tablet coating 2004
TRANSCRIPT
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CHEE 440 1
Tablet CoatingTablet Coating
Why coat tablets?
Types of coatings
sugar coating
film coating press coating (compression coating)
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CHEE 440 2
Sugar CoatingSugar Coating
stages involved sealing of tablet core
subcoating
smoothing
colouring
polishing
printing
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CHEE 440 3
Film CoatingFilm Coating
involves spraying a solution ofpolymer + pigments +
plasticizers onto a rotated, mixed tablet bed
forms a thin, uniform film on tablet surface
materials
polymers
solvents
plasticizers
colorants
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CHEE 440 4
Film FormationFilm Formation
latex particles dispersed
in aqueous phase
formation of thin film with
water evaporation through film
continuous film
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CHEE 440 5
Coating ProcessCoating Process
coatingpans
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CHEE 440 6
Coating ProcessCoating Process
fluid beds
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CHEE 440 7
Important Processing ParametersImportant Processing Parameters
inlet and bed temperatures
relative humidity
atomization airpressure
liquid spray rate
droplet size
drying time
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CHEE 440 8
Coating ProblemsCoating Problems
picking/chipping
roughness
sticking
film cracking/peeling
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CHEE 440 9
Normal CoatingNormal Coating
Descri tiRec stit tilevel
Aver ewei t
iA lic ti examples
HPMC basedA eoussystem
11% to15% 2.5%
HPMC basedOr anicsolventsystem
5% 2.5%
HPMC basedA ueous/Or anicSolvent/
HydroAlcoholicsystem
A ueous 11%
Or anic Solvent5%
Hydro Alcoholic9%
2.5%
PVA basedA ueoussystem
20% to25% 2.5%
Amoxycillin, Azithromycin, Atenolol,Amlodipine, Amitriptyline, AmpicilinCiprofloxacin, Cephadroxil ,Cimitidine, Calcium Tablets, Citrizine
, Chloroquine Phosphate,Clarithromycin, Erythromycin,Ferrous Fumarate,Famotidine,Ferrous Sulphate, Ibuprofen,Indapamine, Losartan Potassium,Levamisole, Methyl-Dopa,Metronidazole+Tinidazole,Metronidazole, Methyl Coblamine,Mefenamic Acid, Metoprolol Tartrate,
Norfloxacin,Nifidipine,Norfloxacin+Tinidazole,Ofloxacin,Paracetamol, Quinine Sulphate,Roxythromycin, Secnidazole,Sildenafil Citrate, Trimetazidine,Tinidazole, Tinidazole-Doxycycline,Tinidazole+ Tetracycline, Verapamil
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CHEE 440 10
EntericEnteric--coatedcoated
coating resists dissolution or disruption in stomach
but not in intestines
used for drugs that are unstable, irritating to
stomach
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CHEE 440 11
Enteric CoatingEnteric Coating
DescriptionReconstitutionlevel
Averageweightgain
Application ** examples
Organic EntericCoating system,Cellulose Acetate
Phthalate based
5% 8%
Aqueous coatingsystem & Organicenteric coatingsystem. HydroxyPropyl Methyl
Cellulose Phthalate
based system.
Organic: 5%Aqueous: 10%
8%
Methacrylic acidcopolymer type "C"USP/NF basedsystem
Aqueous 20%
Hydro Alcoholic10%
Organic System10%
9%
Aspirin, Bisacodyl
Diclofenac Sodium
Doxylamine Succinate
Garlic Tablets,Omeprazol,
Pentaprazole,
Pentoxyfyline, Rabeprazol ,
Serrosipeptadise
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CHEE 440 12
Press CoatingPress Coating
use of compression to form coat around a pre-formed core
used mainly to separate chemically incompatiblematerials
also dual release patternspossible