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F 1 �� � � � � � '23 4 2C '6 4 0 ' � � � � � � � � � �� � � � #)( *+ , � *:; +, �! "D E ?@ A

G 1 � � � � � � -� '23 4 5 '6 4 5 � H$ I$ , > � H$ I$ , > � H$ I$ , >

J 1 � � � � � � -� '23 4 5 '6 4 0 �! " := = $ = $ , �! " : = = $ = $ , �! " : = = $ = $ ,

K 1 � � � � � � -� '23 4 2C '6 4 5 ' � � � � � � � � � �� � � � #)( *+ , � *:; +, � " D E ?@ A

L 1 � � � � � � -� '23 4 2C '6 4 0 ' � � � � � � � � � �� � � � * :; + , � *:; +, � " D E ?@ A

M 1 � � � � -� '23 4 2C ' � � � � � � � � � �� � � � * :; + , � *:; +, � *:; +,

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predisposing allele frequency

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phenocopy/penetrance

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~ �Figure 1 e

predisposing allele frequency

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~ �Figure 2 a

predisposing allele frequency

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Ztot and log(LRexp)log(LRlin)

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~:�Figure 2 b

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~��Figure 3: Optimal weight of sib quartet relative to sib pair

optimal S, rho=.9, Ztot

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