, 427

M. tuberculosum 121, 379 - residues 426

Mycoplasma 188, 212, 292 aetiology of M. infection - antigen 241 - arthri tis 240 growth inhibition test 241 hemagglutination inhibition

245 infection 212, 240 metabolic inhibition test M. gallisepticum 241 M. meleagridis 240 M. orale 194 M. synoviae 214, 240 pathogenicity 245

240

241,

241

rapid slide agglutination test 241

myeloma 202 myeloperoxidase 134 myocarditis 212 myoglobin 165

~acetyl-S-glucosaminidase 293, 358, 414

N-acetyl-galactosaminyl transferase 410

Naproxen 386 nasal septal perforation 154 nasopharyngeal carcinoma 432 Neisseria meningitidis 182 neoantigens 191 neoplasma

hemopoietic - 59 - of histiocytes 346 lymphoreticular - 65 mesenchymal - 59

neoplastic cells 340 nephritis

complement"and neutrophil de-pendent - 101

immune complex - 109 lupOid - 157 nephrotoxic - 99, 101 post-streptococcal -

nephrotic syndrome 401, neuraminidase 155, 222 neuroblastoma cells 201

154, 157 402

Newcastle disease virus 192 nitrogen mustard 100, 118 nodules

rheumatoid - 19, 33, 198

secondary 426 subcutaneous - 19, 428

nonpermissiveness 62, 81 abnormal - 81 of host cells 62

nucleolus 334 nucleus membrane 334 nylon wool column 399

oedema angioneurotic - 156 carrageenan-induced 372 inflamma tory - 213, 244

oncogene 62 oncorna virus 59, 189, 204 orchi tis 437

455

osteoarthrosis 195, 291, 349, 408 osteoblast 213 osteoclast-activating factor (OAF)

290 osteo-neogenesis 245 osteoporosis 291 oxazolone 35 oxidases 400 oxyphenbutazone 413

£anniculitis 19 chronic - 137 nodular - 119

pannus 12, 32, 169, 213, 263, 293 - formation 216, 354

papain 127, 406 papova viruses group 191 parabiosis 328 paramyxovirus 191 paraprotein 202 Pasteurella 233 pathobiochemistry 408 penicillamine 370, 413 penicillin 239, 279, 304, 379 peptidoglycan 428

cleavage by lysozyme 265 - polysaccharide complex 258

pericarditis 203 peritonitis 320 permeabili ty

capillary - 29 - factors 29, 370 organ-specific - 221 vascular - 97, 99, 154, 370, 376

persistence - of antigen 4, 114, 269, 278,

291, 373, 384, 422, 423 autoimmune - 422 - of microbial remnants 269, 422

456

persistence - of synovitis 175 viral - 77, 114

phagocytosis 128, 131, 178, 302, 338, 377, 428

phagolysosomes 427 phenylbutazone 386, 411, 413 phosphatase, (acid) 122, 358, 377 phosphodiesterase 385 phosphorylation 418 phytohaemagglutinin (PHA) 38, 79,

204 125J-Iabelled 204 lymphocyte activation 381 response of RA lymphocytes 204

picric acid 129 picryl chloride 35 pinocytosis 222, 281, 302 plague assay 80 plasma cells 33, 44, 118, 124, 192,

244, 256, 327, 334, 354, 428 - accumulation in synovium 28,

169 binucleate - 338 - infiltration 34, 52, 216, 349,

356 virus particles in - 195

plasmacytoid cells 346 plasmacytosis 44

interfollicular - 332 plasmapheresis 156 plasmin 137 plasminogen 137 plasminogen activator 302 platelets 96, 98, 229

- aggregation 222, 371 platelet activating factor (PAF)

97 pleurisy 203 pleuropneumonia-like organisms

see mycoplasma pneumococcus 263, 292

- somatic C-polysaccharide 128 -, polymerised 128

type III polysaccharide 397 pokeweek mitogen (PWM) 80, 204,

436 response of RA lymphocytes to -

204 poly adenylic acid (Poly A) 54 polyanions 414 polyarteritis 77

- nodosa 82, 119, 152 polyarthalgia 198 polyarthritis 291, 372

chronic - 216, 257, 408 polyethylene glycol 153, 182

- precipitation 153, 182 polykaryocyte 195, 329, 354

macrophage - 329 polylysine 354

arthritogenicity of - 354 complexes with hyaluronate 353 hydrolysis 360 preparation 354

polymerase 190 DNA-dependent RNA - 417 DNA-dependent DNA - 417 RNA-dependent DNA - 60, 195, 417 inhibition of RNA - 416

polymorph nuclear depressing agent 189

polyphenylalanine inhibition of synthesis 417 synthesis 406

polysaccharides complexes with peptidoglycan 258 complexes with mucopeptide 269 pneumococcal C - 128 polymerisation 410 streptococcus C - 259 tissue - 261 type III pneumococcal - 397

polyoma virus 73, 109 polystyrene latex particles 305 polysynovitis 23 poly-U 406 polyvinyl-pyrrolidone 113

clearance of - 113 125J -Iabelle d 108

post streptococcal sequelae 256, 290 pregnancy 137 pressure dialysis 129 promonocytes 304

DNA content 317 DNA synthesis 317 DNA synthesis time - 306 G2-phase 312 mitotic activity - 315 S-phase 317

properdin factor B 157 propionic acid derivatives 370 prostaglandin (PG) 20, 192, 222, 259,

285, 302, 370, 376 chemotactic for PMN 291 erythema 377 generation 3H-Iabelled

258, 302 380

lymphocyte regulation 383 production by macrophage 381 suppression of - 441 vascular permeability 377

prostaglandin synthetase 259, 292, 386

prostaglandin synthetase inhibition of - 370

proteases acid - 117, 122, 131, 134, 290 activated - 281 leukocyte - 124 neutral - 290

proteochondroitin sulfate 410 biosynthesis 409 degradation 412

protein core 408 proteinuria 71, 101 proteoglycan 200, 352, 407, 413

age-dependence of composition 408

- aggregates 413 composition 408 degradation 413 heterogeneity 407 specific 407 structure 407 subunits 408

proteokeratan sulfate 410 protoplast 280 provirus 61 pseudo lymphoma 344, 345 Pseudomonas 233 puromycin 411 purpura

anaphylactic - 82 anaphylactoid - 155 Henoch-Schonlein - 152, 156,

157 hypergammaglobulinaemic 156 intermediate complex - 155 thrombocytopenic 71

pyrogen 302 pyroninophily 334

rabbits New Zealand White - 141 "Old English" - 354 White Kunath - 165

radioimmune presipitation assay 67 radioimmunoassay 55, 60, 66, 75,

85, 86, 195, 259, 380, 426 radiography 215 radioresistance 396 radiosensitivity 396 rat strains

Sprague-Dawley 215 Wistar 215, 258

Raynaudi disease 82 reactive pathology 440 receptor loss 385 Reiter's disease 221

renal tubular acidosis 156 reovirus 212 replication

viral - 62, 77 assay of viral - 80

457

reticular cells 334 reticulo-endothelial system 95, 155 reticulocytosis 52 reticulum cell sarcoma 346 reverse transcriptase 60, 195, 417 rhagocyte 171 rhesus monkey 195 rheumatic diseases

predilection sites 221 rheumatic fever 221, 256, 291 rheumatoid arthritis 4, 28, 33, 48,

77, 82, 164, 188, 216, 238, 257, 327, 331, 353, 376, 408, 422, 424, 428 viral involvement in - 189

rheumatoid factor 121, 123, 126, 153, 197, 214, 216, 243, 252, 346, 370, 422, 436 IgG-type 284, 437 IgM-type 202, 284, 437 local formation 123, 164 phagocytosis of - 164 in relatives of RA patients 23 self-associating - 423

rheumatoid-like factor 118, 164 rhino virus 438 ribonuclease 282, 320 ribosome 407 Rickettsia-like bodies 152 RNA

genomic 60 messenger - 61, 418 synthesis 196, 418 transcription 61

rosette formation 80 rubella virus 191 Russel bodies 338

~alicylate 386, 419 salivary gland 344 Salmonella 292 sarcoidosis 82, 327, 397, 428 sarcoma 59, 61

immunoblastic - 346 scleroderma 82 selectivity

- of drug action 400 interactive - 392 schedule-dependent - 393

Sephadex 165

458

septicaemia 82 meningococcal - 81 streptococcal - 261

serotonin 96 serum

- albumin see albumin anticomplementary - 158 foetal bovine - 85, 250, 304,

378 fractionation of - 54 - globulin 241 guinea pig - 378 preparation of mouse - 306

serum sickness see immune complex disease

sex hormones 57 shock

anaphylactic - 97 lipopolysaccharide-induced - 98 - phase in erysipelothrix infec-

tion 229 vascular - 221

Shwartzman reaction 152 sialic acid 155 silent gene 63 silica 7, 305, 381, 429 simian sarcoma associated virus

(SSAV) 66 sindbis virus 65 single pulse method 328 SjOgren's syndrome 52, 156, 331,

343 antisalivary gland antibodies

346 chronic bronchitis 343 histopathology 343, 344 hyperglobulinaemia 345 keratoconjunctivitis 156, 343 lymphoid proliferation 344 vaginal dryness 343 xerostomia 343

skin - reactions

- Arthus-type 5 - delayed type 5

- test 142, 250, 397 smallpox virus 196 SP 104

- virions 75 - plasmocytoma 73

spleen B-Iymphoid dependent areas 342 - cells 37, 53, 72, 112 Felty's syndrome 342 rheumatoid arthritis 342 T-dependent zones 342

splenectomy 339

splenomegaly 52, 198, 241, 331 spondylitis ankylopoetica 221 staphylococcus 227, 233, 263

- abscesses 121 - aureus 120, 240

starch 381 "starry sky" effect 334 streptococcus 233, 256, 425

- abscess 280 - antibodies 259 - antigen 119, 291

arthritis 258, 280 cell free extract 258, 278 cell wall components 257, 269 C-polysaccharide 259 degradatation 426 extracellular products 282 fragments 264 group A - 120, 256, 261, 284 group B - 437 hemolytic 155, 261 immune complexes 257 - infection 122, 256, 439 intracellular 264, 270, 272, 275 intralysosomal 271, 273 isolation from lesions 269 L-form arthritis 290 L-forms 257, 279, 291 lysins 428 mitogen 257, 282, 290 mitogenic factor of L-forms 280 M-protein 266 persistence of cell wall components

278 - pharyngitis 440 polysaccharide antigens 122 protein antigens 122 protoplasts 280 St. viridans 261 - tonsillitis 121 toxins 439

streptodornase 392 streptokinase 138, 281, 392 streptolysin 259

- 0 259, 279 - S 278, 279

streptomyces 269, 292 streptomycin 304, 379 streptozyme 259 sucrose gradient centrifugation 54 SV40 virus 195 synovectomy 349 synovia 11, 218, 355, 430 synovial cells 256, 264

cytotoxic effects on - 265 - hyperplasia 213, 244, 282 - hypertrophy 213, 244

synovial cells proliferating - 327 - receptor 190

synovial fluid 256, 363 - cells 363 rheumatoid - 366

synovial lavage 358 synovial membrane 183, 213, 241,

359, 430 capillaries 196 hyperplasia 11, 264 hypertrophy 11, 264 infiltration 11, 356 lymphocytes 202 rheuma toid - 91 villous formation 244

synovial stroma 349 synovitis 28, 164, 212, 245, 257,

290 acute - 169 auto-immune - 164, 175 chronic - 5, 169 model 19 persistence 175 subacute 169 by streptococcal mitogens 282

syphilis 340 systemic lupus erythematodes (SLE)

52, 64, 71, 77, 82, 109, 152, 203, 331, 402, 423

T cell 35, 48, 49, 52, 57, 80, 190, 203, 391, 430 - activation 48, 381 defective suppressor - 53 helper - 53, 57 mitotic response 38 - regulation 53, 112 suppressor - 49, 53, 57, 112

tendon 244 mineralisation

teno-synovitis 212 Thiotepa 418 testosterone 195 tetanus toxoid 202

245

112,

thoracic duct drainage 203, 370, 384

thrombin 138 thrombocytes

see platelets thrombosis 117, 137

aortic - 230 fibrin-rich - 221, 230 micro - 222

thymectomy 18, 54, 56 thymidin

14C-labelled - 79 3H-labelled - 305,

thymocytes 399 thymus

atrophy 395 cells 398 cortex 396 necrosis of - cortex

thyroidi tis 437 Hashimoto's - 438 viral - 438

thyroglobulin 438 tingible bodies 340 tissue injury 96 tolerance

- to DNA 424

327, 383

396

- to endogenous antigen 423 high zone - 41, 374 - induction 108, 424 loss of - 204, 425 low zone 374

tonsil cells 85 tonsillitis 121 toxins 430

cardio - 292 cholera - 396 cyto - 290 diphtheria - 86 endo - 137, 281, 425, 439 erythrogenic - 281 tetanus - 202

transfer factor 433 transferrin 107, 110, 198 transforma tion

lymphocyte - 334 mesenchymoid - 352 viral 188

transmission of infection 63 Trasylol 138 Trypan blue 303, 353, 378 tuberculosis 82, 327 twins

monozygotic -dizygotic -

433, 434 434

ulceration 122, 278 ultrafiltration 165 ultracentrifugation urate 381 urticaria 156, 221

chronic - 82

vaccinia virus 79 varicella virus 196

153, 437

459

460

vasculitis allergic - 19, 119, 152 Arthus-like - 134 chronic - 118 cryoglobulinaemic - 154 cutaneous - 118, 146, 158 extra-articular - 199 iatrogenic - 122 immune complex - 52, 290 intestinal - 154 leucocytoclastic - 117, 125 mononuclear cell - 121 necrotizing - 33, 119 neutrophil-infiltrated - 117,

121 nodular - 119, 137 rheumatoid - 19 spontaneous -subclinical -widespread -

vasoactive amines

117, 146 23

152 96

vesicular stomatitis virus 65, 78, 84, 192

vinca alkaloids 401 viral infection

inappropriate expression of -60, 429

- in neuroblastoma cells 201 mixed - 65 non-expressed - 424 permissiveness of host cells to

63 persistenct - 65, 77, 188, 200 resistance to - 77

viral interference 84, 89, 197 virus

activation of endogenous - 64 cytopathic - 188

- determinants 424 ecotropic - 64 endogenous - 63 ether-resistant RNA - 212 - genome 190 - gen products 190, 197 - glycoproteins 201 haemadsorbing - 81 heat-resistant RNA - 212 helper - 61 inappropriate expression

429 integra ted 201 non-cytopathic 188 non-replicating 424 phenotypically mixed - 65 - proteins 189

virus-coded - 189 virus-induced - 189

slow - 188 xenotropic -

virus receptor 63, 109

80

Xenon clearance 377 xerostomia 343 xylosyl transferase 410

~ellow fever virus 84 Yersinia enterocolitica 292

~ymosan 293

60,

Current Problems in Immunology

Bayer-Symposium I, held at Grosse Ledder near Cologne, W. Germany, Oct. 11-13, 1968.

Editors: O. WESTPHAL, H.-E. BOCK, E. GRUNDMANN 135 figures, XI, 349 pages. 1969. ISBN 3-540-04424-8

Lectures and discussions from an inter­national symposium on problems of theo­retical and clinical immunology and im­munopathology.

New Aspects of Storage and Release Mechanisms of Catecholamines Bayer-Symposium n, held at Grosse Ledder, Oct. 9-12,1969.

Editors: H.J. SCHUMANN, H.-G. KRONEBERG 116 figures, X, 301 pages. 1970. ISBN 3-540-05051-5

International Experts - among them two Nobel Price Winners 1970 - attending an International Symposium, report latest results of this research field on sympa­thetic transmitting substances.

Bacterial Infections Changes in their Causative Agents. Trends and Possible Basis

Bayer-Symposium III, held at Grosse Ledder, Oct. 23-27, 1970.

Editors: M. FINLAND, W. MARGET, K.BARTMANN 53 figures. VIII, 231 pages. 1971. ISBN 3-540-05557-6

The changes which have been observed in the agents causing bacterial infection are attracting increasing clinical attention. The 19 papers given at this symposium and the discussions which followed present a good picture of the complexity of the factors involved.

Psychic Dependence Defmition, Assessment in Animals and Man; Theoretical and Clinical Implications

Bayer-Symposium IV, held at Grosse Ledder, Sept. 27-0ct. 1, 1972.

Editors: L. GOLDBERG, F. HOFFMEISTER 47 figures. X, 244 pages. 1973. ISBN 3-540-06478-8

This symposium presents the pharmacol­ogical, psychological, and social aspects of human and animal drug dependence. In addition, the book discusses the theo­retical (ethical and legal) and clinical implications of such behavior.

Proteinase Inhibitors Bayer-Symposium V. Proceedings of the 2nd International Research Conference on Proteinl!Se Inhibitors, held at Grosse Ledder, Oct. 16-20, 1973.

Editors: H. FRITZ, H. TSCHESCHE, LJ. GREENE, E. TRUSCHEIT 410 figures. XVI, 751 pages. 1974. ISBN 3-540-06775-2

Contents: Plasma Proteinase Inhibitors. -Proteinases and Proteinase Inhibitors in Fertilization. - Pancreatic Proteinase In­hibitors. - Characterization and Structure of New Inhibitors. - Structure-Function Relationships. Physical-Chemical Studies of Enzyme-Inhibitor Interactions. Molecular Aspects of Enzyme-Inhibitor Interactions. - Organic Chemical Models and Low-Molecular-Weight Inhibitors. -Inhibition of Non-8erine Proteases. -Evolution of Specificity of Proteinase In­hibitors. - Proteinases and Inhibitors in Biological Systems. - Resume.

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Springer-Verlag Berlin Heidelberg New York

Molecular and Cellular Mechanisms in Disease

J. VAN LANCKER, M.D., Department of Pathology, U.C.L.A. School of Medicine, Los Angeles, USA

411 figures, 68 tables. XX, 1168 pages. 1976. (In 2 parts, not available separately) ISBN 3-540-06932-1

Fields: Pathology, General Medicine, Molecular Biology. Of interest to pathologists, practicing and clinically oriented physicians of all spe­cialities, advanced medical students.

Recent Results in Cancer Research Fortschritte der Krebsforschung Progr~s dans les recherches sur Ie cancer Editor in Chief: P. Rentchnick Vol. SS

Cancer Active Immunotherapy Immunoprophylaxis and Immunorestoration An Introduction

G. MATHE, Villejuif, France

123 figures, 87 tables. XV, 405 pages. 1976. ISBN 3-540--07601-8

Pathology of Rheumatic Diseases H.G. FASSBENDER, University ofMainz Translated from the German Edition by G. LOEWI, Harrow 444 figures. XI, 353 pages. 1975. ISBN 3-540-07289-6

Contents: History of the Rheumatic Diseases. - Components of Connective Tissue. - Reactions. - Rheumatic Fever.­Rheumatoid Arthritis. - Juvenile Rheu­matoid Arthritis and Still's Disease. -Sjogren's Syndrome. - Ankylosing Spon­dylitis. - Psoriatic Arthritis. - Gout. -Chondrocalcinosis. - Osteo-Arthritis. -

Non-Articular Rheumatism. - Experi­mental Arthritis. - References. - Subject Index.

Distribution rights for Japan: Igaku Shoin Ltd. Tokyo

Gram-Negative Bacterial Infections and Mode of Endotoxin Actions Pathophysiological, Immunological, and Oinical Aspects

Editors: S. URBASCHEK, R. URBA­SCHEK, Abteilung fur Immunologie und Serologie, Klinikum Mannheim der Uni­versitat Heidelberg, E. NETER, State University of New York at Buffalo

155 partly colored figures. XIV, 524 pages, 1975. ISBN 3-211-81292-X

Contents: Microbiology and Epidemiol­ogy. - Immunology. - Nonspecific Resis­tance and Endotoxin Tolerance. - Patho­physiology. - Hemodynamics and Meta­bolism. - Pharmacology. - Blood Coagu­lation. - Clinical Aspects Including Shock. - Burn Disease.

Virology Monographs / Die Virusforschung in Einzeldarstellungen Continuing / Fortfiihrung von Handbook of Virus Research / Handbuch der Virus­forschung. Editors: Gard, S., Hallauer, C., Meyer, K.F.

Vol. 13: K.E.K. ROWSON, B.W.J. MAHY Lactic Dehydrogenase Virus 54 figures, IV, 121 pages. 1975. ISBN 3-211-81270-9

Vol. 14: L.PHILIPSON, U.PETTERSSON U. LINDBERG Molecular Biology of Adenoviruses

20 figures, III, 115 pages. 1975. ISBN 3-211-81284-9

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