Novel Technologies to assess Gut Health Claims for Carbohydrates

Subthema 1: Synthesis and structural analysis of functional oligosaccharides

Name: Prof. Dr. Lubbert DijkhuizenAffiliation: University of Groningen/ Microbiology

Contact: L.Dijkhuizen@rug.nl

Synthesis and structural analysis of functional oligosaccharides

State of the art: Availability CharacterizedFructo-, Galacto-, (Iso)Malto- + +?Xylose-, Pectin-, Mannan-, Chito- (+) (+)??Glucose1,2-1,3-1,4; IMO-MALT (+) -Glucansucrase acceptor products (+) -Plant cell wall oligo’s (+) -Human Milk oligo’s (+) -“CCC new oligo’s” - -

Synthesis and structural analysis of functional oligosaccharides

New technologies:Enzyme discovery and engineering:synthesis of tailor-made oligo’s:

monosaccharides, linkages

Structural analysis:In vitro: newly synthesized oligo’sIn gut: modification, degradation, during passage