Type 1 Diabetes

Jennifer McVean, MDSeptember 23, 2010

Outline

• Type 1 diabetes: increasing incidence and prevalence

• Exciting research and developments in type 1 diabetes

• Juvenile Diabetes Research Foundation and The Walk to Cure Diabetes

Type 1 Diabetes

• Autoimmune Disease• White blood cells attack & destroy islet cells in

pancreas which produce insulin• Absolute insulin deficiency• Symptoms: polyuria, polydipsia, weight loss• Requires lifelong treatment with insulin given

by injection or subcutaneous infusion

Type 1 Diabetes

• One of the most common chronic diseases of childhood

• In the US:– 13,000 new childhood diagnoses per year– Prevalence for ages 0-19 years is:

1/300 – 1/500– Number of new patients annually has tripled in

the past 20 yearswww.cdc.gov

0

10

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30

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50

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1950 1960 1970 1980 1990 2000

Finland

Sweden

Colorado

Germany

T1D incidence is rising 3-5% per year

Incidence /100,000/ yr in children aged 0-14

REWERS

Immune Therapies

Beta Cell Therapies

Complications Therapies

Glucose Control

Therapeutic Areas

Stop the Attack!

Restore Beta Cells!

Prevent, Stop, Reduce!

Tight Control!

Omnipod tubeless CSII

Continuous Glucose Monitoring

Integrated CSII & CGMS

What’s ahead…

• http://abcnews.go.com/video/playerIndex?id=8046715

JDRFMission: to find a

cure for type 1 diabetes and its complications

Who is JDRF?

• Founded in 1970 by parents of children with type 1 diabetes

• Raises money and advocates for government spending for type 1 diabetes research

• Global leader in funding research toward a cure for type 1 diabetes

• Sets the agenda for diabetes research worldwide • Largest charitable funder of type 1 research

JDRF• Has funded more than $1.4 billion

in research • JDRF annually receives top rankings from

organizations that rate charities • More than 80 percent of our

expenditures directly support research and research-related education

Sunday, October 3 at Myrick Park12pm Registration

1pm Walk