2006

Fused pyridine derivativesR 0450 Synthesis and Biological Evaluation of Modified Acridines: The Effect of N- and

O-Substituent in the Nitrogenated Ring on Antitumor Activity. — With a view to obtaining novel antitumor agents, various kinds of compounds such as (VIII) and (IX) are synthesized. Products of type (IX) are more effective than those of type (VIII). The substituent in position C-11 is very important for cytotoxicity. The most active deriva-tive, a C-11 ATP analogue of (VIII), is selected as a development candidate for further evaluation. — (SANCHEZ, I.; RECHES, R.; CAIGNARD, D. H.; RENARD, P.; PUJOL*, M. D.; Eur. J. Med. Chem. 41 (2006) 3, 340-352; Lab. Quim. Farm., Fac. Farm., Univ. Barcelona, E-08028 Barcelona, Spain; Eng.) — K. Schneider

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