yellow fever virus by wendy buahin cheryl lamptey
Post on 19-Dec-2015
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TRANSCRIPT
Objectives
Background on Yellow Fever History of Yellow Fever What type of virus is it? Current events and topics Questions and Comments
What is Yellow Fever?
Acute viral disease
Caused by an aborvirus
RNA virus
Mosquitoes are the 1̊ vector
Human and Monkeys are affected
YFV History
Outbreak in Philadelphia
Spanish American War-1898
Virginia Outbreaks
Dr. Carlos Finlay
Dr. Walter Reed
Bold ExperimentDr. Carlos Finlay
Dr. Walter Reed
YFV Vaccine
Used since the 1930’s Scientists at the Rockefeller
Foundation in New York developed a live vaccine (17D)
The 17D vaccine was first tested in 1936 in New York and in 1937 in Brazil.
Classification
Group:Group IV ((+)ssRNA) Family: Flaviviridae Genus: Flavivirus Species: Yellow fever virus
YFV Complete Genome
http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=genome&gi=10413
Accession: NC_002031 Total Bases Sequenced: 10862 bp Completed: Jan 14, 2003.
Current Issues & Topics Minas Gerias, Brazil -Between January and March 2001, an outbreak of
jaundice and hemorrhagic fever occurred in the state of Minas Gerias, Southeast region of Brazil, in which a mortality rate of 53% was reported. Seroconversion, virus isolation, histopathological and immunohistochemical findings, and reverse transcription-polymerase chain reaction (RT-PCR) identified yellow fever virus (YFV) as the etiological agent responsible for the outbreak. Partial nucleotide sequence analysis from a fragment of the YFV genome spanning parts of nonstructural (NS) 5 gene and 3’ noncoding region (3’ UTR) showed that the YFV involved in this outbreak belongs to South American genotype 1 and differs from the Brazilian virus identified in 1966. J Med. Virol. 68:620-627, 2002
Norfolk, Virginia- The steamer Ben Franklin en route to NY from St. Thomas, Virgin Islands which had a YF epidemic raging, made an emergency stop at Hampton Roads. Her cargo contained the larvae of the Aedes aegypti and was a “Pandora’s Box”. By beginning of the winter frost 2,000 people had perished. http://www.norkolkhistorical.org/highlights.36.html
References http://en.wikipedia.org/ http://www.ncbi.nlm.nih.gov/ http://www.scholar.google.com http://www/cdc.gov http://www.astdhpphe.org Journal of Medical Virology 68:680-627
(2002)