5th Ocular Oncology Day

Chair: Doris Hadjistilianou

Venue LocationHotel Garden2, Custoza st, 53100 Siena

RegistrationFor registrations, please visit the website: www.formazionedeventisrl.it.

CME AccreditationThis event has obtained from the Italian Ministry of Health, no. 9 CME Credits for:Orthoptists / Assistants in Ophthalmology, Nurses, Surgeons in: Oncology, Forensic Medicine Pediatrics, Ophthalmology, Neuroradiology, Radiotherapy and Genetic Medicine.The CME Credits will be awarded only to those who have:- Participated to the entire duration of the event- Completed the evaluation form of the event- Completed the CME questionnaire.

Organizing Secretary & CME Provider no. 447

3, Guadagnolo st, 00139 RomaTel: 06 87 188 886 / Fax: 06 87 192 213E-mail: info@formazionedeventisrl.it www.formazionedeventisrl.it

General Information

Siena, December 2nd-3rd, 2016Hotel Garden Sala Delle Camelie

Honorary PresidentsTero Kivela

Emilio Balestrazzi

Sponsored by

Ass. no pro� t “In fondo ai tuoi occhi”

Università degli studi di Siena

formazione ed eventi

International BoardL. Zografos, F. Munier, H. Kiratli, D. Gombos, M. Jager,

A.Schallenburg, T. Kivela, R. Aljamal, M. Popovic, A. Moll, S. Saakyan , A. Amiryan, P. De Graaf , M. De Jong

Local commetteeM. Blasi, C. Mosci, L. Pierro, V. Mazzeo, C. Mazzini

AIEOP BoardC. Favre, F. Fagioli, M.L. Garrè, R. Cozza, E. Basso,

A. Castellano, D. Galimberti, A. Tamburini

Scientifi c SecretaryM. Borri, G. Coriolani, S. De Francesco, G. Esposti

Angi M.Ariani F.Bacci T.Balestrazzi A.Balestrazzi E.Blasi M.A.Borri M.Bracco S.Brombin A.Caini M.Capozzoli M.Caputo R.Castellano A.Cennamo G.Chiarotti I.Coriolani G.Cozza R.De Francesco S.Esposti G.Fazio S.Fusco F.Cennamo G. Galimberti D.Galluzzi P.Garrè M. L.Guglielmucci D.Hadjistilianou D.Imperatore V.Litasova Y.

RelatoriMaestrini L.Martino F.Mazzeo V.Mazzini C.Mellace P.Menicacci F.Miele A.Monti L.Mora P.Mosci C.Neri G.Nucci P.Oldani B.Pagliara M.Pavese L.Pecorella I.Pieretti G.Pierro L.Pinto A.M.Rana F.Renieri A.Romanzo A.Russo I.Scaramuzzi M.Serafi no M.Sergenti J.Tarantello A.Tedesco S.Valente P.

Aljamal R.

Amiryan A.

Andreeva T.

Cohen V.

De Graaf P.

De Jong M.

Galley M. T.

Gombos Dan S.

Ivanova O.

Jager M.

Kiratli H.

SpeakersKivela T.

Marinkovic M.

Moll A.

Munier F.

Patel S.P.

Popovic M.

Saakyan S.

Schallenburg A.

Thomas A.

Vishnevskia-Dai V.

Zografos L.

14:00 Registration

CASE REPORTSModerators: R. Caputo, V. Mazzeo, C. Mazzini

14:30 Iris melanoma in a child: local treatment and long-term follow-up results S. V. Saakyan, O. Ivanova MOSCA

14:35 The neverending vs ending stories of three uveal melanomas. one more year follow-up V. Mazzeo, L. Lodi, BOLOGNA-FERRARA

14:40 Co-existence of intraocular and orbital lymphoma: does it rare condition? A. G. Amiryan, T. Andreeva MOSCA

14:45 Retinal astrocytic hamartoma: optical coherence tomography classifi cation and correlation with tuberosis sclerosis complex M. Scaramuzzi, M. Serafi no, P. Nucci MILANO

14:50 A rare case of multiple recurrent conjunctival malignant melanoma during 27 years. An. Balestrazzi, I. Giannico, I. Pecorella, E. Balestrazzi GROSSETO-ROMA

14:55 Conjunctival melanoma during pregnancy R. Aljamal LONDON

15:00 Mutational analysis in a patient with uveal and cutaneous melanoma DS. Gombos, S. Patel HOUSTON

15:05 Complex combined therapy for relapsed conjunctival melanoma G. Pieretti, A. Miele, N. Santoro, S.Rizzo, C. Mazzini FIRENZE

15:10 Masquerade syndrome in childhood: a tricking case S. Tedesco, P. Mora PARMA

15:15 OCT angiography in the diagnosis and follow up of choroidal tumors G. Cennamo NAPOLI

Friday December 2nd 15:20 The accordion SMCL V. Mazzeo, L. Lodi BOLOGNA-FERRARA

15:25 Eyelid lesion in a 4-year-old boy: a tricky case J. Sergenti, C. Bertone, M. Zecca, P. E. Bianchi PAVIA

15:30 Osteoma of the choroid G. Esposti, S. De Francesco SIENA

15:35 Diff erential diagnosis of peripheral exudative haemorrhagic chorioretinophaty (pehcr) in adult patient P. Mora, S. Tedesco PARMA

15:40 An accidental diagnosis of a rare intarorbital tumor - a multidisciplinary approach M. Pasti, B. Zamma Gallarati, C. De Libero, F. Mussolini, R. Caputo FIRENZE

15:45 Discussione

16:00 SESSION 1: Immunology in Ocular Oncology Moderators: M. Jager, S. P. Patel 16:00 Invited Lecture: Immunology and therapy in uveal melanoma M. Jager LEIDEN

16:20 Resistance to immune therapy in uveal melanoma S.P. Patel HOUSTON

16:40 SESSION 2: Filming the Intraarterial Chemotherapy Moderators: S. Bracco, D. Hadjistilianou, D. Gombos16:40 The IA story in progress S. Bracco, S. Cioni, P. Gennari, D. Romano, I. Vallone SIENA16:48 IA experience in Padua F. Causin PADOVA

16:56 Toxicities reported with intra-arterial chemotherapy for retinoblastoma Ds. Gombos, E. Shortridge HOUSTON

17:04 Conclusions D. Hadjistilianou SIENA

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17:20 SESSION 3: Nursing in Ocular Oncology Moderators: M.T. Galley, L. Maestrini17:20 Nursing management of patients receiving intraarterial chemotherapy M. T. Galley, A. Thomas LAUSANNE

17:27 Retinoblastoma: life stories L. Maestrini, C. Begani SIENA

Saturday December 3rd

08:00 Opening Ceremony

08:30 Invited Lecture: Nevus versus uveal melanoma T. Kivela HELSINKI

09:00 SESSION 4: Uveal Melanoma Moderators: E. Balestrazzi, M. Blasi, C. Mosci09:00 Uveal melanoma with optic nerve invasion MM. Pagliara, MA. Blasi ROMA

09:06 Long-term visual acuity preservation after proton therapy for parapapillary melanoma A. Schalenbourg, A. Pica, J. Hrbacek, H. Wagner, L. Vallat, C. Bergin, Dc. Weber, L. Zografos LAUSANNE

09:12 Stereotactic radiosurgery in uveal melanoma A. Miele, G. Pieretti, S. Rizzo, C. Mazzini FIRENZE

09:18 New frontiers in the radiotherapy of uveal melanoma C. Mosci GENOVA

09:24 Our experience in leiden with ruthenium with or without TTT in uveal melanoma M. Marinkovic LEIDEN

09:30 Prognostic biopsy in uveal melanoma: why, when and how? M. Angi MILANO

09:36 Familial and hereditary uveal melanomas T. Kivela HELSINKI

09:42 Extraocular extension of uveal melanoma: diagnosis and management V. Cohen LONDON

09:48 Optical density ratio of the sub-retinal fl uid in choroidal melanoma and metastasis as a novel additional diagnostic tool V. Vishnevskia-Dai, A. Leshno, A. Barak, D. Zur, Sh. Gabai, I. Moroz, M. Neudorfer TEL AVIV 09:54 I125 brachytherapy and vitrectomy in the treatment of uveal melanoma complicated with vitreous hemorrhage. F. Genovesi-Ebert, E. Di Bartolo, F. Cresti PISA10:00 Discussion10:10 Key Note Lecture: Contribution of modern multimodal imaging techniques in the management of uveal melanomas L. Zografos LAUSANNE 10:30 Coff e break10:45 SESSION 5: Imaging in Ocular Oncology Moderators : A. Moll, H. Kiratli, L. Pierro10:45 The role of SD-OCT in the diagnosis and management of intraocular tumors H. Kiratli ANKARA 10:52 A novel handheld optical frequency domain 1050nm imaging system: clinical study with pediatric retinoblastoma patients A. Moll, C. Nadiarnykh, N. Mcneill, M.I. Bosscha, P. De Graaf, F. Verbraak, J.F. De Boer AMSTERDAM10:59 The role of color doppler imaging in distinguishing malignant from benign eye lesions L. Monti, I. Chiarotti, P. Galluzzi SIENA 11.06 Choroidal osteoma, angioOCT diff erent patterns L. Pierro MILANO 11:10 Discussion11:25 Invited Lecture Role of anti-VEGF therapy in the management of retinoblastoma F. Munier LAUSANNE11:45 SESSION 6: MRI in Ocular Oncology Moderators: A. M. Pinto, L. Monti, P. De Graaf11:45 The value of dynamic contrast enhanced and diff usion weighted imaging in planning the right treatment in retinoblastoma patients P. Galluzzi SIENA

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11:51 MRI-based assessment of the pineal gland in a large population of children aged 0–5 years and comparison with pineoblastoma M. De Jong AMSTERDAM

11:57 Radiogenomics in retinoblastoma R. W. Jansen, M. C. De Jong, I. E. Kooi, S. Sirin, S. Göricke, H. J. Brisse, P.Maeder, P. Galluzzi, P. Van Der Valk, J. Cloos, I. Eekhout, J. A. Castelijns1 , A. C. Moll, J. C. Dorsman, P. De Graaf AMSTERDAM

12:05 Discussion

12:40 Lunch

14:00 SESSION 7: Chemo regimens in ocular oncology Moderators: M. Popovic, E. Basso D. Galimberti

14:00 The role of adjuvant systemic chemotherapy in advanced retinoblastoma with histologic risk factors after primary enucleation D. Galimberti, D.F. Guglielmucci, M. Caini, G. Coriolani, F. Carra, S. Grosso SIENA

14:07 “RTB AIEOP 012”: Presentation of the new regimen of treatment I. Russo ROMA

14:14 Treatment-related general side eff ects: a comparison between intravenous and intraarterial therapy in retinoblastoma M. Popovic LAUSANNE

14:21 Successes and failures of combined intra-arterial and intravitreal chemotherapy: a four years experience D. Hadjistilianou , S. De Francesco, M. Borri SIENA

14:28 Discussion

15:00 SESSION 8: Extraocular retinoblastoma Moderators: R. Cozza, A. Castellano, A. Tamburini

15:00 Update on extraocular retinoblastoma: current and innovative treatment strategies I. Russo ROMA

15:07 Extraocular retinoblastoma:response to intensivechemotherapyand outcome in 4 cases M. L. Garre, E. Lanino, G. Morana, P. Capris GENOVA

15:14 Extraocular retinoblastoma: an unusual case D. Hadjistilianou, G. Coriolani, D. Galimberti, E. Basso, D. Guglielmucci, F. Carra, M. Caini, P. Galluzzi, P. Toti SIENA15:21 Discussion

15:30 SESSION 9: Retinoblastoma and More Moderators: T. Kivela, F. Munier15:30 Cytology of aqueous fl uid and ocular washings following intravitreal injection of chemotherapy for retinoblastoma DS. Gombos, E. Shortridge, M. Chintagumpala, C. Herzog, P. Chevez-Barrios HOUSTON

15:35 Massive optic nerve invasion in retinoblastoma D. Hadjistilianou, G. Coriolani, P. Galluzzi, S. Defrancesco, M. Borri, D. Galimberti, M. Caini, D. Guglielmucci SIENA

15:40 Familiar neonatal retinoblastoma: a case of inappropriate Management. A. Romanzo ROMA

15:45 The role of enucleation in radiologically detectable optic Nerve Invasion: A Case Series P. Valente ROMA

15:50 Reasons for late relapses of retinoblastoma S. V. Saakyan, T. A. Andreeva MOSCA

15:55 Intravitreal melphalan and topotecan in the management of vitreous disease in retinoblastoma (our experience on some 40+ patients) H. Kiratli ANCARA

16:00 1Parent inheritance of rb1 hypomorphic mutations and somatic mosaicism can explain low penetrance in retinoblastoma V. Imperatore, A. M.Pinto, E. Gelli, E. Trevisson, C. Lo Rizzo, V. Morbidoni, G. Roversi, L. Dosa, S. Amitrano , S. Somma, M. Bruttini, P. Toti, M. F. Antonucci, T.Hadjistilianou, S. De Francesco, E. Gusson, M. A. Mencarelli, F. Mari, A. Renieri , F. Ariani SIENA

16:05 The “does” and “does not” in surgery for intraocular pediatric tumors F. Menicacci, S. Defrancesco, F. Neri, C. Menicacci, D. Hadjistilianou SIENA

16:10 Discussion

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16:30 SESSION 10: Residents Session: rapid fi re presentations Moderators: G. Chimenti, M. Borri, D. Hadjistilianou

16:30 Melanocytoma of the ciliary body in a child F. Fusco, F. Martino, D. Hadjistilianou, M. Borri, S. De Francesco, B. Colucci SIENA

16:34 Coats disease and norrie disease in the same family A. Tarantello, T. Bacci, L. Mazzera, R. Caputo SIENA

16:38 Amartoma of the optic disk S. Fazio, Y. Litasova, F. Rana SIENA

16:42 Mystery Case G. Esposti, S. De Francesco, M. Borri, L. Zografos SIENA

16:46 Retinoma and controlateral malignant transformation of retinoma M. Capozzoli, P. Mellace, B. Oldani TORINO-SIENA

17:00 Retinoblastoma or medulloepithelioma? D. Hadjistilianou, G. Neri, E. Latronico, L. Pavese, A. Brombin MODENA-SIENA

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Notes

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