who challenges and priorities for immunization policy making philippe duclos, who science and...
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WHO Challenges and priorities for immunization policy making
Philippe Duclos, WHOPhilippe Duclos, WHOScience and Technology Options Assessment,Science and Technology Options Assessment,STOA – AVIESAN Workshop, June 19STOA – AVIESAN Workshop, June 19thth 2012, 2012,European Parliament, BruxellesEuropean Parliament, Bruxelles
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Health Statistics and Informatics: for information you can trust
Major causes of death in neonates and children under five globally – 2010
•7.6 millions deaths a year in children < 5 year •About one third of all child deaths linked to malnutrition
•Children in low-income countries about 18 times more likely to die
•63% (4.8 millions) infectious diseases
Crédit to Colin Mathers – Unpublished -confidential
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The world is getting heavier!The world is getting heavier!
Source: World Health Statistics: A snapshot of Global Health, 2012, World Health Organization WHO/IER/HIS/12.1
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“Climate change is the greatest global health threat of the 21st century”
University College London (UCL) Lancet Commission
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Global coverage estimates, 1990-2010 DTP3, Measles, HepB3, Hib3, PCV3 and Rota
Source: WHO/UNICEF coverage estimates 2010 revision. July 2011
458,000 unvaccinated infants (DPT3) in EURO, 201029% live in countries eligible for GAVI Alliance funding
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1,900 0 1,900950 Kilometers
Countries with % of districts achievingat least 80% DTP3 coverage, 2010
Countries with % of districts achievingat least 80% DTP3 coverage, 2010
100 % districts (59 countries or 31%)80-99 % districts (35 countries or 18%)50-79 % districts (32 countries or 17%) No data (43 countries or 22%)
Not applicable 0-49 % districts (24 countries or 15%)
The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. WHO 2012. All rights reserved
Source: WHO/UNICEF estimates and WHO/IVB database, September 2011193 WHO Member States. Date of slide : 12 June 2012.
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European Region, reported measles incidence, 2011
European Region, reported measles incidence, 2011
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The Global World and VaccinesThe Global World and VaccinesOpportunities
Rekindled political & public health interest
Resources allocated and innovative financing mechanisms – GAVI $4.3 billion
Progress made with coverage
Global targets set
"Pharma" engagement
Rich pipeline of new vaccines
Decade of Vaccines
Challenges
Conflicting priorities
Vaccine field tends to be vertical
Weak health services
Lack of transparency about costing
Changing epidemiology
Lacks grassroots activism
Threatened by vaccine "hesitancy"
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“We envision a world where children, families, and communities enjoy life protected from the threat of disease. The purpose of the Decade of Vaccines is to extend the full benefits of immunization to all people, regardless of
where they live”
“We envision a world where children, families, and communities enjoy life protected from the threat of disease. The purpose of the Decade of Vaccines is to extend the full benefits of immunization to all people, regardless of
where they live”
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WHO Vaccine Position PapersWHO Vaccine Position Papers
Position papers = Key reference documents
Developmental and review process (follow recommendations of SAGE, extensive peer review, evidence-base, periodic updating)
Format Weekly Epidemiological Record Current structure (Intro, background (Disease epidemiology, the pathogen, disease), info on vaccines (composition, safety, immune response, efficacy and effectiveness, cost effectiveness and any other relevant issue), WHO position on vaccine use)
Additional posting of information on the web: Grading of Recommendations Assessment, Development and Evaluation (GRADE) tables, references, summaries (one pager and PowerPoint presentation)
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Aspects for which there is a lack of data to support decision making
Aspects for which there is a lack of data to support decision making
Effectiveness in developing countries and herd immunity
Adjust schedules: reduce number of doses, dose spacing and duration of protection (alleviate number of booster doses)
Vaccines co-administration
Risk groups: immunodeficient, pregnant women, very young and very old
Impact of vaccination strategies
Cost-effectiveness studies
Need good and coordinated surveillance
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Communication methods for vaccine-hesitant populations
Use of vaccine in humanitarian emergencies
Accessibility to affordable vaccines and WHO's role
Use of vaccines in immunocompromised populations
Optimizing immunization schedules
Non specific effects of vaccines
Impact of introduction of new vaccines on strengthening of immunization and health systems
Maternal immunization to enhance the protection of mothers and infants
Involvement of the private sector
Strengthening of NITAGs
Thiomersal
Vaccine stockpiles
Recommendations on use of specific vaccines and monitoring of implementation and impact
New Challenges: SAGE’s Agenda 2012 -2014
New Challenges: SAGE’s Agenda 2012 -2014
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Current political commitment does not translate into significant changesReporting transparency – some member states fail to report VPD cases or forward samples to regional laboratories for confirmation – political context"Denominator" remains a problem in several member statesSignificant (negative) impact of health system changes/reforms on immunization programme implementationNeed fair salaries for immunization and surveillance personnel including laboratory staff to maintain skilled workforce Expanding assistance to National Immunization Technical Advisory Groups Self-procuring member states face higher cost (e.g. >10USD per dose of pentavalent vaccine or MMR) in absence of competitionVaccination acceptance a raising problem with varying underlying causes
European Region: some specific challenges
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WHO research priorities WHO research priorities Biomarkers
Assess performance, strategic information and support decision making – validate vaccine coverage and assess population susceptibility How to differentiate natural infection from vaccinationDefinition of correlates of protection
Implementation researchIdentify problems in programmes implementation and their determinants, develop and identify and implement solutionsPlatform for researchers to share research results, and assess their potential contribution to global immunization vaccine policies and practicesEstablish networks and intercountry collaboration
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Decade of Vaccines R&D at global level to maximize vaccination benefits:
preliminary list of activities
Decade of Vaccines R&D at global level to maximize vaccination benefits:
preliminary list of activities
Short term New communication methodsRepresentative epidemiological and impact studies to guide cost-effectivess studiesOperational research on different approaches to immunize during the entire life course and in situation of emergencies
Mid termAdjuvants: access and know howAdministration without needlesThermostabilityNew production methodsRegulatory research
Long termImprove understanding of
innate and adaptative immunitymicroorganismscauses of variability in response to vaccines
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Research and development of vaccine policies
Research and development of vaccine policies
Need to identify research priorities to facilitate decision making and adjustment of policies
Need for dialogue and exchange of information
Continuous process
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Thank youThank you
With acknowledging the input and assistance provided by WHO colleagues and particularly that from Dina Pfeifer (EURO) and Laure Dumolard (HQ)
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Current vaccines and vaccines on the horizon•
•1960 •1980 •2000•// •//•Diphtheria
•Pertussis
•Tetanus
•YF •Influenza
•Polio
•Measles
•JE•Rubella•HepB
•Hib (conj)•Typhoid
•Cholera•Pneumo (conj)•Rotavirus•HPV•Mening (conj)
•Dengue
•Malaria•TB
•HIV/AIDS
Traditional EPI
New and underused vaccines
Futurevaccines
•Source – WHO, 2005
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