DataMining In BioInformatics Bioinformatics Bioinf ormatic is a discipline of quant itative analysis of information relating to biological macromolecules with the aid of computers. The development of bioinformatics as a field is the result of advances in both molecular biology and computer science over the past 30–40 years. • Bioinformatics is the science of storing, extracting, organizing, analyzing, interpreting and utilizing information from biological sequences and molec ule s. Bio informat ics can be als o defin ed as th e appli cati on of computer technology to the management of biological information The rapid developments in genomics and proteomics have generated a large amount of biological dat a. Which is pres ent in the different Biological databases. Anal yzing large bi ol ogical data sets req uir es makin g sense of the data by inferr ing struc ture or genera lizations from the data. Drawing conclusio ns from these data requires sophisticated computational analyses.Bioinformatics consists of two subfields: the development of computational tools and databases and the application of these tools and databases in generating biological knowledge to better understand living sys tems. These two subfields are complementary to each other. Database A database is a computerized archive used to store and organize data in such a way that information can be retrieved easily via a variety of search criteria. Databa ses are co mpos ed of co mputer hardware and so ft ware fo r data management. The chief objec ti ve of the dev elo pment of a database is to or ganize data in a set of st ructured records to enable easy retrieval of infor matio n. Type of Biolog ical databa ses: Biologi cal databa ses can be divided into many categories on type of therie organization , type of molecules they contain. We primarily divides atabases on the bases of biological molecules they contain molecules. 1. Nuc leot ide Acid Databas es: Conta inin g the nucl eic acids bot h DNA and RNA eg. Genbank, EBI nucleotide, DDBJ. 2. Protein Databases: These contains in forma tion on protein molecules. Like sequences, Functional annotation ,post-transcriptional modifications etc. Protein(NCBI),Swiss-prot, Pfam,PRINT,CATH etc. 3. Structural Databases: These cont ain s informat ion about the structural features of biomolecules. Including there their 3-D structure. The main archieve in t his is PDB containing the experimently determined strctures.
