OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETYAND THE JAPANESE SOCIETY OF DRUG DELIVERY SYSTEM

VOLUME 245, 10 JANUARY 2017 ISSN: 0168-3659

COVER STORYThe drug delivery field needs a well-diversified technology portfolio

Vol. 245 JOURNAL OF CONTROLLED RELEASE 10 JANUARY 2017

CONTENTS

Cited in: BIOSIS/Biological Abstracts; CAB Abstracts; Chemical Abstracts Services; Current Contents (Life Sciences); EMBASE/Excerpta Medica; International Pharmaceutical Abstracts; PUBMED/MEDLINE/Index Medicus; Polymer Contents; Science Citation Index. Also covered in the abstract and citation database Scopus®. Full text available in ScienceDirect ®

Available online at www.sciencedirect.com

05054

Cover Story The drug delivery field needs a well-diversified technology portfolio

K. Park (West Lafayette, USA) 177

Reviews Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug

delivery systems S. Gupta and V. Jhawat (Mullana, Ambala, India ) 15

The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis A. Jain and K. Cheng (Kansas City, United States ) 27

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges M.M. Wen, N.S. El-Salamouni, W.M. El-Refaie, H.A. Hazzah, M.M. Ali, G. Tosi, R.M. Farid, M.J. Blanco-Prieto, N. Billaand A.S. Hanafy (Alexandria, Egypt; Modena, Italy; Pamplona, Spain; Selangor, Malaysia) 95

Biodegradable nano-polymers as delivery vehicles for therapeutic small non-coding ribonucleic acids A. Mokhtarzadeh , A. Alibakhshi , M. Hashemi , M. Hejazi , V. Hosseini , M. de la Guardia and M. Ramezani ( Tabriz, Tehran, Mashhad, Gonabad, Iran; Valencia, Spain ) 116

Research papers Triple-amiRNA VEGFRs inhibition in pancreatic cancer improves the efficacy of chemotherapy through EMT regulation

J. Huang , H. Mei , Z. Tang , J. Li , X. Zhang , Y. Lu , F. Huang , Q. Jin and Z. Wang ( Nantong, China ) 1 Tumor-targeted micelle-forming block copolymers for overcoming of multidrug resistance

A. Braunová , L. Kostka , L. Sivák , L. Cuchalová , Z. Hv ̌ ezdová , R. Laga , S. Filippov , P. ̌ Cernoch , M. Pechar , O. Janou ̌ sková , M. ̌ Sírová and T. Etrych ( Prague, Czech Republic ) 41

Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents A.R. Fernandes , J. Jesus , P. Martins , S. Figueiredo , D. Rosa , L.M.R.D.R.S. Martins , M.L. Corvo , M.C. Carvalheiro , P.M. Costa and P.V. Baptista ( Caparica, Lisboa, Portugal ) 52

Rational design of protamine nanocapsules as antigen delivery carriers J.V. González-Aramundiz , E. Presas , I. Dalmau-Mena , S. Martínez-Pulgarín , C. Alonso , J.M. Escribano , M.J. Alonso and N.S. Csaba ( Santiago de Compostela, Madrid, Spain; Santiago, Chile ) 62

Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma S. Kotopoulis , E. Stigen , M. Popa , M.M. Safont , A. Healey , S. Kvåle , P. Sontum , B.T. Gjertsen , O.H. Gilja and E. McCormack ( Bergen, Oslo, Norway ) 70

Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment M. Huo , Y. Zhao , A.B. Satterlee , Y. Wang , Y. Xu and L. Huang ( Chapel Hill, USA; Nanjing, Shenyang, Zhenjiang, China ) 81

Thermally triggered release of the bacteriophage endolysin CHAP K and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA) H. Hathaway , J. Ajuebor , L. Stephens , A. Coffey , U. Potter , J.M. Sutton and A.T.A. Jenkins ( Bath, UK; Cork, Ireland ) 108

siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model J.M. Freire , I. Rego de Figueiredo , J. Valle , A.S. Veiga , D. Andreu , F.J. Enguita and M.A.R.B. Castanho ( Lisbon, Portugal; Barcelona, Spain ) 127

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin F. Teodorescu , G. Quéniat , C. Foulon , M. Lecoeur , A. Barras , S. Boulahneche , M.S. Medjram , T. Hubert , A. Abderrahmani , R. Boukherroub and S. Szunerits ( Lille, France; Skikda, Algeria ) 137

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