tumor tissue registry - uscap · tumor tissue registry "soft tissue tumors'' minutes...

13~1

CALIFORNIA TUMOR TISSUE REGISTRY

"Soft Tissue Tumors''

Minutes -·Subscription B

February,2008

SUGGESTED READING (~neral Topics from Reeeot Literature):

Risk Factors for Pancreatic Cancer. Case-Control Study. Hru;.')an MM, Bondy Ml., et at. AmJ Gastroen~ro/2001; 102:2696-2707.

Rountinely Assessed Morphological Features Correlate with Microsatellile Instability Status in Endometrial Cancer. Shia J, Black 0, et aL Hum Patlro/2008; 39:116-125.

The Utility of Fluorescence lo-Situ Hybridization (FISH) in the Diagnosis of Myxoid Soft Tissue Neoplasms. DownsKelly, Goldblum JR eta!. Am J Surg Patho/2008; 32:8-13.

Lymph Nodes after Preoperative Chcmoradiotberapy for Rectal Carcinoma. Number, Status and Impact on Survival. Laurent C, ct ol. AmJ Surg Patlro/2008; 32:45-50.

Malignant Germ Cell Tumours in the Elderly. A Histopathological Review of 50 Cases in Men Aged 60 Years or Over. Berney DM, Warren AY, et al. Mod Patho/2008; 21:54-59.

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: [email protected] Web site & Case of the Month: www.cttr.org

FILE DIAGNOSES

(Preferably submitted on website at www.cttr.org. Click "subscriptions", then "submit answers.")

Case 1:

Case 2:

Ca.5e 3:

Case 4:

Case S:

Case6:

Case 7:

Case 8:

Case9:

CITR Subscription B

Lymphangioma, anterior mediastinum T-Y2300, M-91700

Cranial fasciitis T-Y0160, M-76130

Intra-abdominal (desmoids) fibromatosis T-Y4100, M-76100

Myxoid neurofibroma, scalp T-Y0160, M-95400

Scbwannoma, forearm T-Y8500, M-95600

Leiomyoma, lung T-28000, M-88900

Embryonal rhabdomyosarcoma, neck (congenital) T-Y0600, M-89003

Monophasic synovial sarcoma, beel T-Y9600, M-88013

Alveolar soft part sarcoma, tbigh T-Y9120, M-95813

Ca.~e 10:

2

Bxtraskeletal osteosarcoma, thigh T-Y9100, M-91803

CTfR. f<bnwy, 2008; "Minuleo" (Subscript;.., B)

Case No. 1 - Accession No. 30408

E.wondido - Hemangioma Glendale - Lymphangioma NeWj)Ort Beach (College Hos1lill~U • Thymus with lymphangioma Palo Alto - Mediastinallymphaogiomatosis San Die~:<> (Naval MediCI!! Ccgtcr) - Lymphangioma Sap francisco (l.JCSF Fcllow'i) - Lymphangioma Woodland Hills - Mediastina! lymphangiomatosis Alabama (!JAB) - Mediastinum lymphangioma Ocoraia (College Hospital) - Lymphangioma !Hjnojs ()ieartland Region•l Medical Center) - Mesothelioma Kansas (Coffeyville Regionnl Medical Centet) - Lymphangioma Kansas (Peterson Luboratory Services) - Lymphangioma Milcyland (National Naynl Medical Centel) - Lymphangioma Michigan Q'ath Servjccs Wcs! Michl gap,) - STUMP New York (Stony Brook University Melli cal C<;n!cc) - Lymphangioma New York (SUNY Downstate Medical Center) - Lymphangioma, mediastinum North Carolina (Wake f oresJ Uniye!§jty School of Medicine) - Lymphangioma PcnMylvania (Conemaugh Memorial Medical Center) - Lymphangioma.tosis Pennsylvania (Prexel Medjca! Centet) - Lymphangiomyomatosis Texas. Crystal Beach - Caslleman's disea.~e Texas. Lubbock - Thymoma Texas (Scott & White Memorial Hospital) • Lymphangioma Texas (fhe Methodist Hospital) - Lymphangioma Wisconsin. Madison - Lymphangioma Canada (Sherbrooke University HO'!J2ital) - Lymphangiomatosis Ireland CUniversitv CoUeae Ho:;pital) - Mediastina.! lymphangioma ll!nan (t\l;ahi General !:!osP11nl) - Lymphangioma of mediastinum Spajp. viao • Lymphangioma United Kingdom (Radcliffe Hospital) - Lymphangiomatosis

Case I - Diagnosis: Lymphangioma, anterior mediastinum

T -Y2300, M-91700

Cusc 1 - References:

February, 2008 B

Bossert T, Gummert IF and Mohr FW. Giant Cyslic Lymphangioma of the Mediastinum. E11r J Cartfiotlloroc S11rg 2002; 21(2):340. Bttlejewski .s, Burduk D, Szukul6ki J, et aL Lymphanaioma and Lymphangiomyomatosi~The Same Lesion'/ Otoloryngol Pol

2004: 58(5):903-906. ZJsls C, Rootogianni D, Charalambous E, et al. LympbangioDJAtousHamartoma. Cause or Byshlnder of the Isolated

Cllylopericardium? J Thorne Ctudi~NascSurgWOS; 130(4):1201·1202. Augustin F, SchmidT and Bodocr J. The Robolic Approach for Mediastinal Lesions. Int 1 Mt:J Robot 2006; 2(3):262-270. Park JG, Aubry MC. Godfrey JA, et al. Mediastinal Lymphangioma. Mayo Oinic Experience of 25 Casts. Mayo Clin Proc 2006;

81(9):1197-1200.


Escondido - lnflanamatory royofiboblastie rumor O!codal~ • Inflammatory myofibroblastic tumor Newoort Beach (College Hospital) - Fibrous meningioma Palo Alto - fibroma San Diego (Naval Medical Center) - lnflammalory myofibroblastic tumor Snn Francisco (JJCSF fellows) - tnmntile fibromatosis Woodland Hills - Cranial fascii tis Alabama (!JAB) - Solitary fibrous tumor

C1111. l'<bMJY, 2008; ~Minutes'" (Subs<riptioa 8)

February, 2008 B

3

Georgia (Q>!!eoc Hospillll) - Juvenile hyaline fibromatosis Dlinois (Heartland Regional Medical Center) - Inflammatory myofibroblastic tumor Kansas (O!ffevvillc Regional Medical Center) - Leiomyosarcoma, low grade Kansas (.Peterson Laboratory Service§) - Myofibroma Maryland (National Naval Mcdicul Center) - Infantile myofibroma Michigan (Path Services West MichiillJU - Metanephric adenoma New York (Stony Brook University Medical Centcc) - Infantile myofibroma New York <SVNY Downstate Medical Center) - Cranial fasciitis North Carolina (Wake Fo=t University School of Medicine) - Cranial fasciitis Pennsylvania (Conemaugh Memorial Medical Centec) - Infantile fibrosarcoma PeMSylvania (Drexel Medical CeDjcc) - Infantile myofibromatosis Texas, Crystal Beach - Meningioma Texas. Lubbock - Fibrous meningioma Texas (Scott & Wbite Memorial Hospital) - Myofibroma Texas Cfbe Methodist Hospital) - Cranial fasciitis Wisconsin. Madison - Fibrous tumor of infancy (infantile fibromatosis) Canada <Sherbrooke University Ho~!lllilU - Myofibroma lre!apd (trniyersjjy College Hospital) - Meningeal solitary fibrous tumor Japan (Asahi General Hospital) - Myofibroma Spaip. Vigo - Cranial fasciitis United Kingdom (Radcliffe Hospital) - Inflammatory myofibrob!astic tumor

Case 2 - Diagnosis; Cranial fusciitis

T-Y0!60, M-76130

Outside Conwl!allon; Cheryl Coffin, M.D.; Salt Lake City: "Cranial fasciitis".

Qng 2 . References: Hussein MR. Cranial l'asciitis of Cbildhood. A Case Report and Review of Litcrarure. J Cutatt Ptl[ilo/2008; 35(2):212·214. Yebenes M, Gilabe~e M, Romani J, et al. Cranial Fa.o;ciiris in nn 8-Ycar·Oid Boy. CliniCal Al)d H;stoparhologic Features. Pediatr

Dermato/2001; 24(4):26-30. Oh CK, Whang SM, Kim BG, et al. Congenital Cranial Fasciitis-"Watch and Wait" or Early Intervention. Pediatr D<rmato/2001;

24{3):263-266. CUmming:; TJ, George 'I'M, FucbsHE, ct al. 1be Patbology of BxttacraniaJ Scalp and SlruU Masses in Young Cbildn:o. CJin

Neuropatho/2004; 23(1):34-43. Keyserling HF, Cnstillo M and Smith JK Cranial Fasciills of Childhood. AJNR Am J Nem·oradU;f 2003; 24(?):1465-1467.


Escondido - Intra-abdominal fibromatosis Glendale - Aggressive mesenteric fibromatosis Nel\!pOrt Beach (,College Hm;pita!) - Malignant GIST Palo Alto -Spindle cell neoplasm of myoepithelial origin San Diego (Nayal Medical Centc() - Intra-abdominal fibromatosis San Francisco OJCSf Fellows) - Fibromatosis Woodland Hills - Fibromatosis Alabama (JJAB) - Low-grade fibrosarcoma Georgia (.Col !eKe Hospital\ - Fibromatosis Illinois (Heartland Regional Medjcal Center) - Fibromatosis Kansas (Coffevvmc Regional Medical Center) - Myo6bromatosis Kansas (.Petc!ljOn Laboratory Servi""') - Mesenteric fibromatosis Maryland (National Naval Medical Center) - Abdominal fibromatosis (desmoid) Michigan (Path Services West MjchiiJlrV - Wilm's rumor, diffuse blastema! New York (Stony Brook University Medical Center,) - Gastrointestinal stromal tumor

February, 2008 8

4 <.TIR, Febnwy, 2008; "Minutes-" (Sub!crip<iOII B)

New York CSUNY Qownstate Medical Center) - Mesenteric fibromatosis (dcsmoid tumor) Nonh Carolina (Wake forest University Scbool of Medicine) - Mesenteric fibromatosis Pennsylvania CO>ncm•u•h Memorial Medical Center) - Eibrosan:oma Pennsylvania IJ2rcxel Medjcal Center) - Fibromatosis Texas. Crystal Beach • Gastrointestinal stromal tumor Tpxas. Lubbock • Oesmoid tumor Tpxas (Scott & White Memorial Hospital) • Fibromatosis Texas ITbe Methodist Hospital) - Gastrointestinal stromal tumor Wjmnsjp. Madison • Desmoid tumor (fibromatosis) Capada (Shcrbrooke University HtMpilal) - Deep fibromatosis Ireland OJniversitv O>Uegc Hospi!a!) - Mesenteric fibromatosis lltpan (,Asahi General Hospital) • Mesenteric fibromatosis Snaln. Yiao - fibromatosis Upitcd Kingdom <Radcliffe Hospital) - Fibromatosis

Case 3 • Diagnosis: Intra-abdominal (desrooid) fibromatosis

T-Y4100, M-76100

Case 3 • References: Dumo C, Mooga N, Bapnt B, et a!. Does Early colectomy Increase Desmoid Ri•k in Familial Adenomntous Polyposis? Cli11

Oas~roenrerol Herx•tol 2001; 5(10):1190-1194. Krcuzberg B, KoudelovaJ, Ferda J, et al. Diagnostic Problems of Abdominol Desmoid Tumors in Various Locations. liur J Radio/

2007: 62(2):180-185. Okuno S. The &igma of Demoid Thmors. C<m Trear Options Qncqf 2006; 7(6):438443. Stun NJ and Qark SK. CUrrent Ideas in Desmoid Tumours. Pam Cancer 2006; 273-285. Lat<hrord AR. Stun NJ, Neale K, ct al. A 1~ Year Review of Surgery for Desmoid Disease Associated with Familial Adeoomotous

Polyposis. Br JSurg 2006; 93(10):1258-1264.

Case No. 4 • Accession No. 30204

E:'iC!)ndido - Schwannoma Glegdale - Atypical neurofibroma ~ort Beach (O>Ilcgc Hm;lliliJI) - Neurofibroma Palo Ajto • Myxoid liposarcoma Sap pjg~o t;Naval Medical Ccptec) - Schwannoma with ancient change Sap francisco (J.ICSF Fellow:;) • Neurofibroma Woodland Hills - Neurofibroma Alabama (J.IAB) - Neurofibroma Goor~a (O>Uege Hosphal) • Neurofibroma llljnojs (Heartland Regjonnl Medical Center) - Schwannoma K.'IDsas (O>ffevville Regional Medical Center) - Myxoid neurofibroma Kansas (Peterson Lal!or.uocy Services) - Neurofibroma Maryland t;National Naval Medical Cente!) - Neurofibroma Mjchigan (Path Secyjccs West Michigan) - Wilm's tumor New York (Stony Brook Unjycrsitv Medical Cenjct) - Ancient schwannoma

February, 2008 B

New York (SUNY Downstate Medical Cent«) - Peripheral nerve sheath tumor favor scbwaonoma, scalp Nonh Carolina (Wake Fo!J:I!! University School of Medicine) - Neurofibroma Pennsylvania (Olnemaugh Memorial Medical O:plcr) - Atypical schwannoma Pennsylvania IJ2rexcl Mcdjcal Cente[) - Myxoid neurofibroma, cncapsultatcd TSlllas. Crystal Beach • fibroxanthoma Texas. Lubbock • Neurilemmoma

C1TR. FebNuy, 2008; "Minutes" (Sullo<tiplioa B) 5

Texas (SC!lU & White Memorial Hospital) - Spindle cell lipoma Tcxa< Qbc Methodist Hospital) - Pleomorphic hyalinizing angiocctatic tumor Wisconsin. Madiwo - Neurilemmoma Cana!la (Sbertuooke University llospiJal) - Myxoid neurofibroma/scbwannoma Ireland QJniversity CollegeHospiJal) - Benign peripheral nerve sheath tumor Japan (A.•ahi General Hospital\ - Neurofibroma Spain. Yi&U - Schwannoma Uni)Cd Kin~dom (Radcliffe HospiJQI) - Schwaonoma

Qlse 4 .. Diagnosis: Myxoid neurofibroma, scalp

T-Y0160, M-95400

qg.g 4 .. References: Yooo SB and Park SB. A Study of 77 Clscs of SUJgjcally &cised Scalp and SlruD Masses In Pediatric Patient& Childs Nerv Sysr

2008; 24(4):459-465. Kovarik CL. Hsu MY and Cockerell CJ. Neurofibromatous Changes In Dermatofibrosarcoma Protuberans. A Potential Pilfall In

The Oiag)losis of a Serious Cutaneous Soft Tissue Neoplasm. J Cutan Pat!ro/2004; 31(7):492-496. AgarAm Nl', Prakash Sand Antoocscu CR. Deep·Seated Plexiform Scbwannoma. A Pathologic Study of 16 Cases and Comparative

Analysis with the Superficial Variety. Am J Surg Parllo/200S; 29(8):1042-1048. Koga T, lwasaki H, lsbiguro M, et al. Losses In Chromosomes 17.19, and 22q in Neurofibromatosis Type I and Sporadic

Neurofibromas. A Comparative ~nomic Hybridization Analysis. Cywgenet2002; 136(2):113-120.

Case No. S - Accession No. 30357

fgndjdo ~ Schwannoma Glendale - Cellular scbwannoma Ncw:port Beach (College Hospital) - Schwannoma Palo Alto -Cellular scbwannoma San Diego (Naval Medical Centcc) - Schwannoma San Francisco (UCSF Fellows) - Schwan noma Woodland Hms - Scbwannoma Alabama QJAB.) - Schwannoma Georgia (.College Hosoita!) - Cellular scbwannoma Illinois Qieartlapd Regional Medical Center) - Cellular scbwannoma Kansas (Coffeyville Regional Medical Center) • Scbwannoma Kansas (Peterson !.aboratorv Service() - Schwannoma Maryland (National Naval Medical Center) • Schwannoma Michigqn (Path Services Wesl Michigl\!!) • Renal cell carcinoma New York (Stony Brook Uniyersily Medical Center) - Scbwannoma New York (SUNY Downstate Medical Center) - Schwannoma, forearm North Carolina (Wake Forest Unjvcrsjty School or Medicine) • Scbwanuoma PeJ!!ISylvania (Conemaugh Merpgrial Medical Center) - Scbwannoma PeJ!!ISylyania (Prexcl Medical Ceptcr) - Schwannoma Ieru Cmtal Beach - Scbwannoma TexAA. Lubbock - Neurilemmoma Texas (Scon & White Memorial Hospital) - Scbwannoma Texas Qbe Methodist Hospital) - Schwan noma Wisconsin. Madison - Neurilemmoma Qw.Qda (Sherbrooke University HosJliiD.U - Schwannoma l.t!lliuld..I\Jnjyersity College Hospital) • Schwan noma JapaQ (.Asahi General Hospital) - Schwunnoma Spajo. Yieo - Schwannoma .United KinGdom (Radcliffe Homital) - Schwannoma

F ebruary, 2008 B

6 CITR, FebNaty, ZOOS; "Miout.,... (Subscription B)

CaseS - Diagnosis: Schwannoma, forearm

T-Y8500, M ·95600

Ql.<e 5 - Refcrcoces: Uncoski CJ, Hatler GO and Bush DC. Benig11 Nerve Thmors oftbe Hand and the Forearm AmJ 0rrJwp11J(JI; 36(3):E32-36. Akambi Sonoussi K and Duben T. Scbwannomas of the Peripheral Nerve in the Hand aod Upper Umb. Analysis of 14 Cases. Chir

Main 2006; 25(3-4):131-135. French. Hoang JH, Simon SL, Nagpal S, ct a\. Management of Patient• with Scbwannomatosis. Repon of Six Cases and Review of the

Uterature. Surg Neuro/ 2004; 353-361. Huaog JH, Samadani U ond Zager EL Cases Studies for illustration and Discussion. Peripheral Nerve Tumors. Ne11ro>-urg Clin N

Am 2004; l.'i(2):241-249. Katsumi K, Ogose A, Hotta T, ct at. Plexiform Scbwannoma of the Fo=nn. Skl~tal RadW/2003; )2(12):719-723.


Escpndido - Inflammatory myofibroblastic tumor Glendale - l..ciomyosarcoma Newport Beach (CoUege HospiJal\ - Myolipoma Palo Alto -Myolipoma San Diego (Naya! Medical CcD!Cr) - lo11ammatory myofibroblastic tumor Woodland Hms - Myomatous hamartoma of lung Alabama (!JAil) - Rhabdomyosarcoma, spindle ccU type Georgia (.College Hoslli!;!U • Lymphaogiomyoma(tosis)

February, 2008 B

Illinois (Heartland Regional Me<lical Center) - Smooth muscle tumor of uncertain malignant potential Kansas (Coffc;yyille Rcmona1 Medical Center> · Rhabdomyosarcoma Kansas (Petcc;on laboratory Services) .. Leiomyoma Macyland (National Naval Medical Center) • Solitary fibrous tumor Michit:an (Path Secyiccs West Michigan) - Renal cell cancinoma New York (Stony Brook Unjyersjty Medical Ccnte[) - Leiomyoma New York (SUNY Downstate Medical Center) - Rhabdomyoma, long North carolina (Wake Forest Unjvcrsitv $choo! of Medici JIG) - lo1lammatory myofibroblastic tumor Pegnsylvania (Conemaugh Memorial Medical Center) - lnllammatory myofibroblastic tumor fennsylvania (Drexel Medlen! Q;nter) - UP<Jmyoma Icxa.<, Crvstal Beach - InDnmmatory pseudotumor fibrohistiocytic Texas. Lubbock - Leiomyosarcoma Texas (Sco!! 41. White Memorial Hosnital) - Angiomyolioma Texas Cfhc Methodist Hospital) - Smooth mu:>ele tumor witb uncertain malignant potential Wisconsin. Madison - Smooth muscle tumor, probably leiomyosarcoma Canada <Shcrbrooke University Hospital) - Leiomyoma Ireland (Unjyc~jty College Hospital) - InOammatory myofibroblastic tumor Japan (Asahj General Ho:;lli!;IU - lnflammatory myolibrob!O$tic tumor Spain. Vjgg - Rhabdomyoma United Ki nadom (Radcliffe Hospital) - Angiomyolipoma

Case 6- Diagnosis; Leiomyoma, lung

T-28000, M-88900

Directors comment: Please note the lack of mitot.ic figures nod lack of nccrotiis (coagulative). drc

Case 6 - References: Nucci MR, Drapkin R. Cin PO, et at. Dislillctive Cytogenetic Profile in Benig11 MelaSU$i>ing Lciomyoma. Pathogenetic:

lmpUcaUons. Aml Surg PotJzo/2001; 31(5):'737-743.

crrn, Fcbru•zy. 2008; •MJnutes" (Sobsaiptioo B) 7

OIY11ZZa A, Rossi G, Paci M, ct al. Primary Leiomyoma or the Lung. with Clear-Cell Features and Admixed Alveolar Spaces. Description ora Ca."' Presentiog with Pncumotborax. Pathb~Dgial?IXJ3; 95(2):1()8-114.

1-fistal M, Hardisson D, Ricstra MI.., et aL Multiple Pulmonary Lciomyomatous Hamanomas Associated with a Bronchogenic Cyst in a Man. Arch Pathol Lab Med 2003; 127(4):194-196.

Panoo KT, Cheng L, Papavero V, et al. Benigo Metastasizing Leiomyoma. Clo nality, Telomere Length and Clinicopathologic Analysis. Mod Parho/2006; "1 9(1):130-140.


Escondido - Fetal rhabdomyoma Glendale - Embryonal rhabdomyosarcoma Newpon Beach (College Ho'lJlita!) • Rhabdomyoma Palo Alto - Fetal rhabdomyoma San Diego (Naval Medical Center) • Infantile rhabdomyoma San Eraocisco (UCSF Fellows) - Rhabdomyoma Wpodlaod Hills • Fetal rhabdomyoma with extramedullary hcmatopicsis Alabama IUAB) • Fetal rhabdomyoma Georgia (College Hospital) - Fetal rhabdomyoma !llinojs CRean land Regional Medical Center) - Embryonal rhabdomyosarcoma Kansas (Coffeyvme Regional Medical Cepter) - Rhabdomyosarcoma, botryoid type? Kansas (Peterson Laboratory Servicc!i) - Fetal rhabdomyoma, cellular Macylagd (National Nayal Medical Center) - Fetal rhabdomyoma Mil<b.igan (Path Scryjces West Michil:an) - Renal cell carcinoma, papillary New York !Stony Brook University Medical Center) - Rhabdomyoma New York ISUNY Downstate Medical Center) - Fetal rhabdomyoma, neck North Carolina (Wake Forest UniveQity Scbool of Medicine) - Infantile myofibroma Penn.<vlvania IConeroaugh Memorjal Medical Center\ - Embryonal rhabdomyosarcoma Pennsylvania (j)rexel Medical Cenrct) • Rhabdomyomatous mesenchymal hamartoma Texas, Crystal Beach - Fetal rhabdomyoma Texas Lubbock • Rhabdomyoma TcXJJ.• (Scott & Whjte Memorial Ho~Jlilru) - Rhabdomyosarcoma TelG!S 01Jc Methodjst Ho.spita!) • Intermediate fetal rhabdomyoma Wisoon.<tin Madison • Fetal rhabdomyoma Canada (Sherbrooke University Hospital) - Rhabdomyosarcoma (embryonal-type) Ireland (University College Hospital\ - Embryonal rhabdomyosarcoma Japan (A, ahj General Hospital) • Fetal rhabdomyoma Spain. Yigo • Embryonal rhabdomyosarcoma United Kingdom (Radcliffe Ho.<piJal) - Fetal rhabdomyoma

Case 7. Diaenos!s: E mbryonal rhabdomyosarcoma, neck (congenital)

T-Y0600, M-89003

Case 7 - References:

:February, 2008 B

Ahmed AAand Tsol<os M. Sinonasal R!labdomyosarooma In Children and Young Adults. Tnt J Surg Patho/2007; LS(2):160-16S. Hosoi H, Teramukai S. Matswnoto Y, et at. A Review o(33l R!labdomyosarcoma Cases in Patients Treated Betw.;cn 1991 and 2002

in Japan. 1111 J Clin Onco/2001; 12(2):137-145. Brecher AR, Rcycs-Muglca M, Kamino H, ct al. Congenital Primary Cutaneous Rhabdomyosarcom& in a Neonate. Pediotr

Dermatol2003; 20(4):335-338. Yoshino K. Takeuchi M. Nakayama M, ct al. Coogenital Cervical R!labdomyosarcomn Arising in One Fcllls of a Twin Pregn:mcy.

Fetal Diagn Tlrtr2005; 20(4):291-295. Gillespie MB, Marshall DT, Day TA, eta!. Pediatric Rllilbdomyosarcoma of the Head and Neck. Cun Treat Options Onco/2006;

7{1):13-22. Simon JH, Paulino AC. Smith RB, et al. Prognostic Factors in Head and Neck Rhabdomyosarcoma. Head Neck 2002; 24 (5):468-

473.

8 CITR. Fcb111ary, 2008; "Minu!C$" (SIII>!cripcioo 8)


Escondido • Synovial sarcoma Glendale - Monophasic synovial sarcoma Newport Beach (College Hospital) • Synovial sarcoma Palo Alto • Synovial sarcoma San Di!:io (Naval Medical Center.) • Monophasic synovial sarcoma San fr•ncisco NCSF Fellows) • Monophasic synovial sarcoma Woodland Hills • Synovial sarcoma, monophasic Alabama (UA§) • Synovial sarcoma, monophasic type Georgia (Olllcge Hospital) • Monomorphic synovial sarcoma Pljnojs (Heartland Regional Medical Centro - Synovial sarcoma, monophasic

February, 2008 B

Kansas (Olffevville ReKional Medical Center) • Monophasic spindle cell synovial sarcoma Kansas (.PetC!SQn l,abora!ory Seryjs;es) - Synovial sarcoma Maryland (Natjonal Naval Medical Center) • Monophasic synovial sarcoma Michigan (Path Scryig;s West Mlchi&illl) • Small cell carcinoma New York (Stony Brook Universily Medical Center) • Monophasic synovial sarcoma New York CStJNY Qownstate Medical Center) • Synovial sarcoma, monophasic, heel North Carolina {Wake Forest Upjycrsity School of Medicine) • Synovial sarcoma Pennsylvania (Copcmaugh Memorial Medical Center) • Monophasic synovial sarcoma Pennsylvania (Proxcl Medical Cenlcr) • Synovial sarcoma Texas. Crystal Beach • Synovial sarcoma Texas, Lubbock • Synovial sarcoma Texas (Scott & Wbite Memorial He.<pital) - Monophasic synovial sarcoma Texas (The Methodist Hospital) · Synovial sarcoma Wisconsin, M•diwn - Synovial sarcoma Canada (Sherbrooke University Hos~ - Synoviai sarcoma (bipbasic type) Ireland (UnjycrniiY College Hospital) · Monomorphic synovial sarcoma Japan (Asahi General Hospital) • Synovial sarcoma, monphasic fibrous type Spain, Vlgo • Synovial sarcoma United Kim:dom (Radcliffe Hospital) - Synovial sarcoma

Case 8 • Diagnosis; Monophasic synovial sarcoma, heel

I· Y9600, M -8801 3

Case 8 - References: Bergman S, Brownlee NA, Geisinger KR. Diagnostic Pitfalls Associated with Fine-Needle Aspiralioo Biopsy in a Patient with the

Myxoid Variant ofMonopbasie Fibrous Synovial San:oma. Diagrt CyropatJw/2006; 34(11):761·767. Ev>ing CA, Zakowski MF and Lin 0. Monophasic Synoviol Sarcoma. A CytoloaJc Spectrum. D1lzgn CyUJpalho/2004; 30(1):19-23. Klijanienko J, Caillaud JM and Lagace R, ct al. Cytohistologic Correlations in 56 Synovial Sarcoma in 36 Patients. The Instirut

Curie Experience. Diagn Cytopat/ro/2002; 27(2):96· 102. Fisher C. Montgomery E, Healy V, et al. Ollponin and H·Caldcsmon Expression in Synovial Sarcoma. The Usc of Calponin in

Diagnosis. 1/~opatho/2003; 42(6):588-593. Paulino AC. Synovial Sarcoma Proanosric Factms ®d Patterns of Failure. Am J Clin Onro/2004; 27(2): 122-127.


Escondido - Alveolar soft part sarcoma Glendale · Alveolar soft part sarcoma Newport Beach (College Hospital) • Alveolar soft part sarcoma ]1alo Alto · Alveolar soft parts sarcoma San Diego (Nayal Medical Cenlc!) • Alveolar soft part sarcoma

CTI1t, February. 2008; "MinutCS'" (Subs<rip<ioo B)

February, 2008 B

9

San Francisco (UCSF Fellows) - Alveolar soft parts sarcoma WO<XIIand Hjlls - Alveolar soft part sarcoma Alabama ()JAB) - Clear cell sarcoma of soft tissue Georgia (College Ho.<pjtal) - Alveolar soft part sarcoma illinois (Heartland Re~jogal Medical Center) - Alveolar soft part sarcoma Kansas (Q!fCQvvme Rc~opal Medical Center) - Alveolar soft part sarcoma Kansas CJ>etcrsoo Laboratory Services) - Alveolar soft part sarcoma Maryland CNatjopal Naval Meclica! Center) - Alveolar soft part sarcoma Mjchigap (l'ath Service.• West Michigan) - Transitional cell carcinoma, low grade New York (Stony Brook Univecyjty Medical Center) - Alveolar soft pan sarcoma New York (SUNY Downstate Mec!ical Center) - Alveolar soft part sarcoma, thigh North O~rolina I)Vake Forest Upjyersity School ofMcilidnQ) - Al veolar soft part sarcoma Peppsylyjmja (Copcmaugh Memorial Medical Center) - Alveolar soft parts sarcoma Penpsylyanjn (Prcxel Medical Centec) - Alveolar rhabdomyosarcoma Texas, Crys!nl Bench - Alveolar soft part sarcoma Texas !.ybbock - Alveolar soft part sarcoma Texas (Scott & While Memorial Hospjtal) - Alveolar wft part sarcoma Texas (The Methodist Hospital) - Pleomorphic rhabdomyosarcoma Wisconsin, Madison - Alveolar soft part sarcoma Canada (Sbcrbrpokc University Hospital) - Alveolar sarcoma Ireland ().lojycrsj!y College Ho.spilal) - Alveolar soft part sarcoma Japan GMahi Gcocml Hospital) - Alveolar soft part sarcoma Spain. Viao - Alveolar soft part sarcoma United Kip~dom CRadcliffe Hospital) - Alveolar soft part sarcoma

Case 9- Dipgnosls: Alveolar soft part sarcoma, thigh

T-Y9120, M-95813 Case 9 - References: Kayton ML, Meyc,. P, Wexler LH, et al. Clinical Presentation, Treatment, and Outcome of Alveolar Soft Part Sarcoma in Children,

Adolescents, nnd Young Adults. J Pediatr Surg 2006; 4!(1):187-193. Gupta S, Jain S ond Sodhani P. Alveolar Soft Part Sarcoma. A Bore Entity with Unique C}1omo!pholoical Features. Cytopmhol

2003; 14(1):40-41. Lopez-Ferrer I', Jimencz-Hcffermao JA, et al. Cytologic Features of Alveolar Soft Pan Sarcoma. Rcpon of Three Cases. Diag11

CylcfX'drol 2002; 27(2):115-119. l..ogrono R, Wojtowycz MM and Wunderlich DW. Fine Needle Aspiration Cytology and Core Biopsy in the Diagnosis of Alveolar

Soft Pan Sarcoma Presenting with Long Metastases. A Case Repon. Acta Cyro/1999; 43(3):464-470. Nakashima Y, Kotoura Y, Kasakunt K, et aL Alveolar Soft-Part San:oma. A Report ofTen Cases. Clin Orthop Re/ar Res 1993

(294): 259-266.


Escondido - Myositis ossi.ficans G!egdall; - Bxtraskclclal osteosarcoma Ncw_port Beach (Ol!!egc Hospital) - Myositis ossi6caos P:~o Alto - Bxtrnskclelal osteosarcoma San Diego (Nayal Medical Center) - Myositis ossi6cans San Francjsco ().ICSF fellows) - Extraskeletal osteos1•rcoma Woodland Hjl!s - Extraskclctal osteosarcoma Alabama ()JAB) • Myositis ossifican Gcoriia (College HospiW) - Myositis ossificans Dlinojs Qicanlapd Regional Mc4ical Center) - Soft tissue oSlcosarcoma Kansas (Coffcyvmc Regional Mc4ical Center) - Myositis ossificans Kansas (l'ctcrson I.aboraiory Scrvjces) - Extraskelctal oSteosarcoma Marvlapd (National Naval Medical Center) - Ext!l!Skelctal osteosarcoma

February, 2008 B

Michigan (l'atb Services West Michigan) - Transitional cell carcinoma, high grade

10 CITR, February, ZOOS; "Minul.,. (Subscriplion B)

New York (Stony Brook Ugjyersity Medical Ceotcr\ • Extraosseous osteosarcoma New York ~UNY Downstate Medical Center) • Myositis ossificans Nonh Caro!jna (Wake Forest Upjvcrsitv School of Mec!icio~) • Extraskeletal osteosarcoma ~y!vania (Conemauah Memorial Medical Ceme!) • Myositis ossificans ~ylvania (Drexel Medjcnl Center) • Myositis ossificans Tcxus. Crystal Beach - Myositis ossificans Tcxus. Lubbock - Extrnskelctal osteosarcoma Tcxus (Soott & White Memorial Hospital) • Extraskelcta! osteosarcoma Texns (The Methodist HoSJ)i!al,) - Myositis ossificans Wj:;mgsin. Madison . Extrnskeletal osteosarcoma Canada CSherhrooke University Hospital) - Extraskeletal osteosarcoma Ireland (.Universitv Co!lcac Hospital) - Myositis ossilicans ,[apap (Asahi General Ho.<Jlilill) · Myositis ossificans Spajn. Yigo - Osteosarcoma Unjlcd Kingdom (Radcliffe Hospital) - Extra.•kclctal osteosarcoma

Case 10 • Diagnosis: Extrnskelctal osteosarcoma, thigh

T-Y9100, M-91803

Ca.5e 10 - References: Goldstein-Jackson SY, Gosbeg;:r G, De!Jing G, eta!. l!xtraskeletal Osteosarcoma Has a Favourable ProgJ~osls Wben 'fieated Ukc

Conventional Osteosarcoma. J Cancer Res Clin Onco/ 2005; 131(8):520·526. Abramovici LC, Hytiroglou P, Kelln RM, et al. Well-Differentiated Extraskeletal Osteosarcoma. Repo rt of2 Cases, l with

DediffereJ1tiation. flm11 Por/w/ 2005; 36(4):439-443. KJijihara M, Sugawara Y, Hirata M, ct al. Extraskeleu.l Ostoosarcoma in the Thigh. A Case Report. Radi/Jr Mcd 2005; 23(2):142-

l~. lee JS, Fc!Sdl JF, Wasdha! DA. ct a!. A Review of 40 Patients with Extraskelew Ostcooarcoma. Can«r 1995; 76(11):2253-2259. Dhillon KS, Suntbaralingam S and Maurer HJ. Extraskelew Osteosarcoma or the Thigh. Med J Moloy.Jio 1993; 48(4):453-456.

CITR, Febnwy, 2008; "Miautes" (Sobocriplion B) II

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CALIFORNIA TUMOR TISSUE REGISTRY

Soft Tissue Tumors Study Cases, Subscription B

February, 2008

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 L-oma Lindo, Cullfornia 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cnrli2l!inkline.com Web site & Case of the Month: www.cttr .org

Target audience: l>racticing pathologists and pathology residents.

Gonl: To acquaint the participant with the histologic fearures of a variety of benign and

malignant neoplasms and rumor-like conditions.

Obiettives: The participant will be able to recognize morphologic features of a variety of benign

and malignant neoplasms and tumor-like conditions and relate those processes to pertinent references in the medical literature.

Educational methods and media: Review of representative glass slides with associated histories. Feedback or\ consensus diagnoses from participating pathologists. Listing of selected references from the medicalliterarure.

Principal faculty: Donald R. Chase, MD

CMF. Credit: Lorna Linda University School of Medicine designates this continuing medical

education activity for up to 2 hours of Category I of the Physician's Recognition A ward of the American Medical Association.

CME credit is offered for the subscription year only.

Accreditation; Loma Linda University School of Medicine is accredited by the Accreditation

Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Study Cases, February, 2008; Subscription B 2

Contributor: Edgar Fischer, M.D. Case No. 1 - February, 2008 B Albuquerque, NM

Tissue from: Anterior mediastinum Accession #30408

Clinicul Abstract: An 11-year-old girl presented with a recurrent soft tissue mass centered in the anterior

mediastinum, with involvement of the thymus, p leura, lung parenchyma and pericardium.

Gross Pathology: The specimen consisted of a 25 x 15 x 1.6 em, ISO gram soft tissue mass with a tan-white,

somewhat spongy cut surface.

Special Studies: Positive: 0 2-40

Contributor: LLUMC Pathology (cz) Lorna Linda, CA

Tissue from: Skull

Clinical Abstract:

Case No. 2 - February, 2008 B

Accession #30355

A 1-month-o\d male infant was found to have a 4.0 x 5.0 em skull mass. The lesion was easi ly separated from the dura and scalp at surgery.

Gross Pathology: The 27 gram specimen consisted of two pink-tan soft tissue fragments measuring 4.0 x 3.5 x

2.5 em and 3.0 x 3.0 x 1.5 em. The external surface was pink-tan, fairly smooth and unremarkable. Sectioning revealed rubbery to firm white-tan tissue.

Study Cases, February, 2008; Subscriplion B 3

Contr ibutor: LLUMC Pathology (gws) Lorna Linda, CA

Tissue from: Mesentery

Clinical Abstract:


Accession #30437

This 49-year-old woman presented with an abdominal mass. A composite resection, including the abdominal tumor with adherent small bowel and colon segments, was perfonned.

Gross Pathology: The 2,300 gram, 21.0 x 19.0 x 12.0 em composite resection included the tumor surrounded and

intersected by a 49.0 x 5.0 x 5.0 em segment of transverse colon and matted loops of small intestine. The outer surfaces of the large and small intestines were smooth, glistening and unremarkable. Serial sectioning of the specimen revealed a 13.0 x 12.0 x 11.0 em mass that was adherent to the loops ofthe small intestine and the transverse colon. The cut surface of the mass was yellow-tan with areas of cystic degeneration. Opening of the loops of the small intestine revealed focal areas where the tumor was invading into the intestinal wall.

Special Studies: Positive: Smooth muscle actin (faint, focal positivity). Negative: Desrnin, Muscle specific acti n, S-100 protein, CD117, CD34.

Contributor: LLUMC Pathology (rc) Lorna Linda, CA

Tissue from: Scalp

Clinical Abstract :


Accession #302-04

A 56-year-old man with poorly-controlled type II diabetes underwent resection of a 7 x 4 em mass from his right parietal scalp. The clinical impression was of a benign lipoma.

Gross PatholoLry: The specimen consisted of a 3.5 x 1.5 em tan-white skin ellipse with an underlying 5.0 x 2.5 x

2.0 em well-encapsulated, tan-white mass. The outer surface of the mass was smooth and glistening. Sectioning of the mass revealed a tan-yellow cut surface with focal areas of hemorrhage.


Contributor: Robert Zuch, M.D. Case No. 5 - February, 2008 B Baldwin Park, CA

Tissue from : Left forearm Accession #30357

Clinical Abstract: A 28-year-old man noticed a non-tender, 1.5 em left distal forearm mass . The mass was

excised.

Gross Pathology: The 1.0 x 0.6 x 0.3 em specimen consisted of a red-tan, finn tissue fragment

Specia l Studies: Positive: S-1 00 protein.

Contributor : Jin Mei, M .D. Case No. 6 - February, 2008 B Hang.chou, China

Tissue from: Right Lung Accession #30434

Clinical Abstract: A 31 -year-old man presented with bouts of coughing of one week' s duration. During workup,

a mass was identified in the right upper lobe of !he lung.

Gross Pathology: The 12 x 9 x 3 em lobectomy specimen contained a poorly circumscribed tan mass was seen on

the surface of !he lobe. The surface of !he mass was largely smooth. It had a light yellow and soft cut surface.

Special S tudi.es: Positive: Desmin. Negative: Smooth muscle actin.

Study Cases, February, 2008; Subscription B s

Contributor: Omar Yousef, M.D. Case No. 7 - February, 2008 B Albuquerque, NM

Tissue from: Neck Accession #30323

Clinical Abstract: This 1-day-old baby girl was known to have an anterior cervical mass prior to delivery. Pre

operatively, a teratoma was favored.

Gross Pathology: The tumor was 7.0 x 6.0 x 6.0 em with a brown, fleshy, homogeneous cut surfuce. There was

no hemorrhage or necrosis.

Special Studies: Positive: Desmin, Myogen in, MyoD I , Myoglobin (focally).

Contributor: Alexander Lyster, M.D. Case No. 8 - February, 2008 B Victoria, TX

Tissue from: Right heel Accession #30240

Clinical 1\bst.-act: A 24-ycar-old man presented with a mass in his right heel. The mass was excised.

Gross Pathology: 'l11e 15 x 11 x 8 em firm, nodular, gray-white mass had a sol id, flat, white to tan, whorled or

trabecular fibrous 'cut surface.

Special Studies: Negative: Positive:

Desmin, S I 00 and I-IMB45 Cytokeratin (CAM5.2)


Contributor: LLUMC Pathology {knc) Lorna Linda, CA

Tissue from: Right Thigh

Clinical Abstract:


Accession #30258

A 34-year-old woman presented with a large mass in her right thigh.

Gross Pathology: The 465 gram, 16.0 x 15.0 x 7.5 em specimen consisted of pink-tan muscle and yellow-tan fat

surmounted by an 8.0 x I .0 em ellipse of brown skin. Within the muscle was a 13.0 x 8.0 x 4.0 em firm, fibrous, white-tan mass. Adjacent to the tumor, within the fibrous tissue and fat, were several white-tan nodules ranging up to 0.8 em.

Contributor: Deepak Mohan, M.D. Case No. 10 - February, 2008 B Los Angeles, CA

Tissue from: Right Thigh Accession #30216

Clinical Abstract: A woman in her seventies presented with an intramuscular thigh mass which did not involve

the femur.

Gross Pathology: The 13.0 x 6.5 x 5.0 em specimen contained a 6.0 x 4.0 x 3.0 em firm to hard, ovoid mass.

Sectioning revealed a well-circumscribed, tan-yellow, focally myxoid lesion with gritty calcifications and no necrosis or hemonhage. The adjacent muscle was red-brown and compressed, but uninvolved by the tumor.

Siudy Cases, February, 2008; Subscription D 7

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