PROFICIENCY TESTING SERVICEAMERICAN ASSOCIATION OF BIOANALYSTS

205 West Levee St. ! Brownsville, TX 78520-5596800-234-5315 ! 281-436-5357 ! Fax 713-781-5008

PARTICIPANT STATISTICS URINE DRUG SCREEN FIRST QUADRIMESTER 2014

Barbiturates

Name Present Absent Present Absent Name Present Absent Present AbsentAbbott Architect 1 1 Lin-Zhi 30 30Alere 1 1 MedTox Profile series 26 26All chromatographic methods 2 2 BioRad TOX/See 23 22Noble One Step 1 1 MedTox Profile V 1 21 21 1

Total Population 5 1 0 8 Alere 16 16Flagging ***** ***** Biosite TRIAGE 16 16

Assay Value (μg/dL) Siemens Dimension 14 13 1iCup 14 14Syva Emit II, Emit II Plus 13 14Microgenics DRI 12 12

Name Present Absent Present Absent Redwood BioTech One Step 1 10 10 1Carolina 4 4 Innovacon 8 8Lin-Zhi 31 31 Roche Cobas 8 8Microgenics DRI 7 7 OneStep 3rd party, OEM 7 6 2Mindray BS-200 3 1 4 Alfa Scientific InstantView 6 6Siemens Dimension 4 4 MedTox Verdict-II 6 6Syva Emit II, Emit II Plus 9 9 Carolina 5 4 1

Total Population 86 4 4 86 iCassette 5 5Flagging ***** ***** Express Diag DrugCheck 5 5

Assay Value (mg/dL) Beckman Coulter DXC 5 5Alere Signify 5 5

Amphetamines Mindray BS-200 4 3 1Noble Multi-CLIN 4 4

Name Present Absent Present Absent Redwood Multi-Line 3 3ABM Rapid Drug Screen 3 3 Total Population 3 331 326 9AimScreen 2 1 3 Flagging ***** *****Alere 16 16 Assay Value (ng/mL)

Alere Signify 5 5Alfa Scientific InstantView 9 9 BenzodiazepinesAll chromatographic methods 4 4Beckman Coulter DXC 7 7 Name Present Absent Present AbsentBeckman Synchron Emit 3 3 Alere 16 16BioRad TOX/See 23 24 Alere Signify 5 5Biosite TRIAGE 16 16 Alfa Scientific InstantView 7 7BioView 3 3 All chromatographic methods 4 4Carolina 5 5 Beckman Coulter DXC 6 6Express Diag DrugCheck 5 5 BioRad TOX/See 24 23iCassette 6 6 Biosite TRIAGE 16 16iCup 18 18 BioView 3 3Innovacon 9 9 Carolina 5 5Integrated E-Z Split 4 4 Express Diag DrugCheck 5 5Lin-Zhi 31 1 32 iCassette 5 5MedTox Profile series 28 28 iCup 17 17MedTox Profile V 18 2 1 19 Innovacon 9 9MedTox Verdict-II 7 7 Lin-Zhi 32 32Microgenics DRI 13 13 MedTox Profile series 27 27Mindray BS-200 3 1 4 MedTox Profile V 21 21Noble Multi-CLIN 13 2 15 MedTox Verdict-II 7 7OneStep 3rd party, OEM 8 2 10 Microgenics DRI 13 13OneStep OEM 3rd party wvd 3 1 4 Mindray BS-200 4 4Redwood BioTech One Step 9 1 1 9 Noble Multi-CLIN 4 4Roche Cobas 5 3 8 Redwood BioTech One Step 1 11 1 11Siemens Dimension 14 14 Redwood Multi-Line 3 3Siemens Viva ser 3 3 Roche Cobas 8 8Syva Emit II, Emit II Plus 17 17 Siemens Dimension 14 14

Total Population 370 18 5 384 Siemens V-Twin 3 3Flagging ***** ***** Syva Emit II, Emit II Plus 14 13

Assay Value (ng/mL) Total Population 3 350 5 345Correct responses are defined as those reflecting agreement among 80% or more of all participants. Flagging ***** *****Unacceptable responses are indicated by "****" on the Flagging line of each specimen. Assay Value (ng/mL)

Specimen-1

AcetaminophenSpecimen-1 Specimen-2

31.1 µg/dL

Specimen-2

4300

AlcoholSpecimen-1 Specimen-2

169 mg/dL

Specimen-1 Specimen-2

Specimen-2

2180

Specimen-1

Page 2 URINE DRUG SCREEN FIRST QUADRIMESTER 2014

Cocaine Metabolite

Name Present Absent Present Absent Name Present Absent Present AbsentLin%Zhi 28 28 ABM+Rapid+Drug+Screen 3 2 1Syva+Emit+II,+Emit+II+Plus 19 19 AimScreen 5 5Siemens+Viva+ser 15 15 Alere 16 16MedTox+Profile+V 12 12 Alere+Signify 5 5MedTox+Profile+series 3 3 Alfa Scientific InstantView 24 24Immunalysis 3 3 All chromatographic methods 4 4Microgenics+Cedia+DAU 3 3 Beckman Coulter DXC 7 7

Total Population 1 123 1 122 Beckman Synchron Emit 3 3Flagging ***** ***** BioRad TOX/See 24 23

Assay Value (mg/dL) Biosite TRIAGE 16 16BioView 3 3

Cannabinoids BMC Fastect 3 3Carolina 5 5

Name Present Absent Present Absent Express Diag DrugCheck 6 6ABM Rapid Drug Screen 3 3 iCassette 6 6AimScreen 5 5 iCup 19 19Alere 16 16 Innovacon 10 10Alere Signify 5 5 Integrated E-Z Split 3 3Alfa Scientific InstantView 24 1 23 Lin-Zhi 32 32All chromatographic methods 4 4 MedTox Profile series 27 26 1Beckman Coulter DXC 7 7 MedTox Profile V 1 20 20 1Beckman Synchron Emit 3 3 MedTox Verdict-II 7 7BioRad TOX/See 23 23 Microgenics DRI 14 14Biosite TRIAGE 16 16 Mindray BS-200 4 3 1BioView 3 3 Noble Insta-Screen 3 3Carolina 4 4 Noble Multi-CLIN 16 16Express Diag DrugCheck 6 6 OneStep 3rd party, OEM 16 16iCassette 6 6 OneStep OEM 3rd party wvd 1 19 20iCup 18 18 Redwood BioTech One Step 1 11 11 1Innovacon 10 10 Redwood Multi-Line 3 3Integrated E-Z Split 4 4 Roche Cobas 8 8Lin-Zhi 32 32 Siemens Dimension 14 13 1MedTox Profile series 26 26 Siemens Viva ser 16 16MedTox Profile V 22 22 Siemens V-Twin 4 4MedTox Verdict-II 7 7 Syva Emit 3 4Microgenics DRI 13 13 Syva Emit II, Emit II Plus 35 35Mindray BS-200 4 4 Syva RapidTest 3 3Noble Insta-Screen 3 3 Total Population 5 472 467 10Noble Multi-CLIN 16 16 Flagging ***** *****OneStep 3rd party, OEM 10 10 Assay Value (ng/mL)

Redwood BioTech One Step 1 11 1 11Roche Cobas 8 8 CotinineSiemens Dimension 14 14Siemens Viva ser 16 16 Name Present Absent Present AbsentSiemens V-Twin 4 4 Innovacon 4 4Syva Emit 3 3 Microgenics DRI 3 3Syva Emit II, Emit II Plus 35 35 Total Population 0 21 1 20Syva RapidTest 3 3 Flagging ***** *****

Total Population 3 441 5 439 Assay Value (pg/mL)

Flagging ***** *****Assay Value (ng/mL)

Name Present Absent Present AbsentTotal Population 0 7 1 6Flagging ***** *****

Assay Value (pg/mL)

Correct responses are defined as those reflecting agreement among 80% or more of all participants.Unacceptable responses are indicated by "****" on the Flagging line of each specimen.

Specimen-1 Specimen-2

2005

Specimen-1 Specimen-2Buprenorphine

Specimen-1 Specimen-2

Specimen-1

Specimen-1 Specimen-2

Specimen-2

Lysergic Acid Dieythlamide

Page 3 URINE DRUG SCREEN FIRST QUADRIMESTER 2014

MDMA (Ecstasy) Methamphetamine

Name Present Absent Present Absent Name Present Absent Present AbsentAlere 3 3 BioRad TOX/See 25 25Alere Signify 5 5 MedTox Profile series 23 23Alfa Scientific InstantView 3 3 Lin-Zhi 21 21BioRad TOX/See 21 21 MedTox Profile V 20 1 19BioView 3 3 OneStep OEM 3rd party wvd 19 19Carolina 3 3 iCup 1 17 18Express Diag DrugCheck 5 5 OneStep 3rd party, OEM 13 13iCup 12 12 Alere 12 12Innovacon 5 5 Redwood BioTech One Step 1 10 1 10Lin-Zhi 24 23 Alfa Scientific InstantView 8 8Microgenics DRI 4 4 Innovacon 6 6Noble Multi-CLIN 4 4 Express Diag DrugCheck 5 5OneStep 3rd party, OEM 5 5 iCassette 4 4Redwood BioTech One Step 1 4 1 4 BioView 3 3Siemens Dimension 3 3 Redwood Multi-Line 3 3

Total Population 2 151 3 149 Integrated E-Z Split 3 3Flagging ***** ***** Noble Multi-CLIN 1 3 4

Assay Value (ng/mL) Total Population 6 246 5 247Flagging ***** *****

Assay Value (ng/mL)

Methadone Methaqualone

Name Present Absent Present AbsentAlere 8 8 Name Present Absent Present AbsentAlfa Scientific InstantView 6 6 Syva Emit II, Emit II Plus 3 3BioRad TOX/See 21 21 Diag Reag Inc (DRI) 2 2Biosite TRIAGE 5 5 Total Population 13 3 0 16Carolina 6 6 Flagging ***** *****Express Diag DrugCheck 5 5 Assay Value (ng/mL)

iCup 10 8 2Innovacon 7 6 1 OpiatesLin-Zhi 31 30 1MedTox Profile series 21 20 1 Name Present Absent Present AbsentMedTox Profile V 20 20 AimScreen 5 5Microgenics DRI 11 11 Alere 16 16Mindray BS-200 4 3 1 Alere Signify 5 5Noble Multi-CLIN 3 3 Alfa Scientific InstantView 24 23 1OneStep 3rd party, OEM 8 8 All chromatographic methods 4 4Redwood BioTech One Step 1 10 10 1 Beckman Coulter DXC 7 7Roche Cobas 1 6 7 BioRad TOX/See 24 23Siemens Dimension 11 11 Biosite TRIAGE 16 16

Total Population 3 267 253 16 Carolina 5 4 1Flagging ***** ***** Express Diag DrugCheck 6 6

Assay Value (ng/mL) iCassette 7 7iCup 19 16 3

Methadone Metabolite Innovacon 9 9Integrated E-Z Split 4 4

Name Present Absent Present Absent Lin-Zhi 32 32ABI+SureStep 1 1 MedTox Profile series 28 28AimScreen 1 1 MedTox Profile V 1 19 19 1All+chromatographic+methods 2 2 MedTox Verdict-II 7 7Immunalysis 1 1 Microgenics DRI 14 14Microgenics+DRI 2 2 Mindray BS-200 4 3 1OneStep+3rd+party,+OEM 1 1 Noble Multi-CLIN 16 15 1Roche+Cobas 1 1 OneStep 3rd party, OEM 16 14 2Siemens+V%Twin 1 1 OneStep OEM 3rd party wvd 20 20Syva+Emit+II,+Emit+II+Plus 1 1 Redwood BioTech One Step 1 11 11 1US+Diagnostics+ProScreen 1 1 Roche Cobas 7 7

Total Population 1 23 6 18 Siemens Dimension 14 13 1Flagging ***** Siemens Viva ser 16 16

Assay Value (ng/mL) Siemens V-Twin 4 4*Due to a lack of participant consensus, Specimen 2 was not evaluated this event. Syva Emit II, Emit II Plus 35 34

Total Population 4 474 458 19Correct responses are defined as those reflecting agreement among 80% or more of all participants. Flagging ***** *****Unacceptable responses are indicated by "****" on the Flagging line of each specimen. Assay Value (ng/mL)

Specimen-1

Specimen-1

Specimen-2

1,500

3640

Specimen-1

750

Specimen-1 Specimen-2

Specimen-1

Specimen-2

Specimen-2Specimen-2

Specimen-1 Specimen-2

Page 4 URINE DRUG SCREEN FIRST QUADRIMESTER 2014

Oxycodone Propoxyphene

Name Present Absent Present Absent Name Present Absent Present AbsentAlere 3 3 Alere Signify 5 5Alere Signify 5 5 All chromatographic 3 3All chromatographic methods 3 3 BioRad TOX/See 3 3BioRad TOX/See 14 1 15 Carolina 4 4Carolina 4 1 3 iCup 4 4Express Diag DrugCheck 5 5 Innovacon 5 5iCassette 4 4 Lin-Zhi 6 6iCup 14 14 MedTox Profile series 21 21Innovacon 7 7 MedTox Profile V 19 19Lin-Zhi 32 32 Microgenics DRI 9 9MedTox Profile series 19 6 13 OneStep 3rd party, OEM 3 3MedTox Profile V 20 20 Redwood BioTech One 1 3 1 3Microgenics DRI 6 6 Syva Emit II, Emit II Plus 6 6Mindray BS-200 3 1 4 Total Population 1 123 1 123Noble Multi-CLIN 4 4 Flagging ***** *****OneStep 3rd party, OEM 10 1 2 9 Assay Value (ng/mL)

OneStep OEM 3rd party wvd 19 1 3 17Redwood BioTech One Step 5 1 1 5Redwood Multi-Line 3 3Roche Cobas 3 1 4 Name Present Absent Present Absent

Total Population 228 7 20 215 Alere 9 9Flagging ***** ***** Alere Signify 5 5

Assay Value ng/mL Alfa Scientific InstantView 3 3All chromatographic methods 3 3

Phencyclidine BioRad TOX/See 23 23Biosite TRIAGE 14 14

Name Present Absent Present Absent Express Diag DrugCheck 3 3Alere 11 11 iCassette 3 3Alere Signify 5 5 iCup 5 5Alfa Scientific InstantView 8 8 Innovacon 5 5All chromatographic methods 4 4 MedTox Profile series 1 20 21Beckman Coulter DXC 6 6 MedTox Profile V 21 21BioRad TOX/See 19 19 MedTox Verdict-II 3 3Biosite TRIAGE 11 11 Noble Multi-CLIN 5 5Carolina 5 5 OneStep 3rd party, OEM 6 6Express Diag DrugCheck 4 4 Redwood BioTech One Step 7 7iCassette 5 5 Syva RapidTest 3 3iCup 7 7 Total Population 2 169 2 169Innovacon 9 9 Flagging ***** *****Lin-Zhi 25 25 Assay Value (ng/mL)

MedTox Profile series 22 22MedTox Profile V 21 21MedTox Verdict-II 6 5Microgenics Cedia DAU 4 4Microgenics DRI 10 10Noble Multi-CLIN 15 15OneStep 3rd party, OEM 7 7Redwood BioTech One Step 1 11 1 11Roche Cobas 6 6Siemens Dimension 13 13Syva Emit II, Emit II Plus 13 13

Total Population 2 320 5 316Flagging ***** *****

Assay Value (ng/mL)

Correct responses are defined as those reflecting agreement among 80% or more of all participants.Unacceptable responses are indicated by "****" on the Flagging line of each specimen.

Specimen-2

Specimen-2Specimen-1

Specimen-2

Specimen-2

Specimen-1

Tricyclic antidepressantsSpecimen-1

495

Specimen-1