Dr. Bharat B. Aggarwal, Ph.DFounding Director,

Anti In�ammation Research Institute San Diego, California

United States of America

Former Professor of

Experimental Therapeutics,

Cancer Medicine and Immunology,

The University of Texas

M. D. Anderson Cancer Center,

Houston, Texas

info@aureabiolabs.combbaggarwal@gmail.com

Turmeric or curcumin ? “Cureit”/Acumin – Recreating turmeric matrix with active curcuminoids

“Turmeric” which is curcuma longa L., has been used for at least 2500 years, mostly in India and China. Turmeric

has a long tradition of its use in food, medicine, cosmetics, etc. Although there were many research work has

been published about curcumin, which is obtained from turmeric, comparatively little is known about turmeric

itself. Studies revealed that there are more than 250 bioactive molecules in turmeric other than curcuminoids.

Natural product research found that there is a good synergetic interaction between other active molecules like

turmerin (protein), dietary �bers etc., with curcuminoids. Now, it is also believed that the activity of curcumin is

maximum when it is inside the turmeric matrix, because some of the activities of turmeric can be mimicked by

curcumin, other activities are curcumin-independent. Out of the many bioactive molecules present in Cureit-

/Acumin, the prominent molecules are listed below, which are only present in this curcuminoid formulation.

The challenge is to recreate the curcumin

inside the turmeric matrix e�ectively. Aurea

Biolabs developed a novel way to recreate the

turmeric matrix with active curcuminoids

(~49 %) by a method known as Polar-

Nonpolar Sandwich (PNS) technology.

Bio-e�cacy

A study conducted in rheumatoid arthritis (RA) shows that Cureit/Acumin can provide signi�cant improvement

in treatment e�cacy in active RA. Active rheumatoid arthritis patients, who received Cureit/Acumin (500 mg X

2) for a period of 90 days, reported statistically signi�cant change/decrease in their clinical symptoms towards

the end of the study.

This was evident from changes in the ACR Response, DAS 28, HAQ DI, QOL-SF36, VAS questionnaires

administered by the physician/designee. Even the CRP, ESR and RA factor values recon�rm the e�cacy results.

Therefore, it is concluded that a standardized extract of Cureit/Acumin is safe and e�cient in the management

of rheumatoid arthritis. So Cureit/Acumin acts as very e�cient analgesic, anti-in�ammatory, and e�cient in the

management of RA. This result shows the importance of having a curcuminoids with complete turmeric

extracts as there are many anti-in�ammatory molecules acts synergistically with curcumin.

Cureit/Acumin is more potent than the curcuminoids alone and it can interact with multiple molecular targets

involved in a wide variety of diseases. Cureit/Acumin meets great promise, safety, e�cacy, and a�ordability. In

vitro, in vivo, and human clinical studies have all established promise of Cureit/Acumin and revealed its

therapeutic value.

During the absorption of any nutrient molecule irrespective of its

source, must traverse the inner intestinaal wall to gain access to the

blood stream. It must pass through the walls of the surface epithelial

cells, behind which are capillaries through whose walls it must also

pass. All cell walls are made of lipids, and the molecules most easily

absorbed through them are of like fat – soluble. The curcuminoids lies

in this catogory. But because the curcuminoids are fat soluble and not

water soluble, they tend to arrive at the cell walls in the form of

relatively large, undissolved particles rather than as induvidual mole-

cules. Such molecules (molecular aggregates) are very poorly

absorbed. In the case of water soluble molecules, it would be readily

S. No. Compound Structure Pharmacological properties1. β-Elemene Induced apoptosis in glioblastoma cells

Exhibited antiproliferative activities against human cervix epitheloid carcinoma, gastric carcinoma, and leukemia cells

Enhances the radiosensitivity of lung adenocarcinoma xenograft

2. Bisacurone Downregulates TNF-induced VCAM-1expression in HUVECs

Possess anti inflammatory properties

3. Calebin A Inhibits growth and induced apoptosis in drug-resistant human gastric cancer cells.

Protect neuronal cells from amyloid insult

4. Curcumene Anti oxidant Anti inflammatory

5. Curdione Inhibited the production of PGE2 in LPS-stimulated mouse macrophages through the suppression of COX-2

6. Cyclocurcumin Inhibited the proliferation of human breast cancer cells

7. Volatile / fixed oil Turmerones and related compounds Anti-inflammatory Inhibits the growth of cancer cells Inhibits induces apoptotic bodies and

DNA fragmentation in leukemia cells, induces DNA fragmentation and caspase activation in human breast cells

8. Bisabocurcumin Antioxidant Anti-inflammatory Anticancer

9. Proteins 2 kDa protein5 kDa protein9 kDa protein

Biologically active molecule carriers Anti-inflammatory Anticancer

10. Dietary fibers Antioxidant Anti-inflammation Enhance the bioavailability of

biologically active molecules11. Acidic polysaccharides Ukonan A

Ukonan BUkonan CUkonan D

Phagocytosis activity Immunomodulatory effect Anti-inflammatory Anti-neoplastic activities

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The graphical representation of the mean concentrations (ng/mL) of the three formulated curcuminoids at di�erent intervals of time.

absorbed, because they arrive at the cell walls as individual molecules. But it is known that the cell walls are lipidic,

which means that they tend to repel these water soluble molecules, and thus these molecules also poorly

absorbed. Generally, hydrophilic molecules dissolve easily in the GI tract but may be poorly absorbed, where as

hydrophobic molecules do not dissolve easily but would probably be readily absorbed if they did. Whether the

nutrient molecules are taken with or without food often makes a di�erence, owing to the absorption- enhancing

or absorption inhibiting e�ects of other compounds in the intestinal soup. Aurea biolabs developed the bioavail-

able curcumin – Cureit/Acumin based on this concept.

Increase in Bioavailability

A study has been coducted to compare the plasma bioavailability of total curcuminoids of three di�erent curcumin

formulations in healthy male adult after single oral dose. The novel ‘curcumin inside the natural turmeric matrix’

formulation contains curcuminoids with turmeric proteins, �bers, minerals, carbohydrates and essential oil of

turmeric (Cureit/Acumin). This has been compared with two other formulations of curcuminoids. One was curcum-

inoids with turmeric essential oil from turmeric rhizome (Volatile oil formulation) and the other one was curcumi-

noids which formulated with lecithin and cellulose (Phospholipid formulation). It was concluded that the di�erent

curcumin formulation containing turmeric proteins, �bers, minerals, carbohydrates and essential oil of turmeric

(Cureit/Acumin) is not only safe and well tolerated by healthy human volunteers but also exhibited statistically

signi�cant higher bioavailability relative to the curcumin formulations with volatile oils of the turmeric rhizome

and phospholipid complex. The adjuvants like �bers, essential oils or carbohydrates enhance the bioavailability of

the phenolic compounds considerably.

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Be a par tner wi th c l in i ca l ly tes ted curcumin leader - Cure i t

August , 2016Aurea News le t te r