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Fibril.lació auricular i stents a la Síndrome Coronària Aguda
Antonia Sambola MD, PhD, FESCUnitat Cures agudes cardiològiquesHospital universitari Vall d’Hebron
SCA i anticoagulants d’acció directa. Qüestions pràctiques
High risk bleeding…. NO longer contraindication for DES?
Ariotti S, JACC Cardiovasc Interv 2016;9:426–436.
RCT N= 828 patients
- indication to oral anticoagulants 12%- Patients with AF ???
ZEUS TRIAL
N=828
Philip Urban, Alexandre Abizaid, Ian T. Meredith, Stuart J. Pocock, Didier Carrié, Christoph Naber,
John Gregson, Samantha Greene, Hans Peter Stolland Marie-Claude Morice for the LEADERS FREE Investigators
Biolimus-Coated vs. Bare-Metal Coronary Stents in High Bleeding Risk Patients
Valgimigli M, J Am Coll Cardiol 2015;65:805–815.
N=2466
Summary
•The last European guidelines on myocardial revascularization recommend using DES in any PCI, irrespective of concomitant anticoagulant therapy.
•There is limited evidence suporting this strategy.
• it is difficult to extrapolate the results of these trials the full population of patients with AF.
Anticoagulants acció directa post-IAM. Associats a doble
antiagregació?
SCA i anticoagulants d’acció directa. Qüestions pràctiques
ANTITROMBOTICOS EN PACIENTES CON FA Y SCA
1.Rapsomaniki et al. Eur Heart J Qual Care Clin Outcomes 2016: 2; 172–1832.Wolf P et al, Stroke 1991;21:983–988; 3 Lamberts M et al Circ lation 2012 126 1185 1193
Tasa
s de
inci
denc
ia b
ruta
(e
vent
os p
or 1
00pe
rson
as-a
ño-±
EE)
Muerte por causas CV más IM más ictus isquémico
Hemorragia mortal y no mortal
0
10
20
30
40Triple terapia (AVK más AAS másclopidogrel)AVK más antiagregante plaquetario
DAP (AAS más clopidogrel)
La triple terapia con AVK reduce los eventos tromboembólicos, pero dobla el riesgo hemorrágico en pacientes con FA+ICP
Registro danés (2000-2009; N = 11 480 pacientes)
Lamberts M et al, Circulation 2012;126:1185–1193
Triple or dual therapy?Duration dual or triple therapy?
VKA or DOAC?
Which dose of DOAC?
Which DOAC?
Dose of anticoagulation in combination withantiplatelet agents
Lower rates of ISTH major or CRNM bleeding with dabigatran vs warfarin in patients with or without ACS (50% ACS)
Baseline characteristics were similar in patients with or without ACSACS, acute coronary syndrome; D, dabigatran; W, warfarin. Oldgren et al. Presented at AHA 2017
Patie
nts w
ith o
utco
me
even
t (%
)
14.7
27.8
D 110 mgdual therapy
(n=509)
W tripletherapy(n=475)
HR: 0.47 (95% CI: 0.35–0.63)
ACS
16,1
26,1
D 110 mgdual therapy
(n=472)
W tripletherapy(n=505)
Non-ACS
HR: 0.57 (95% CI: 0.43–0.76)
P for interaction = 0.34
20,5
27.1
0
5
10
15
20
25
30
35
D 150 mgdual therapy
(n=391)
W tripletherapy(n=369)
ACS Non-ACSP for interaction = 0.57
19,9
24,4
D 150 mgdual therapy
(n=372)
W tripletherapy(n=394)
HR: 0.67 (95% CI: 0.50–0.90)
HR: 0.76 (95% CI: 0.56–1.03)
Results were consistent for ISTH and TIMI classifications of major bleeding
(see Appendix I)
No significant interaction between treatment and patients with or without ACS in primary safety endpoint
22
Similar efficacy with dabigatran vs warfarin in patients with or without ACS (50% ACS)
15 mg
What type of antiplatelet agent?
Dual antiplatelet therapy choice in patients withindication for oral anticoagulation
Ticagrelor*†
(N=327)Clopidogrel†‡
(N=2398)
Indication for PCI, n (%)Stable angina/positive stress test
78 (23.9) 1104 (46.0)
Acute coronary syndrome
240 (73.4) 1135 (47.3)
Staged procedure or other¶ 70 (21.4) 562 (23.4)
DAPT trial complexity factors, n (%)
No clinical/proceduralfactor
67 (20.5) 941 (39.2)
Clinical complexity factor
193 (59.0) 981 (40.9)
Procedural complexity factor
16 (4.9) 254 (10.6)
Both clinical and procedural complexity factors
51 (15.6) 222 (9.3)
Sólo 16% con Ticagrelor
PIONEER-PCI REDUAL-PCI
Sólo 13% con Ticagrelor
ESC Guidelines 2017 and consensus documentEHRA2018
Valmigli ESC update antiplatelet EHJ 2017 Lip et al Europace 2018; Neumann ESC Guidelines myocardial revasc. EHJ 2018 Steffel EHRA consensus 2018
• Apixaban 5mg b.i.d or apixaban 2.5 mg b.i.d. if at least two of the following: age>_80 years, body weight <_60 kg or serum creatinine level >_1.5 mg/dL (133 lmol/l
• Dabigatran 110 mg b.i.d.; Edoxaban 60 mg q.d. or edoxaban 30 mg q.d. if any of the following: creatinine clearance (CrCl) of 30–50 mL/min, body weight <_60 kg, concomitant use of verapamil or quinidine or dronedarone;
• Rivaroxaban 20 mg q.d. or rivaroxaban 15 mg q.d. if CrCl 30–49 mL/min.
REGISTRATION• Early fee deadline: 20 December• Late fee deadline: 04 February
Acute Cardiovascular Care 2019 2-4 March 2019, Malaga, Spain
Programme highlights
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• 3i: Innovative, interactive, and inspiring education
• Test, explain, and translate 2018 ESC Guidelines
• Case-based and how-to sessions
Característica Grupo 115 mg de
rivaroxaban1 v/d + un
antiagregante plaquetario (N = 709)
Grupo 22,5 mg de
rivaroxaban2 v/d + DAP
(N = 709)
Grupo 3AVK + DAP(N = 706)
Inhibidor de P2Y12 en el periodo basal, n (%)
Clopidogrel 660 (93,1) 664 (93,7) 680 (96,3)
Prasugrel 12 (1,7) 11 (1,6) 5 (0,7)
Ticagrelor 37 (5,2) 34 (4,8) 21 (3,0)
Urgencia de la revascularización, n (%)
Programada 428 (60,4) 430 (60,6) 449 (63,6)
Urgente 281 (39,6) 279 (39,4) 257 (36,4)
Tipo de acontecimiento inicial, n (%)
IMSEST 130 (18,5) 129 (18,4) 123 (17,8)
IMEST 86 (12,3) 97 (13,8) 74 (10,7)
Angina inestable 145 (20,7) 148 (21,1) 164 (23,7)
Gibson CM et al, New Engl J Med 2016; doi: 10.1056/NEJMoa1611594]
COMPARISON WITH EXPERT CONSENSUS NORTH AMERICAN PERSPECTIVE