the steroidogenic pathways - genova diagnostics, …steroidogenic pathway_poster-complex-24x36.indd...
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11-DeoxycortisolCorticosterone
Pregnanediol Pregnanetriol
THS
a-THF THF THE 2-MeO (E1+E2)2-OH (E1+E2)
16a-OH(E1)
4-OH (E1+E2) 4-MeO (E1+E2)
Etiocholanolone
Androsterone Androstanediol11β -OH-Androstenedione
Adrenosterone
11-OH-Androsterone
11-OH-Etiocholanolone
11-Keto-Androsterone 11-Keto-Etiocholanolone
Cholesterol
Pregnenolone
Progesterone 17-OH-Progesterone
17-OH-Pregnenolone
Androstenedione
DHEA Androstenediol
Estrone (E1)
Estriol (E3)
Estradiol (E2)
DHT
Testosterone
Cortisol(active)
Cortisone(inactive)
1A1 = Cytochrome p450 1A1 (CYP1A1)3A4 = Cytochrome p450 3A4 (CYP3A4)1B1 = Cytochrome p450 1B1 (CYP1B1)COMT = Catechol-O-Methyl-transferase
ESTROGEN METABOLISM:
3βHSD = 3beta-Hydroxysteroid dehydrogenase 5α = 5alpha-Reductase5β = 5beta-ReductaseCYP11β1 = 11beta-Hydroxylase11βHSD = 11beta-Hydroxysteroid dehydrogenase17βHSD = 17beta-Hydroxysteroid dehydrogenase17,20 Lyase = 17,20 Desmolase CYPc17 = 17alpha-HydroxylaseCYP19 = AromataseCYP21 = 21-Hydroxylase
ENZYMATIC STEPS:
Mineralocorticoids
11
17-Hydroxysteroids1 Keto Androsterone eto t oc o a o o e11
17-Ketosteroids
4-OH (E1+E2) 4-MeO (E1+E2)
Estrogen MetabolitesMeasurable in Urine
Measurable in Blood
Measurable in Saliva
Hormones measurable by Genova Diagnostics:
3βH
SD
17,20 Lyase
17,20 Lyase
3βH
SDC
YP21
CYPc17
CYPc17
CYP
21C
YP11
b1
5α
5β 5β
11βHSD
3βH
SD
5α
5β
5α 5β
COMT
Aromatase (CYP19)
3βH
SD
COMT
17βHSD
3A4
1A1
5α3α
HSD
17βHSD
1B1
17βHSD
5β
5α
Aromatase (CYP19)
17βHSD
AVAILABLE ACROSS THESE PROFILES:
Excess adipose, alcohol, zinc deficiency, stress,hyperinsulinemia,
inflammation, licorice, vitamin D3 (in osteoblasts), forskolin,
isoproterenol
Polycyclic aromatic hydrocarbons, PCBs
Hops, bioflavonoids,grapefruit
(-)
(+)(+)
(+) (+)
(-)
(-)
(+)
(-) (-)
(+) (+)
(-) (-) (+)
Congenital adrenal hyperplasia (CAH), smoking, E2, progesterone, azole
antifungals, spironolactone
Insulin resistance, obesity, PCOS, androgenic alopecia, essential HT, high-carb diet,
sodium restriction, DHEA
Celiac disease, 5α-reductase inhibitors (e.g., finasteride, saw palmetto, pygeum, stinging
nettle), flaxseed, soy isoflavones, EGCG, quercetin, progesterone, some progestins
Hyperglycemia, azole antifungals, aging, smoking, dioxin toxicity, HIV, licorice,
etomidate, liarozolePhytoestrogens, flaxseed, licorice,
progestins, tamoxifenAlcohol, IL-6, abdominal obesity, DHEA,
forskolin
CAH, chronic ETOH ingestion, PCB toxicity, progestins, isoflavonoids, metformin, troglitazone, trilostane
Hyperadrenalism, hyperthyroidism, hyperinsulinemia, PCOS, IL-4 and IL-13, IGF-1, forskolin Smoking, dioxin, isoflavones,
flaxseed, procyanidins, flavonoids, EGCG, epilobium, vitamin C, anastrazole, etc;
chrysin, stinging nettles, and other flavonoids;
ketoconazole, metformin
Crucifers, berries, I3C, DIM, soy, flaxseed, caffeine, rosemary, exercise, thyroxine
Excess sugar or n6 fats, cimetidine, OCPs
(+)(-)
Grapefruit, peppermint oil, rosemary, wild yam, anti-fungals & other medications(-)
(-)
(-)
Hypothyroidism, pesticide exposure, smoking, caffeine, various medications(+)
(+)
(+)
COMT support: Adequate methionine, Mg, B vitamins, GSH; reduce stress, rule out Hg toxicity & oxidative stress
Insulin resistance,obesity,
fatty liver, nonalcoholic steatohepatitis
Licorice
Hyperglycemia, hyperinsulinemia, PCOS (ovary), stress, alcohol, antiepileptics
(+) (+)
(-) (-)
More cortisol:Obesity (esp. visceral),
metabolicsyndrome, hypothyroid, inflammation, essential HT,c ortisol resistance, cholestasis, hypoxia, licorice, vitamin D,
grapefruit, forskolin
Less cortisol:Good insulin sensitivity,
hyperthyroidism,reduced inflammation,
Na restriction, hGH(via IGF-1), E2,
coffee, rosiglitazone, ketoconazole
Sodium depletion, high prolactin
CAH, DHEA, azole antifungals, etomidate, metyrapone
CAH, late-onset adrenal hyperplasia, primary adrenal insufficiency, ankylosing spondylitis, increased salt
cravings, resveratrol, soy isoflavonoids, DHEA, omeprazole
PCB toxicity, DHEA, antiepileptics
(-) (-)
The Steroidogenic Pathways
© 2017 Genova Diagnostics
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