Superiorwound

closure

1. Chee SP. Clear corneal incision leakage after phacoemulsification–detection using povidone iodine 5%. Case Report. Int. Ophthalmology 2005 Aug-Oct:26:175-179.

2. Mifflin MD, Kinard, K, et al. Comparison of Stromal Hydration Techniques for Clear Corneal Cataract Incisions: Conventional Hydration versus Anterior Stromal Pocket Hydration. Journal of Refractive Surgery. 2012 Jun; 38(6):933-937.

3. Herretes S, Stark WJ, et al. Inflow of ocular surface fluid into the anterior chamber after phacoemulsification through sutureless corneal cataract wounds. American Journal of Ophthalmology. 2005;140;737-740.

4. Masket S, Hovanesian J, et al. Use of a calibrated force gauge in clear corneal cataract surgery to quantify point-pressure manipulation. J Cataract Refract Surg. 2013 Feb 21.

0%

20%

40%

60%

80%

100%

Spontaneous leak Spontaneous or with minimal touch

(ч0.25 ozf)

50.0%(244/488)

76.0%(371/488)

Cumulative leak rates prior to device placement*

Clear corneal incisions leak

Propensity for leakage has been demonstrated in several additional studies.1-4

Challenges or forces on the eye, such as touching or sneezing, may promote leaks.

More protection should be administered for vulnerable wounds.

Superior to sutures for prevention of wound leaks

0%

10%

20%

30%

40%

ReSure Sealant Suture

Per protocol leak rates following device placement*

4.1%(12/295)

34.1%(60/176)

p<0.0001

Significantly fewer adverse events in the ReSure group vs. the suture group (p<0.0001).

94.1% of sealant cases were rated “easy” or “very easy” to use.

No safety concerns were reported.

Patients were comfortable overall.

* ReSure Sealant Pivotal Clinical Trial results. Ocular Therapeutix Inc., data on file.

Effectively seals clear corneal incisions

Safe and comfortable for the patient

36 Crosby Drive, Ste. 101Bedford, MA 01730

www.ocutx.com

Customer service: 877-628-8998

sales@ocutx.com

ReSure is a registered trademark of Ocular Therapeutix, Inc. © 2014 Ocular Therapeutix, Inc. All rights reserved.

ML 079 Rev B

Clinical Use in Cataract Surgery

ReSure Sealant is indicated for intraoperative management of clear corneal incisions (up to 3.5mm) with a demonstrated wound leak for which a temporary dry surface can be achieved, in order to prevent postoperative fluid egress from such incisions following cataract surgery with intraocular lens (IOL) placement in adults.

Cataract Patients withPrevious Ocular Surgeries

Post-refractiveRK*LASIK*PRK*

Post-glaucoma filteringTrabeculectomy*Tube shunt*

Standard Cataract Surgery Suture replacement*Incisions up to 3.5 mmLeaky wounds (temporarily dried)Visible internal/external gapeIrregular/asymmetric woundsHigh myopesCorneal ectasia (keratoconus)*Phaco burn*Patients at Risk for Eye Trauma

Mentally disabled*Patients in assisted livingElderly

High-Risk Cataract Patients MRSA*Monocular*Diabetic*Immunocompromised*Undergoing chemotherapy*Long-term systemic steroids*

Premium Cataract Patients ToricMultifocalAccommodatingFemtosecond*

Combination Cataract(when cataract surgery is performed first)

MIGS*Pars Plana Vitrectomy** Not evaluated in the ReSure Sealant pivotal clinical trial

For more information, visit www.resuresealant.com.

Product

ReSure SealantReSure Sealant

Product Number

RS-1004-US-5RS-1004-US-10

Units per Box

510

Complex Cataract CasesSmall pupil

Iris hooks*Malyugin ring*

Capsular tension ring*Dense cataractLens explant/exchange*