the patched (ptc) gene
DESCRIPTION
The PATCHED (Ptc) Gene. Brendan McQuellon. What is PATCH. Transmembrane surface receptor Binds ligands of Hedgehog(Hh) family. Weinberg, 2007. Normal Ptc Role. Controls cell fate by inhibiting Hh/Shh signaling Inhibits the transcription of Hh/Shh target genes Can regulate the cell cycle. - PowerPoint PPT PresentationTRANSCRIPT
The PATCHED (Ptc) The PATCHED (Ptc) GeneGene
Brendan McQuellonBrendan McQuellon
What is PATCHWhat is PATCH
• Transmembrane surface receptor
• Binds ligands of Hedgehog(Hh) familyWeinberg, 2007
Normal Ptc RoleNormal Ptc Role
• Controls cell fate by inhibiting Hh/Shh signaling
• Inhibits the transcription of Hh/Shh target genes
• Can regulate the cell cycle
Shh/Ptc/Gli pathwayShh/Ptc/Gli pathway
Weinberg, 2007
http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg
Shh/Ptc/Gli pathwayShh/Ptc/Gli pathway
Weinberg, 2007
http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg
Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.phpwww.pressthebuttons.com/
Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.phpwww.pressthebuttons.com/
Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php
www.pressthebuttons.com/
Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
Goodrich et al, 2007 www.pressthebuttons.com/
How KO’s were madeHow KO’s were made
Goodrich et al., 1997
Heterozygous MiceHeterozygous Mice
Goodrich et at., 1997
Heterozygous MiceHeterozygous Mice
Goodrich et at., 1997
How does Ptc relate to cancer?How does Ptc relate to cancer?
• Gorlin Syndrome– Basal Cell Carcinomas
– Medulloblastomas
• Sporadic Instances
• Ionizing Radiation
http://www.medicalecology.org/images/atmosphere/skincancer1.gif
How does Ptc relate to cancer?How does Ptc relate to cancer?
• Meningiomas, Breast and Esophageal carcinomas
• Shh/Ptc pathway hyperactive in many other cancers