the 7 steps of homology modeling. 1: template recognition and initial alignment
Post on 20-Dec-2015
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![Page 1: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/1.jpg)
The 7 steps of Homology modeling
![Page 2: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/2.jpg)
1: Template recognition and initial alignment
![Page 3: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/3.jpg)
1: Template recognition and initial alignment
2: Alignment correction
![Page 4: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/4.jpg)
![Page 5: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/5.jpg)
1: Template recognition and initial alignment
2: Alignment correction
![Page 6: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/6.jpg)
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
![Page 7: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/7.jpg)
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
4: Loop modeling
![Page 8: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/8.jpg)
4: Loop modeling
Known structure GVCMYIEA---LDKYACNC
Your sequence GECFMVKDLSNPSRYLCKC
![Page 9: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/9.jpg)
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
4: Loop modeling
5: Sidechain modeling
![Page 10: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/10.jpg)
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
4: Loop modeling
5: Sidechain modeling
6: Model optimization
![Page 11: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/11.jpg)
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
4: Loop modeling
5: Sidechain modeling
6: Model optimization
7: Model validation
![Page 12: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/12.jpg)
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
4: Loop modeling
5: Sidechain modeling
6: Model optimization
7: Model validation
8: Iteration
8: Iteration
8: Iteration
8: Iteration
![Page 13: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/13.jpg)
Model!
1: Template recognition and initial alignment
2: Alignment correction
3: Backbone generation
4: Loop modeling
5: Sidechain modeling
6: Model optimization
7: Model validation
8: Iteration
8: Iteration
8: Iteration
8: Iteration
![Page 14: The 7 steps of Homology modeling. 1: Template recognition and initial alignment](https://reader036.vdocuments.net/reader036/viewer/2022081420/56649d4b5503460f94a29358/html5/thumbnails/14.jpg)
7 steps of homology modeling
1: Template recognition and initial alignment2: Alignment correction3: Backbone generation4: Loop modeling5: Side-chain modeling6: Model optimization7: Model validation8: Iteration
Alignment
Modeling
Correction