victor tambunan - universitas...
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Victor TambunanDepartment of Nutrition
Faculty of MedicineUniversitas Indonesia
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References
Krause’s Food & Nutrition Therapy 12th ed., 2008 ---- L.K. Mahan & S. Escott-Stump
Modern Nutrition in Health and Disease 10th ed., 2006 ---- M.E. Shils et al
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GASTROINTESTINAL TRACT
Upper Gastrointestinal (GI) Tract• Esophagus• Stomach• Duodenum
Lower GI Tract• Small intestine• Large intestine• Rectum
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Gastroesophageal Diseases
Gastroesophageal reflux disease (GERD)
Gastritis and peptic ulcer disease
Gastric cancer
Dumping syndrome6
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GERD consists of irritation & inflammation of the esophagus in response to reflux of gastric acid into the esophagus
Symptom:
heartburn Factors that contribute to GERD:
Excessive volume of acidic contents in the stomachLooseness of lower esophageal sphincter (LES)Motility disorders in the esophagus
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Medical Nutrition Therapy
Objectives:1. Prevent esophageal reflux2. Prevent pain & irritation of the
inflamed esophageal mucosa1. ↓ the erosive capacity or acidity of
gastric secretion
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Nutrition Care Guidelines for Reducing Gastroesophageal Reflux:
1. Avoid large, high-fat meals2. Not eating within 3 to 4 hours before retiring3. Avoid tobacco smoking4. Avoid alcoholic beverages5. Avoid caffeine containing foods & beverages6. Stay upright & avoid vigorous activity soon after eating7. Avoid tight-fitting clothing, esp. after a meal8. Consume a healthy, nutritionally complete diet with
adequate fibre9. Avoid acidic & highly spiced foods when inflammation
exists10. Reduce weight if overweight
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Alcohol
Chocolate
Fatty foods
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relaxing the LES & inducing GERD
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Gastritis & peptic ulcers may result when• infectious• chemical• neural abnormalities
disrupt mucosal integrity of the stomach or duodenum
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The most common cause: Helicobacter pylori infection
H. pylori infection is responsible for:
Most cases of chronic inflammation of gastric mucosa
Peptic ulcer
Atrophic gastritis
Gastric cancer
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Acute gastritis: refers to rapid onset of inflammation & symptoms
Chronic gastritis: may occur over a period of months to decades, w/ increasing & decreasing of symptoms
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Atrophic gastritis:
chronic inflammation w/ deterioration of the mucous membrane & glands, resulting in:
achlorhydria (loss of secretion of HCl) loss of intrinsic factor
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Factors that may also compromise mucosal integrity and ↑ the chance of acquiring acute & chronic gastritis
• Chronic use of aspirin or other NSAIDs
• Steroids
• Alcohol
• Erosive substances
• Tobacco
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Medical Nutrition Therapy
∼ as for peptic ulcersIn patients w/atrophic gastritis: evaluate vitamin B12 status
because lack of intrinsic factor & HCl
results in malabsorption of vitamin B12
In chronic gastritis: ↓ absorption of Fe, Ca, & other nutrients
occurs because ↓ gastric acid can ↓ their bioavailability
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Primary causes:H. pylori infectionGastritisAspirin & other NSAIDsCorticosteroidsStress-induced ulcer
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Involve two major regions:- Stomach- Duodenum
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Excessive use or high concentration drinks (alcohol) can:
damage gastric mucosaworsen symptoms of peptic ulcersinterfere w/ ulcer healing
Beers & wines: ↑↑ gastric secretion
Coffee & caffeine: stimulate acid secretion ↓ LES pressure
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Medical Nutrition Therapy
• Avoid alcohol∀ ↓ consumption of spices, esp. chili, cayenne, &
black peppers. Turmeric may inhibit adhesion of H. pylori to the gastric wall
• Avoid coffee & caffeine∀ ↑ intake of n-3 & n-6 fatty acids• Use probiotics as complementary therapy• Regular use of cranberries which contain phenolic
antioxidants may have the capacity to help eradicate H. pylori
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Frequent small meals may:
↑ comfort↓ the chance for acid refluxstimulate gastric blood flow
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persons w/ peptic ulcers should avoid consuming large meals, esp. before retiring, to reduce latent increases in acid secretion
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Cancer of the stomach can lead to malnutrition because of:• Excessive blood & protein losses, or• Obstruction & mechanical interference w/ food intake
more commonly
Consumption of fruits, vegetables, & selenium may have a modest role in the prevention of GI cancersAlcohol & overweight ↑ the riskOther factors:- Chronic infection w/ H. pylori- Smoking- Intake of highly salted or pickled foods- Inadequate amounts of micronutrients
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the risk
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Dietary regimen is determined by:• Location of the cancer• Nature of the functional disturbance• Stage of the disease
Patients w/ advanced, inoperable cancer should receive a diet that is adjusted to their tolerances, preferences, and comfortAnorexia: almost always present from the early stages.In the later stages:- liquid diet or- parenteral nutrition (intravenously)
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Medical Nutrition Therapy
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Dumping syndrome: a complex physiologic response to the rapid emptying of hypertonic contents into the duodenum & jejunum
May occur as a result of: total or subtotal gastrectomy manipulation of the pylorus after fundoplication after some gastric bypass procedures for
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Nutrition care:Frequent small mealsHigh-protein, moderate-fat foods w/ sufficient calories. Complex CHOs (starches) can be included. Simple CHO (lactose, sucrose, & dextrose) should be limitedSufficient fibres (pectin in fruits, or guar gums) beneficial because they ↓ upper GI transit time & ↓ the rate of glucose absorption
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Medical Nutrition Therapy
Prime objective: to restore nutrition status & quality of life
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Nutrition care: ……………………….. (cont’d)
Limit the amount of liquids taken w/ meals, but adequate amounts should be consumed during the day, small amounts at a timeLie down immediately after meals & avoid activity an hour after eatingVery small quantities of hypertonic, concentrated sweets (soft drinks, juices, pies, cakes, cookies, and frozen desserts) can be ingestedLactose, esp. in milk & ice cream, are poorly tolerated, but cheeses & yogurt are better
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Diet for preventing symptoms of dumping syndrome:
Moderate fat (30% of calories intake) High protein (20% of calories intake) Low in simple CHO
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helps the patient achieve & maintain optimal weight & nutritional status
When intake is inadequate vit. D & Ca supplements may be needed
When steatorrhea (+) → give oil or fat which high in medium-chain triglycerides (MCTs)
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• Intestinal gas & flatulence
• Constipation
• Diarrhea
• Steatorrhea
• Gastrointestinal stricture & obstruction
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Instestinal Gas & FlatulenceCauses: Inactivity ↓ GI motility Aerophagia Dietary components GI disorders
Medical nutrition therapy:Reduce intake of CHO that are likely to be malabsorbed & fermented
e.g. legumes, soluble fibre, resistant starches, & simple CHO such as fructose & alcohol sugars 30
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Constipation
Most common causes:
Ignoring the urge to defecate Lack of fibre in the diet Insufficient fluid intake Inactivity Chronic use of laxatives
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Medical Nutrition Therapy
Consumption of adequate amounts of both soluble & insoluble dietary fibreFibre: colonic fecal fluid microbial mass stool weight & frequency the rate of colonic transit
softens feces & makes them easier to pass
Adequate water32
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Recommended amount of dietary fibre
about 14 g/1000 kcal
Fibre can be provided in the form of:Whole grainsFruitsVegetablesLegumesSeedsNuts
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Diarrhea
Causes may be related to:
Inflammatory diseaseInfections w/ fungal, bacterial, or viral agentsMedicationsOverconsumption of sugarsInsufficient or damaged mucosal absorptive surfaceGI resectionsMalnutrition
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Medical Nutrition TherapyFirst step in managing diarrhea: replacement of necessary fluids & elctrolytes, using:
electrolyte solutions soups & broths vegetable juices other isotonic liquids
Later: Starchy CHOs (cereals, breads) Low-fat meats Added small amounts of vegetables & fruits,
followed by lipids 35
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Probiotics
Modestly successful in:
Antibiotic-related diarrhea Traveler’s diarrhea Bacterial overgrowth Several types of pediatric diarrhea
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Steatorrhea
Steatorrhea:
excessive fat in the stool caused by disease or surgical resection of organs involved in the digestion & absorption of lipid
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Medical Nutrition Therapy
Steatorrhea can result in chronic weight loss → may require ↑ calorie intake, mainly in the form of protein & complex CHOs
MCTs can be given because: able to enter the portal vein for transport to the
liver without micelle formation digestion & absoprtion, & resynthesis into triglycerides in intestinal cell
easier to be absorbed in the abscense of bile acids
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Food source of MCTs:coconut oil
Micronutriens supplementation:Fat-soluble vitaminsCaZnMg
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because losses are ↑ as a result of insoluble soaps’ formation
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Gastrointestinal Strictures & Obstruction
Causes (partially or completely obstruction):Instestinal tumorsScarring from GI surgeriesInflammatory bowel disease (IBD)Peptic ulcerRadiation enteritis
If parts of the GI are partially obstructed
obstructions from foods may occur
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The most common foods that may cause obstructions are fibrous plant foods
Phytobezoars:obstructions in the stomach that result from the ingestion of plant foods
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Restricted-fiber diet → limit fruits, vegetables, & coarse grains
Provide <10–15 g of dietary fibre, usually in the form of small particle size such as vegetable & fruit juices, cereals, & breads
In distal obstructions or strictures: Keep the feces soft by:
including moderate amounts of fibre, but of small particle size (such as juices)
adequate water
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Medical Nutrition Therapy
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Some Diseases and Conditions Associated with Malabsorption
• Inadequate digestion Pancreatic insufficiency Gastric resection
• Altered bile salt metabolism w/ impaired micelle formation
Hepatobiliary disease Bacterial overgrowth
• Abnormalities of mucosal cell transport Biochemical or genetic abnormalities
- Disaccharidase deficiency e.g. lactase deficiency- Celiac disease (gluten-sensitive enteropathy)
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Some Diseases and ……………… (cont’d)
Inflammatory or infiltitative disorders- Crohn’s disease- Ulcerative colitis- Radiation enteritis- Short-bowel syndrome
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• Abnormalities of intestinal lymphatics & vascular system
Instestinal lymphangiectasia Chronic congestive heart failure
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Two major forms of IBD:
Crohn’s disease
Ulcerative colitis
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Clinical characteristics:
Diarrhea Fever Weight loss Anemia Food intolerances Malnutrition Growth failure Extraintestinal manifestations (arthritic,
dermatologic, & hepatic)46
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4747Crohn’s disease Colitis ulcerative
Segments of inflamed bowel
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Abnormal activation of the mucosal
immune response Secondary systemic
response
Unknown “irritant”Viral? Bacterial?Autoimmune?
Genetic predisposition
Damage to the cells of the small and/or large intestinew/ malabsorption, ulceration, or stricture
- Diarrhea- Weight loss- Poor growth
Pathophysiology of inflammatory bowel disease
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Medical Nutrition Therapy
IBD patients are at ↑ risk of malnutrition
primary goal of MNT to restore & maintain the nutritional status
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Energy: energy requirements are not greatly ↑
Protein: protein needs may ↑ but rarely >50% than normal needs
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Vitamins & mineral supplementation:• folic acid, vitamins B6, and B12• Zn, K, and Se
Small, frequent feedings may be tolerated better
Small amounts of isotonic, liquid, oral supplements may be valuable
If fat malabsorption (+)
foods made w/ MCTs useful to ↑ calories intake & for absorption of fat-soluble nutrients
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↑ n-3 fatty acids intake antiinflammatory effect
Probiotics can modify the microbial flora
Prebiotics (such as oligosaccharides): alter the mixture of microorganisms in the
colonic flora favoring lactobacillus & bifidobacteria suppressing pathogenic or opportunistic microflora ↑ production of SCFAs
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Risk factors associated w/ the onset of exacerbations of IBD include:
↑ sucrose intake
lack of fruits & vegetables
dietary fibre <<
red meat >>
alcohol
altered n-6/n-3 fatty acid ratios
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