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xxviii ContentsVOLUME 1

Introduction1. Introduction 3

Sandhya A Kamath

SECTION 1 Epidemiology1. Principles of Epidemiology of Communicable Diseases 7

Jugal Kishore, Tanu Anand

2. Principles of Epidemiology of Non-Communicable Diseases 11Jugal Kishore, Tanu Anand

SECTION 2 Clinical Approach1. Approach to a Febrile Patient 19

DB Kadam

2. Pain - A General Approach 24Mangesh Tiwaskar

3. Chest Pain 27Ajaykumar U Mahajan

4. Dyspnoea 32Udai Lal

5. Cough and Hemoptysis 36Haridas B Prasad

6. Palpitations 39Milind Phadke

7. Abdominal Pain 43Pravin Rathi

8. Lymphadenopathy 48Vrinda Kulkarni

9. Oedema and Anasarca 50Sekhar Chakraborty

10. Ascites 53Neelam Narendra Redkar

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xxix11. Jaundice 57 Aniruddha Y Phadke

12. Constipation and Diarrhoea 61 Prabha Sawant

13. Weight Loss and Cachexia 65 A Muruganathan, Gowri Sankar Murugan

14. Altered Sensorium 69 Mrinal Kanti Roy, Sujoy Sarkar

15. Syncope 73 Amar R Pazare

16. Dizziness and Vertigo 75 Sanjiv Maheshwari

17. Approach to Ataxia 78 CS Narayanan

18. Motor Weakness 81 Uma Sundar

19. Sensory Loss 84 Rajinder K Bansal

20. Fever with Rash 86 Yojana Gokhale

SECTION 3 Infectious Dieseases

A. GENERAL CONSIDERATIONS

1. Basic Considerations of Infections 95 MVS Subbalaxmi

2. Laboratory Diagnosis of Infections 96 Camilla Rodrigues, Anand Shah

3. Syndromic Approach to Infectious Diseases 102 Mahendra Dadke

4. Antimicrobial Therapy: PKPD of Antimicrobials 108 Rajeev Soman

5. Inhibitors of Cell Wall Synthesis 109 Vasudeva Acharya

6. Protein Synthesis Inhibitors and Folate Metabolism Inhibitors 111 Raman Gaikwad

7. Miscellaneous & Newer Antibiotics 113 Ashwini Tayade

8. Antibiotic Resistance & Antimicrobial Stewardship 118 Abdul Ghafur

9. Infections in the Immunocompromised Host 119 Priscilla Rupali

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xxx 10. Hospital-Acquired Infections/Nosocomial Infections 123 A Murali

11. Hospital Infection Control 125 Rohini Kelkar

B. BACTERIAL INFECTIONS : GRAM-POSITIVE INFECTIONS

12. Staphylococcal Infections 127 Ram Gopalakrishnan

13. Streptococcal Infections 129 Surabhi Madan

14. Pneumococcal Infections 130 Preeti M Pillai

15. Enterococcal Infections 134 Sujata Baveja

16. Diphtheria 136 Sandeep B Bavdekar

17. Listeria 139 BR Bansode

18. Clostridial Infections 140 Vidya Devarajan

C. BACTERIAL INFECTIONS : GRAM-NEGATIVE INFECTION

19. Meningococcal Infections 146 Neha Gupta

20. Gonococcal Infections 151 Uday S Khopkar, Prachi V Gole

21. Typhoid Enteric Fever 154 George K Varghese

22. Bacillary Dysentery 156 Tanu Singhal

23. Cholera 159 Jaya Chakravarty

24. Enterobacteriaceae 162 Nitin Shinde

25. Haemophilus Influenzae Infections 164 M Sabir

26. Legionnaire’s Disease 167 Shruti Tandan-Pardasani

27. Plague and Other Yersinia Ifections 168 Vipul Shah

28. Enterobacteriaceae Infections 171 Mahesh Kumar Lakhe

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xxxi29. Melioidosis (Burkholderia) 173 Ayesha J Sunavala

30. Pseudomonas 177 Anup Warrier

31. Acinetobacter 179 Vasant Nagvekar

32. Pertusis (Whooping Cough) 181 Sanjeevani Satish Masavkar

D. BACTERIAL INFECTIONS : MISCELLANEOUS BACTERIAL INFECTION

33. Syphilis 182 HR Jerajani

34. Non-Syphilitic Treponematoses 186 Taru Garg

35. Leptospirosis 187 Bharat Dattatraya Purandare

36. Other Spirochaetal Infections: Lyme Disease & Rat Bite Fever 190 K Tewary

37. Brucellosis 193 Syed Manzoor Kadri

38. Donovanosis 196 Vidya Kharkar

39. Actinomycosis 198 Smrati Bajpai Tiwari

40. Bartonella Infections 200 Pallavi Bhargava

41. Nocardiosis 201 Kirti C Sabnis

E. BACTERIAL INFECTIONS : MYCOBACTERIAL INFECTIONS

42. Laboratory Diagnosis of Tuberculosis 204 Gita Nataraj

43. Treatment of Drug-Susceptible Tuberculosis (TB) 207 Sujeet Rajan

44. Treatment of Drug Resistant Tuberculosis 210 Prahlad P Prabhudesai, Abha Pandey

45. Non-tuberculos Mycobacteria & their Infections 213 Aruna Poojary

46. Leprosy 217 Usha Naraindas Khemani

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xxxii F. BACTERIAL INFECTIONS : RICKETTSIAL, CHLAMYDIAL AND MYCOPLASMA INFECTIONS

47. Rickettsial Infections 229 Rajeev Raina

48. Chlamydial Infections 232 Prasanta Kumar Bhattacharya

49. Mycoplasma Infections 235 Arvind Ghongane

G. PROTOZOAL DISEASES

50. Malaria 238 Kavitha Saravu

51. Amoebiasis and Giardiasis 245 Jyotirmoy Pal, Subhadeep Gupta

52. Leishmaniasis 251 Shyam Sundar

53. Toxoplasmosis 255 Madhukar Rai

54. Trypanosomiasis 258 Prashant P Joshi

55. Cryptosporidiosis, Trichomoniasis, Balantidiasis and Cystoisospora 261 Atul Bhasin

H. HELMINTHIC DISEASES

56. Ankylostomiasis, Ascariasis and Other Nematodal Infections 263 Narender Pal Jain, Rishu Bhanot

57. Tapeworm and Hydatid Diseases 274 Jyoti Jain

58. Filariasis and Other Related Infections 279 TK Suma

59. Schistosomiasis / Bilharziasis 284 Anita Nambiar

I. FUNGAL INFECTIONS

60. Systemic Fungal Infections 286 Atul Prabhakar Kulkarni, Suhail Sarwar Siddiqui

61. Pneumocystis Jirovecii Pneumonia 292 V Ramasubramanian

J. VIRAL INFECTIONS

62. Basic Considerations of Viral Diseases 295 Dilip Mathai

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xxxiii63. Herpes Virus Infections 301 Aditya Prakash Misra

64. Human Papilloma Virus and Parvovirus Infection 305 Kavita Joshi

65. Influenza (Incl SARS, MERS, Avian Flu and Metapneumovirus) 307 Swati Rajagopal

66. Dengue 312 GD Ravindran

67. Japanese Encephalitis 320 Pettarusp Murzban Wadia

68. Ebola and Marburg Infections 323 Bhupen Barman, Kaustubh Bora

69. Rabies 325 Tarun Kumar Dutta

70. Viral Gastroenteritis 330 Preeti Shanbag

71. Measles (Rubeola), Mumps, Rubella and Other Viral Exanthemas 331 Anupama Mauskar

72. Zika Virus Infection 335 Harsh Toshniwal

73. Hantavirus Infections 338 Sara Chandy, Dilip Mathai

74. Chikungunya 340 Vikram Londhey

75. Viral Infections in Transplant Recipients 342 Subramanian Swaminathan, Sujata Rege

76. Nipah Virus Infection 344 Chandni Radhakrishnan

SECTION 4 HIV Medicine1. Epidemiology of HIV / AIDS 349 Naval Chandra, Alaka Deshpande

2. HIV Virology, Immunology and Laboratory Diagnosis 353 Sunil K Arora, Gurleen Mehta

3. Pathophysiology of HIV/AIDs 357 Ameet Dravid

4. Antiretroviral Therapy 364 BB Rewari

5. HIV Drug Resistance 371 Alaka Deshpande

6. Non-opportunistic Infection Complications in HIV 374 Anil Kumar Tripathi, D Himanshu

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xxxiv 7. Opportunistic Infections 377 Sanjay Pujari

8. Non-pharmacologic Interventions & Prevention in HIV (including vaccine development) 382 R Sajithkumar

9. HIV Vaccine 385 Ramesh S Paranjape

10. ART and Drug Interactions 386 Atul K Patel, Ketan K Patel

SECTION 5 Medical Genetics1. Molecular Genetics, Human Genome Project and Genomic Medicine 393 KM Girisha

2. Mendel and Beyond 400 Ratna Dua Puri

3. Mutations and Molecular Pathology 406 Prajnya Ranganath

4. Conventional and Molecular Cytogenetics 412 Ashutosh Halder

5. Molecular Diagnostics 421 Ashwin Dalal

6. Cancer Genetics 426 Rajiv Sarin

7. Treatment of Genetic Disorders 431 Shagun Aggarwal

8. Genetic Counselling and Prenatal Diagnosis 436 Shubha R Phadke

9. Next Generation Sequencing: Future Medicine 443 Madhulika Kabra, Neerja Gupta

SECTION 6 Immunology1. An Overview of the Immune System 451 Amita Aggarwal, Sita Naik

2. Immunology of Infectious Diseases 458 Sita Naik

3. Autoimmune Diseases: Immune Mechanisms and Diagnosis 460 Ramnath Misra, Amita Aggarwal

4. Primary Immunodeficiency Disorders: Approach and Diagnosis 464 Surjit Singh, Amit Rawat

5. Pharmacological Manipulation of the Immune System 469 Mitali Chatterjee, Alakendu Ghosh

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xxxv6. Immunology of Organ and Hematopoietic Stem Cell Transplantation 477 Narinder K Mehra, Neeraj Kumar

SECTION 7 Rheumatology1. Basic Considerations of Rheumatology 485 Rohini Handa

2. Soft Tissue Rheumatism and Regional Rheumatic Pain Syndromes 489 Ved Chaturvedi

3. Low Back Pain 494 Ghan Shyam Pangtey, Hemant Gopal

4. Osteoarthritis 501 Siddharth Kumar Das

5. Gout and Other Crystal Arthritides 505 URK Rao

6. Rheumatoid Arthritis 512 AN Malaviya

7. Spondarthritides 533 Milind Y Nadkar

8. Sjogren’s Syndrome 540 Uma Kumar, Sauvik Dasgupta

9. Systemic Lupus Erythematosus 543 Rohini Satish Samant

10. Antiphospholipid Syndrome 549 Vikas Agarwal, Anupam Wakhlu

11. Inflammatory Muscle Disease 552 Alakendu Ghosh

12. Systemic Sclerosis 557 Shefali Khanna Sharma

13. The Vasculitides 560 Pradeep Bambery

14. Mixed Connective Tissue Disease (MCTD) & Overlap Syndromes 569 G Narsimulu, Rajendra Vara Prasad

15. Rheumatic Manifestations of Systemic Diseases 573 D Debashish Danda

16. Miscellaneous Rheumatic Disorders 580 Binoy J Paul

17. Emergencies in Rheumatology 585 Madhumita P Das

18. Tropical Rheumatic Diseases 589 Aman Sharma

19. Biologics & Biosimilars in Rheumatology 592 VS Negi, KG Chengappa

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xxxvi 20. Pregnancy and Rheumatic Diseases 597 Sushant Shinde

SECTION 8 Nutrition1. Nutrition: Basic Considerations 601 SV Madhu

2. Assessment of Nutritional Status 604 Prema Ramachandran

3. Severe Acute Malnutrition 607 Alka R Jadhav

4. Water Soluble Vitamins 616 Charulata Vikram Londhe

5. Fat Soluble Vitamins 618 Archana Sonawale

6. Minerals, Trace Elements and Antioxidants 623 Shibendu Ghosh

7. Food Allergy and Food Intolerance 626 Uliyar V Mani

SECTION 9 Metabolism1. Basic Consideration of Metabolism 631 SK Singh, Saurabh Singh

2. Inborn Errors of Carbohydrate Metabolism 632 Rajesh Khadgawat, Aashima Gupta

3. Disorders of Protein Metabolism 637 Sidhartha Das, Saroj Kumar Tripathy

4. Disorders of Lipid and Lipoprotein Metabolism 641 SK Wangnoo

5. Disorders of Adipose Tissue and Obesity 648 Soumitra Ghosh

6. Disorders of Aminoacid Transport and Metabolism 651 Archana Kher

7. Unspecified Disorders of Metabolism 654 Deep Dutta

8. Disorders of Iron Metabolism and Iron Overload Syndromes 655 Sudhir Mehta, Laxmi Kant Goyal

9. The Porphyrias 664 Dhanpat Kumar Kochar, Abhishek Kochar

10. Amyloidosis 669 Manisha Sahay

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xxxvii11. Wilson’s Disease 674 S Sinha, AB Taly

SECTION 10 Bone Disorders1. Vitamin D in Health and Disease 683 CV Harinarayan

2. Bone and Mineral Metabolism in Health and Disease 687 Subhankar Chowdhury, Soumik Goswami

3. Investigations and Diagnosis of Bone Disorders 693 Sameer Aggarwal, Ravinder Goswami

4. Radiological Manifestations of Common Metabolic Bone Disorders 698 Arun Kumar Gupta, Devasenathipathy Kandasamy

5. Rickets and Osteomalacia 706 Anuradha Vaman Khadilkar, Neha Kajale

6. Osteoporosis 708 Meeta Singh, Harinder Singh

7. Developmental Disorders of the Bone 713 Jubbin Jacob

8. Fluorosis 717 D Raja Reddy

9. Miscellaneous Bone Disorders 723 Thomas V Paul, Nitin Kapoor

SECTION 11 Endocrinology1. Basic Considerations of Endocrinology 731 Sanjay Kalra

2. Endocrine Disorders: A Clinical Approach 733 Shashank R Joshi

3. Disorders of Hypothalamus and Pineal Gland 736 Bashir Ahmad Laway, Abdul Hamid Zargar

4. Disorders of Anterior Pituitary 739 KVS Hari Kumar

5. Disorders of Posterior Pituitary 749 Gumpeny Ramachandra Sridhar

6. Disorders of Thyroid Glands 751 Nikhil Tandon, Nishant Raizada

7. Disorders of Parathyroid Glands 762 Ambrish Mithal, Beena Bansal

8. Disorders of Adrenal Glands 765 Eesh Bhatia, Vijayalakshmi Bhatia

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xxxviii 9. Disorders of Puberty 774 Manoj Chadha, Gayatri Ghanekar

10. Disorders of Growth and Development 778 Nalini S Shah

11. Polyglandular Endocrine Syndromes 785 Ameya Joshi

12. Disorders of Male Gonads 790 Nishant Raizada

13. Endocrine Disorders of Female Gonads 795 Premlata K Varthakavi

SECTION 12 Diabetology1. Basic Consideration in Diabetes Mellitus 811 AG Unnikrishnan, Suganthi Kumaran

2. Pathophysiology of Diabetes Mellitus and its Various Sub Types 814 Viswanathan Mohan

3. Lifestyle Management in Diabetes 820 Yash Pal Munjal, Anupam Prakash

4. Oral Anti-diabetes Drugs 824 Anil Bhansali, Ashu Rastogi

5. Insulins 828 Siddharth N Shah

6. In Hospital Management of Diabetes Mellitus 834 K Felix Jebasingh, Nihal Thomas

7. Acute Complications of Diabetes Mellitus (Hypoglycaemia, DKA, HHS, Lactic Acidosis) 837 Samar Banerjee

8. Diabetic Kidney Disease 847 Rakesh Kumar Sahay

9. Diabetes and the Eye 852 Anjali Nicholson, Maneck Nicholson

10. Diabetic Neuropathy 859 Benny Negalur

11. Diabetic Foot in the India Scenario 863 Vijay Viswanathan, Anitha Rani A

12. Sexual Dysfunction in Diabetes 865 Sarita Bajaj

13. Diabetes and Pregnancy 868 V Seshiah, V Balaji

14. Macrovascular Complications in Diabetes 870 Rajesh Rajput, Vaibhav Pathak

15. Use of Technology in Diabetes Mellitus 873 KM Prasanna Kumar

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xxxix16. Prevention of Diabetes Mellitus 877 Ambady Ramachandran, Chamukuttan Snehalatha

SECTION 13 Haematology1. Haematopoiesis 885 RV Shaji, Renu Saxena

2. Approach to Anemia and Polycythemia 892 M Mahapatra, DK Mishra

3. Approach to Bleeding and Thrombosis 899 Shashikant Apte, Sukesh Nair

4. Approach to Disorders of Granulocytes and Monocytes 905 Pravas Mishra, Neelam Varma

5. Nutritional Anaemia 909 Subhash Varma

6. Hereditary Haemolytic Anemia 915 VP Choudhry

7. Acquired Haemolytic Anemia 929 Farah Jijina

8. Aplastic Anaemia 934 Biju George

9. Myelodysplastic Syndromes 938 Tulika Seth

10. Acute Myeloid Leukaemia 942 Vikram Mathews

11. Chronic Myeloid Leukemia & Other Myeloproliferative Neoplasma 947 M Joseph John

12. Acute Lymphoblastic Leukaemia 953 Navin Khattry

13. Chronic Lymphocytic Leukemia 955 Dinesh Bhurani

14. Lymphoma and Other Lymphoid Neoplasms 960 Reena Nair, Neeraj Arora

15. Plasma Cell Disorders 968 Pankaj Malhotra

16. Platelet Disorders 973 Prantar Chakrabarti

17. Coagulation Disorders 977 Alok Srivastava

18. Transfusion Medicine 983 Neelam Marwaha, Dolly Daniel

19. Hematopoietic Stem Cell Transplantation 987 Mammen Chandy

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xl SECTION 14 Oncology1. Development in Cancer 997 Tapan K Saikia

2. Principles of Cancer Biology and Pathology 999 Anita M Borges

3. Cancer Screening and Prevention 1004 Atul Sharma, Raja Pramanik

4. Principles of Drug Treatment of Cancer 1009 Lalit Kumar, Prabhat Singh Malik

5. Principle of Radiotherapy 1017 GK Rath

6. Head and Neck Cancer 1023 VP Gangadharan

7. Breast Cancer 1025 Vinay H Deshmane

8. Gastroesophageal Cancer 1032 Mohandas K Mallath

9. Hepato – Biliary Cancers 1037 Varun Goel, DC Doval

10. Colorectal Cancer 1039 K Govind Babu

11. Benign and Malignant Tumors of the Tracheobronchial Tree 1042 Anant Mohan, Avneet Garg

12. Genitourinary Cancers 1051 Sudeep Gupta, Amit Joshi

13. Gynaecological Cancers 1055 PP Bapsy, Sonal Dhande

14. Bone and Soft Tissue Sarcomas 1062 Manish Agarwal

15. Cancer of Unknown Primary Site 1070 Hemant Malhotra

16. Paraneoplastic Syndromes 1078 Senthil Rajappa

17. Cancers of the Predisposed Host (Cancer Proneness) 1083 Raghunadharao Digumarti, Praveen Adusumilli

18. Carcinoid Syndrome 1086 K Pavithran

19. Supportive Care in Cancer 1088 Madhuchanda Kar, Rakesh Roy

20. Oncological Emergencies 1094 Prasanth Ganesan

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xliSECTION 15 Nephrology1. Structure and Function of the Kidney 1101 Sandeep Mahajan, Yasir Rizvi

2. Kidney Disease – A Clinical Approach 1108 Vijay Kher

3. Acute Kidney Injury 1113 Vivekanand Jha

4. Chronic Kidney Disease 1122 Ashok L Kirpalani, Hardik K Shah

5. Primary Glomerular Diseases 1130 Vinay Sakhuja, Raja Ramachandran

6. Secondary Glomerular Diseases 1138 OP Kalra, Deepak Jain

7. Infections of the Kidney and Urinary Tract 1146 Valentine Lobo

8. Vascular Injury to Kidney 1154 AS Narula, AK Hooda

9. Tubulo-interstitial Diseases of the Kidney 1158 Sree B Raju

10. Cardio-renal Syndrome 1162 Viswanath Billa, Deepa Usulumarty

11. Inherited Kidney Diseases (Including Polycystic Kidney Disease) 1165 Alan F Almeida

12. Nephrolithiasis and Urinary Tract Obstruction 1172 Jacob George

13. Integrating Kidney Health in Primary Care 1175 Rohina Joshi

14. Dose Adjustment in Patients with Renal Impairment and Drug Nephrotoxicity 1177 Shrirang Bichu, Parag Tilve

15. Pre Dialysis Care, Nutrition, Palliative Care, Vaccination in Patients with Chronic Kidney Disease 1181 Ankur Gupta

16. Dialysis and Other Extracorporeal Therapies 1185 NK Hase

17. Kidney Transplantation 1196 N Gopalakrishnan

SECTION 16 Environmental Medicine1. Basic Considerations of Environmental and Occupational Diseases 1205 Velu Nair

2. Climate Change: Health and Disease 1210 UK Sharma

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xlii 3. Air Pollution and Smoke Related Disorders 1214 BNBM Prasad

4. Drowning 1224 Vivek Kumar

5. High Altitude Medicine 1227 Yanamandra Uday

6. Aerospace Medicine 1236 Deepak Gaur

7. Heat Related Illness 1240 Vattaparambil Sabid Syed

8. Electric Shock and Lightning Injury 1247 V Bhatti

9. Radiation Hazard 1253 DN Karan

10. Medical Aspects of Disaster Management 1258 Velu Nair, CS Makhani

11. Hospital Environment 1266 Shankar Subramanian

VOLUME 2

SECTION 17 Pulmonology1. Respiratory System: Basic Anatomy and Physiology 1273 SK Chhabra

2. Pulmonary Disorders - A Clinical Approach 1282 Jyotsna M Joshi

3. Diagnostic Procedures in Pulmonary Disorders 1286 Karan Madan

4. Upper Respiratory Tract Infections 1288 Nimish M Shah

5. Bronchial Asthma 1290 Virendra Singh, Nishtha Singh

6. Chronic Obstructive Pulmonary Disease 1298 Parvaiz A Koul, Irfan Hussain

7. Pneumonia 1308 KT Prasad, Digambar Behera

8. Suppurative Pleuro-pulmonary Diseases 1314 Srinivas Rajagopala

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xliii9. Pulmonary Tuberculosis 1325 Agam Vora

10. Fungal Infections of the Lungs 1329 Ashok Shah

11. Diffuse Interstitial Lung Disease 1336 SK Jindal

12. Eosinophilic Lung Diseases and Tropical Pulmonary Eosinophilia 1342 VK Vijayan

13. Sarcoidosis 1347 Randeep Guleria, Pawan Tiwari

14. Sleep Disordered Breathing – An Overview 1357 JC Suri

15. Disease of Pleura, Mediastinum, Diaphragm and Chest Wall 1363 Vijay Hadda

16. Cor Pulmonale 1371 Sandeep Singh, Siddharthan Deepti

17. Pulmonary Rehabilitation 1376 Deepak Talwar, Mir Shad Ali

18. Lung Transplantation 1381 Ashutosh N Aggarwal

SECTION 18 Cardiology

A. INTRODUCTION

1. Basic Considerations in Cardiology 1389 Upendra Kaul, Parneesh Arora

2. Cardiovascular Diseases: A Clinical Approach 1396 Gurpreet S Wander, Suraj Kumar

B. DIAGNOSIS OF CARDIOVASCULAR DISORDERS

3. Electrocardiology 1405 Yash Y Lokhandwala, Gopi Krishna Panicker

4. Exercise Testing 1420 Prafulla G Kerkar, Aniruddha Pawar

5. Echocardiography 1428 Satish Kumar Parashar

6. Cardiac Imaging: Computed Tomography and Magnetic Resonance Imaging 1440 Angelica Romero, Aalap Chokshi, Jagat Narula, Amir Ahmadi

7. Nuclear Cardiology 1453 Vikram R Lele

8. Cardiac Catheterisation and Angiocardiography 1457 Samuel Mathew, Abhishek Goyal

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xliv C. HEART FAILURE

9. Heart Failure (Clinical Presentation and Pathophysiology) 1464 Saumitra Ray

10. Management of Heart Failure 1467 Santanu Guha, Avik Karak

11. Cardiac Transplantation 1482 Jamshed J Dalal, Nandkishore Kapadia

D. VALVULAR HEART DISEASE AND INFECTIVE ENDOCARDITIS

12. Acute Rheumatic Fever 1489 Manojkumar Rohit, Drarshan Krishnappa

13. Valvular Heart Disease 1494 Neeraj Parakh, VK Bahl

14. Infective Endocarditis 1505 Shyam S Kothari, Ravi S Math

E. CORONARY ARTERY DISEASE

15. Atherosclerosis 1518 V Dayasagar Rao, D Sarath Babu

16. Ischemic Heart Disease (IHD): Pathophysiology and Diagnosis 1526 Satyavan Sharma, Nikhil Raut

17. Acute Coronary Syndrome-NSTEMI 1531 Ashok Seth, Vivudh P Singh

18. Acute ST Elevation Myocardial Infarction (STEMI) 1536 Ajit S Mullasari, Srinivasan Narayanan

19. Chronic Stable Angina 1548 VK Bahl, Neeraj Parakh

20. Coronary Arteriorgraphy and Percutaneous Coronary Intervention 1552 Nihar Mehta

F. HYPERTENSION

21. Hypertension and its Management 1557 Sandhya A Kamath

G. ARRHYTHMIAS AND SUDDEN CARDIAC DEATH

22. Bradyarrhythmias 1568 Naved Aslam

23. Tachyarrhythmias 1575 Amit Vora

24. Sudden Cardiac Arrest 1584 Ashish K Thakur

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xlvH. MISCELLANEOUS

25. Congenital Heart Disease 1592 Sivasubramanian Ramakrishnan, Sunita Maheshwari

26. Heart in Systemic Diseases 1599 Meenakshi Chenniappan

27. Diseases of Myocardium 1605 Ajay Bahl

28. Diseases of the Pericardium 1618 Sanjay Tyagi, Ankit Bansal

29. Diseases of the Aorta 1629 Manotosh Panja, Soumitra Kumar

30. Vascular Disorders of the Extremities 1638 NN Khanna, Suparna Rao

31. Pregnancy and Heart Disease 1649 Amal Kumar Banerjee

32. Venous Thrombo Embolism (VTE) - Deep Vein Thrombosis and Pulmonary Embolism 1655 BC Srinivas, JR Vijaykumar, RK Pinjala

33. Pulmonary Hypertension 1668 Sandeep Bansal, Preeti Gupta

34. Cardiac Tumours 1672 PP Mohanan, Benjo Vazhappilly, Julian Jhony Thottan

35. Prevention of Cardiovascular Disease 1675 HK Chopra, AK Pancholia

36. Mega-trials in Cardiology 1683 Sundeep Mishra

SECTION 19 Gastroenterology1. Basic Considerations in Gastrointestinal Diseases 1689 V Pratap Mouli, Vineet Ahuja

2. Clinical Approach to a Patient with Gastrointestinal Diseases 1693 AC Anand

3. Investigation of Gastrointestinal Disorders 1697 Ashok Chacko

4. Gastrointestinal Endoscopy and Imaging 1700 Mathew Philip

5. Oesophageal Disorders 1705 Shobna Bhatia, Abhishek Sadalage

6. Diseases of the Stomach and Duodenum 1713 Deepak N Amarapurkar

7. Functional Gastrointestinal Disorders 1721 Uday C Ghoshal

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xlvi 8. Inflammatory Bowel Disease 1728 Ajit Sood, Vandana Midha

9. Abdominal Tuberculosis 1732 Govind K Makharia

10. Malabsorption 1741 BS Ramakrishna

11. Ischaemic Bowel Disease 1746 Puneet Dhar

12. Gastrointestinal Bleeding 1750 Rajesh Upadhyay

13. Gastrointestinal Manifestations of Systemic Diseases 1755 Gourdas Choudhuri, Varun Gupta

14. Acute Pancreatitis 1760 Pramod Kumar Garg

15. Chronic Pancreatitis & Pancreatic Tumours 1770 Akash Shukla, Alisha Chaubal

SECTION 20 Hepatology1. Basic Considerations in Hepatobiliary Disorders 1779 Vivek Anand Saraswat

2. Hepatobiliary Disorders: Clinical Approach and Investigations 1783 Nagaraja Rao Padaki

3. Hepatobiliary Disorders: Imaging 1791 Shrinivas B Desai

4. Acute Viral Hepatitis 1800 Rakesh Aggarwal

5. Chronic Viral Hepatitis 1806 Radha K Dhiman, Madhumita Premkumar

6. Chronic Non-viral Hepatitis and Cholestatic Diseases 1814 CE Eapen

7. Alcoholic Liver Disease 1816 Ashish Kumar

8. Cirrhosis of the Liver 1824 Philip Abraham

9. Non-cirrhotic Causes of Portal Hypertension 1829 Yogesh K Chawla, Arka De

10. Nonalcoholic Fatty Liver Disease 1833 Ajay Duseja

11. Acute Liver Failure 1837 SK Acharya, Shalimar

12. Parasitic Infections of the Liver 1842 MP Sharma, Vaibhav Gupta

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xlvii13. Toxic and Drug-induced Liver Injury 1845 Harshad Devarbhavi

14. Liver Transplantation 1846 Manav Wadhawan

15. Pregnancy and Liver Disease 1849 Ashish Goel

16. Diseases of the Gall Bladder and Biliary Tract 1853 Usha Dutta, Bipadabhanjan Mallick

17. The Liver in Systemic Diseases 1862 Amit Goel

18. Inherited Metabolic Disorders of the Liver 1865 Aabha Nagral

SECTION 21 Neurology1. Neurological Disorders: Basic Considerations and Clinical Approach 1875 MV Padma Srivastava, VY Vishnu, RS Wadia

2. Clinical Neurophysiology 1885 J Kalita, UK Misra

3. Neuroimaging 1892 Rakesh K Gupta

4. Epilepsy 1897 Sanjeev V Thomas, Deepak Menon

5. Disorders of Speech 1910 Apoorva Pauranik

6. Disorders of Cranial Nerves 1922 SP Gorthi, Aparajita Chatterjee

7. Ischemic Cerebrovascular Diseases 1938 Subhash Kaul

8. Hemorrhagic Cerebrovascular Diseases 1949 Jeyaraj Durai Pandian, Aishwarya Aggarwal

9. Cerebral Venous Sinus Thrombosis 1956 D Nagaraja, N Karthik

10. Bacterial Meningitis and Brain Abscess 1961 Ravindra Kumar Garg, Imran Rizvi

11. Neurotuberculosis 1966 Roop Gursahani

12. Neuro-ophthalmology 1973 Vivek Lal, Aastha Takkar

13. Viral Encephalitis 1980 Thomas Iype

14. Slow Virus Infections and Prion Disease 1983 SK Shankar

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xlviii 15. Fungal & Parasitic Diseases of Nervous System 1987 Manish Modi, Manoj Kumar Goyal

16. Raised Intracranial Pressure and Hydrocephalus 1997 Daljit Singh, Vikas Kumar

17. Dementia 2000 PS Mathuranath

18. Hypokinetic Movement Disorders 2006 Kalyan B Bhattacharyya, Subhadeep Gupta

19. Hyperkinetic Movement Disorders 2013 Sanjay Pandey

20. Cerebellar Disorders 2016 M Netravathi, PK Pal

21. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases 2040 BK Bajaj

22. Demyelinating Disorders of the Central Nervous System 2047 Lekha Pandit

23. Nutritional and Toxic Disorder of the Nervous System 2054 Usha Kant Misra, Jayantee Kalita

24. Metabolic Disorders of Nervous System 2059 Vrajesh Udani, Neelu Desai

25. Intracranial Space-Occupying Lesions 2072 P Sarat Chandra, PN Tandon

26. Head Injury 2080 Satish B Dharap

27. Peripheral Neuropathy 2087 AK Meena, Sireesha Yareeda

28. Disorders of the Autonomic Nervous System 2101 Ajith Sivadasan

29. Myasthenia Gravis 2105 Sumit Singh

30. Diseases of Muscles 2108 SV Khadilkar

31. Non-compressive Myelopathies 2118 Jimmy A Lalkaka

32. Compressive Myelopathies 2124 Chandrashekhar E Deopujari, Chandan Mohanty

SECTION 22 Psychiatric Medicine1. Assessment in Clinical Psychiatry 2133 Shubhangi R Parkar

2. Organic Mental Disorders 2138 PK Dalal, SK Kar

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xlix3. Substance Use Disorders 2143 Yatan Pal Singh Balhara

4. Psychosis and Schizophrenia 2149 Dinesh Kumar Kataria, Prerna Kukreti

5. Mood Disorders 2153 Ajita Nayak

6. Neurotic Disorders 2156 Henal R Shah

7. Emergency Psychiatry 2161 Bharat Panchal

8. Sexual Disorders 2164 Neena Sawant

9. Biological and Somatic Treatment of Psychiatric Disorders 2168 Sandeep Grover

10. Psychotherapies 2173 Mukesh Samani

11. Psychosomatic Disorders 2177 GK Vankar

SECTION 23 Critical Care Medicine1. Basic Considerations in Critical Care 2183 Dilip R Karnad

2. Approach to a Critically Ill Patient 2185 Mayur H Patel

3. Monitoring of Critically Ill Patients 2188 JV Peter

4. Respiratory Failure and Mechanical Ventilation 2193 Dhruva Chaudhry, Mansi Gupta

5. Fluid Balance 2199 Anuj M Clerk

6. Electrolyte Disturbances 2207 Srinivas Samavedam

7. Acid-base Disorders 2215 Shivakumar Iyer

8. Sepsis 2221 Suresh Ramasubban

9. Acute Respiratory Distress Syndrome 2225 Subhash Todi

10. Neurocritical Care, Brain Death and Organ Donation 2229 Kayanoosh Jay Kadapatti

11. Nutrition in the Critically Ill Patient 2233 JV Divatia, Jacob George

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l 12. Hemodynamic Disturbances and Shock 2239 Bhuvana Krishna, Sriram Sampath

SECTION 24 Poisoning & Toxicology1. Basic Considerations in Poisoning and Toxicology 2249 Praveen Aggarwal

2. Plant Poisoning 2252 DKS Subrahmanyam, Mukta Wyavahare

3. Recreational Drug Overdoses 2257 Narinder Pal Singh, Anish Kumar Gupta

4. Organophosphorus Compound Poisoning 2263 Trupti H Trivedi

5. Aluminium Phosphide and Other Metal Phosphide Poisoning 2267 Ashish Bhalla

6. Other Pesticide Poisoning 2269 Shashikala A Sangle, Neha R Suryawanshi

7. Toxic Alcohols 2272 ND Karnik

8. Toxic Gas Poisoning (Including Industrial Gases, CO Poisoning) 2275 Tejas Prajapati

9. Corrosive Acid and Alkali Poisoning 2279 Sandeep Garg, Pinkesh Parmar

10. Snakebite 2283 SP Kalantri, Sumedh Jajoo

11. Scorpion Sting 2289 Himmatrao Saluba Bawaskar, Pramodini Himmatrao Bawaskar

12. Heavy Metal Poisoning including Copper Sulphate 2297 Debendra Nath Guha Mazumder

13. Epidemic Dropsy 2303 Partha Sarathi Karmakar

14. Drug Overdose 2306 Vikas Loomba

15. Miscellaneous – Including Household and Other Poisoning 2314 Vikas Suri, Udit Narang

SECTION 25 Diagnostic Imaging1. Imaging Modalities – An Overview 2321 Saugata Sen

2. Plain Radiographs and Procedures 2325 Ashu Seith Bhalla

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li3. Role of Ultrasound in Medicine 2339 Nitin Chaubal

4. Computed Tomography 2348 Bhavin Jankharia

5. Magnetic Resonance Imaging 2359 Raju Sharma, Devasenathipathy Kandasamy

6. Nuclear Medicine 2372 BR Mittal, Harmandeep Singh

7. Patient Safety 2386 Bhavin Jankharia

SECTION 26 Gerontology1. Medicine in an Ageing World 2391 AB Dey, Indani Hrishikesh

2. Ageing Biology 2395 Indrajeet Singh Gambhir

3. Principles and Practice of Geriatrics and Therapeutics in Older Adults 2399 Y Sathyanarayana Raju, Yadati Rahul

4. Geriatric Syndromes 2402 Prashun Chatterjee

5. Preventive Geriatrics 2406 Arvind Mathur

SECTION 27 Other Specialities1. Immunisation in Adults, Travel Medicine and the Use of Vaccines 2411 Falguni S Parikh

2. Sexual Medicine 2419 Prakash Kothari

3. Sports and Exercise Medicine 2423 Aashish Contractor, Anant Joshi

4. Diet in Medical Disorders 2426 Sudha Vidyasagar

5. Tobacco Smoking - Related Diseases and Tobacco Cessation 2430 Raj Kumar

6. Perioperative Management 2437 Prabha Adhikari

7. Legalities in Medical Practice 2441 Amrita G Shenoy, Gopinath N Shenoy

8. Clinical Pharmacology for the Physician 2446 Urmila Thatte, Nayan Chaudhari

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lii 9. Yoga and Medicine 2451 BB Thakur, Damodar Thakur

10. Communication Skills 2455 Santosh Bandopant Salagre

11. Medical Ethics 2461 Sunil K Pandya

12. Palliative Care 2463 Mary Ann Muckaden

13. Insurance Medicine 2472 Asha Sapre

14. Regenerative Medicine: From Concept to Reality 2475 Soniya Nityanand, Naresh Kumar Tripathy

15. Futuristic Medicine 2483 Vishal Gupta, Priya Bhate