trans-radial approach in overweight patients hakim ben amer, md on behalf the trop study group
TRANSCRIPT
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Trans-Radial approach Trans-Radial approach in in
Overweight PatientsOverweight PatientsHakim Ben Amer, MD
On behalf the TROP study group
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Predicting vascular complications in percutaneous coronary
interventions18,137 PCI pts in northern New England (1997-1999); vascular complication* 2.98%
Variables associated with increased risk in the multivariate analysis Age >or=70 OR 2.7 Female gender OR 2.4Body surface area <1.6 m OR 1.9History of congestive heart failure OR 1.4Chronic obstructive pulmonary disease OR 1.5Renal failure OR 1.9Lower extremity vascular disease OR 1.4Bleeding disorder OR 1.68Emergent priority OR 2.3Myocardial infarction OR 1.7Shock OR 1.86>or=1 type B2 lesions OR 1.32 type C lesions OR 1.7 3-vessel PCI OR 1.5Thienopyridines OR 1.4Glycoprotein IIb/IIIa inhibitors OR 1.9
Piper WD Am Heart J. 2003 Jun;145(6):1022-9Piper WD Am Heart J. 2003 Jun;145(6):1022-9
*Vascular complications: access-site injury requiring treatment or bleeding requiring transfusion*Vascular complications: access-site injury requiring treatment or bleeding requiring transfusion
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Complications following diagnostic Complications following diagnostic coronary angiography: Predicting coronary angiography: Predicting
factorsfactors
Ammann CCVI 2003;59:13-18Ammann CCVI 2003;59:13-18
Factor All complications Major complications
Vascular complications
Heart failure (Killip>1)
0R 2.16; 95% CI 1.12-4.16;
p= 0.03
Left / Right catheterization
0R 2.62; 95% CI 1.46-4.7; p= 0.003
Senior physician (> 500)
0R 0.58; 95% CI 0.34-0.98;
p= 0.04
French: <6, =6, >6 0R 2.6; 95% CI 1.53-4.41; p= 0.0004
0R 2.35; 95% CI 1.0-5.51; p= 0.05
0R 2.54; 95% CI 0.93-7.02; p= 0.07
Smoking 0R 2.76; 95% CI 1.14-6.73;
p= 0.02
0R 3.93; 95% CI 1.28-12.06;
p= 0.01
Body weight (/10 kg)
0R 1.23; 95% CI 0.95-1.44;
p= 0.1
0R 1.4; 95% CI 1.01-1.95; p= 0.04
7,412 consecutive diagnostic cardiac catheterizations between 1990 and 20007,412 consecutive diagnostic cardiac catheterizations between 1990 and 2000
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Impact of Access Site Hematoma With Transfusion in Patients Undergoing Percutaneous Coronary Intervention
6613 PCI (98-00)(NHLBI): hematoma w transfusion 1.8% (97% femoral)
Predictors: Older age, Lower BMI, Female, renal disease, HTN, AMI, 3-VD, GPIIb/IIa -, Postprocedure heparin
Independent predictors: Older age, female, thrombotic lesion, 3-VD, renal disease, emergent PCI, prior aspirin
Procedural death: 10.3% w HWT 1.2% w/o HWT p <0.001 death/MI: 18.1% 3.55% <0.001
HWT is a predictor of death/MI (OR = 3.49; 95% CI: 1.98-6.14)
J. Slater Am J Cardiol 2003 (suppl) 92: J. Slater Am J Cardiol 2003 (suppl) 92: 18L 18L
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Clinical Significance of Bleeding Complications
From Blankenship Am Heart J 1999; 138: S287-S296From Blankenship Am Heart J 1999; 138: S287-S296
Median Length of Hospital Stay
(Day)
Extra Cost Others
Any Vascular Site Bleeding or Vascular Complication (Surgical)
+ 1Incapacitation (days-weeks)Return to normal activity delay
Major or Minor Vascular Site Bleeding or Vascular Complication (Surgical)
+ 2 + 1327 $ -
Major Vascular Site Bleeding or Vascular Complication (Surgical)
+ 4 + 5896 $ -
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Radial / Femoral Approach meta-analysis: Entry site complications
Agostini P JACCAgostini P JACC
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TransRadial ApproachIn OverWeight Patients
- Multicentric European Registry, - Coronary angiography (CA) or angioplasty (PCI)- Centres where there is at least one operator with a wide experience in the transradial approach for CA and PCI. - We include in the registry all the overweight patients with BMI 35, undergoing CA and/or PCI whatever the vascular approach chosen by the operator. -The primary end point is the occurrence of complications delaying the hospital discharge.
TROP Study Group
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TROP CentersTROP Centers
- Bergamo (Italy)- Brighton (England)- CHU Caen, (France)- HEP la Roseraie, (France)- Clinic Barcelona, (Spain)- Hôpital Bichat, Paris (France)- ICPS, Massy (France)- ICPS, Quincy (France)- Meixoeiro, (Spain)- Riga, (Latvia)- Szeged, (Hungary)- Val-de-Grâce (France)- Valle de Hebron, (Spain)
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3224
3619
1719
2761
64
2924
48
0 20 40 60 80
Riga (L)
Caen (F)
Szeged (H)
Roseraie (F)
Val de Grace (F)
Barcelona (S)
Quincy (F)
Bergamo (I )
Massy (F)
Bichat (F)
Valle Hebron (S)
Meixoeiro (S)
Brighton (E)
TROP Study Group
N = 346
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Clinical DatasMean Age 61.2 +/- 10.9 years (30/83)Sexe (Male) 52.9 %
Mean Weight 108 +/- 15 Kg (79/155)Mean Height 1.67 +/- 0.1 M (1.45/1.90)Mean BMI 38.7 +/- 3.4 Kg/m2 (35/56)
Renal Insuf 7.8%
TROP Study Group
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Clinical Datas
TROP Study Group
64,4
11,3
24,3
8,4
0
10
20
30
40
50
60
70
ANGIO
PCI
ANGIO + PCI
EMERGENCY
%
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Clinical Datas
TROP Study Group
RadialN = 249
FemoralN = 97
Angio (%) 171 (49.4) 52 (14.7)
PCI (%) 19 (5.5) 21 (6.1)
Angio/PCI (%) 59 (17.1) 25 (7.2)
P = .0006
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73,968,5
23,5
41,6 38,4
0
20
40
60
80
Clinical Datas
TROP Study Group
%
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18,5
5,5
17,3
4,63,2
1,70
5
10
15
20
Clinical Datas
TROP Study Group
%
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Vascular AccessTransradial approach IT: 249/346 (71.9%)Transradial approach AC: 243/346 (70.2%)
Reasons for using Femoral access: 97/346 (28.1%)- Physician choice (76): 78.4%- Dialysis (1): 1%- Need for 7F catheters (5): 5.2%- Abnormal Allen test (1): 1%- CABG (double Mam) (4): 4.1%- No or to small radial (4): 4.1%- Other (ring, prior rad failure…) (6): 6.2%
TROP Study GroupIT: Intention To TreatAC: After Cross over
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Vascular Access
Cross over: 17 (4.9%) - Radial to femoral: 9 (3.6%)- Radial to radial: 4 (1.6%)- Femoral to radial: 3 (3.1%)- Radial to Ulnar 1 (0.4%)
TROP Study Group
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Vascular Access: Size
TROP Study Group
34
211
89
120
50
100
150
200
250
Patients
4 F
5 F
6 F
7 F
N
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INDICATIONS
TROP Study Group
4,9 6,1
89
0
20
40
60
80
100
Valvulopathy
Cardiac I nsuffi .
I schemic
%
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Clinic Presentation
TROP Study Group
4,64,4
19,9
11,6
39,3
7,2
13
0
10
20
30
40
Atypical chest pain
ACS ST elevated
ACS ST not elevated
Silent ischemia
Stable angina
Post MI
No ischemia
%
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Documented Ischemia
TROP Study Group
39,9
34,1
17,9
6,4
1,70
10
20
30
40
Patients
No test
EKG
Scintigraphy
Stress test
Other
%
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Vascular AccessRadial difficulties: 249 patients
- Failure: 10 (4%)- No difficulty 210 (84.3%)
- Catheterism diff. 10 (4%)- Spasm 6 (2.8%)- Loops 10 (4%)- Others 2 (0.8%)- TOTAL 29 (11.6%)
TROP Study Group
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CAD extension39,9
29,7
17,9
12,5
4
0
10
20
30
40
No vessel
One vessel
Two vessels
Three vessels
Left Main
TROP Study Group
%
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PCI (N = 124 pts)- Transradial access: 78/124 (62.9%)- Femoral access: 46/124 (38.1%)
- PCI success/Vessel: 163/169 (96.5%)- Clinical Total Success: 118 (95.2%)- QMI: 4 (3.2%)- MACE: 1 (3.2%)- Emergent CABG: 0 (0%)- Death: 0 (0%)
TROP Study Group
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Fem vs Rad access
Radial (n=243)
Femoral (n=103)
P
Mean age (y) 61.2 +/- 11.3 60.5 +/- 10.1 NS
Male (%) 138 (56.7) 56 (54.4) NS
BMI (Kg/m2) 39 +/- 14 38 +/- 5 0.04
TROP Study Group
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Radial (n=243)
Femoral (n=103)
P
Hypertension (%) 180 (70) 76 (70) NS
Hypercholesterolemia (%) 165 (68) 72 (70) NS
Family History (%) 41 (17) 40 (39) 0,001
Smokers (%) No Current Past
137 (56)30 (12)60 (25)
60 (58)17 (16)26 (25)
NS
Diabetes (%) No ID NID
137 (56)24 (10)82 (34)
65 (63)9 (9)
29 (28)
NS
Fem vs Rad access
TROP Study Group
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Fem vs Rad access
TROP Study Group
Radial (n=243)
Femoral (n=103)
P
Prior MI (%) 37 (15) 27 (26) NS
Prior CABG (%) 11 (45) 8 (8) NS
Prior PCI (%) 42 (18) 17 (16) NS
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Radial (n=243) Femoral (n=103) P
Nb Cath used Angio (n) 1.9 +/- 0.8 2.3 +/- 0.7 0,0005
Contrast Total (ml) 159 +/- 95 189 +/- 102 0.01
Contrast Angio (ml) 117 +/- 64 122 +/- 70 NS
Total Duration (min) 35.3 +/- 25.4 55.6 +/- 23.3 0.0001
Angio Duration (min) 26.1 +/- 19.0 31.3 +/- 17.7 0.03
Hosp stay (d) 3.7 +/- 4.1 4.4 +/- 4.6 NS
Hosp stay after C (d) 1.7 +/- 2.2 2.7 +/- 4.3 0.02
Vascular complication (%)*
3 (1.2) 3 (2.9) NS
Hematoma (%) 4 (1.6) 9 (8.7) § 0.001
Fem vs Rad access
TROP Study Group* With transfusion §: with 8 Closing Device
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Impact of Weight for in Hospital Outcome after PCI
RM, Minuella Am J cardiol 2004;93:1229-32
BMI (kg/m2)
N=95435< 18,5N=924
18,5/24,9N=25010
25/29,9N=41175
30/34,9N=19329
35/39,9N6252
>40N=2745
P
Death (%) 3,8 1,1 0,8 0,7 0,6 1,4 0,001
TransmuralMI (%)
0,5 0,3 0,3 0,4 0,3 0,3 0,227
EmergentCABG (%)
0,9 1,3 1,1 1,1 1,2 0,8 <0,001
MACE (%) 5 2,6 2,1 2,0 1,8 2,4 <0,001
VascularInjury (%)
1,4 0,6 0,5 0,5 0,5 0,9 <0,001
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Conclusion 1
• Obesity is a risk factor for CAD (Hypertension, Dyslipidemia, Diabetes)
• Obesity is more frequent in female gender• Obesity is a factor of complication in
diagnostic angiography and coronary intervention
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Conclusion 2
• Preliminary analysis of this study• Radial approach in obese patients reduces
the rate of vascular complications• Subgroup analysis (pending) is necessary to
better define patients at higher risk, interest of closure devices for femoral procedures…
• Potential other advantage of radial approach: prevention of infectious complication
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Bleeding Complications
F.V Aguirre et al, Circulation 1995;91:2882-90
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Bleeding complications
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Comparison of the Risk of Vascular Complications Associated With Femoral and Radial Access Coronary
Catheterization Procedures in Obese Versus Nonobese Patients
N Cox, Am J Cardiol 2004;94:1174–1177
Distribution of patients who underwent cardiac catheterization procedures by BMI
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Comparison of the Risk of Vascular Complications Associated With Femoral and Radial Access Coronary
Catheterization Procedures in Obese Versus Nonobese Patients
N Cox, Am J Cardiol 2004;94:1174–1177
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Comparison of the Risk of Vascular Complications Associated With Femoral and Radial Access Coronary
Catheterization Procedures in Obese Versus Nonobese Patients
N Cox, Am J Cardiol 2004;94:1174–1177
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Comparison of the Risk of Vascular Complications Associated With Femoral and Radial Access Coronary
Catheterization Procedures in Obese Versus Nonobese Patients
N Cox, Am J Cardiol 2004;94:1174–1177
Vascular complications by BMI. The patients with the smallest BMIs experienced the highest rate of vascular complications
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Comparison of the Risk of Vascular Complications Associated With Femoral and Radial Access Coronary
Catheterization Procedures in Obese Versus Nonobese Patients
N Cox, Am J Cardiol 2004;94:1174–1177
Overall vascular complication rate in nonobese and obese (BMI >30.0) patient subgroups stratified by vascular access
approach
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Comparison of the Risk of Vascular Complications Associated With Femoral and Radial Access Coronary
Catheterization Procedures in Obese Versus Nonobese Patients
N Cox, Am J Cardiol 2004;94:1174–1177
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Low-Normal or Excessive Body Mass Index: Newly Identified and Powerful Risk Factors for Death and Other ComplicationsWith Percutaneous Coronary Intervention
Stephen G. Ellis, Am J Cardiol 1996;78:642-64
Major Cardiac Outcomes and Complications
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Low-Normal or ExcessiveBody Mass Index: Newly Identified and Powerful Risk Factors for Death and Other Complications With Percutaneous Coronary Intervention
Stephen G. Ellis, Am J Cardiol 1996;78:642-64
Peripheral Vascular Complications
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Low-Normal or ExcessiveBody Mass Index: Newly Identified and Powerful Risk Factors for Death and Other Complications With Percutaneous Coronary Intervention
Stephen G. Ellis, Am J Cardiol 1996;78:642-64
Independent Correlates of Death With and Without BMI
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Low-Normal or ExcessiveBody Mass Index: Newly Identified and Powerful Risk Factors for Death and Other Complications With Percutaneous Coronary Intervention
Causes of Death
Stephen G. Ellis, Am J Cardiol 1996;78:642-64
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Low-Normal or ExcessiveBody Mass Index: Newly Identified and Powerful Risk Factors for Death and Other ComplicationsWith Percutaneous Coronary Intervention
Stephen G. Ellis, Am J Cardiol 1996;78:642-64
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Impact of Body Mass Index on Outcome AfterPercutaneous Coronary Intervention (The Obesity
Paradox)
H Gurm, P. Topol Am J Cardiol 2002; 90: 42-45
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Impact of Body Mass Index on Outcome AfterPercutaneous Coronary Intervention (The Obesity
Paradox)
H Gurm, P. Topol Am J Cardiol 2002; 90: 42-45
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Impact of Body Mass Index on Outcome AfterPercutaneous Coronary Intervention (The Obesity
Paradox)
H Gurm, P. Topol Am J Cardiol 2002; 90: 42-45
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Impact of Body Mass Index on Outcome AfterPercutaneous Coronary Intervention (The Obesity
Paradox)
H Gurm, P. Topol Am J Cardiol 2002; 90: 42-45
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Impact of BMI on Short- and Long-Term FU in Patients Undergoing Coronary Revascularization: Insights From
BARI
H. Gurm J Am Coll Cardiol 2002;39:834–40
Procedural Characteristics of Study Patients According to BMI
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Impact of BMI on Short- and Long-Term FU in Patients Undergoing Coronary Revascularization: Insights From
BARIIncidence and Odds Ratios of In-Hospital Events According to BMI: PTCA
Group
H. Gurm J Am Coll Cardiol 2002;39:834–40
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Impact of BMI on Short- and Long-Term FU in Patients Undergoing Coronary Revascularization: Insights From
BARI
H. Gurm J Am Coll Cardiol 2002;39:834–40
Incidence and Odds Ratios of In-Hospital Events According to BMI: CABG Group
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Impact of BMI on Short- and Long-Term FU in Patients Undergoing Coronary Revascularization: Insights From
BARI
H. Gurm J Am Coll Cardiol 2002;39:834–40
Incidence and OR of Long-Term Mortality According to BMI: PTCA Group (n=2,090)
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H. Gurm J Am Coll Cardiol 2002;39:834–40
Impact of BMI on Short- and Long-Term FU in Patients Undergoing Coronary Revascularization: Insights From
BARIIncidence and OR of In-Hospital Events According to BMI: CABG Group
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Obesity a risk for CABG surgery
N.J.O. Birkmeyer Circulation 1998;97:1689-94
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Obesity a risk for CABG surgery
N.J.O. Birkmeyer Circulation 1998;97:1689-94
CVA Cerebrovascular AccidentSWI Sternal Wound infection