Corso di Formazione in SBQOrganizzato dal Dott. Mario Siniscalchi Calvizzano, Napoli, 18 Novembre 2012

Hotel Da Donato

Teoria Microcircolatoria Semeiotico-Biofisico-Quantistica dell’Aterosclerosi

Dott. Sergio Stagnaro

Sergio Stagnaro (2003). Arteriosclerotic Constituti on. Microcirculatory Theory of the Arteriosclerosis.

http://www.semeioticabiofisica.it/semeioticabiofisi ca/Documenti/Eng/Costituzione%20arteriosclerotica%20engl.doc

Sergio Stagnaro and Simone Caramel (2012). Quantum Biophysical Semeiotics Microcirculatory Theory of Atherosclero sis – www.sisbq.org ,

Journal of Quantum Biophysical Semeiotics,http://www.sisbq.org/uploads/5/6/8/7/5687930/ats_qb s__mctheory.pdfSergio Stagnaro and Simone Caramel (2012). The Role of Inherited Vasa

Vasorum Remodeling in QBS Microcirculatory Theory of Atherosclerosis.http://www.sisbq.org/uploads/5/6/8/7/5687930/ats_theory__qbs.pdf

Infarto Miocardico in Cifredopo il Framingham Heart Study dopo il Framingham Heart Study -- 19481948 --

IncidenzaOgni anno 150.000; Ogni giorno 410; Ogni ora 17

MortalitàOgni anno 80.000; Ogni giorno 19; Ogni ora 9

Fattori di Rischio circa 300 (Ipotesi ad hoc !)

il 30% di infartuati NON ha fattori di rischio il 50% di soggetti CON fattori di rischio NON ha IMA

Esiste senza dubbio il Reale Rischio Congenito di C VD!

Stagnaro Sergio. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canad. Med. Associat. Jour. CMAJ, 14 Dec 2009,

http://www.cmaj.ca/content/181/12/E267/reply#cmaj_el_253801Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific,

Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org,

29 April, 2009 http://www.athero.org/commentaries/comm907.asp

Quantum Biophysical Semeiotics

QBS is an extension of traditional, academic, orthodox, physical Semeiotics.

QBS utilises both Deterministic Chaos and Quantum Physics .Quantum Physics .

QBS allows doctors to interpret a large number of signs in order to bedside detect disorders, since their potential, initial, stages, e.g., Constitution-Dependent, Inherited Real Risks.

Gastric Aspecific Reflex

Gastric Aspecific Reflex Parameter Values

Stimulation Intensity plays a central Role in QBS

a) Latency Time (in sec.): tissue oxygenation, tissue pH

b) Intensity (in cm.): seriousness of underlying disorder

c) Reflex Duration (in sec.): Microcirculatory Functional Reserve

d) Disappearing Time (in sec.): important parameter value, which parallels fractal Dimension of upper and lower Ureteral Reflex Oscillations, i.e., vasomotility and vasomotion

Artery QBS Evaluation-- Psychokinetic Diagnostic --

Small, Mean-Intense, Intense digital Pressure allows doctor to assess, respectively:

1. Artery Thikening (in toto Ureteral- Choledocic- A.G.- Reflex), and Vasa Vasorum Amount, Vasomotility and Vasomotion Vasa Vasorum Amount, Vasomotility and Vasomotion

2. Artery Vasomotility and Vasomotion

3. Artery Compliance, Basal and under Insulin, Adiponectine, Boxer’s Test, Restano’s and Valsalva’s Manoeuvre

Ungueal Pressure : Cytochine Tissue Level

Prof. Claudio AllegraDirector Angiology Dept.

S.Giovanni Hospital –Rome

Microcirculation: this unknown

Patogenesi dell’ATS nei Secoli• Aristotele notò “ossa nel cuore”.• Nel 1500 Antonio BENIVIENI e Gabriele FALLOPPIO notarono l’indurimento

arterioso e lo descrissero in modo raffinato.• Nel 1600 Lorenzo BELLINI in una donna di 90 aa. osservò calcificazioni

arteriose.

• Nel 1600-1700 Herman BOERHAAVE (1668-1738) fu il PRIMO ad accennare alla patogenesi dell’ATS, interpretandola come incapacità dei Vasa Vasorum a nutrire la parete arteriosa, con strumenti rudimentali per lo studio del microcircolo congiuntivale!

• Nel 1800 Morgagni notò che l’ATS è indipendente dall’età!• Nel 1883 Johan Friedrich LOBSTEIN – chirurgo patologo franco-tedesco -

conia il termine “Arteriosclerosi”.• Nel 1904 Felix Jacob MARCHAND - patologo tedesco - crea il termine

“Aterosclerosi”.• Nel 1856 Virchow, Anitchkov e Chalatov (1913) formulano la teoria della

“insudazione ” e Rokitansky nel 1842 quella della “incrostazione ”, ripresa poi da Duguid (1946)]

• Recenti teorie: “Response to Injury ”, Ross, Glomset e Harker (1973 e 1986); della “Response to Retention ”, K. J. Williams e I. Tabas (1995); ACIDITY THEORY OF ATHEROSCLEROSIS, Carlos Monteiro (2006), sulla base della Myogenic Theory of Myocardial Infarction, Quintiliano H. de Mesquita (1972) .

ATS Natural History

With kind Permission of Prof. C. AllegraWith kind Permission of Prof. C. Allegra

Herman Boerhaave(Voorhout, December 31,1668 – Leiden, September23, 1738) was a Dutchbotanist, humanist andbotanist, humanist andphysician of Europeanfame. He is regarded asthe founder of clinicalteaching and of themodern academic hospital.His main achievement wasto demonstrate the relationof symptoms to lesions.

Microcirculation, accord. to Prof. C. Allegra

Small Artery, accord. to Hammersen

Vasomotility e Vasomotion

VasomotilityHighest Activation and Microcirculatory Failure

Allegra’s Syndrome:type II and III Pathological

Microcirculatory Activation

Genoma⇓

⇓ Parenchima ⇔⇔⇔⇔ Microvasi ⇓

Stagnaro Sergio. Biological System Functional Modif ication parallels Gene Mutation.www.Nature.com , March 13, 2008 http://blogs.nature.com/nm/spoonful/2008/03/gout_ge ne.html

Stagnaro Sergio. Quantum Biophysical Semeiotics: The Theory of Angio biopathy . http://sciphu.com/ , 11 May, 2009. http://wwwshiphusemeioticscom-stagnaro.blogspot.com

Sergio Stagnaro and Simone Caramel (2011). Skeletal Muscle Cell Glycocalix Evaluation during CFS Treatment corroborates Andras Pellionisz's Fractal Genome Recursive

Function Principle.

http://www.sisbq.org/uploads/5/6/8/7/5687930/cfsglycocalyx.pdf

Rimodellamento Microcircolatorionelle Arterie e nel relativo Parenchima

Cellule staminali di identica origine mesodermica provvedono alla formazione sia dei parenchimi sia dei relativi macro- e micro-vasi, inclusi i Vasa Vasorum.

Localizzazione dei DEB Fisiologici

Localizzazione dei DEB neoformati-patologici

Caotino’s SignCaotino’s Sign

Segno di Caotino Negativo Fisiopatologia

Segno di Caotino PositivoFisiopatologia

Significati del Segno di Caotino

1) Reale Rischio Congenito di CAD: nel 90% ca.2) Costituzione Aritmogena, ARVD…3) Pervietà Setto Inter-Atriale e -Ventricolare4) Valvulopatie varie4) Valvulopatie varie5) Patologia del Pericardio6) Aneurisma del seno di Valsalva IIIa + v …

7) Pregresso IMA (tl 2 sec.; Int. ≥ 1 <3 cm.)8) Presenza di Stent (tl 3 sec.; Int ≥ 3 cm.)

Etcetera…

Antognetti’s Signreliable in bed-side Diagnosing CVD Inherited Real Risk, and overt CVD, even initial or silent. Exclusively in ATS, “intense” digital pressure, applied on every large Artery, brings about “simultaneously” Aspecific Gastric Reflex, different in INTENSITY!

Reflex Intensity parallels underlying disorder seriousness. Reflex Intensity parallels underlying disorder seriousness. (Localised Stimulation, Glycocalyx Assessment, a.s.o.)

CVD IRR: Int. < 1 cm;

CVD: Int. ≥ 1 cm.

ATS QBS Microcirculatory Theory Principles

1) CAEMH , conditio sine qua non of common Disorders, as CVD, DM., Cancer, and so on. ;TISSUE ACIDOSIS (LDL-electronegative; Misfolfing; Chaperons, ATP!; ↑ ODC ↑ Polyamines); MITOCHONDRIAL HETEROPLASMY intra-cellular and inter-cellular (precise disorder location).

2) CAEMH modifies mit-DNA of Parenchymal and Artery Wall Cells, e.g., end artery Vasa Vasorum.

3) According to Angiobiopathy Theory, parenchymal Alterations parallel Alterations of Artery Wall Cell s.3) According to Angiobiopathy Theory, parenchymal Alterations parallel Alterations of Artery Wall Cell s.Involved by CAEMH Parenchymal Cells need less Blood Supply than the normal ones, bringing about Vasa Vasorum

Microcirculatory Remodelling: type I, subtype b) newborn-pathological Endoarteriolar Blocking Devices.

4) Artery Vasa Vasorum - less numerous than those of related, thinner Veins, except pulmonary Artery - are fewer in the Aorta Wall from Renal Artery Level.

5) Due to Vasa Vasorum Remodelling, A.V. Anastomoses are persistently open -Bloof-Flow Centralization - Shear Stresslowering, and thus Blood-Sludge, ↑ Endothelial Dysfunction, and SMC Proliferation (↑ poliamines due to ↑ ODC) and Migration (FMFs).

6) Locally Endothels Mitochondria are impaired in HP Zone due to Embriological Reason. As a consequence, blood cells, lipids and proteins Infiltration may occur at this Level, BUT after years from Birth, worsening media-intimal thickening, and later causing atheromatous Plaques.

QuantumQuantum --BiophysicalBiophysical--Semeiotic Semeiotic

Microcirculatory Theory of AtherosclerosisMicrocirculatory Theory of Atherosclerosis

Stage I: From Birth → I st. YearStage I: From Birth → I st. Year ..

Vasa Vasorum, involved by Inherited Real Risk of AT S, show altered Dynamics: Vasa Vasorum, involved by Inherited Real Risk of AT S, show altered Dynamics: in Health, during the First Decade, Vasomotility an d Vasomotion Diastole lasts 7in Health, during the First Decade, Vasomotility an d Vasomotion Diastole lasts 7-- 9 sec. 9 sec. (from the eleventh year = 6 sec). On the Contrary, in ATS IRR Physician observes Type II, (from the eleventh year = 6 sec). On the Contrary, in ATS IRR Physician observes Type II,

“slight”, dissociated Microcirculatory Activation; Vasomotility Diastole lasts 6,5 sec. while “slight”, dissociated Microcirculatory Activation; Vasomotility Diastole lasts 6,5 sec. while Vasomotion Duration is 6 sec. ; only at Rest: pH N N. Vasomotion Duration is 6 sec. ; only at Rest: pH N N.

Allegra’s Syndrome. Slight Glycocalyx Function Imp airment!Allegra’s Syndrome. Slight Glycocalyx Function Imp airment!Allegra’s Syndrome. Slight Glycocalyx Function Imp airment!Allegra’s Syndrome. Slight Glycocalyx Function Imp airment!

Stage II: after I st. Year → 5 YearsStage II: after I st. Year → 5 Years ..

Type II “worse”, dissociated Microcirculatory Act ivation, even at Rest → pH ↓ → PolyType II “worse”, dissociated Microcirculatory Act ivation, even at Rest → pH ↓ → Poly--diamines, Jaluronic Acid Fragments, Fibroblastdiamines, Jaluronic Acid Fragments, Fibroblast--Der ived End.1 ↑ → Cell ProliferationDerived End.1 ↑ → Cell Proliferation--Migration Stimulation → Artery Intimal Thikening. Migration Stimulation → Artery Intimal Thikening. Glycocalyx Function significant Impairment: Interst itial Matrix alteration, BoundGlycocalyx Function significant Impairment: Interst itial Matrix alteration, Bound--Free WaterFree Water

Stage III: after 5 Years → 10 YearsStage III: after 5 Years → 10 Years ..

Type III dissociated Microcirculatory Activation → pH ↓ → local Endothel and Tissue Damage → Type III dissociated Microcirculatory Activation → pH ↓ → local Endothel and Tissue Damage → cellular Infiltration and initial Plaque Formatio n → subsequent artery Lumen Narrowing. cellular Infiltration and initial Plaque Formatio n → subsequent artery Lumen Narrowing. Glycocalyx Function worse ImpairmentGlycocalyx Function worse Impairment

Reale Rischio Congenito di ATSBlue Therapy

a) Dieta Mediterranea, intesa etimologicamente (Esercizio muscolare, Peso Reale e Peso Ideale in Relazione ottimale, Evitare Evitare Evitare Evitare Fumo di TabaccoFumo di TabaccoFumo di TabaccoFumo di Tabacco, … , … , … , …

b) Melatonina (es., Melatonina-Coniugata, sec. Di Bella-b) Melatonina (es., Melatonina-Coniugata, sec. Di Bella-Ferrari)

c) Istangioprotettori: Acqua Termale Sulfidrilica (es. “La Puzzola”), Vit B, Cellfood, Carnetina, Bioflavonoidi, Antocianosidi (es. di MIRTILLO), …

d) Terapia Fisica: LLLT, NIR-LED, CEM-TECH, …

ConclusioneLa Teoria Microcircolatoria SBQ dell’Aterosclerosi è fondata su ICAEM,

ETEROPLASMIA MITOCONDRIALE e ACIDOSI ISTANGICA. Il Ruolo centrale è svolto dalla Valutazione dei Vasa Vasorum, a partire dal Primo Giorno di Vita.

La Teoria offre originali e soddisfacenti Risposte a Domande finora aperte.

A partire dalla nascita, la Teoria consente di riconoscere rapidamente e di localizzare su vastissima scala, a costo zero, il RRC di CVD, mediante il Segno di Antognetti, e la predisposizione alla calcificazione arteriosa o le calcificazioni in atto (1). la predisposizione alla calcificazione arteriosa o le calcificazioni in atto (1).

La Blue Therapy, impiegata in modo tempestivo, ottimale e personalizzato, fa scomparire il RRC di CVD, secondo il Principio della Funzione Ricorsiva del Genoma Frattalico di

Andras Pellionisz, da noi corroborato clinicamente (2).

Infine, la SBQ rende possibile il monitoraggio terapeutico delle lesioni aterosclerotiche.

1) Simone Caramel and Sergio Stagnaro (2012). Vascular calcification and Inherited Real Risk of lithiasis. Frontiers In Endocrinology 3:119. doi: 10.3389/fendo.2012.00119

http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full[MEDLINE]

2) Sergio Stagnaro and Simone Caramel (2011). Skeletal Muscle Cell Glycocalix Evaluation during CFS Treatment corroborates Andras Pellionisz's Recursive Fractal Genome Function Principle. http://www.sisbq.org/uploads/5/6/8/7/5687930/cfsglycocalyx.pdf