Young Investigator Awards

Early Career Award Symposium

October 29, 2010

Jeanne Hardy

University of Massachusetts Amherst Department of Chemistry

Projects in the Hardy Lab

• Caspase-7

• Caspase-6

• CA-GFP

• Caspase-9

• Dengue Virus Protease

Protein engineering to make protein therapeutics

Drugs for neurodegeneration

Building an apoptosis reporting mouse to screen for drug toxicity

New class of allosteric inhibitors

New allosteric sites for treating a global health threat.

90’s helix

130’s helix

10 Å

PDB ID: 3K7E

Unique structural features of apo caspase-6Casp-7Casp-6

Sravanti Vaidya

Real-time imaging of single cells

FUTURE:

• Other colors CA-FP• Other proteases• CA-IRFP for whole mice & zebrafish

+ Apoptosis Inducer - Apoptosis Inducer

Table compiled during my first week here:Grant Due Date

Alliance for Cancer Gene Therapy (ACGT) 15-Sep

Beckman Foundation Young Investigator Award 1-Oct-06

Pew Scholars Program in the Biomedical Sciences 1-Nov

The Robert Leet & Clara Guthrie Patterson Trust 1-Nov

Kimmel Foundation Scholar Award Dec 2005?

Juvenile Diabetes Foundation Career Development Awards 16-Jan-06

   

Rita Allen Foundation Scholars 12-Jan-05

American Diabetes Association Career Development award 15-Jan-06

American Diabetes Association Career Development award 15-Jan-06

March of Dimes Basil O’Connor Starter Scholar Award 1-Feb

Concert for the Cure Boston Symphony - must be in first three years of faculty position - HMS only?

1-Apr-06

The David & Lucile Packard Foundation Fellowships 19-Apr-06

Damon Runyon 1-Jul-06

NSF Career Award 18-Jul-06

American Heart Association Scientist Development Grant 12-Jul-06

W. M. Keck Foundation- must have been faculty one but no more than 4 years.

Invitation

http://www.brandeis.edu/givingto/cfr/award-programs.pdf

Awards: Received1. The Medical

Foundation Smith New Investigator Award

2. The Beckman Foundation Young Investigator Award

3. Cottrell Scholar From Research Corporation

Awards: Received1. The Medical

Foundation Smith New Investigator Award

2. The Beckman Foundation Young Investigator Award

3. Cottrell Scholar From Research Corporation

Attempted1. The Medical Foundation Smith New

Investigator Award (Sept 2005)

2. The Beckman Foundation Young Investigator Award (June 2006)

3. Cottrell Scholar From Research Corporation (June 2008)

4. Did not make it through on-campus nomination for Packard 2006

5. NSF CAREER* (July 2007)

NIH R01 in Dec 2007

6. Packard Foundation Fellowship (July 2008)

7. HHMI Early Career Award (Jun 2008)

8. DreyfusTeacher-Scholar Award (Jan 2009)

Contributions to winning a “beauty contest”• Letters of recommendation are very important

– My Post Doc Advisor• Well-loved and well-respected, member of NAS

– Letter writers from Penn, Princeton & UCSF

• Pedigree was good• Unusual background academic/ Industrial

• UC Berkeley / Sunesis Pharmaceuticals

• Turned down jobs at Princeton, Georgia Tech and U. Illinois: the dept head could say that in his letter– I wrote a draft of the department head’s letter.

• Good Proposal

Elements of a Good YI Proposal• Unique idea within my expertise

– Some preliminary data, although not required

• Wrote to the audience

• Good collaborator– Full Professor at UCSD

• my prof when I was a grad student

• Good images

• I followed all the rules applications

An early proposal• Smith

• Can you talk to foundation donors.

Thanks!

The Beckman Foundation Young Investigator Award

NIH R01 GM080532

NSF FTF CCI CHE-0739227

American Cancer Society IRG

Research Corporation Cottrell Scholar Award

Center of Excellence in Apoptosis Research Co-PI: K.D. Tremblay

NSF IGERT in Cellular Engineering DGE-0654128

Genevieve Abbruzzese Jun Chu Lindsay Dawson Dan Fowler Sumana Ghosh Amanda Hogan Kristen Huber Joachim Moch Samantha NIcholls Daniel Seeman Sravanti Vaidya

Elih Velazquez Witold Witkowski Muslum Yildiz

http://people.chem.umass.edu/jhardy/