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IMPORTANT SAFETY INFORMATIONWhat is the most important information I should know about TRIUMEQ?• Serious allergic reaction (hypersensitivity reaction). TRIUMEQ

contains abacavir. Patients taking TRIUMEQ may have a serious allergic reaction to abacavir that can cause death. Your risk is much higher if you have a gene variation called HLA-B*5701. Your healthcare provider can determine with a blood test if you have this gene variation. If you get symptoms from 2 or more of the following groups while taking TRIUMEQ, call your healthcare provider right away: 1. fever; 2. rash; 3. nausea, vomiting, diarrhea, or stomach pain; 4. generally ill feeling, extreme tiredness, or achiness; 5. shortness of breath, cough, or sore throat. Your pharmacist will give you a Warning Card with a list of these symptoms. Carry this Warning Card with you at all times.

If you stop taking TRIUMEQ because of an allergic reaction, never take TRIUMEQ or any other medicine that contains abacavir or dolutegravir again. If you take TRIUMEQ or any other abacavir-containing medicine again after you have had an allergic reaction, within hours you may get life-threatening symptoms that may include very low blood pressure or death. If you stop TRIUMEQ for any other reason, even for a few days, and you are not allergic to TRIUMEQ, talk with your healthcare provider before taking it again. Taking TRIUMEQ again can cause a serious allergic or life-threatening reaction, even if you never had an allergic reaction to it before. If your healthcare provider tells you that you can take TRIUMEQ again, start taking it when you are around medical help or people who can call a healthcare provider if you need one.

• A buildup of acid in your blood (lactic acidosis). Lactic acidosis can happen in some people who take TRIUMEQ. This serious medical emergency can cause death. Call your healthcare provider right away if you feel very weak or tired; have unusual muscle pain; have trouble breathing; have stomach pain with nausea and vomiting; feel cold, especially in your arms and legs; feel dizzy/light-headed; or have a fast/irregular heartbeat.

• Severe liver problems. Severe liver problems can happen in people who take TRIUMEQ. In some cases, these severe liver problems can lead to death. You may be more likely to get lactic acidosis or serious liver problems if you are female, very overweight, or have been taking nucleoside analogue medicines for a long time. Call your healthcare provider right away if you get any of the following signs or symptoms:

yellow skin, or the white part of the eyes turns yellow; dark urine; light-colored stools; nausea; itching; or stomach-area pain.

• Worsening of hepatitis B virus in people who have HIV-1 infection. If you have HIV-1 and hepatitis B virus infections, your hepatitis virus infection may get worse if you stop taking TRIUMEQ. Do not stop taking TRIUMEQ without fi rst talking to your healthcare provider, so he or she can monitor your health.

• Resistant hepatitis B virus. If you have HIV-1 and hepatitis B, the hepatitis B virus can change (mutate) during your treatment with TRIUMEQ and become harder to treat (resistant).

• Use with interferon and ribavirin-based regimens. If you’re taking TRIUMEQ and interferon, with or without ribavirin, tell your healthcare provider about any new symptoms. Liver disease might get worse in patients who are taking HIV-1 medicines and interferon.

Who should not take TRIUMEQ?• Do not take TRIUMEQ if you: have the HLA-B*5701 gene variation have ever had an allergic reaction to abacavir, dolutegravir, or

lamivudine take dofetilide (Tikosyn®) have certain liver problemsWhat are other possible side effects of TRIUMEQ?• People with a history of hepatitis B or C virus may have an increased

risk of developing new or worsening changes in certain liver tests during treatment with TRIUMEQ. Your healthcare provider may do tests to check your liver function before and during treatment with TRIUMEQ.

• When you start taking HIV-1 medicines, your immune system may get stronger and begin to fi ght infections that have been hidden in your body for a long time. Tell your healthcare provider right away if you start having new symptoms after starting your HIV-1 medicine.

• Changes in body fat can happen in people who take HIV-1 medicines.• Some HIV-1 medicines, including TRIUMEQ, may increase your risk

of heart attack.The most common side effects of TRIUMEQ include: trouble sleeping, headache, and tiredness. These are not all the possible side effects of TRIUMEQ. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

TRIUMEQ is a once-a-day pill used to treat HIV-1. TRIUMEQ should not be used by itself in some people. Take TRIUMEQ exactly as your healthcare provider tells you.Is it time for you? Ask your doctor.

APPROVED USESTRIUMEQ is a prescription medicine used to treat Human Immunodefi ciency Virus-1 (HIV-1) infection in adults. HIV-1 is the virus that causes AIDS. It is not known if TRIUMEQ is safe or effective in children under the age of 18. TRIUMEQ is not for use by itself in people who have or have had resistance to abacavir, dolutegravir, or lamivudine.

TRIUMEQ does not cure HIV-1 or AIDS. You must stay on continuous HIV-1 therapy to control HIV-1 infection and decrease HIV-related illness.

©2014 ViiV Healthcare group of companies. All rights reserved. Printed in USA. DTR045R0 November 2014

Not an actual patient. Testimonial is based on a collection of real patient experiences.

What should I tell my healthcare provider before taking TRIUMEQ?• Before you take TRIUMEQ, tell your healthcare provider if you: have been tested and know whether or not you have a gene variation called HLA-B*5701. have or had liver problems, including hepatitis B or C infection; have kidney problems;

have heart problems, smoke, or have diseases that increase your risk of heart disease such as high blood pressure, high cholesterol, or diabetes; drink alcoholic beverages; or have any other medical condition.

are pregnant or plan to become pregnant. It is not known if TRIUMEQ will harm your unborn baby.

are breastfeeding or plan to breastfeed. Do not breastfeed if you take TRIUMEQ.• You should not take TRIUMEQ if you also take: abacavir (EPZICOM, TRIZIVIR, or ZIAGEN) lamivudine (COMBIVIR®, EPIVIR, EPIVIR-HBV®, EPZICOM, or TRIZIVIR) emtricitabine (EMTRIVA®, ATRIPLA®, COMPLERA®, STRIBILD®, TRUVADA®) • Tell your healthcare provider about all the medicines you take, including prescription

and nonprescription medicines (for example, antacids; laxatives; vitamins such as iron or calcium supplements; anti-seizure medicines; other medicines to treat HIV-1, hepatitis, or tuberculosis; metformin; and methadone) and herbal supplements (for example, St. John’s wort). TRIUMEQ may affect the way they work, and they may affect how TRIUMEQ works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Please see brief summary of Prescribing Information for TRIUMEQ on the following pages.

Important Safety Information continued on next page.

Filename58522 58522_58522_M01_DTR045R0_CouchSpread_

Art Director

Artist

M. Culbreth

Kerry

User / PrevUs-Last Modified

CMYK

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GSK Triumeq

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GSK/ViiV Healthcare

Client Name: GSK/ViiV HealthcareProduct: TriumeqJob Number: 0000058522_M01_DTR045R0_FCADCaption: “I have the courage to start HIV…” (Man on Couch) Media: 4/C Bleed Magazine Spread + PBW +PBW + 1/2PBW

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AD: M. CulbrethAE: M. HalleProd: I. Waugh

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