Upload File

the ins and outs of human challenge studies - who...john s oxford and juliette r oxford* blizard...

  • Home
  • Documents
  • The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
28
The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London

Upload: others

Post on 09-Aug-2020

1 views

Category:

Documents


0 download

Report

TRANSCRIPT

Page 1: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology

The ins and outs of

Human Challenge studies

John Oxford DSc FRCPE

Professor of Virology,

Queen Mary College, London

Page 2: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 3: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 4: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 5: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 6: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 7: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 8: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 9: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 10: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 11: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 12: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 13: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 14: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 15: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 16: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 17: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 18: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 19: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 20: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 21: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 22: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology

Influenza Specific Protein

Responses- Baseline

Page 23: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 24: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 25: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 26: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology
Page 27: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology

SUMMARY

Technical

1.Virus wild type to GMP level.

2.Sourced by WHO laboratory (A/Bergen/2016?)

3.HI antibody of <15 still important.

Volunteers

1.Healthy, young.

2.Older and even asthmatic.

3.Attention to nearby A&E department.

4.Tamiflu stock

Ethics

1. Hippocratic oath.

Pathology/Safety

1.Phase I study of drug/vaccine.

2.Virus is pre-studied and titrated.

3.However, the mixture is novel.

Page 28: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology

Bart's pantry bart's pantry-1928

NYC Marathon 2011 - Bart's voorbereiding #2

Bart's Senate Presentation€¦ · Cackling geese Canada goose Historic: 400,000 1970s: 50,000 1984: 26,000

Oxford Activity Sheets4 Oxford Rooftops 4. 5 Oxford Rooftops 4. 6 Oxford Rooftops 4. 7 Oxford Rooftops 4. 8 Oxford Rooftops 4. 9 Oxford Rooftops 4. 10 Oxford Rooftops 4. 11 Oxford

Oxford OXFORD CND

a handbook for supervising doctors in training · Dr Claire Blizard, Chair, Prevocational Accreditation Committee, CETI ... Dr Marie-Louise Stokes, Senior Medical Advisor, CETI

Bart's friends new york city relief : the relief bus-2061

Blizard Institute Core Pathology Atlas of Tinctorial Stains

SPECIAL CHRISTMAS SERVICES - Felmersham · Electrical Services Martin Blizard 782527 Electrical Services Mick Bowyer 783472 General Building Renovation work Allan Levene 781918 Odd

BART's 2016 Bond Measure

OXFORD ALLOYS, INC. COATED ELECTRODES Nickel Alloys Oxford Alloy A 10 Oxford Alloy C-276 11 Oxford Alloy 55 12 Oxford Alloy 59 13 Oxford Alloy 99 14 Oxford Alloy 112 15 Oxford Alloy

Oxford Martin School - University of Oxford

Bart's Handbook: Punctuation, Grammar, and Word Usage

OxfOrd dictiOnaries - Oxford University Press

The History of Geriatric Medicine in Malaysiain Ireland and his Geriatric Medicine training at Oxford and St Bart's, London. He returned to Malaysia in 1992 and together with Srinivas,

The OXFORD UPDATE - Oxford University Press · The Oxford Update April-June 2020 Oxford University Press Oxford University Press is a department of the University of Oxford. It furthers

St. artholomew’s Anglican hurchchurchofstbarts.org/Chatters/CHATTERJUNE2015.pdfSt. artholomew’s Anglican hurch St. Bart's Web Information Also see our Facebook page for more! St

OXFORD English Grammar OXFORD

OXFORD PAPERBACK REFERENCE - fd.unl.pt · OXFORD UNIVERSITY PRESS Great ClarendonStreet, Oxford oxa sm-Oxford UniversityPress is a departmentoftheUniversityof Oxford. It furthers

REGULAR MONTHLY ACTIVITIES - Felmersham · Electrical Services Martin Blizard 782527 Electrical Services Mick Bowyer 783472 General Building Allan Levene 781918 Odd Jobs (babysitting

Oxford Medicine - University of Oxford

Blizard Institute: Career Development Talks for PhDs

Oxford Handbook of Distributive Justice (Oxford: Oxford ... · 1 Distributive Justice and Climate Change1 Forthcoming in Oxford Handbook of Distributive Justice (Oxford: Oxford University

St Bart's Roby

Working with Biological Agents - Blizard Institute€¦  · Web viewProcedures and Guidance Notes for working with biological agents and materials No ... Leptospira interrogans

OXFORD HIGH SCHOOL - Oxford Schools

Improving governance - The St. Bart's Multi-Academy Trustsbmat.org/.../Improving_governance-document-Jan17.pdf · Improving governance December 2016, No. 160053 3 Introduction When

The Oxford Handbook of Philosophy and Psychiatry (Oxford: Oxford

NYC Marathon 2011 - Bart's voorbereiding #1

Oxford Archaeology - Louth County Council · Oxford Archaeology Oxford Archaeology is the largest archaeological practice in Britain, with bases in Oxford (formerly Oxford Archaeological

BART's Proposed Seat Ordinance

SUPREME COURT OF ALABAMA parte Vulcan Materials.pdf · Ex parte Vulcan Materials Company PETITION FOR WRIT OF MANDAMUS (In re: James Blizard d/b/a Blizard Construction Company and

Oxford Handbook of Perceptual Organizationgestaltrevision.be/pdfs/oxford/Smithson-Perceptual_organization_of... · Oxford Handbook of Perceptual Organization Oxford University Press

Oxford Area School. Christchurch Oxford Where is Oxford Area School?

Oxford Plastics USA | Oxford Plastics