why to apply for a grant?
TRANSCRIPT
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Why to apply for a grant?
Department of Medical Biotechnology,Faculty of Biochemistry, Biophysics and Biotechnology,
Jagiellonian University
Alicja Józkowicz
mail: [email protected]; tel: 12-664-6411 or 519-347-621;room: 3.035.
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- More and more people are earning PhDs in science, technology and engineering.
* Such expansion results in an extraordinary amount of good research.* Most of those with PhDs quickly find good jobs outside academia.
PhDs like mushrooms…
PhD in Poland
PhD students, December 2014
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But:
- Unlimited growth could dilute the quality of PhDs.
- Expansion is driven without giving thought to how the labour market will accommodate those who emerge.
- PhD holders are slogging through 5-10 years of poorly paid postdoctoralfellowships, applying for a permanent academic position.
- The system is driven solely by the supply of research funding.
- Currently you can survive as long as you are rewarded with grants(which pay for PhD students and staff) and publications.
PhDs like mushrooms…
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If you have become a PI…
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PhD and salary in Poland
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A) Different institution for every stage from undergraduate to faculty position.* currently the most recommended* it is good to move if you have that flexibility (new research strategies, new
collaborations)
B) Two or more institutions, the same for consecutive stages.* common believe: it isn't in a student's best interest to stay from undergrad to
grad; they should move on.* For postdoc: moving to another institution (preferentially abroad) is necessary.
There are dedicated funds for postdoc coming back – this gives a chance to establishnew lab.
C) All stages at one place.* they stayed at the same place because no one else wanted them (?)* they are so awesome, University didn't want them to leave (?)
- Academia is not one-size-fits-all, and there is room for all sorts of career paths
Stay or go?
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Stay or go?
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- The career structure in universities is broken, particularly in the life sciences.
- Fellowships are few, every advertised academic post draws a flood of candidates.
- Researchers face a widening chasm between their cycles of contract workand a coveted PI position.
What after postdoc?....
- The system needs only onereplacement per lab-head position, but over the course of career, a typical biologist will train dozens of suitable candidates.
- Landing a lab-head positionrequires a strong publication record(needed: skills, hard work and luck)
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What after postdoc?....
- To force a highly trained postdoc from research is a waste of time and public expense.
But:
- Beyond research, there are science-related jobs, such as in:
* publishing,* grants’ administration, * auditing,* public engagement.
- These positions seldom require more than a doctorate, if that.
”Were you:A: satisfied…B: fairly satisfied…C: unsatisfied”
Also:
- The ageing postdoc, when starting again in a different career, after long period of relatively low pay, can be years behind in terms of savings and pensions.
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If you want to become a team member
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- Research technician is an important (priceless!) part of a scientific lab, participating in high-tech, high-profile studies.
- The research technicians: * set up, operate, and maintain the lab equipment; * are profesionally trained in taking and collecting data, performing
experiments [or: caring for the plants and animals used in studies];* interpret data, develop conclusions;* are the highest quality specialists (very often the best trained in the
team) in application of demanding techniques.
- The work performed by the research technician is extremely valuable and well trained and educated persons are always in demand.
If you want to become a team member
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If you want to become a team member
- Be ready to introduce new techniques and optimize methods used in youlab.
- Be aware that your duties are repetitive and your results will be (often) presented by someone else.
- But:* you do not need to think about research funds* you do not need to prepare, run and report research project* you can go home at 5 pm and forget about lab - your free time is yours
(if you are PI scientist you simply do not have anything like ”free-time”)
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First of all:
- Be genuinely interested in your subject area. The most importantmotivation: just interest in science, not career development plan.
Then:
- Get a doctorate early (but not too early…) on in your academic career.- Learn to work independently, demonstrating that you are able to defineoriginal research questions.- Publish your work in the best possible journals. - Take every opportunity to present at conferences, workshops, etc.- Get personal funding. - Collaborate. - Learn to accept criticism – objective peer review. - Enjoy your work and don’t be afraid to break the rules.
If you want to become a PI
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It helps if...
- you have made a successful postdoc abroad, or at least at another university, or at least in another department…- you have good publications (in high impact journals, well cited)
- you have a number of first/last authorships on papers
- your PhD mentor is not on the author list on all your articles (you havepublications from a postdoc training)
- you have successfully finished your own research project for PhD students oryoung investigators
- after postdoc fellowship you have returned to research constellation different from where you were brought up
- you can propose a research project which is novel, excellent, doable etc.
- you are lucky…
If you want to become a PI
You must…- win a high-budget grant to rent a lab space, employ first PhD students, run a research… No other ways. You must regularly win good research projects.
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If you want to become a PI
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Department of Medical Biotechnology
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Grant:
- project conceived by investigator
- agency supports or assists
- performer defines details and retains scientific freedom
- agency maintains oversight
Contract:
- project conceived by agency
- agency procures service
- agency exercises direction or control
- agency closely monitors
Grant versus contract
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The grant process is never wasted
- Grants allow you to take control of your scientific development.- Grants free us to do the kind of research we are really interested in- Grants bring us:
* prestige/independence* reagents, programs, licences etc. * travels and participating the conferences* equipment,* team,* lab space
- As a young investigator – you can increase your salary.
If you have got it:
- Writing a project (even not awarded) requires you to focus your thoughts and precize your research plans
- Armed with reviewers comments the second proposal is always stronger
If you have failed:
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You can get it
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Technical science
Humane science
Life science
You can get it
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050
100150200250300350400450
Jagiellonian University University of Warsaw
num
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Number of projects in 2011/2012
020000000400000006000000080000000
100000000120000000140000000160000000180000000
Jagiellonian University University of Warsaw
fund
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100
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Humane Science Technical Science Life Science
Num
ber o
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Jagiellonian University University of Warsaw
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Humane Science Technical Science Life Science
fund
s [P
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Jagiellonian University University of Warsaw
438 379 zł
205 502 zł
485 351 zł
You can get itFunds awarded in 2011/2012
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You can get it
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02468
1012141618
Jagiellonian University University of Warsaw
num
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Maestro
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Jagiellonian University University of Warsaw
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2 359 149 zł
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Jagiellonian University University of Warsaw
num
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Opus
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Jagiellonian University University of Warsaw
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330 249 zł
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Jagiellonian University University of Warsawfu
nds
[PLN
]
1 209 895 zł
You can get it
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You can get it
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0
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Jagiellonian University University of Warsaw
num
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Fuga
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1000000
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Jagiellonian University University of Warsaw
fund
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370 083 zł
020406080
100120140160180
Jagiellonian University University of Warsaw
num
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Preludium
02000000400000060000008000000
1000000012000000140000001600000018000000
Jagiellonian University University of Warsaw
fund
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101 285 zł
You can get it
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A long time ago....
in Krakow.....
I was born to be a scientist.
My personal experience
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Education:
Master thesis
PhD thesis
Habilitation
Mechanisms of rejection of the skin allografts and xenografts in Anuranamphibians
Comparison of time-budgets of theMute Swans (Cygnus olor) winteringin urban and rural areas
PPAR and angiogenesis –effect of PPARg ligands on endothelial cells.
My personal experience
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Good place: Houston
My personal experience
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capsidcapsidgenomegenome
ITRITR E1E1 ITRITR
Wild Wild typetype virusvirus
First First generationgeneration vectorvector
GutlessGutless vectorvector
transgenetransgene ITRITR
transgenetransgene ITRITRstufferstuffer
ITRITR
ITRITR
Adenovirus, E1 and gutless vector
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Effect of single injection with apoE gutless vector
Kim et al. PNAS 2001
HdAd-gen-apoE
apoE-control
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Good place: Vienna
My personal experience
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Vascular lesion formation at 14 days after a wire-injury of femoral arteries in the wild-type and HO-1-/- mice
Duckers et al. Nature Med 2001
WT mice HO-1-/- mice
HO-1 deficiency augments neointima formation in mice
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Coming back to the best place - Kraków
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L’Oreal for Women and Science
Habilitation fellowship
- 1 800 zł/per month for year (my salary this time was 1 200 zł)
- private money – I could buy some small equipment and reagents
- cosmetics
- pleasure for family (cannot be overestimated)
- covering the costs of printing the habilitation thesis
My personal experience
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pretty, but...
- furniture
- pipettors
- apparatus for electrophoresis
- reagents
- laboratory plasticware
My personal experience
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The Wellcome Trust
International Senior Research Fellowship
in Biomedical Science
Ministry of Science and Higher Education
NCN, FNP
Individual grantsSolicited grants
POIG - infrastructural grantsPOIG - research grants
Cooperation with industryADAMEDSELVITA
PHARMENABiovico
My personal experience
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PhD students
Maciej CieślaSzymon CzaudernaWitold NowakJacek StępniewskiAgata SzadeKrzysztof SzadeAnna JagiełłoMateusz TomczykBart ChristDamian KlóskaMonika Żukowska
Researchers
Prof. Józef DulakProf. Alicja JózkowiczDr. Agnieszka JaźwaDr. Neli Kachamakova-TrojanowskaDr. Agnieszka ŁobodaDr. Karolina Bukowska-StrakovaDr. Urszula FlorczykDr. Anna Grochot-PrzeczekDr. Magdalena KozakowskaDr. Hevidar Taha
Technical and administrative staff
Agnieszka Andrychowicz-RógJanusz DrebotElżbieta ŚliżewskaEwa WernerJoanna Uchto Karolina HajdukKarolina Kordeczka
Department of Medical Biotechnology
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Publications:Ateroscler Throm Vasc Biol, J Exp Med, Science, Nature Med, Circulation, PLoS One, Am J Pathol, Proc Natl Acad Sci USA, JACC, Cardiovasc Res, Oncogene, FASEB J, JBC, Free Radic Biol Med, Antioxid Redox Signal,Cancer Lett, General Comp Endocrinology, BBRC, Thromb Haemosthasis,Prostaglandins & Other Lipid Mediators, Clin Sci, Gene,& inne…
Grants:a) Ministry of Science and Higher Education (IUVENTUS)b) Wellcome Trust International Senior Research Fellowshipc) EU – 6 FP – the European Vascular Genomic Network – EVGNd) POIG – 2.1, 2.2, 1.1.2e) Foundation for Polish Science: START, Homing, Pomost, Venturesf) NCN: Maestro, Harmonia, Preludium, Opusg) NCBiR: PBS, Strategmedh) cooperation with industry (agreements with 4 companies)
Last year our papers have been citted >400 time
Department of Medical Biotechnology
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Typical cell culture: cell lines and primary cells
PACAcLDL
BM PAC
Satellite cells
Cell cultures
Dr Magdalena Kozakowska
B16(F10)
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Angiogenesis: in vivo models
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Histology
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Image Stream Fortessa
Flow and image cytometry
MoFlo
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5 years and 7 mln PLN ago
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4 years and 7 mln PLN ago
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Then…
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…and now
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- To provide a comprehensive overview of the grant writing process:* how to identify funding sources* how to develop a writing timeline, * how to create and manage a team/how to work as team member, * how to talk to program officers and reviewers,* elements of the complete grant package, * NCN/FNP/MNiSW procedures and review process.
- To provide step by step instructions for developing each section of the researchproject:
* background and rationale, * description of methods, * schedule, * budget and cost justification,* presenting a grant proposal to the reviewer board* managing and reporting a research project
Major aim:
- To provide the knowledge needed to write a fundable research grant (Preludium) in the NCN format.
Objective of the course
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Additional aims:
- To provide a knowledge on: * intellectual property laws, patenting and commercialization,* practical aspects of cooperation with commercial partners. * research reproducibility, reliability of published data, side effects of ”publish or
perish” paradigm* pros and cons of teamwork, benefits and traps of research consortia
Objective of the course
- You will prepare a collective or individual proposal according to the "Preludium" scheme. We will discuss:
* common errors in grantsmanship and hints how to avoid them.* examples of well and purely done work
- You will prepare also a revision of classmates’ proposal for discussion at the reviewer panel. We will discuss:
* grant application review criteria,* rules related to grant reviewing.
Training:
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Passing the course:
- Sending a project proposal and revision of classmate project. [till March 31st – please, send me the names of group members and preliminary title of the project]
Objective of the course
Criteria:
- Preparing a grant proposal (individual or collaborative) according to the "Preludium" scheme – 75% (please, send it till May 20th)
- Grant revision (individual) – 25% (please, send it till June 14th)
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What about your project?
Deadlines:
March 31st – submission of names of team members and preliminarytitle of your project)
May 20th – submission of your project to my email address (everythingbut Polish 5-page description and CV of supervisor)
May 24th – receiving a few projects (and evaluation form) for revision
June 14th - submission of your evaluation forms to my email address(individual or team work)
June 16th – summary of the most frequent mistakes or best ideas in yourprojects and reviews.
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Thank you
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If you want to become a team member