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Prediction of toxicity in concurrent chemoradiation for non-small cell lung cancerUijterlinde, W.I.
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Citation for published version (APA):Uijterlinde, W. I. (2014). Prediction of toxicity in concurrent chemoradiation for non-small cell lung cancer
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Download date: 25 Feb 2019
Prediction of toxicity in concurrent chemoradiation for non-sm
all cell lung cancer Wilm
a Uijterlinde
Prediction of toxicity inconcurrent chemoradiation for
non-small cell lung cancer
Wilma Uijterlinde
29761 Uijterlinde.qxp_Omslag 30-08-14 10:28 Pagina 1
UitnodigingVoor het bijwonen van de
openbare verdediging van hetproefschrift
Prediction of toxicity inconcurrent
chemoradiation for non-small cell lung cancer
Op vrijdag 31 oktober 2014 om 14 uur
In de AgnietenkapelOudezijds Voorburgwal 229-231
te Amsterdam
Aansluitend receptie
Wilma [email protected]
06 24 14 89 24
Paranimfen
Peter [email protected]
06 55 69 70 99
Liesbeth [email protected]
06 27 40 66 80
29761 Uijterlinde.qxp_Uitn kaart 02-09-14 09:09 Pagina 1
Prediction of toxicity in concurrent chemoradiation
for non-small cell lung cancer
Wilhelmina Ida Uijterlinde
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The work presented in this thesis was performed at the Netherlands Cancer
Institute/Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval
system or transmitted, in any form or by any means, without permission of the
author.
© 2014 W. Uijterlinde.
Cover design and layout: Ferdinand van Nispen, Citroenvlinder-dtp.nl, Bilthoven,
The Netherlands.
Original images by the department of nuclear medicine of the Netherlands
Cancer Institute/Antoni van Leeuwenhoek.
Printing: GVO drukkers en vormgevers, Ede, The Netherlands.
ISBN: 978-90-9028-512
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Prediction of toxicity in concurrent chemoradiation
for non-small cell lung cancer
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het college voor promoties ingestelde
commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 31 oktober 2014, te 14:00 uur
door
Wilhelmina Ida Uijterlinde
geboren te Tiel
29761 Uyterlinde.indd 3 28-08-14 09:30
Promotores: Prof. dr. P. Baas
Prof. dr. M. Verheij
Copromotor: Dr. M.M. van den Heuvel
Overige leden: Prof. dr. M.B. van Herk
Prof. dr. C.R.N. Rasch
Prof. dr. D.K.M. de Ruysscher
Prof. dr. E.F. Smit
Prof. dr. J.T. Annema
Faculteit der Geneeskunde
29761 Uyterlinde.indd 4 28-08-14 09:30
Voor mijn vader, in liefdevolle herinnering
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Contents of this thesis
Chapter 1 Introduction 9
Chapter 2 Prediction of acute toxicity grade ≥3 in patients with
locally advanced non-small cell lung cancer receiving
Intensity Modulated Radiotherapy and concurrent low
dose cisplatin
15
Chapter 3 Acute esophagus toxicity in lung cancer patients after
Intensity Modulated Radiotherapy and concurrent
chemotherapy
33
Clinical parameters and timelines for predicting esophagus
toxicity in concurrent chemoradiation with IMRT for locally
advanced non-small cell lung cancer
49
Severe late esophagus toxicity in NSCLC patients treated
with IMRT and concurrent chemotherapy
67
Chapter 4 Additional weekly Cetuximab to concurrent chemo
radiotherapy in locally advanced non-small cell lung
carcinoma: efficacy and safety outcomes of a randomized,
multi-center phase II study investigating
87
Chapter 5 Treatment adherence in concurrent chemoradiation
in patients with locally advanced non-small cell lung
carcinoma: results of daily intravenous prehydration
107
Chapter 6 Fractures of thoracic vertebrae in patients with locally
advanced non-small cell lung carcinoma treated with
intensity modulated radiotherapy
123
Chapter 7 Discussion and future perspectives 141
Chapter 8 Summary 149
Nederlandse samenvatting 155
List of abbreviations 159
Dankwoord 160
Curriculum 164
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