toxicology: poisons and alcohol...toxicology: poisons and alcohol 27 people in the news john...
TRANSCRIPT
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Toxicology: Poisons and Alcohol
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Kendall/Hunt Publishing Company2
Chapter 8
Toxicology: Poisons and Alcohol
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Objectives
You will understand:
The danger of using alcohol.
A quantitative approach to
toxicology.
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You will be able to:
Discuss the connection of blood alcohol levels
to the law, incapacity, and test results.
Understand the vocabulary of poisons.
Design and conduct scientific investigations.
Use technology and mathematics to improve
investigations and communications.
Identify questions and concepts that guide
scientific investigations.
Communicate and defend a scientific argument.
Objectives, continued
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Toxicology
Toxicology—the study of the adverse e ects of chemicals or
physical agents on living organisms
Types:
Environmental—air, water, soil
Consumer—foods, cosmetics, drugs
Medical, clinical, forensic
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Forensic Toxicology
Postmortem—medical examiner or coroner
Criminal—motor vehicle
accidents (MVA)
Workplace—drug testing
Sports—human and animal
Environment—industrial, catastrophic, terrorism
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Toxicology
Toxic substances may:
Be a cause of death
Contribute to death
Cause impairment
Explain behavior
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Historical Perspective of Poisoners
Olympias—a famous Greek poisoner
Locusta—personal poisoner of Emperor Nero
Lucretia Borgia—father was Pope Alexander VI
Madame Giulia To ana—committed over 600 successful
poisonings, including two popes
Hieronyma Spara—formed a society to teach women how to
murder their husbands
Madame de Brinvilliers and Catherine Deshayes—French
poisoners
AND many others through modern times.
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The Severity of the Problem
“If all those buried in our cemeteries who were poisoned
could raise their hands, we would probably be shocked
by the numbers.”
—John Harris Trestrail, Criminal Poisoning
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People of Historical Significance
Mathieu Orfila—known as the
father of forensic toxicology,
published in 1814 Traité despoisons which described thefirst systematic approach to
the study of the chemistry
and physiological nature of
poisons
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Aspects of Toxicity
Dosage
The chemical or physical form of the substance
The mode of entry into the body
Body weight and physiological conditions of the victim,
including age and sex
The time period of exposure
The presence of other chemicals in the body or in the dose
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Lethal Dose
LD50 refers to the dose of a substance that kills half the test
population, usually within four hours
Expressed in milligrams of substance per kilogram of body
weight
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Toxicity Classification
relatively harmlessmore than 1 quartOver 15 g/kg
practically nontoxicto a quart5–15 g/kg
slightto a pint500–5,000 mg/kg
moderateto an ounce50–500 mg/kg
highto a teaspoon1–50 mg/kg
extremea taste to a drop
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Federal Regulatory Agencies
Food and Drug Administration (FDA)
Environmental Protection Agency (EPA)
Consumer Product Safety Commission
Department of Transportation (DOT)
Occupational Safety and Health Administration (OSHA)
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Symptoms of Various Types of Poisoning
Symptom/EvidenceCharacteristic burns around the lips and
mouth of victim
Red or pink patches on the chest and
thigh, unusually bright red lividity
Black vomit
Greenish-brown vomit
Yellow vomit
Co ee-brown vomit, onion or garlic odor
Burnt almond odor
Extreme diarrhea
Nausea and vomiting, unconsciousness
possibly blindness
Type of PoisonCaustic poison (lye)
Carbon monoxide
Sulfuric acid
Hydrochloric acid
Nitric acid
Phosphorus
Cyanide
Arsenic, mercury
Methyl (wood) or isopropyl
(rubbing) alcohol
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Critical Information
Form
Common color
Characteristic odor
Solubility
Taste
Common sources
Lethal dose
Mechanism
Possible methods ofadministration
Time interval of onset ofsymptoms
Symptoms resulting from an acuteexposure
Symptoms resulting from chronicexposure
Disease states mimicked by poisoning
Notes relating to the victim
Specimens from victim
Analytical detection methods
Known toxic levels
Notes pertinent to analysis of poison
List of cases in which poison was used
—John Trestrail from Criminal Poisoning
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To Prove a Case
Prove a crime was committed
Motive
Intent
Access to poison
Access to victim
Death was homicidal
Death was caused by poison
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Forensic Autopsy
Look for:
• Irritated tissues
• Characteristic odors
• Mees lines—single transverse white bands on nails
Order toxicological screens
• Postmortem concentrations should be done at the scenefor comparison.
• No realistic calculation of dose can be made from asingle measurement.
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Human Specimens for Analysis
Blood
Urine
Vitreous humor of eyes
Bile
Gastric contents
Liver tissue
Brain tissue
Kidney tissue
Hair/nails
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Alcohol—Ethyl Alcohol (C2H5OH)
Most abused drug in America
About 40 percent of all tra c deaths are alcohol-related
Toxic—a ecting the central nervous system, especially the brain
Colorless liquid, generally diluted in water
Acts as a depressant
Alcohol appears in blood within minutes of consumption; 30–90
minutes for full absorption
Detoxification—about 90 percent in the liver
About 5 percent is excreted unchanged in breath, perspiration,
and urine
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Rate of Absorption
Depends on:
Amount of alcohol consumed
The alcohol content ofthe beverage
Time taken to consume it
Quantity and type of foodpresent in the stomach
Physiology of the consumer
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BAC: Blood Alcohol Content
Expressed as percent weight per
volume of blood
Legal limit in all states is 0.08
percent
Parameters influencing BAC:
• Body weight
• Alcohol content
• Number of beverages consumed
• Time since consumption
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BAC Calculation
Male
BAC =
Female
BAC =
Burn-o rate of 0.015 percent per hour, but can vary:
0.071 × (oz) × (% alcohol) body weight
0.085 × (oz) × (% alcohol) body weight
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Henry’s Law
When a volatile chemical is dissolved in a liquid and is brought to
equilibrium with air, there is a fixed ratio between the
concentration of the volatile compound in the air and its
concentration in the liquid; this ratio is constant for a given
temperature. THEREFORE, the concentration of alcohol in
breath is proportional to that in the blood.
This ratio of alcohol in the blood to alcohol in the alveolar air is
approximately 2,100 to 1. In other words, 1 ml of blood will
contain nearly the same amount of alcohol as 2,100 ml of
breath.
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Field Tests
Preliminary tests—used to determine the degree of suspect’sphysical impairment and whether or not another test is justified
Psychophysical tests—three basic tests:
• Horizontal gaze nystagmus (HGN): follow a pen or small
flashlight, tracking left to right with one’s eyes. In general,
wavering at 45 degrees indicates 0.10 BAC.
• Nine-step walk and turn (WAT): comprehend and execute
two or more simple instructions at one time
• One-leg stand (OLS): maintain balance; comprehend and
execute two or more simple instructions at one time
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The Breathalyzer
More practical in the field
Collects and measures alcohol content
of alveolar breath
Breath sample mixes with 3 ml of 0.025 percent K2Cr2O7 in sulfuric
acid and water:
2K2Cr2O7 +3C2H5OH + 8H2SO4 → 2Cr2(SO4)3 + 2K2SO4 + 3CH3COOH + 11H2O
Potassium dichromate is yellow; as concentration decreases, its
light absorption diminishes, so the breathalyzer indirectly
measures alcohol concentration by measuring light absorption
of potassium dichromate before and after the reaction with
alcohol.
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Generalizations
During absorption, the concentration of alcohol in arterial blood is
higher than in venous blood.
Breath tests reflect alcohol concentration in the pulmonary artery.
The breathalyzer also can react with acetone (as found in
diabetics), acetaldehyde, methanol, isopropyl alcohol, and
paraldehyde, but these are toxic and their presence means the
person is in serious medical condition.
Breathalyzers now use an infrared light-absorption device with a
digital readout. Prints out a card for a permanent record.
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People in the News
John Trestrail is a practicing toxicologist who has consulted
on many criminal poisoning cases. He is the founder of the
Center for the Study of Criminal Poisoning in Grand Rapids,
Michigan, which has established an international database to
receive and analyze reports of homicidal poisonings from
around the world. He is also the director of DeVos Children’s
Hospital Regional Poison Center. In addition, he wrote the
book Criminal Poisoning, used as a reference by lawenforcement personnel, forensic scientists, and lawyers.
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More Information
Read more about forensic toxicology at truTV’s Crime
Library:
http://www.crimelibrary.com/criminal_mind/forensics/
toxicology/2.html