tuesday 13 december 2016 poster session 16:15 - 17:45

Tuesday 13 December 2016 Poster Session 16:15 - 17:45

- Neuorpharmacology PB002 TRPA1 receptor is a potential drug target in multiple sclerosis

E. Pinter, E. Saghy, E. Sipos, P. Acs, K. Bolcskei, K. Pohoczky, A. Kemeny, Z. Sandor, E.

Szoke, G. Setalo Jr., S. Komoly

University of Pecs, Hungary

PB003 Effects of vascular endothelial growth factor-A165b on pain behaviour in a model of

osteoarthritis in rat

F. Almahasneh1,2, N. Beazley-Long1,2, Z. Blackley1, D. O. Bates1 L. F. Donaldson1,2 1University of Nottingham, UK, 2Arthritis Research UK Pain Centre, UK,

PB005 Inhibition of Calcium/calmodulin dependent protein kinase II and neuronal nitric

oxidesynthase: a combination approach for treatment of cerebral ischemia

reperfusion injury

L. K. Bhatt, S. George

Dr Bhanuben Nanavati College of Pharmacy, India

PB006 Effect of chronic exposure of losartan in mouse prenatal alcohol exposure (pae) model

A. Takyi

Brighton Pharmacy School, UK

PB007 Maternal immune activation: A viable candidate for modelling neurodevelopmental

disorders in rats?

J. Oladipo, J. Neill, J. Miyan

University of Manchester, UK

PB008 Jieyu Anshen granule improves depressive-like behaviors and cognitive impairment in

a rat model of post-stroke depression

Y. Du, Y. Song, T. Wang, Y. Zou, F. Fu.

School of Pharmacy, China

PB009 Effect of escitalopram, a selective serotonin reuptake inhibitor, on bone turnover

markers in Wistar rats: the role of gut and brain derived serotonin

D. Vohora, R. Wadhwa

Hamdard University, India

PB011 Cofilin mediates lps-induced microglial cell activation and associated neurotoxicity

through nf-κb and jak-stat pathways

Q. M. Alhadidi, Z. A. Shah 1University of Toledo, USA

PB012 Role of peroxisome proliferator-activated receptors-alpha (PPARɑ) and the transient

receptor potential vanilloid receptor (TRPV1) in mediating the anti-nociceptive effects

of palmitoylethanolamine in rat

M. Alsalem1, A. Altarifi2, A. Imraish3

1The University of Jordan, Jordan, 2Jordan University for Science and Technology, Jordan, 3The University of Nottingham, UK

PB013 The DAGL-α inhibitor DO34 impairs acquisition rate, but not expression, extinction, or

forgetting, of spatial memory in C57BL/6J mice

L. D. Schurman1, M. C. Carper1, D. Ogasawara2, B. F. Cravatt2, A. H. Lichtman1 1Virginia Commonwealth University, USA, 2The Scripps Research Institute, USA

PB014 Decreased ethanol consumption in C57BL/6 mice following treatment with the GSK3B

inhibitor Tideglusib

A. D. van der Vaart1, J. L. Jurmain1, M. F. Miles1,2 1Virginia Commonwealth University, USA, 2VCU Alcohol Research Center, USA

PB015 Sex and agonist-specific mechanisms of cannabinoid tolerance

A. H. Redmond, E. L. Ferguson, A. M. Kline, C. M. Nealon, D. J. Morgan

Pennsylvania State University College of Medicine, USA

PB016 An investigation of the pharmacology of vortioxetine at human 5-HT3 receptors

A. Roberts, G. Grafton, S. Larkin, S. Butterworth, R. Myerson, A. J. Cooper, N. M. Barnes

University of Birmingham, UK

PB017 Characterisation of a rat model of bortezomib induced painful neuropathy

N. A. Duggett, S. J. Flatters

King's College London, UK

PB018 Altered open field and nocturnal homecage locomotor activity in the olfactory

bulbectomized rat model of depression

Z. McAleavey, J. P. Kelly

National University Ireland, Ireland

PB019 Continuous monitoring of individual rats when group housed in the home cage to

assess drug induced changes in activity and temperature

K. Tse1, A. Keerie1, R. Sillito2, R. Collier1, M. Pilling1, C. Vickers3, K. Chapman3, J.

Armstrong2, W. Redfern1 1AstraZeneca, UK, 2Actual Analytics, UK, 3NC3Rs, UK

PB020 High fat diet induced obesity in mice as a model to study the biological mechanisms

linking depression associated with obesity

Y. Kurhe, R. Mahesh

Birla Institute of Technology & Science (BITS), India

PB021 Kainate Receptors: A potential therapeutic target for neuropsychiatric disorders

M. Koromina, H. M. Knight, I. R. Mellor

University of Nottingham, UK

PB022 Effects of chronic administration of the GABAB receptor agonist baclofen on body

weight and food intake in the mouse

I. S. Ebenezer, J. Leadbetter, N. Farah, K. Bhargava

University of Portsmouth, UK

PB023 Effects of the gut hormone ghrelin and the GABAB agonist baclofen on food intake and

the microstructure of feeding behaviours in the rat

I. S. Ebenezer, K. Valko, M. Clenahan


PB024 A tamoxifen analog reduces amphetamine-stimulated dopamine efflux and reinforcing

behaviors

M. Gnegy, C. Carpenter, A. Zestos, R. Altshuler, B. Guptaroy, H. Showalter, R. Kennedy,

E. Jutkiewicz

University of Michigan, USA

PB025 Xiao-xu-ming decoction attenuates neuroinflammation induced by LPS via down-

regulation of TLR4/MyD88 signaling pathway in BV2 cells

Y. H. Wang, H. Yang, X. Cheng, Y. L. Yang, Y. Lyu, G. H. Du

Chinese Academy of Medical Sciences & Peking Union Medical College, China

PB026 Simulating maintained cocaine self-administration behaviour in rats using a receptor-

based pharmacokinetic/pharmacodynamic model

B. L. Bauer1, H. N. Wetzel2, A. B. Norman2 1The College of Wooster, USA, 2University of Cincinnati College of Medicine, USA

PB027 Identification of residues involved in the dopamine transporter-G protein beta gamma

subunits interaction and dopamine efflux

J. A. Pino, G. Torres

University of Florida, USA

PB028 Xyloketal B alleviates cerebral infarction and neurologic deficits by suppressing

ROS/TLR4/NF-κB inflammatory signaling pathway in mouse middle cerebral artery

occlusion model

L. Chen, G. Wang

Sun Yat-sen University, China

PB029 Differing effects of opioid receptor agonists in human isolated colon

J. Broad, F. Scott, A. J. Palmer, M. Kouassi, S. F. Elahi, G. J. Sanger

Barts and the London School of Medicine and Dentistry, UK

PB030 Allosteric modulation of the metabotropic glutamate receptor 5 in native cells:

implications for CNS disorders and pain therapies

K. Sengmany1,2, S. Albold2, P. J. Millns1, M. J. Garle1, A. Christopoulos2, S. P. Alexander1,

K. J. Gregory2 1University of Nottingham, UK, 2Monash Institute of Pharmaceutical Sciences, Australia

PB031 Investigating the roles of kappa opioid receptors in neurochemical changes caused by

stress and drugs of abuse

Q. Ma, S. Wonnacott, S. Bailey, C. Bailey

University of Bath, UK

PB032 FK866 an inhibitor of the pro-inflammatory cytokine visfatin attenuates pain and

inflammation in a rodent model of acute inflammation and obesity

N. Alorfi, S. Dolan

Glasgow Caledonian University, UK

PB033 An assessment of social cognition in the olfactory bulbectomized rat model of

depression

K. L. McHugh1, H. Doherty1, D. Deaver2, M. Roche1, D. P. Finn1, J. P. Kelly 1 National University Ireland, Ireland, 2Alkermes Inc., USA,

PB034 Modulation of the non-adrenergic non-cholinergic relaxation of the rat gastric fundus

by KCa1.1 channels

D. Curro, V. Ipavec,

Catholic University of the Sacred Heart, Italy

PB035 Effects of the GABAB receptor agonist baclofen on food intake and the microstructure

of feeding behaviours in the rat

I. S. Ebenezer, R. Jones, Q. Yiew


PB036 Effect of repeated abstinence on chronic ethanol self-administration in the monkey

D. C. Allen1, K. A. Grant1,2 1Oregon Health and Science University, USA, 2Oregon National Primate Research Center,

USA

PB037 Kv2.1 and the dopamine transporter interact in dopaminergic neurons

J. J. Lebowitz, J. A. Pino Reyes, D. Sambo, H. Khoshbouei, G. E. Torres 1University of Florida, USA

PB038 MicroRNAs and cocaine addiction: Role for non-proteolytic ubiquitination

P. Bali, A. Smith, P. Kenny

Icahn School of Medicine at Mount Sinai, USA

PB039 Intra-articular injection of trkB/Fc chimera attenuates pain behaviour in two models

of osteoarthritis pain in the rat

P. R. Gowler1,, R. Suzuki2, D. Walsh1,, V. Chapman1

1University of Nottingham, UK, 2Pfizer Neusentis, UK

PB040 The effects of fluoxetine exposure during pregnancy in the rat

N. A. DeSanctis, J. P. Kelly

National University of Ireland, Ireland

PB041 Novel shark antibodies engineered to characterise and improve delivery of

therapeutics across the blood-brain barrier

A. L. Fleckney1, R. C. Brown1, S. Drndarski1, K. B. Wicher2, L. Rutkowski3, S. A. Thomas1 1King's College London, UK, 2Ossianix Inc., UK, 3Ossianix Inc., USA

PB042 The effects of the hypoxia mimetic protocatechuic acid ethyl ester on cell viability and

synaptic plasticity in rat hippocampal slices

S. Lanigan, M. Pickering, J. J. O'Connor

1University College Dublin, Ireland,

PB043 GABAB(1) receptor isoforms differentially modulates locomotor properties of morphine

L. Rojo Gonzalez1, P. Zanos2, C. Wu1, Y. Chen3, A. Bailey4 1University of Surrey, UK, 2University of Maryland, USA, 3King's College London, UK, 4St.

George's University of London, UK

PB044 Activation of the FFA3 receptor inhibits anion secretion via a predominantly neuronal

mechanism in mouse descending colon mucosa

I. R. Tough1, T. W. Schwartz2, H. M. Cox1

1King's College London, UK, 2University of Copenhagen, Denmark

PB045 In vitro and in silico assessment of stimulant properties of novel psychoactive

substances (NPS)

J. Opacka-Juffry1, M. Sahai1, B. Loi2, N. Dutta3, V. Barrese3, C. Davidson4 1University of Roehampton, UK, 2University of Hertfordshire, UK, 3St George’s University

of London, UK, 4University of Central Lancashire, UK

PB046 The effect of olfactory bulbectomy on reproduction and offspring development in the

rat

H. Doherty, J. P. Kelly

National University of Ireland, Ireland

PB047 Biased signaling at the D2 dopamine receptor reveals a molecular switch for β-arrestin

recruitment

R. B. Free1, A. M. Moore1, A. E. Moritz1, L. S. Chun1, E. C. Gonye1, T. Beuming2, L. Shi1, D.

R. Sibley1 1NIDA/NIH 2Schrodinger Inc, USA

PB048 Transporter interaction of warfarin, a traditional oral vitamin K antagonist with the

mouse blood-brain barrier in vitro: Evidence for BCRP involvement

H. Wang1, P. Muresan1, G. Sekhar1, R. Brown1, J. P. Patel1,2, R. Arya2, S. A. Jones1, S. A.

Thomas1

1King's College London, UK, 2King’s College Hospital NHS Foundation Trust, UK

PB049 The effect of metergoline on D amphetamine induced depression of visual activity in

the Superior Colliculus

T. B. Riley, L. Hetherington, P. G. Overton

The University of Sheffield, UK

PB050 Ganglioside GQ1b induces dopamine release through the activation of Pyk2

Z. Zhang, S. Chu, N. Chen

Chinese Academy of Medical Sciences and Peking Union Medical College, China

PB051 IMM-H004 protects against delayed neuronal death induced by transient global

cerebral ischemia via upregulation the formation of surviving-HBXIP complex

S. Chu1,2, Z. Zhang1, N. Chen1,2 1Chinese Academy of Medical Sciences and Peking Union Medical College, China, 2Hunan

University of Chinese Medicine, China

PB052 Characterisation of the cold-sensitivity of the sympathetic nervous system

T. J. Buijs, B. Vilar, S. Innes, P. A. McNaughton


PB053 Novel analgesic compounds inducing alternative splicing of VEGF-A through SRPK1

inhibition

A. A. Tranholm1, Z. Blackley1,2, J. Batson1,2, H. D. Toop2,3, S. Oltean4, J. C. Morris2,3, D. O.

Bates1,2, L. F. Donaldson1,2 1University of Nottingham, UK, 2Exonate Ltd, UK, 3University of New South Wales,

Australia, 4University of Bristol, UK

PB054 Intranasal OT reduces cocaine conditioned locomotion and elicits changes in

endocannabinoid receptors within the mesolimbic system

A. N. Figueroa-González, G. C. Molina-Castro, A. J. Loyola-Vélez, A. Marti-Mendoza, E.

Torres-Hernández, C. S. Maldonado-Vlaar

University of Puerto Rico, Puerto Rico

PB056 Is TRPV-1 receptor the missing link in treatment of depression?

L. Nabi, J. Keeble, V. Mondelli, C. Pariante

Kings College London, UK

PB057 Inhibition of the firing activity of locus coeruleus neurons by EP3 receptors in rat brain

slices

A. Nazabal, A. Mendiguren, J. Pineda

University of the Basque Country, Spain

PB058 Effect of caffeine on alcohol consumption in wistar rats

A. Okhuarobo, Z. Sule, I. Igbe

University of Benin, Nigeria

PB059 Characterizing a novel tool to monitor pharmacologically-induced changes in GABAAR

trafficking

J. Lorenz-Guertin1, J. Pilli1, M. Zhang2, A. Waggoner2, T. C. Jacob1 1University of Pittsburgh, USA, 2Carnegie Mellon University, USA

PB060 Neuroprotective potential of targeting metabotropic glutamate receptor 4 in a partial

lesion rat model of Parkinson’s disease

E. C. Mann, S. Duty


PB061 Electrophysiological characterisation of dorsal spinal neuronal responses and the

inhibitory effect of aspirin triggered resolvin D1 in paclitaxel induced peripheral

neuropathy in rats

P. Meesawatsom, G. Hathway, V. Chapman.


16:15 - 17:45

- Molecular and Cellular Pharmacology PB062 The importance of Rho-associated kinase-induced calcium sensitization as a

component of Bradykinin -induced pharmacomechanical coupling in rat ureteric

smooth muscle

A. Alfituri, T. Burdyga

University of Liverpool, UK

PB063 FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation

J. Wang, U. Jo, S. Joo, H. Kim

Stony Brook University, USA

PB065 Exploration of dynamic structural landscape in ligand-bound IP3 receptors

A. Chandran, X. Chee, T. Rahman

University of Cambridge, UK

PB066 Integrated functional pharmacology, metabolomics and bioinformatic analyses

investigates novel pathways associated with the activity of oxytocin and ritodrine on

the myometrium

E. E. Bafor1, E. G. Rowan2, R. Edrada-Ebel2 1University of Benin, Nigeria, 2Strathclyde Institute of Pharmacy and Biomedical Sciences,

UK,

PB067 The gut hormone INSL5 activates multiple signalling pathways in the human

enterocyte cell line NCI-H716

S. Y. Ang1, D. S. Hutchinson1, B. A. Evans1, M. Kocan2, R. J. Summers1 1Monash University, Australia, 2University of Melbourne, Australia

PB068 Role of adipokines in pain associated with obesity and diabetes

A. Aibinu, S. Dolan

Glasgow Caledonian University, UK

PB069 Evaluation of a Novel NIK inhibitor for the treatment of multiple myeloma

M. Varley1, C. West2, S. Mackay2, P. Brennan1, C. Pepper1 1Cardiff University, UK, 2University of Strathclyde, UK

PB070 β3-Adrenoceptor desensitisation in HEK cells: a role for biased agonism?

A. Okeke, M. B. Michel, M. C. Michel

Johannes Gutenberg University, Germany

PB071 Morphine tolerance in dorsal root ganglion nociceptors is induced by mediators in

colon tissue of chronic morphine treated mice

R. A. Mischel, W. L. Dewey, H. I. Akbarali

Virginia Commonwealth University, USA

PB072 ML290, a small allosteric biased agonist at RXFP1

R. J. Summers1, M. Kocan1, M. Sarwar1, S. Ang1, J. Xiao2, J. J. Marugan2, M. A. Hossain3, C.

Wang1, D. S. Hutchinson1, C. Samuel1, A. I. Agoulnik4, R. A. Bathgate3, 1Monash University, Australia, 2NIH, USA, 3The Florey Institute of Neuroscience and

Mental Health, Australia, 4Florida International University, USA

PB073 Monitoring trafficking of angiotensin and chemokine receptor complexes using

bioluminescence resonance energy transfer (BRET)

K. D. Pfleger E. K. Johnstone,

Harry Perkins Institute of Medical Research, Australia

PB075 Fibroblast growth factor 21 regulates hepatic lipid metabolism and liver injury in a

mouse model of chronic alcohol-induced liver disease

W. Feng

University of Louisville, USA

PB076 Mechanism of anti-diabetic, lipid inhibition and anti-oxidant activity of palmatine via

proteomics

P. N. Okechukwu1, S. O. Ekeuku1, T. S. Sen1, S. N. Siyumbwa1, A. Simbun1, G. A.

Akuwoah1, G. R. Froemming2 1UCSI University, Malaysia, 2University Technology Mara, Malaysia

PB077 Investigation of the active antiarrhythmic components of the multi-herbal medicine

xin su ning

Y. Ma1, T. Wang1, C. Ellory1, R. Wilkins1, C. Carr1, P. Mao2, J. Jiang2 1University of Oxford, UK, 2Shaanxi Momentum Pharmaceutical Company, China

PB078 Attenuation of Akt/p-Akt pathway mediated podocyte apoptosis via berberine

treatment in diabetic nephropathy

W. Ni, L. Tang, H. Ding

Anhui Medical University, China

PB079 Metformin upregulates anti-angiogenic thrombospondin-1 in tumour microvascular

endothelial cells exposed to 2-deoxyglucose

S. M. Samuel, Y. Majeed, H. Ding, C. R. Triggle

Weill Cornell Medicine-Qatar, Qatar

PB081 Effects of Zizyphus jujube fruit extract on Nrf2 pathway in paracetamol-induced liver

injury in rats

N. A. Sallam1, S. R. Khalil1, O. M. Abd El-Raouf2, H. M. Said1 1Cairo University, Egypt, 2National Organization for Drug Control and Research, Egypt

PB082 The effect of receptor expression level on positive allosteric modulation (PAM) of

human dopamine D1 receptor

H. M. Saunders, E. McIver, J. C. Jerman

MRC Technology, UK

PB083 Characterisation of lipidated probes using fluorescence correlation spectroscopy

Q. N. Mai1, S. J. Briddon2, N. A. Veldhuis1, N. W. Bunnett1, S. J. Hill2 1Monash University, Australia, 2The University of Nottingham, UK

PB084 Novel nucleoside derivatives for effective ovarian cancer stem cells treatment

J. Ma1, M. Rabbani1, L. Peng2, A. Wong1 1The University of Hong Kong, Hong Kong, 2Centre Interdisciplinaire de Nanoscience de

Marseille, France

PB085 A glycolytic target for somatostatin-mediated inhibition of glucose metabolism in

pancreatic beta-cells

J. Alahmed, S. Chan, P. Smith


PB086 The role of PP2A and related proteins in human brain microvascular endothelial cells

in response to Pro and anti-inflammatory cytokines

G. Casey, M. Ward, J. Spiers

Trinity College Dublin, Ireland

PB087 Nur77 regulates hypoxia induced epithelial to mesenchymal transition in colon cancer

cells

S. Deng1, J. Zeng2, A. Wong1 1University of Hong Kong, Hong Kong, 2Xiamen University, China

PB088 Comparison of a reporter gene, cAMP and cell impedance assay to monitor mGluR7

activity

E. Chevalier, G. McGregor, L. Dickson, P. Mitchell

Takeda Cambridge Ltd, UK

PB089 Functional characterisation of native GRPR activity in an immortalised cell line

T. Cheung, H. Hunter, L. Dickson, P. Mitchell

Takeda Cambridge Ltd, UK

PB090 ATP-evoked P2X7 receptor modulates the activation of pro-inflammatory cytokine IL-

1β in urothelial cells

K. Harkin, K. Srivastava, C. Breen, K. D. McCloskey

Queen's University Belfast, UK

PB091 Doping the immune system: marijuana's effect on human neutrophil funtion

M. Wiley, V. Nizet, P. Insel, R. Corriden. Biomedical Sciences

University of California, USA

PB092 Role of phospholipase D2 in focal adhesions and cell spreading in human lung

microvascular endothelial cells

M. Shaaya, P. Fu, S. Vogel, A. Karginov, V. Natarajan

University of Illinois at Chicago, USA

PB093 Exploring the antioxidative properties of Quercetin and its isomer Morin in preventing

trophoblast oxidative stress.

V. J. Ebegboni, J. M. Dickenson, S. D. Sivasubramaniam.

Nottingham Trent University, UK

PB094 Low molecular weight fucoidan inhibits fibrotic processes in diabetic nephropathy

H. Zhou

Peking University, China

PB095 Identification of which p2 receptor subtypes mediating purinergic ca2+ signals in

isolated rat detrusor muscle cells

A. Bengreed

Leicester University, UK

PB096 Cofilin activity modulation by CXCL12 and JAK/STAT signaling

S. C. Mills

University of East Anglia, UK

PB097 Salidroside regulates inflammatory response via TLR4/TAK1 in vitro and in vivo

L. Lian, Y. Wu, J. Nan, M. Jiang, K. Xia, B. Cui

Yanbian University, China

PB098 NUDCD1 regulates cell proliferation, migration, and invasion in human colorectal

cancer

B. Han, K. Xu, Y. Bai, Y. Liu, L. Zhou

Sichuan University, China

PB099 Knock-down of G proteins alters alcohol induced behaviour in Drosophila

melanogaster

B. Aleyakpo1, O. Umukoro1, R. Kavlie2, O. Corcoran1, S. O. Casalotti1 1University of East London, UK, 2University College London, UK

PB100 Lysophosphatidic acid (LPA) induced expression of mir-145, mir-1 and mir-133 in P19

stem cells

A. Nasraddin, A. Baydoun, S. Thakur

University of Hertfordshire, UK

PB102 Regulation of the ApoL1 protein in African Americans using apocynin

C. T. Fearce1, D. Eatman2, M. A. Bayorh2 1Spelman College, USA, 2Morehouse School of Medicine, USA

PB103 Is there a link between long term use of antihypertensive agents and cancer

development?

L. A. Jamil1,2, H. M. Wallace2 1Usmanu Danfodiyo University, Nigeria, 2University of Aberdeen, UK

PB104 The neoflavonoid latifolin isolated from dalbergia odorifera attenuates hypoxia and

reoxygenation injury by reactive oxygen species scavenging and nrf2 activation in h9c2

cardiomyocyte

R. Liu, Y. Luo, L. Chen, D. Wang, F. Shao, Y. Cui

Jiangxi University of TCM, China,

PB105 Tiron offers protection against H2O2-induced mitochondrial DNA damage

D. V. Meyer1, E. F. Green2, M. A. Birch-Machin3, E. Hatch2 1Coventry University, UK, 2Newcastle University, UK

PB106 CCL3 promotes MCF-7 breast cancer cell migration through CCR1 and CCR5 signal

transduction

G. R. Keil, A. Mueller

University of East Anglia, UK

PB107 Based on energy metabolism to investigate the anti-tumour effect of

pulsatillachinensissaponins

L. Chen, Z. Guan, Y. Zhou, Y. Cui, Y. Luo, X. Li

Jiangxi University of TCM, China

PB108 Effects of Ornithogalum Caudatum Ait (Liliaceae) total saponins on inflammatory

factors in LPS-stimulated RAW 264.7 cells

Y. Wu, L. Lian, J. Song, J. Zhang, J. Nan

College of Pharmacy, China

PB109 Characterisation of the signalling mechanisms involved in the induction of

cyclooxygenase-2 by interleukin-4

S. Manoj, W. Morgan, S. S. Ayoub

University of East London, UK

PB110 Effect of age and pregnancy on the expression of melanocortin receptors 4 and 5 in

the mouse female reproductive axis

N. Berruien1, P. R. Le Tissier2, J. F. Murray2, C. L. Smith1 1University of Westminster, UK, 2University of Edinburgh, UK,

PB111 Protective effect of standardized amentoflavone isolated from juniperus communis L.

against Freund’s adjuvant induced arthritis in rats (histopathological and x-ray

analysis)

S. Bais

Rayat Institute of Pharmacy, India

PB112 Both permeability and immunosuppressive effects of palmitoylethanolamide and

cannbidiol act through down regulation of phosphorylated intracellular signalling

phosphoproteins

D. Couch, E. Theophilidou, J. Lund, S. O'Sullivan


PB113 Exploring novel Multidrug Resistance-associated protein (MRP) inhibitors in rat

hepatocytes in suspension

T. De Vocht1, E. Hoeben2, P. Annaert1 1KULeuven, Belgium, 2Janssen, Belgium

PB114 Role of Osteopontin fragments generated by thrombin cleavage on human cells in

vitro and on EAE in vivo

B. Ferrara1, A. Chiocchetti1, E. Boggio1, U. Dianzani1, C. Dianzani1, L. Gigliotti1, C. Comi2,

N. Clemente1, M. Soluri1, G. Cappellano3, E. Toth1, D. Raineri1 1Dipartimento di Scienza e Tecnologia del Farmaco, Italy, 2Department of Translational

Medicine, Italy, 3Laboratory of Autoimmunity, Austria

PB115 Cardioprotective effect of neoflavonoid latifolin isolated from dalbergia odorifera on

isoproterenol-induced myocardial ischemia in rats

L. Chen, X. Li, R. Liu, Y. Luo, Y. Cui, F. Shao, D. Wang

Jiangxi University of TCM, China

PB116 The effect of the N-alkyl substituent on the affinity of alprenolol and oxprenolol

analogues at the human β1 and β2 adrenoceptor (AR)

E. P. Sousa, S. N. Mistry, J. G. Baker


PB117 A role for dopamine in appetitive signalling in the model genetic organism C. elegans

I. Vasilescu, S. Zarroug, R. J. Walker, L. Holden-Dye, S. Glautier, V. O'Connor

University of Southampton, UK,

PB118 Internalization and trafficking of proteinase activated receptor 4 (PAR4) is mediated

by clathrin-mediated endocytosis

P. Thibeault, C. Vanderboor, R. Ramachandran

University of Western Ontario, Canada

PB119 Further characterisation of vascular responses to ligands of the calcium-sensing

receptor family

V. Ho, K. Sabarwal, P. Tate, R. Bhamra,

St George's University of London, UK

PB120 Cellular pharmacokinetic and pharmacodynamic alterations of elvitegravir in response

to ethanol exposure in HIV infected monocytic cells

N. M. Midde, N. Sinha, L. B. Pradeep, B. Meibohm, S. Kumar

University of Tennessee Health Science Center, USA

PB121 Development of a fluorescent ligand competition binding assay for the gastrin

releasing peptide BB2 receptor

D. Nesheva1, L. F. Medeiros1, H. Verli2, R. Roesler2, S. N. Mistry1, N. D. Holliday1 1University of Nottingham, UK, 2Universidade Federal do Rio Grande do Sul, Brazil

PB122 An extracellular loop 2 mutation P198A prevents the action of the antagonist RC3095

at the gastrin releasing peptide BB2 receptor

L. F. Medeiros1, D. Nesheva1, H. Verli2, R. Roesler2, N. D. Holliday1 1University of Nottingham, UK, 2Universidade Federal do Rio Grande do Sul, Brazil,

PB123 Characterising the functional kinetics of OX1 antagonists using a novel fluorometric

imaging plate reader (FLIPR) assay

S. Groom1,2, R. Mould1, K. Bennett1, M. Barnes1, A. Brown1 1Heptares Therapeutics, UK, 2University of Bath, UK

PB124 RGL1 as a novel target for the anti-cancer effects of celecoxib

S. I. Mazi, G. Galaris, H. H. Gashaw, J. A. Mitchell, N. S. Kirkby

Imperial College London, UK

PB125 C-peptide induces S6 ribosomal protein phosphorylation in the pancreatic β-cell line,

INS-1E.

A. M. Janabi1,2, S. J. Ennion1, G. B. Willars1

1University of Leicester, UK, 2University of Kufa, Iraq,

PB126 Ligand-dependent temporal patterns of signalling and receptor phosphorylation at

NMU2

H. S. Qassam1,2, A. J. Butcher1, A. B. Tobin3, G. B. Willars1

1University of Leicester, UK, 2University of Kufa, Iraq, 3University of Glasgow, UK

PB127 The ventilatory stimulant, doxapram, is an equally potent inhibitor of the human two-

pore domain potassium (K2P) channels, TASK-3 (KCNK9) and TASK-1 (KCNK3)

K. P. Cunningham1, D. E. MacIntyre2, A. Mathie1, E. L. Veale1

1University of Kent, UK, 2Galleon Pharmaceutical Inc, USA

PB128 Influence of intermedin/adrenomedullin-2 on nephrotoxic drug-related injury to

human renal mesangial and tubular epithelial cells

K. Harkin1, A. N. Metcalfe1, M. T. Harbinson1, M. Campbell1, J. P. Spiers2, D. Bell1 1The Queen's University of Belfast, UK, 2Trinity College Dublin, Ireland

16:15 - 17:45 - Integrated Systems Pharmacology

PB129 A mathematical model of a humanized anti-cocaine monoclonal antibody's effects on

cocaine distribution to the brain in mice

H. N. Wetzel, T. Zhang, A. B. Norman

University of Cincinnati, USA

PB130 Human phyisome on a chip: Merging tissue engineering and systems pharmacology

M. Cirit1, N. Tsamandouras1, C. Maass1, L. Griffith1, C. Stokes2 1Massachusetts Institute of Technology, USA, 2Stokes Consulting, USA

PB131 Antidiabetic activity of Caralluma tuberculata in alloxan-induced rats

N. Syed, M. Aslam

University of the Punjab, Pakistan

PB132 Effects of D-Galactose insulin tolerance, serum lipids and renal function: A Comparison

between young mice treated with D-Galactose and 24 months old mice

W. Hull1, W. Chadwick2, K. Brown2, S. McSweeny2, D. Bedford2, C. Theimermann1 1William Harvey Research Institute, UK, 2Takeda Cambridge Ltd, UK

PB133 Tetrodotoxin insensitive electrical field stimulation induced contractions on Crotalus

durissus terrificus corpus cavernosum

R. D. Campos, F. T. Monica, R. L. Rodrigues, J. R. Moscoso, R. A. Moreno, J. C. Cogo, E.

Antunes, G. De Nucci

University of Campinas, Brazil

PB134 A new resource, IUPHAR Guide to immunopharmacology

S. D. Harding1, E. Faccenda1, S. Ireland1, A. J. Pawson1, J. L. Sharman1, C. Southan1, S. P.

Alexander2, S. Anderton1, C. Bryant3, A. P. Davenport3, C. Doerig4, D. Fabbro5, F. Levi-

Schaffer6, M. Spedding7, J. A. Davies1

1University of Edinburgh, UK, 2University of Nottingham, UK, 3University of Cambridge,

UK, 4Monash University, Australia, 5PIQUR Therapeutics AG, Switzerland, 6Hebrew

University of Jerusalem, Israel, 7Spedding Research Solutions SARL, France

PB135 Beneficial effects of bacterially-derived tryptophan metabolite indole-3-propionic acid

in vitro and in vivo and its association with obese/T2D patients undergoing bariatric

surgery

C. Cavanaugh, M. Jennis, G. Leo, J. Mabus, J. Lenhard, P. Hornby

Janssen, USA

PB136 Spontaneous gait deficits precede development of pain-like behaviour in experimental

osteoarthritis: investigating a role for Transient Receptor Canonical 5

K. M. Alawi1, N. Saleque1, C. Gentry2, E. S. Fernandes1,2, S. D. Brain1 1King's College London, UK, 2Universidade Ceuma, Brazil

PB137 Power analysis of murine mBSA delayed type hypersensitivity: Therapeutic and

prophylactic dexamethasone as positive control

M. P. Seed, E. Bashford-Snell

University of East London, UK

tuesday 13 december 2016 poster session 16:15 - 17:45

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