the driver of the healthcare system in the 21st century: real-world application examples

The Driver of the Healthcare System in the 21st Century: Real-world Application Examples

Dr. Matthieu-P. Schapranow 2016 Telematics Conference, Potsdam

Feb 24, 2016

■  Patients

□  Individual anamnesis, family history, and background

□  Require fast access to individualized therapy

■  Clinicians

□  Identify root and extent of disease using laboratory tests

□  Evaluate therapy alternatives, adapt existing therapy

■  Researchers

□  Conduct laboratory work, e.g. analyze patient samples

□  Create new research findings and come-up with treatment alternatives

Healthcare Interactions in the 21st Century

Schapranow, Telematics Conference, Feb 24, 2016 2

The Driver of the Healthcare System in the 21st Century

Healthcare Interactions in the 21st Century

Schapranow, Telematics Conference, Feb 24, 2016


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Ind irect In te raction

D irect In te raction

C lin ic ian P atien tR esearcher

P harm aceu tica lC om pany

H ea lthcareP roviders

H osp ita lR esearch

C enterLabora to ry

P atien tA dvocacy

G roup

IT Challenges Distributed Heterogeneous Data Sources

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Human genome/biological data 600GB per full genome 15PB+ in databases of leading institutes

Prescription data 1.5B records from 10,000 doctors and 10M Patients (100 GB)

Clinical trials Currently more than 30k recruiting on ClinicalTrials.gov

Human proteome 160M data points (2.4GB) per sample >3TB raw proteome data in ProteomicsDB

PubMed database >23M articles

Hospital information systems Often more than 50GB

Medical sensor data Scan of a single organ in 1s creates 10GB of raw data Cancer patient records

>160k records at NCT The Driver of the Healthcare System in the 21st Century



Our Approach Analyze Genomes: Real-time Analysis of Big Medical Data

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In-Memory Database

Extensions for Life Sciences

Data Exchange, App Store

Access Control, Data Protection

Fair Use

Statistical Tools

Real-time Analysis

App-spanning User Profiles

Combined and Linked Data

Genome Data

Cellular Pathways

Genome Metadata

Research Publications

Pipeline and Analysis Models

Drugs and Interactions


Drug Response Analysis

Pathway Topology Analysis

Medical Knowledge Cockpit Oncolyzer

Clinical Trial Recruitment

Cohort Analysis

...

Indexed Sources

Integrated Processing and Real-time Analysis of Genome Data in the Clinical Routine

■  Control center for processing of raw DNA data, such as FASTQ, SAM, and VCF

■  Personal user profile guarantees privacy of uploaded and processed data

■  Supports reproducible research process by storing all relevant process parameters

■  Implements prioritized data processing and fair use, e.g. per department or per institute

■  Supports additional service, such as data annotations, billing, and sharing for all Analyze Genomes services

■  Honored by the 2014 European Life Science Award


Standardized Modeling and runtime environment for

analysis pipelines

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■  Query-oriented search interface

■  Seamless integration of patient specifics, e.g. from EMR

■  Parallel search in international knowledge bases, e.g. for biomarkers, literature, cellular pathway, and clinical trials

Medical Knowledge Cockpit for Patients and Clinicians Linking Patient Specifics with International Knowledge


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■  Integrated systems medicine based on real-time analysis of healthcare data

■  Initial funding period: Mar 2015 – Feb 2018

■  Funded consortium partners:

Systems Medicine Model of Heart Failure (SMART)



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Heart Failure

Sleeping disorder

Fibrosis

Blood pressure

Blood volume

Gene ex-pression

Hyper-trophy Calcium

meta-bolism

Energy meta-bolism

Iron deficiency

Vitamin-D deficiency

Gender

Epi-genetics

■  Interdisciplinary partners collaborate on enabling real-time healthcare research

■  Initial funding period: Aug 2015 – July 2018

■  Funded consortium partners:

□  AOK German healthcare insurance company

□  data experts group Technology operations

□  Hasso Plattner Institute Real-time data analysis, in-memory database technology

□  Technology, Methods, and Infrastructure for Networked Medical Research

Legal and data protection

Smart Analysis Health Research Access (SAHRA)



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■  Online: Visit we.analyzegenomes.com for latest research results, slides, videos, tools, and publications

■  Offline: Read more about it, e.g. High-Performance In-Memory Genome Data Analysis: How In-Memory Database Technology Accelerates Personalized Medicine, In-Memory Data Management Research, Springer,

ISBN: 978-3-319-03034-0, 2014

■  In Person: Join us for “Cebit 2016” March 14-20, 2016 in Hanover, Germany

Where to find additional information?



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Keep in contact with us!

Dr. Matthieu-P. Schapranow Program Manager E-Health & Life Sciences

Hasso Plattner Institute

August-Bebel-Str. 88 14482 Potsdam, Germany

[email protected]

http://we.analyzegenomes.com/



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the driver of the healthcare system in the 21st century: real-world application examples

Health & Medicine