t h - helper cell b cell macrophage neutrophil (alternative path) mast cell platelets
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Hematopoiesis from pluripotent stem cells to mature, differentiated, cellular effectors of immunity and more Richard A. Poirier for HHMI/Harvard Immunology Summer Project 2004. T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets. - PowerPoint PPT PresentationTRANSCRIPT
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Hematopoiesisfrom pluripotent stem cells to
mature, differentiated, cellular effectors of immunity
and moreRichard A. Poirier for HHMI/Harvard Immunology Summer Project 2004
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Click on one of the following effector cells to see the sequence of different cells that lead to its production
• Th- Helper Cell• B Cell• Macrophage• Neutrophil (alternative path)
• Mast Cell• Platelets
• Tc Cytotoxic Cell• Dendritic Cell• Neutrophil• Eosinophil• Basophil• Erythrocyte
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T - helper cell pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Lymphoid Stem CellDaughter cell of the Pluripotent Stem Cell, this cell will divide to produce progenitors to either B cell or
T cell lines.
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T cell progenitor leaves the bone marrow and settles in the thymus; will produce Thymocyte cells in the thymus which can, in turn differentiate
into T helper cells, T killer cells, or T memory cells
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The Thymocyte is located in the thymus and divides to produce mature T effector cells…..
Th (helper)Tc (cytotoxic-killer) or Tm (memory)
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Th (helper) cell…when activated by an Antigen Presenting Cell like a macrophage with
antigen, the Th cell will induce rapid growth of white blood cells which help fight infection
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Tc (cytotoxic/”killer”) cell pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Lymphoid Stem CellDaughter cell of the Pluripotent Stem Cell, this cell will divide to produce progenitors to either B cell or
T cell lines.
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T cell progenitor leaves the bone marrow and settles in the thymus; will produce Thymocyte cells in the thymus which can, in turn differentiate
into T helper cells, T killer cells, or T memory cells
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The Thymocyte is located in the thymus and divides to produce mature T effector cells…..
Th (helper)Tc (cytotoxic-killer) or Tm (memory)
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Tc (cytotoxic or “killer”) Cells…Sometimes called CTLs (cytotoxic T lymphocytes,
these may recognize infected “self” cells and destroy them.
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B cell pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Lymphoid Stem CellDaughter cell of the Pluripotent Stem Cell, this cell will divide to produce progenitors to either B cell or
T cell lines.
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B Cell progenitor…found in the bone marrow of higher vertebrates and the Bursa of
Fabricius in birds, these cells will produce antibody producing B cells.
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B Cells… these are found in the blood and , when activated will produce antibodies against particular antigens. Each cell produces antigen
specific antibodies of only one type.
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Dendritic cell pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
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Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils
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Monocytes… act as antigen presenting cells (APCs), as Antibody-Dependent Cytotoxic Cells
(ADCC) , and promote inflammation.
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Dendritic Cell… like the macrophage, this cell is phagocytic it inhabits the tissues looking for
foreign intruders to devour.
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Macrophage pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
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Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils
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Monocytes… act as antigen presenting cells (APCs), as Antibody-Dependent Cytotoxic Cells
(ADCC) , and promote inflammation.
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Macrophage…functions as antigen presenting cell (APC), in inflammation, and in
ADCC (antibody-dependent cell-mediated cytotoxicity
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Neutrophil Pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
![Page 40: T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets](https://reader037.vdocuments.net/reader037/viewer/2022110404/56812e2d550346895d9392c2/html5/thumbnails/40.jpg)
Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils
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Monocytes… act as antigen presenting cells (APCs), as Antibody-Dependent Cytotoxic Cells
(ADCC) , and promote inflammation.
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Neutrophils…function in antimicrobial activity, inflammation response, and antibody-dependent, cell-mediated cytotoxicity (ADCC)
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Alternative Neutrophil pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
![Page 47: T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets](https://reader037.vdocuments.net/reader037/viewer/2022110404/56812e2d550346895d9392c2/html5/thumbnails/47.jpg)
Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils
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Neutrophils…function in antimicrobial activity, inflammation response, and antibody-dependent, cell-mediated cytotoxicity (ADCC)
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Eosinophil Pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
![Page 52: T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets](https://reader037.vdocuments.net/reader037/viewer/2022110404/56812e2d550346895d9392c2/html5/thumbnails/52.jpg)
Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
![Page 53: T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets](https://reader037.vdocuments.net/reader037/viewer/2022110404/56812e2d550346895d9392c2/html5/thumbnails/53.jpg)
Eosinophil Progenitor…will produce eosinophils
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Eosinophil…these cells are active in the immune response to asthma, allergies, and parasites.
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Mast Cell Pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
![Page 59: T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets](https://reader037.vdocuments.net/reader037/viewer/2022110404/56812e2d550346895d9392c2/html5/thumbnails/59.jpg)
Basophil Progenitor… a product of the specialization of Myeloid stem cells, this cell will
produce either Mast Cells or Basophils
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Mast Cell…like the related basophils these cells function in inflammation and allergic response. When mature, they become granulated and are found
in tissues, not in peripheral blood.
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Basophil pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
![Page 65: T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets](https://reader037.vdocuments.net/reader037/viewer/2022110404/56812e2d550346895d9392c2/html5/thumbnails/65.jpg)
Basophil Progenitor… a product of the specialization of Myeloid stem cells, this cell will
produce either Mast Cells or Basophils
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Basophil…this IgE responsive cell is characterized by cytoplasmic granules which, when
released, function in destruction of parasites and also in allergic reactions. The cell releases histamine and
platelet activator and other chemical signals.
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Platelet pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
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Megakaryocyte…fragments into subcellular pieces called platelets
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Platelets…are blood elements without nuclei that circulate and are involved in blood clotting and
inflammation.
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Erythrocyte Pathway
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Pluripotent Stem CellThis is the undifferentiated precursor to all of the
blood cells, red and white, and other immune effector cells, and platelets.
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Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of
specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.
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Erythroid Progenitor…derived from a myeloid stem cell, this is destined to produce the
most common blood cell, the erythrocyte.
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Erythrocytes…or red blood cells (RBCs)are enucleated cells that travel throughout the Circulatory System and carry Oxygen to all parts of the body via
the abundant hemoglobin found within them.
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To learn more about Hematopoiesis click HERE
To see slides of real blood cells, click HERE