youscript, care, seattle, wa (usa)

YouScript® Precision PGx Analytics System

Saving Time. Savings Lives. Saving Money.


YouScript, a Traffic App for Navigating Medication Management

� Most comprehensive drug-gene and drug-drug interaction software

• 2,700 drugs & metabolites

• 11,500 clinical interaction notes

• 14,000 PubMed references & product inserts

• New data updated daily

� Population Risk Analysis

� Ranked Alternate Selector

� Incorporates herbals, over-the-counter and recreational drugs

� Genotype-based drug and dosage recommendations

� Only solution to factor multi-drug and cumulative effects

© 2016 YouScript Inc. All Rights Reserved.


National Priorities: Value-based Care & Precision Medicine

� 10% of healthcare costs spent treating adverse drug events (ADEs)

� 75% of all medicines are processed by genetic-specific enzymes

� More than 90% of the population have genetic variations that can increase their risk for ADEs

� ADEs increased by polypharmacy

� 15% or 50 million U.S. citizens take five or more medications, most are elderly

� 90% of Medicare Value-based by 2018, commercial plans following



Adverse Drug Event Impact Highest in 65+

� Occur in 5.7% of patients annually

� Occur in 33% of patients within

one year of discharge

� Cause 1 in 8 hospitalizations

� Cause 10.7% of readmissions



© 2007 - 2015 Genelex Corporation. All Rights Reserved.

Without YouScript most ADE Causing Interactions Missed

44%

19%

23%

14%

44% Identified by DDI systems

Drug–drug19% Identified by most PGx labs

Drug-gene37% Identified by YouScript alone

Drug-drug-geneMulti-drug

Evidence-based, the additional interaction warnings YouScript provides are derived from

>14,000 curated, peer-reviewed publications and established pharmacokinetic principles.


© 2007 - 2015 Genelex Corporation. All Rights Reserved.

Without YouScript most ADE Causing Interactions Missed

44%

19%

23%

14%

44% Identified by DDI systems

Drug–drug19% Identified by most PGx labs

Drug-gene37% Identified by YouScript alone

Drug-drug-geneMulti-drug

Evidence-based, the additional interaction warnings YouScript provides are derived from

>14,000 curated, peer-reviewed publications and established pharmacokinetic principles.

Only YouScript Covers Them All


Hospitalizations and ER visits increase with YouScript Calculated Risk

� Hospitalizations

� Emergency Department Visits

• Patients 65+ taking 3 or more drugs

including 1 or more impacted by

genetic variability.

• Adjusted for age, gender, race,

Charlson Comorbidity Index, and

known drug-drug interactions,

p<0.00001

0.440.48

0.51 0.5

0.710.77

0.84

0.94

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1

Zero(reference)

Low (>0-20%)

Medium (20-40%)

High (>40%)

YouScript Genetic Risk Score



YouScript Reduces Hospitalizations and ED visits

Testing and YouScript reports resulted in $1132 per patient savings in 4-months

39% reduction 71% reduction

0.00%

2.00%

4.00%

6.00%

8.00%

10.00%

12.00%

14.00%

16.00%

18.00%

Hospitalizations (p=.0273) ED visits (p=.0002)

untested arm

tested arm

© 2016 YouScript Inc. All Rights Reserved.J Med Econ. 2015 Oct 19:1-16

If reproduced across

Medicare, this would prevent

6.7M hospitalizations


Phase 2

CLIA/CAPPGx Testing as

needed:Laboratory analysis of

genotype for 75% most

commonly prescribed

drugs

Personalized Prescribing Suggestions

Genotype Results- CAP, CLIA, NYDOH

Cumulative Risk

Analysis –5 patents

Clinical Literature-14,800

references

Phase 3

YouScript© Actionable PGxReporting Tool

Phase 4

YouScript© Consult Tool:

Clinical Pharmacist or

Clinician Review

(80500)

Phase 5

YouScript© Clinical Decision Support Tool:Interactive Personalized

Prescribing Report

Web-based or EHR-

integrated

Phase 1

YouScript© Risk Stratification:Identify high-risk

polypharmacy patients

with physician

confirmation of

medication issues

*Patent pending



CustomersUnder Contract In Pipeline



Partners

Under Contract In Pipeline



YouScript Management

Chief Financial Officer

• 25+ years of Healthcare

Experience as CFO, COO, CEO

• Experienced in multiple system-

wide implementation

• Experienced in profit and non-

profit startups with VC funding

Janet Carbary

Chief Executive Officer

• 15+ years in Precision

Medicine and PGX analytics

• 20+ years Sales and

Business Development

• Experience managing fast

growth

• Babson MBA, Magna Cum

Laude

Dave GaretsKristine Ashcraft Chief Strategy Officer

• Internationally known HIT Expert

• 25 years CEO, CIO, industry

analyst and author

• HIMSS Analytics, Gartner,

Healthlink, Advisory Board

Company, Next Wave Health

Advisors, Mountain Summit

Advisors


John Nelson Chief Medical Officer

• MD, MPH, board-certified OB/GYN

• President, American Medical

Association, 2004-2005

• Served on Advisory Committee to the

Director of the NIH

• Charter member Prospective Payment

Assessment Commission (now

MedPAC)


“The integration of pharmacogenomic results into the electronic health record is a key

step in the promise of precision medicine to improve patient care. By connecting

electronically, YouScript and Epic are delivering on this promise.”

- Dr. Michael Raff, Director of the Genomics Institute, Multicare Health System

“YouScript’s clinical studies are impressive. Their results point to a tremendous

opportunity for healthcare organizations to enhance their clinical decision support and

improve the effectiveness of their population health programs.”

- Brad Strock, Genomic Workgroup Lead, Epic

© 2016 Genelex Corporation. All Rights Reserved.


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youscript, care, seattle, wa (usa)

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