topical vaccination shows promise in a murine model
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RESEARCH & DEVELOPMENT
Topical vaccination shows promise in a murine model
It may be possible to develop vaccines that are administered topically, according to researchers from the US. They base their comment on the results of experiments involving an animal model in which genetic vectors applied to the skin were shown to elicit an immune response. ·
In the first experiment, an adenoviral vector encoding the human carcinoembryonic antigen (CEA) gene was applied to the skin of anaesthetised mice and allowed to incubate for 30 minutes to 1 hour. One month after vaccination, 23/24 mice were found to produce antibodies against human CEA.
In a second experiment, an adenoviral vector encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF) was applied to the skin of mice in the same fashion. Six of the 14 vaccinated mice subsequently produced antibodies against human GM-CSF.
The researchers note that 'this procedure requires no special skill or equipment and so may reduce medical costs and offer a unique method for vaccination' . . . Tang D-e, Shi Z. Curiel DT. Vaccina.tion onto bare skin. Nature 388: 729-730, 21 Aug 1997 8005'996'
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Inphanna-13 Sep 1997 No. 1104