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POLIMORFISMOLocal do geneCromossomo 6 Posio 22.3

Comparao TPMT*1 x TPMT*2

THIOPURINE DOSING USING THIOPURINE …lab.research.sickkids.ca/.../2013-02-TPMT-guidance-Full-Report.pdf · The Hospital for Sick Children . Technology Assessment at SickKids (TASK)

Pharmacogenomics Eric Jorgenson. Outline Introduction Pharmacogenetics –TPMT –CYP2D6 Pharmacogenomics –GWAS –Gene Expression

NAME: SPECIMEN TYPE: Physician Name: COLLECTION DATE ... · statin-induced myopathy is not increased. TPMT *1/*3A Intermediate Metabolizer Consistent with a moderate deficiency in

TPMT - PeaceGovPH

Pharmacogénétique et Impact thérapeutique...CTMA / TPMT ~4000 samples RNA Genotyping 9.34 % 1998-2013 TPMPT*2 29 0.73 5/24 hetero with another heterovariant (three *3A,one *3B or*21)

IOS Press TPMT and DPD polymorphisms: Efficient screening

Pharmacogenomic of TPMT which affected to plasma level of thiopurine drugs

Pharmacogenomics of DMEs PGEN I Introduction …courses.washington.edu/medch527/PDFs/527_17Thummel_PGEN I...Pharmacogenomics of DMEs PGEN I Introduction and CYP3A, TPMT, ALDH2, UGT,

HHS Public Access - genelex.com · • Victoria M. Pratt: Employee of a fee for service clinical laboratory • Mary V. Relling: Husband and hospital get royalties from TPMT genetic

Approches méthodologiques en pharmacogénétique · Hématotoxicité Myélosuppression. ACTIVITE TPMT : DISTRIBUTION TRIMODALE M/M M/Wt Wt/Wt. METABOLISME DE L’AZA ET LA 6-MP AZA

Clinical Implementation of Pharmacogenetics€¦ · drugs, Feb 2016 • TPMT – MP, TG, azathioprine ... Dunnenberger et al Ann Rev Pharm Tox 2015 . At St. Jude, we can overcome

Schedule of Accreditation United Kingdom Accreditation Service · Roche 9180 Electrolyte Analyser and SOP BI-S-MISC-11 A Serum Lithium Documented in house procedure BI-S-LC-TPMT using

TİOPÜRİN S-METİL TRANSFERAZ (TPMT) - ahmetgnc.com · (6MP) gibi aromatik ve heterosiklik sülfidril bile şiklerin metilasyonunu katalizleyen sitoplazmik bir enzimdir • Normal

FARMACOGENÉTICA DO GENE TPMT NA RESPOSTA A 6 ...repositorio.ufpa.br/jspui/bitstream/2011/7252/1/Dissertacao_Farmaco... · (equipamento 7500 Real-Time PCR System) e os demais polimorfismos

Pharmacogenomics of DMEs PGEN II CYP3A, TPMT, ALDH2, UGT

Biophysical studies of Thiopurine S-methyltransferase (TPMT) variants

FARMACOGENÔMICA Alguns exemplos de possível relevância … · McLeod e Evans. Annu Rev Pharmacol Toxicol, 2001, 41: 101-21. Estudo da TPMT na população Brasileira Reis e cols,

PROMETHEUS TPMT Genetics TPMT Enzyme CLassify · PDF fileMetabolites monitoring identifies treatment failures who may be converted to responders3,c individualize dosing for maximal

Mutaciones en GST y TPMT Para Leucemia

BLAŽ MUHIČ · reakcije, hepatotoksinost, pankreatitis, slabost in bruhanje ne moremo predvideti z č določanjem TPMT (5). 6-MP se uporablja za zdravljenje ALL, uporaba AZA pa se

Pharmacogenomics of DMEs PGEN II CYP3A, TPMT, ALDH2, UGT ...courses.washington.edu/medch527/PDFs/527_13Thummel_PGEN2.pdf · Contribution of CYP3A5 to Hepatic" Tacrolimus Metabolism!

Proyecto de Ley 1 f TPMT C - Archivo Digital de la ... · DISTRITO DE "CHUQUIBAMBA" EN LA PROVINCIA DE 4—L,~ J CAJABAMBA EN EL DEPARTAMENTO DE CAJAMARCA. CONGRESO DE LA REPÚBLICA

2ª Reunión del Grupo de Trabajoimss.gob.mx/sites/all/statics/profesionalesSalud/... · TPMT*1,*2,*3A,*3B,*3C; ITPA (94C>A y IVS2+21); MTHFR (677C>T y 1298A>C); XO (A1936---> G y

SCH BRITSCH 10.13 Wendeplattenhalter 10 Spannzeuge ...TPGH 16 03.. TPMT 16 03.. T15 A02-35096 STAPR/L 1212M16 12 x 12 150 STAPR/L 1616H16 16 x 16 100 STAPR/L 2020K16 20 x 20 125 Wendeplattenhalter

Therapeutic drug monitoring (TDM) of thiopurine drugsarup.utah.edu/media/tpmt/ARUP Educational Lecture... · 2016. 7. 19. · 6-MP + SAM 6. TPMT -MMP. T P M T . centrifuge Add cosubstrates:

The Third Party Monitoring Team (TPMT) and Its Terms of Reference

Suspecting HEPATITIS · IBS (Irritable Bowel Syndrome) • ASCA (Anti Saccharomyces Cerevisiae Antibody) • Protein C & S Functional • Anti Thrombin III Functional TPMT Genotyping

ŽIADANKA O VYŠETRENIE − GENETIKA – RUTINNÁ … · FARMAKOGENETIKA Metabolizmus tiopurínov n TPMT: 238G>C, 460G>A, 719A>G (TPMT) K3/K2 EDTA krv Metabolizmus warfarínu n CYP2C9:

Mutacije, mutageneza, Do sedaj ste spoznali: vpliv ... · -farmakogenetika: u činkovitost terapije s tiopurini (polimorfizmi v genu za TPMT) Genetska raznolikost in človeški genom

A Simple Method for TPMT and ITPA Genotyping Using ... · *1/*1. For the ITPA c.94C[A 12 individuals were heterozygotes, 2 homozygous for the variant allele and the remaining 86 were