www.alzet.com alzet osmotic pumps alzet speakers kit
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www.alzet.comALZET Osmotic Pumps
ALZET Speakers KitALZET Speakers Kit
www.alzet.comALZET Osmotic Pumps
ALZET Osmotic Pump AdvantagesALZET Osmotic Pump Advantages
Ensure around-the-clock exposure to test agents at predictable levels
Permit continuous administration of short half-life proteins and peptides
Convenient method for chronic dosing of laboratory animals
Minimize unwanted experimental variables and ensure reproducible, consistent results
Eliminate the need for nighttime or weekend dosing
Reduce handling and stress to laboratory animals
Small enough for use in mice or very young rats
Allow for targeted delivery of agents to virtually any tissue
Cost-effective research tool
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Injection vs. InfusionInjection vs. Infusion
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Principle of OperationPrinciple of Operation
ALZET pumps have 3 concentric layers: Rate-controlling, semi-permeable membrane Osmotic layer Impermeable drug reservoir
ALZET pumps work by osmotic displacement. Water enters the pump across the outer, semi-permeable membrane due to the presence of a high concentration of sodium chloride in the osmotic chamber. The entry of water causes the osmotic chamber to expand, thereby compressing the flexible reservoir and delivering the drug solution through the delivery portal.
www.alzet.comALZET Osmotic Pumps
www.alzet.comALZET Osmotic Pumps
ALZETALZET®® osmotic pumps are available osmotic pumps are available in three sizesin three sizes
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Together with ALZET pumps, the Brain Infusion Kits permit the continuous delivery of test compounds to the CNS for extended periods of time without external connections, restraints, or frequent handling of laboratory animals.
ALZET Brain Infusion KitsALZET Brain Infusion Kits
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Specifications of ALZET Brain KitsSpecifications of ALZET Brain KitsBrain Kits 1 & 2 Brain Kit 3
Brain Infusion Cannula
Material (tube) Stainless steel
Dimensions (steel tube) 28 gauge 30 gauge
Material (elbow stop, flange) ID = 0.18 mm; OD = 0.36 mm ID = 0.16 mm; OD = 0.31 mm
Material (elbow stop, flange) Polycarbonate
Volume inside tube 0.32 µl 0.23µl
Height Adjustment Spacers
Material Polycarbonate
Dimensions (height) 0.5 mm
Catheter Tubing
Material Polyvinylchloride (Medical grade)
Length 15 cm (approx.)
Inside diameter 0.69 mm (± 0.08)
Outside diameter 1.14 mm (± 0.08)
Volume per 15 cm 56 µl (3.7 µl/cm)
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ALZET Brain Infusion Kits are designed for targeted delivery to the cerebral ventricles or direct microperfusion of discrete brain structures. Available kits
have slightly different cannula designs.
ALZET Brain Infusion KitsALZET Brain Infusion Kits
www.alzet.comALZET Osmotic Pumps
In vitro vs. in vivo pumping rateIn vitro vs. in vivo pumping rate
The typical pumping rate of the Model 2ML4 ALZET Osmotic Pump over time in Sprague Dawley rats after subcutaneous implantation (n=105)
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Typical pumping rate of the Model 2002 ALZET Typical pumping rate of the Model 2002 ALZET Osmotic Pump over time (n-20)Osmotic Pump over time (n-20)
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ALZET Contact InformationALZET Contact Information
ALZET Customer Service(Pricing and Ordering)
Toll free: 1-877-922-5938 Phone: 1-408-253-8574 Fax: 1-408-865-1406
ALZET Technical Support Toll free: 1-800-692-2990 Phone: 1-408-367-4036 Fax: 1-408-865-1406
Mailing AddressDURECT Corporation
P.O. Box 530
Cupertino, CA. 95015-0530
Web Addresswww.alzet.com