welcome to immunology course
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Welcome to Immunology Course. IMMUNOLOGY. Prof. dr Vera Pravica Prof. dr Dušan Popadić Doc. dr Miloš Marković Assist. dr Emina Savić [email protected] Tel. 3643-236 Facebook: Antitelija Limfocitic. Basic terminology. Immunitas (lat.). p rotection , immunity. Immunis,-e (lat.). - PowerPoint PPT PresentationTRANSCRIPT
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Welcome to Immunology Course
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IMMUNOLOGY
Prof. dr Vera PravicaProf. dr Dušan PopadićDoc. dr Miloš MarkovićAssist. dr Emina Savić
Tel. 3643-236Facebook: Antitelija Limfocitic
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Immunitas (lat.) protection, immunity
organs, tissues, cells and molecules involved in defence of the organism
process that results in immunity
resistant to (infectious) disease
Basic terminology
Immunity
Immunization
Immune
Immune system
state of resistance to (infectious) disease
coordinated activity of the immune system
components
Immune response
Immunis,-e (lat.) protected, immune
Protection of senators against prosecution, tax payment and other civil duties in Antic Rome
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Basic function(s) of the immune system
Defense against infectious agents
Recognition and elimination of cancer cells
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viruses
bacteria
helmints
fungi
protozoa
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- mechanisms of recognition of “danger” signal
- mechanisms of activation and regulation of defense
- effector mechanisms of destruction and elimination of pathogens and neutralization of their harmful products
- mechanisms leading to immune response injurious to own tissue
- possibilities for manipulation of the immune response
IMMUNOLOGY investigates
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IMMUNITY
INNATE
(Natural)
(Native)
ADAPTIVE
(Aquired)
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Mechanisms of innate and adaptive immunity
- amplified upon re-exposure to the same pathogen
- fully functional after certain period (days, weeks)
- appears in vertebrates
INNATE IMMUNITY ADAPTIVE IMMUNITY
- filogenetically older
- immediate action
- does not change throughout a lifetime
- early line of defence
Mutually stimulating
- reacts against both infectious and non-infectious substances
- later but more effective
- reacts predominantly against infectious agents
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Principle mechanisms of innate and adaptive immunity
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Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- autotolerance
- specialization
- stimulation of mechanisms of innate immunity
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Types of adaptive immunity
- based on effector mechanismscellular or cell-mediated (T-lymphocytes)humoral (B-lymphocytes)
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Types of adaptive immunity
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Types of adaptive immunity
- based on effector mechanismscellular or cell-mediated (T-lymphocytes)humoral (B-lymphocytes)
- based on manner of activationactivepassive
- based on mode of inductionnaturalartificial
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IMMUNIZATION
PASSIVE
ACTIVE
NATURAL (infection)
ARTIFICIAL (vaccination)
NATURAL(Mother-to-fetus antibody transfer)
ARTIFICIAL (serum therapy)
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Simplified presentation of immune network