The authors have no financial interest in the subject matter of this poster.

Cesar Bernilla MD, Maria A. Henriquez MD, Luis Izquierdo MDInstituto de ojos OFTALMOSALUD. Lima – Peru

To evaluate high order aberrometric outcomes 12 months after corneal collagen cross-linking (CXL) in eyes with keratoconus.

HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

Forty eyes of thirty four patients were included in this prospective, non randomized and single-center clinical study, using scheimplug analyzer Pentacam® version 1.16r63.

HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

Trefoil and coma mean baseline aberrations decrease from -0.0548 +/-0.3562 µm to -0.1963 +/-0.5421µm (p≤0.05) and from -1.6999 +/-1.1862µm to -23.3783 +/-139.2510µm (p≤0.05) respectively.

HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

Total aberrometic coeficient mean baseline were 1.750 +/- 0.4819µm, increasing to 1.893 +/- 0.6293µm at 12 month postoperative. That difference was not significant (p<0.05).

HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

Astigmatic and spherical aberrations mean baseline increase from -0.0282 +/-0.4899µm to 0.0593 +/-0.5281µm (p≤0.05) and from 0.3530 +/-0.7344µm to 0.6033 +/-1.082µm (p≤0.05) respectively.

HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

ORDER ABERRATIONPRE OPERATIVE MEAN

(µm)POST OPERATIVE MEAN

(µm)

Mean aberration coeficient 1.75 (±0.48198) 1.8925 (±0.62936)

3rd Coma -1.6999 (±1.18623) -23.3783 (±139.25109)

3rd Trefoil -0.0548 (±0.35627) -0.1963 (±0.51242)

4th High order astigmatism -0.0491 (±0.48198) 0.1524 (±0.77456)

4th Tetrafoil -0.0294(±0.60129) -0.0543 (±0.52224)

4th Spherical Aberration 0.3513 (±0.73449) 0.6033 (±1.08027)

5th High order coma 0.0488 (±0.28599) -0.0643 (±0.38893)

5th High order trefoil -0.0035 (±0.20314) -0.061 (±0.23362)

5th Pentafoil -0.0121 (±0.19826) -0.0234 (±0.40602)

Table 1. Summary of high order aberrations mean before and 12 months after corneal croslinking treatment.

ORDER ABERRATION MEAN (µm)STANDARD DEVIATION

SIGNIFICANCE LEVEL

Mean aberration coeficient -0.1425 0.59566 0.138

3rd Coma 21.67838 139.30035 0.039

3rd Trefoil 0.14148 0.5478 0.045

4th High order astigmatism -0.20143 0.54335 0.108

4th Tetrafoil 0.02493 0.52694 0.776

4th Spherical Aberration -0.252 0.89643 0.083

5th High order coma 0.113 0.37776 0.066

5th High order trefoil 0.5745 0.26862 0.184

5th Pentafoil 0.0113 0.41496 0.864

Table 2. High order aberrations mean variations 12th months after corneal croslinking treatment. Coma and trefoil aberration reduction was statistically significant (p<0.05).

Fig 1. Coma aberration reduction on a patient treated with Corneal Crosslinking

There was a reduction on coma and trefoil aberrations in patients with keratoconus undergoing crosslinking Pentacam corneal evaluated 12 months after procedure. However there was no statistically significant variation in high order aberrations coeficient.